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Conserved domains on  [gi|496061270|ref|WP_008785777|]
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MULTISPECIES: membrane-bound lytic murein transglycosylase MltC [Citrobacter]

Protein Classification

membrane-bound lytic murein transglycosylase C( domain architecture ID 11485457)

membrane-bound lytic murein transglycosylase C catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
2-361 0e+00

membrane-bound lytic murein transglycosylase MltC;


:

Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 783.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270   2 MKKFLALAVIAPLLISCSSStKKGDSYNEAWVKDTNGFDILMGQFAHNIENLWGFKEVLIAGPKDYVKYTDQYQTRSHIN 81
Cdd:PRK11671   1 MKKYLALALIAPLLISCSST-KKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFNEVLIAGPKDYVKYTDQYQTRSHIN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  82 FDDGTITVETIAGTDPAGHLRRAIIKTLLMGDDPGSIDLYSDVDDIKISKEPFLYGQVVDNTGQPIRWEGRATNFANYLL 161
Cdd:PRK11671  80 FDDGTITIETIAGTNPAAHLRQAIIKTLLMGDDPGSIDLYSDVDDIPISKEPFLYGQVLDNTGQPIRWEGRASNFADYLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 162 QTRLKSRSNGLRIIYSVTINLVPNHLDKRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQH 241
Cdd:PRK11671 160 QNKLQSRSNGLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQH 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 242 SAGKDVFRSQGRSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAAN 321
Cdd:PRK11671 240 TAGKDVFRMKGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAAN 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 496061270 322 IINSMSPGDVYQTLTTRHPSAESRRYLYKVNSAQKSYRRR 361
Cdd:PRK11671 320 IINTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR 359
 
Name Accession Description Interval E-value
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
2-361 0e+00

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 783.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270   2 MKKFLALAVIAPLLISCSSStKKGDSYNEAWVKDTNGFDILMGQFAHNIENLWGFKEVLIAGPKDYVKYTDQYQTRSHIN 81
Cdd:PRK11671   1 MKKYLALALIAPLLISCSST-KKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFNEVLIAGPKDYVKYTDQYQTRSHIN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  82 FDDGTITVETIAGTDPAGHLRRAIIKTLLMGDDPGSIDLYSDVDDIKISKEPFLYGQVVDNTGQPIRWEGRATNFANYLL 161
Cdd:PRK11671  80 FDDGTITIETIAGTNPAAHLRQAIIKTLLMGDDPGSIDLYSDVDDIPISKEPFLYGQVLDNTGQPIRWEGRASNFADYLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 162 QTRLKSRSNGLRIIYSVTINLVPNHLDKRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQH 241
Cdd:PRK11671 160 QNKLQSRSNGLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQH 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 242 SAGKDVFRSQGRSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAAN 321
Cdd:PRK11671 240 TAGKDVFRMKGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAAN 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 496061270 322 IINSMSPGDVYQTLTTRHPSAESRRYLYKVNSAQKSYRRR 361
Cdd:PRK11671 320 IINTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR 359
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 197-356 6.13e-99

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.84  E-value: 6.13e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 197 MVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVFRSQ-GRSGTPSRSFLFDPASNIDTGTAY 275
Cdd:cd16893    2 IVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLgGKGGLPSKSYLFDPENNIDIGTAY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 276 LAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINSMSPGDVYQTLTTRHPSAESRRYLYKVNSAQ 355
Cdd:cd16893   82 LHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKAK 161


                 .
gi 496061270 356 K 356
Cdd:cd16893  162 K 162
Mltc_N pfam11873
Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found ...
 32-193 2.55e-96

Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found associated with pfam01464. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2.


Pssm-ID: 432150  Cd Length: 161  Bit Score: 283.37  E-value: 2.55e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270   32 WVKDTNGFDILMGQFAHNIENLWGFKEVLIAGPKDYVKYTDQYQTRSHINFDDGTITVETIAGTDPAGHLRRAIIKTLLM 111
Cdd:pfam11873   1 FAKDTNALDILVGQFSGNIEKIWGKNEVLVASKKDYVKYTDNYKSRAHIDFDKGIITIETLATKNPKAHLRNAIITTLLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  112 GDDPGSIDLYSDvDDIKISKEPFLYGQVVDNTGQPIRWEGRATNFANYLLQTRLKSRSNGLRIIYSVTINLVPNHLDKRA 191
Cdd:pfam11873  81 PDDPSDVDLYSD-KDIELSGKPFLYGQVLDQDGQPIRWEWRANRFADYLIKNKLKTRKKNGKKVYYVSIPMVANHLDQRA 159


                  ..
gi 496061270  192 HK 193
Cdd:pfam11873 160 YK 161
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 189-361 3.56e-45

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 155.15  E-value: 3.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 189 KRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVqHSAGKDVFRSQGRSgtPSRSFLFDPASN 268
Cdd:COG0741   98 RRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLM-PATARRLGLKLGLG--PSPDDLFDPETN 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 269 IDTGTAYLAMLNNVYLGgidnptsRRYAVITAYNGGAGSVLRVFSNDKIQAANIInsmspgdvyqtlttrhPSAESRRYL 348
Cdd:COG0741  175 IRAGAAYLRELLDRFDG-------DLVLALAAYNAGPGRVRRWLRRNGDRDGEII----------------PYAETRNYV 231

                        170
                 ....*....|...
gi 496061270 349 YKVNSAQKSYRRR 361
Cdd:COG0741  232 KKVLANYAIYRAG 244
 
Name Accession Description Interval E-value
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
2-361 0e+00

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 783.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270   2 MKKFLALAVIAPLLISCSSStKKGDSYNEAWVKDTNGFDILMGQFAHNIENLWGFKEVLIAGPKDYVKYTDQYQTRSHIN 81
Cdd:PRK11671   1 MKKYLALALIAPLLISCSST-KKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFNEVLIAGPKDYVKYTDQYQTRSHIN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  82 FDDGTITVETIAGTDPAGHLRRAIIKTLLMGDDPGSIDLYSDVDDIKISKEPFLYGQVVDNTGQPIRWEGRATNFANYLL 161
Cdd:PRK11671  80 FDDGTITIETIAGTNPAAHLRQAIIKTLLMGDDPGSIDLYSDVDDIPISKEPFLYGQVLDNTGQPIRWEGRASNFADYLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 162 QTRLKSRSNGLRIIYSVTINLVPNHLDKRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQH 241
Cdd:PRK11671 160 QNKLQSRSNGLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQH 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 242 SAGKDVFRSQGRSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAAN 321
Cdd:PRK11671 240 TAGKDVFRMKGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAAN 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 496061270 322 IINSMSPGDVYQTLTTRHPSAESRRYLYKVNSAQKSYRRR 361
Cdd:PRK11671 320 IINTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR 359
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 197-356 6.13e-99

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.84  E-value: 6.13e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 197 MVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVFRSQ-GRSGTPSRSFLFDPASNIDTGTAY 275
Cdd:cd16893    2 IVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLgGKGGLPSKSYLFDPENNIDIGTAY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 276 LAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINSMSPGDVYQTLTTRHPSAESRRYLYKVNSAQ 355
Cdd:cd16893   82 LHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKAK 161


                 .
gi 496061270 356 K 356
Cdd:cd16893  162 K 162
Mltc_N pfam11873
Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found ...
 32-193 2.55e-96

Membrane-bound lytic murein transglycosylase C, N-terminal domain; This domain is found associated with pfam01464. It is the N-terminal structural domain of MltC (Membrane-bound lytic murein transglycosylase C), one of the seven lytic transglycosylases found in the genome of the Gram-negative bacterium Escherichia coli. The role of the N-terminal domain is suggested to be important not as a mere structural extension of the active site beyond what is seen in other lytic transglycosylases but one that creates a peptide-binding site at position +2.


Pssm-ID: 432150  Cd Length: 161  Bit Score: 283.37  E-value: 2.55e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270   32 WVKDTNGFDILMGQFAHNIENLWGFKEVLIAGPKDYVKYTDQYQTRSHINFDDGTITVETIAGTDPAGHLRRAIIKTLLM 111
Cdd:pfam11873   1 FAKDTNALDILVGQFSGNIEKIWGKNEVLVASKKDYVKYTDNYKSRAHIDFDKGIITIETLATKNPKAHLRNAIITTLLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  112 GDDPGSIDLYSDvDDIKISKEPFLYGQVVDNTGQPIRWEGRATNFANYLLQTRLKSRSNGLRIIYSVTINLVPNHLDKRA 191
Cdd:pfam11873  81 PDDPSDVDLYSD-KDIELSGKPFLYGQVLDQDGQPIRWEWRANRFADYLIKNKLKTRKKNGKKVYYVSIPMVANHLDQRA 159


                  ..
gi 496061270  192 HK 193
Cdd:pfam11873 160 YK 161
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 189-361 3.56e-45

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 155.15  E-value: 3.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 189 KRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVqHSAGKDVFRSQGRSgtPSRSFLFDPASN 268
Cdd:COG0741   98 RRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLM-PATARRLGLKLGLG--PSPDDLFDPETN 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 269 IDTGTAYLAMLNNVYLGgidnptsRRYAVITAYNGGAGSVLRVFSNDKIQAANIInsmspgdvyqtlttrhPSAESRRYL 348
Cdd:COG0741  175 IRAGAAYLRELLDRFDG-------DLVLALAAYNAGPGRVRRWLRRNGDRDGEII----------------PYAETRNYV 231

                        170
                 ....*....|...
gi 496061270 349 YKVNSAQKSYRRR 361
Cdd:COG0741  232 KKVLANYAIYRAG 244
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
189-354 4.81e-44

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 150.89  E-value: 4.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 189 KRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVFRSQGRSGTPSRSFLFDPASN 268
Cdd:PRK15470  34 QRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERN 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 269 IDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINSMSPGDVYQTLTTRHPSAESRRYL 348
Cdd:PRK15470 114 ISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLEHVARNHPAPQAPRYI 193


                 ....*.
gi 496061270 349 YKVNSA 354
Cdd:PRK15470 194 YKLEQA 199
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 198-323 1.10e-35

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 125.88  E-value: 1.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  198 VRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVFRsqgrsGTPSRSFLFDPASNIDTGTAYLA 277
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR-----VNPGVDDLFDPEKNIKAGTKYLK 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 496061270  278 MLNNVYLGgidnptsRRYAVITAYNGGAGSVLRVFSNDKIQAANII 323
Cdd:pfam01464  76 ELYKQYGG-------DLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 193-356 7.45e-31

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 114.14  E-value: 7.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 193 KYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQhSAGKDVFRSQGRSGTpSRSFLFDPASNIDTG 272
Cdd:cd16896    3 KYREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMP-ETAEWIAEKLGLEDF-SEDDLYDPETNIRLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 273 TAYLAMLNNVYLGGIDnptsrryAVITAYNGGAGSVLR-----VFSNDKIQAANIinsmspgdvyqtlttrhPSAESRRY 347
Cdd:cd16896   81 TWYLSYLLKEFDGNLV-------LALAAYNAGPGNVDKwlkdgGWSGDGKTLDQI-----------------PFPETRHY 136


                 ....*....
gi 496061270 348 LYKVNSAQK 356
Cdd:cd16896  137 VKKVLKNYK 145
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 194-308 3.96e-27

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 104.48  E-value: 3.96e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 194 YVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQhSAGKDVFRSQGRSgTPSRSFLFDPASNIDTGT 273
Cdd:cd13401    6 YRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMP-ATAKDVAKKLGLP-YYSPRDLFDPEYNIRLGS 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 496061270 274 AYLAMLNNVYLGgidnptSRRYAVItAYNGGAGSV 308
Cdd:cd13401   84 AYLAELLDRFDG------NPVLALA-AYNAGPGRV 111
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 209-356 1.85e-22

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 90.74  E-value: 1.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 209 ESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVFRSQGRsgtpsrsfLFDPASNIDTGTAYLAMLNNVYLGGId 288
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRGVDD--------LFDPEENIRAGARYLRELLDRFGGDL- 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496061270 289 nptsrrYAVITAYNGGAGSVLRVFSNDKIqaaniinsmspgdvyqtlttrhPSAESRRYLYKVNSAQK 356
Cdd:cd00254   72 ------ELALAAYNAGPGAVDRWGGGEVP----------------------PYKETRNYVQRVLAYYQ 111
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 185-310 1.50e-18

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 86.27  E-value: 1.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 185 NHLDKRAHKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQhSAGKDVfrsqgrsGTPSRsflFD 264
Cdd:COG4623  255 RRIEGRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMP-ATAKEL-------GVDDR---LD 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 496061270 265 PASNIDTGTAYLAMLNNVYLGGIDNPTsRRYAVITAYNGGAGSVLR 310
Cdd:COG4623  324 PEQSIRAGAKYLRWLYDRFPEAIDEPD-RWWFALAAYNAGPGHVQD 368
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 198-310 4.49e-16

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 74.88  E-value: 4.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 198 VRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVvqhsagkdvfrsqgrsgTPS--RSF----LFDPASNIDT 271
Cdd:cd13403    1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQL-----------------MPStaRELgvndRLDPEQNIHA 63

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 496061270 272 GTAYLAMLNNVYLGGIDnPTSRRYAVITAYNGGAGSVLR 310
Cdd:cd13403   64 GAKYLRYLRDRFPPDID-EPDRLKFALAAYNAGPGHVRD 101
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 199-359 1.16e-11

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 65.85  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 199 RQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAGKDVfRSQGRSGTPSRSFLFDPASNIDTGTAYlam 278
Cdd:PRK11619 484 RRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTV-KMFSIPGYSSSSQLLDPETNINIGTSY--- 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 279 LNNVYLGGIDNptsrRYAVITAYNGGAGSVLRVFSN--DKIQAANIINSMspgdvyqtlttrhPSAESRRYLYKVNSAQK 356
Cdd:PRK11619 560 LEYVYQQFGNN----RILASAAYNAGPGRVRTWLGNsaGRIDAVAFVESI-------------PFSETRGYVKNVLAYDA 622


                 ...
gi 496061270 357 SYR 359
Cdd:PRK11619 623 YYR 625
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 205-278 9.47e-09

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 52.53  E-value: 9.47e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496061270 205 YGVDESLILAIMQTESSFNPYAVSH-----ADaLGLMQVvqHSAGKDVFRSQGRSgtpSRSFLFDPASNIDTGTAYLAM 278
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRnkngsYD-IGLMQI--NSIWLPELARYGIT---REELLNDPCTNIYVGAWILAR 73
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 205-237 2.70e-06

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 45.76  E-value: 2.70e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 496061270 205 YGVDESLILAIMQTESSFNPYAV-SHADALGLMQ 237
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQ 34
PHA00368 PHA00368
internal virion protein D
 192-285 1.85e-05

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 46.70  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270  192 HKYVGMVRQASRKYGVDESLILAIMQTESSFNPYAVSHADALGLMQVvqhsaGKDVFRSQGRSGTPSRSflFDPASNIDT 271
Cdd:PHA00368    9 SEYDGLFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQF-----TKATAKALGLIVDDDDR--LDPELAIDA 81

                          90
                  ....*....|....
gi 496061270  272 GTAYLAMLNNVYLG 285
Cdd:PHA00368   82 GARYLADLVGKYDG 95
PRK15328 PRK15328
type III secretion system invasion protein IagB;
200-304 2.68e-05

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 44.09  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 200 QASRKYGVDESLILAIMQTESSFNPYAVSH----ADALGLMQVvqHSAGkdvFRSQGRSGTPSRSFLFDPASNIDTGTAY 275
Cdd:PRK15328  24 QAEKMFNIESELLYAIAQQESAMKPGAIGHnrdgSTDLGLMQI--NSFH---MKRLKKMGISEKQLLQDPCISVIVGASI 98

                         90       100
                 ....*....|....*....|....*....
gi 496061270 276 LAMLNNVYlggidnptSRRYAVITAYNGG 304
Cdd:PRK15328  99 LSDMMKIY--------GYSWEAVGAYNAG 119
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 203-350 4.60e-05

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 42.50  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 203 RKYGVDESLI-LAImqTESSFNPYAVSHADALGLMQvvqhsagkdvF-RSQGRS-GTPSRSFL---FDPASNIDTGTAYL 276
Cdd:cd16894    2 LKEGLPEELKyLAL--VESGFNPDAVSSAGAAGLWQ----------FmPATAREyGLRVDSWVderRDPEKSTRAAARYL 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496061270 277 ----AMLNNVYLggidnptsrryaVITAYNGGAGSVLRVFSNDKIQAANIINSMspgdvyqtlttrHPSAESRRYLYK 350
Cdd:cd16894   70 kdlyKRFGDWLL------------ALAAYNAGEGRVRRAIKRAGTDKWEDYYRL------------YLPAETRRYVPK 123
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 189-308 1.26e-04

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 42.20  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 189 KRAHKYVGMVRQASRKYGVDESLILAIMQTESSF-----NPYAVSHADALGLMQVvqhsagkDVfRSQGRSGTPsrsflf 263
Cdd:cd01021   32 NRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAgaaldKNGWGDHGNGFGLMQV-------DK-RYHPPKGAW------ 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 496061270 264 DPASNIDTGTAYLAmlnnVYLGGIDN--PT-SRRYAV---ITAYNGGAGSV 308
Cdd:cd01021   98 DSEEHIEQATGILI----DFIKTVQRkhPSwSPEQQLkggIAAYNAGVGNV 144
CwlT-like cd16891
CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall ...
 194-306 6.88e-04

CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381612 [Multi-domain]  Cd Length: 151  Bit Score: 39.51  E-value: 6.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 194 YVGMVRQASRKYGVDE--SLILAIMQTESSFNpyavshadalglmqvvqhsaGKDVFRSQGRSGTPSRSFLfDPASNIDT 271
Cdd:cd16891    1 YRPLVEKEAKKYGIPEyvPLILAIIMQESGGK--------------------GPDIMQSSESAGLPPNTIT-DPEESIEQ 59

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 496061270 272 GTAYLA-MLN--NVYLGGIDnptsrryAVITAYNGGAG 306
Cdd:cd16891   60 GVKYFAdVLKkaKGKGVDIW-------TAVQAYNFGGG 90
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 206-320 6.88e-04

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 39.45  E-value: 6.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 206 GVDESLILAIMQTESSFNPYAV------------SHADA---------------LGLMQV-VQHsagkdvFRSQGRSGtp 257
Cdd:cd16892    8 GVHPETLAAIVQVESGGNPYAIgvnggklsrqpkTKAEAiatarqliaaghnfdVGLGQInSRN------LARLGLTV-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496061270 258 srSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNggAGSVLRVFSN---DKIQAA 320
Cdd:cd16892   80 --EDVFDPCTNLKAGATILTECYARAKKTGGDGQAALRAALSCYN--TGNFTRGFSNgyvQKVVAA 141
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 212-275 2.23e-03

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 35.85  E-value: 2.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496061270 212 ILAIMQTESSFNP--YAVSHADALGLMQVVQhsagkdvfRSQGRSGTPSRSFLFDPASNIDTGTAY 275
Cdd:cd00442    2 LAAIIGQESGGNKpaNAGSGSGAAGLFQFMP--------GTWKAYGKNSSSDLNDPEASIEAAAKY 59
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
185-309 5.65e-03

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 38.70  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496061270 185 NHLDKRAHKYVGMVRQASRkyGVDESLILAIMQTESSFNPYAVSHADALGLMQVVQHSAgKDVfrsqgrsGTPSRsflFD 264
Cdd:PRK10859 281 RAIDNRLPKYQPLFEKYAG--ELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTA-QSM-------GVTDR---LD 347

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 496061270 265 PASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAvITAYNGGAGSVL 309
Cdd:PRK10859 348 PEQSIRGGARYLQDLMERLPESIPEPERIWFA-LAAYNIGYGHML 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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