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Conserved domains on  [gi|496070619|ref|WP_008795126|]
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MULTISPECIES: MFS transporter [Fusobacterium]

Protein Classification

MFS transporter( domain architecture ID 13023745)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  23403214|26758938|26234418|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 12-409 5.50e-78

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 248.67  E-value: 5.50e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  12 YALG-VSYAIVDQIFAQWILYFYLPSANsslkpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGT 90
Cdd:cd17332    4 YGLGdFGNNLIFQIVSTYLLFFYTDVLG------LSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  91 IPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPG 170
Cdd:cd17332   78 IPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 171 ILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEV-SKVSFKDTIGIIIRNKNFILYLFGMMFFFIGF 249
Cdd:cd17332  158 PLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEkSKLPLLKSLKALLKNRPFLILLLAYLLYFLAF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 250 NNLRAIMNYYVEDIMgyGKKEITNASALLFGAAAICFYPTNK-LSKKYGYRKIMLCCLAMLIVTTSMLFFLGKifPVNFG 328
Cdd:cd17332  238 NIVNTVLVYYFKYVL--GGRAELVLLLLLILSGALLALLPWPpLKKRFGKKKAFFIGLLLAILGLLLLFFLPP--GNLVL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 329 FVLFALIGIPLAGAAFIFPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGNGVSIISAITSG 408
Cdd:cd17332  314 ILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSAS 393


                 .
gi 496070619 409 A 409
Cdd:cd17332  394 A 394
 
Name Accession Description Interval E-value
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 12-409 5.50e-78

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 248.67  E-value: 5.50e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  12 YALG-VSYAIVDQIFAQWILYFYLPSANsslkpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGT 90
Cdd:cd17332    4 YGLGdFGNNLIFQIVSTYLLFFYTDVLG------LSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  91 IPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPG 170
Cdd:cd17332   78 IPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 171 ILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEV-SKVSFKDTIGIIIRNKNFILYLFGMMFFFIGF 249
Cdd:cd17332  158 PLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEkSKLPLLKSLKALLKNRPFLILLLAYLLYFLAF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 250 NNLRAIMNYYVEDIMgyGKKEITNASALLFGAAAICFYPTNK-LSKKYGYRKIMLCCLAMLIVTTSMLFFLGKifPVNFG 328
Cdd:cd17332  238 NIVNTVLVYYFKYVL--GGRAELVLLLLLILSGALLALLPWPpLKKRFGKKKAFFIGLLLAILGLLLLFFLPP--GNLVL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 329 FVLFALIGIPLAGAAFIFPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGNGVSIISAITSG 408
Cdd:cd17332  314 ILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSAS 393


                 .
gi 496070619 409 A 409
Cdd:cd17332  394 A 394
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-400 3.49e-73

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 236.72  E-value: 3.49e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   1 MKKLTTKVQVLYALG-VSYAIVDQIFAQWILYFYLPSAnsslkpFMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKY 79
Cdd:COG2211    4 KKKLSLKEKLAYGLGdLGLNLAFGLLSAYLLYFYTDVL------GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  80 GRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRL 159
Cdd:COG2211   78 GRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 160 SYTAIAIIFPGILIKMIGGkDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEvsKVSFKDTIGIIIRNKNFILYL 239
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE--KVSLKESLKALLKNRPFLLLL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 240 FGMMFFFIGFNNLRAIMNYYVEDIMGYGKKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFL 319
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 320 GkIFPVNFGFVLFALIGIPLaGAAFIFPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGNGV 399
Cdd:COG2211  315 G-PGNLWLLLVLAALAGIGL-GAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392


                 .
gi 496070619 400 S 400
Cdd:COG2211  393 A 393
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 15-393 5.31e-38

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 142.83  E-value: 5.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   15 GVSYAIVDQIFAQWILYFYLPSANsslkpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGTIPLV 94
Cdd:pfam13347   6 ALAAGIKYAGLATYLLYFYTDVLG------LSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   95 LVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPGILIK 174
Cdd:pfam13347  80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  175 MIGG-KDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEV-----SKVSFKDTIGIIIRNKNFILYLFGMMFFFIG 248
Cdd:pfam13347 160 ILGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEdtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  249 FNNLRAIMNYYVEDIMGYGkKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNFg 328
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNG-FAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLF- 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496070619  329 FVLFALIGIPLAGAAFIfPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIIL 393
Cdd:pfam13347 318 LVLYIIIGFGYGSSFFL-PWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLL 381
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
 12-397 3.73e-32

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 126.98  E-value: 3.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   12 YALG-VSYAIVDQIFAQWILYFYLPSAnsslkpFMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGT 90
Cdd:TIGR00792   4 YGFGdFGNDFIFAIVSTYLLFFYTDVL------GLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   91 IPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPG 170
Cdd:TIGR00792  78 IPFSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  171 ILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYST--GEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIG 248
Cdd:TIGR00792 158 PLVSYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIpkNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  249 FNNLRAIMNYYVEDIMGYGKK-EITNASALLFGAAAICFYPtnKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNF 327
Cdd:TIGR00792 238 FNIKNGVQVYYFTYVLGDPELfSYMGSIAIVAGLIGVLLFP--RLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLIL 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  328 GFVLFALIGIPLAGAAFIfppAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGN 397
Cdd:TIGR00792 316 VLIILAGFGQNIVTGLVW---ALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIG 382
PRK11462 PRK11462
putative transporter; Provisional
 4-210 9.90e-20

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 91.15  E-value: 9.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   4 LTTKVQVLYALG--VSYAIVDQIFAqWILYFYLpsansslKPFMAPI-LVSIALAVSRFVDMITDPLVGFLSDKYNSKYG 80
Cdd:PRK11462   6 LSVKEKIGYGMGdaASHIIFDNVML-YMMFFYT-------DIFGIPAgFVGTMFLVARALDAISDPCMGLLADRTRSRWG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  81 RRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLS 160
Cdd:PRK11462  78 KFRPWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATA 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 496070619 161 YTAIAIIFPGILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRER 210
Cdd:PRK11462 158 GGMLSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKER 207
 
Name Accession Description Interval E-value
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 12-409 5.50e-78

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 248.67  E-value: 5.50e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  12 YALG-VSYAIVDQIFAQWILYFYLPSANsslkpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGT 90
Cdd:cd17332    4 YGLGdFGNNLIFQIVSTYLLFFYTDVLG------LSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  91 IPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPG 170
Cdd:cd17332   78 IPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 171 ILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEV-SKVSFKDTIGIIIRNKNFILYLFGMMFFFIGF 249
Cdd:cd17332  158 PLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEkSKLPLLKSLKALLKNRPFLILLLAYLLYFLAF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 250 NNLRAIMNYYVEDIMgyGKKEITNASALLFGAAAICFYPTNK-LSKKYGYRKIMLCCLAMLIVTTSMLFFLGKifPVNFG 328
Cdd:cd17332  238 NIVNTVLVYYFKYVL--GGRAELVLLLLLILSGALLALLPWPpLKKRFGKKKAFFIGLLLAILGLLLLFFLPP--GNLVL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 329 FVLFALIGIPLAGAAFIFPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGNGVSIISAITSG 408
Cdd:cd17332  314 ILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSAS 393


                 .
gi 496070619 409 A 409
Cdd:cd17332  394 A 394
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-400 3.49e-73

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 236.72  E-value: 3.49e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   1 MKKLTTKVQVLYALG-VSYAIVDQIFAQWILYFYLPSAnsslkpFMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKY 79
Cdd:COG2211    4 KKKLSLKEKLAYGLGdLGLNLAFGLLSAYLLYFYTDVL------GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  80 GRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRL 159
Cdd:COG2211   78 GRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 160 SYTAIAIIFPGILIKMIGGkDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEvsKVSFKDTIGIIIRNKNFILYL 239
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE--KVSLKESLKALLKNRPFLLLL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 240 FGMMFFFIGFNNLRAIMNYYVEDIMGYGKKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFL 319
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 320 GkIFPVNFGFVLFALIGIPLaGAAFIFPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGNGV 399
Cdd:COG2211  315 G-PGNLWLLLVLAALAGIGL-GAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392


                 .
gi 496070619 400 S 400
Cdd:COG2211  393 A 393
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 15-393 5.31e-38

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 142.83  E-value: 5.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   15 GVSYAIVDQIFAQWILYFYLPSANsslkpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGTIPLV 94
Cdd:pfam13347   6 ALAAGIKYAGLATYLLYFYTDVLG------LSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   95 LVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPGILIK 174
Cdd:pfam13347  80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  175 MIGG-KDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEV-----SKVSFKDTIGIIIRNKNFILYLFGMMFFFIG 248
Cdd:pfam13347 160 ILGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEdtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  249 FNNLRAIMNYYVEDIMGYGkKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNFg 328
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNG-FAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLF- 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496070619  329 FVLFALIGIPLAGAAFIfPPAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIIL 393
Cdd:pfam13347 318 LVLYIIIGFGYGSSFFL-PWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLL 381
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
 12-397 3.73e-32

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 126.98  E-value: 3.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   12 YALG-VSYAIVDQIFAQWILYFYLPSAnsslkpFMAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGT 90
Cdd:TIGR00792   4 YGFGdFGNDFIFAIVSTYLLFFYTDVL------GLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   91 IPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPG 170
Cdd:TIGR00792  78 IPFSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  171 ILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYST--GEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIG 248
Cdd:TIGR00792 158 PLVSYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIpkNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  249 FNNLRAIMNYYVEDIMGYGKK-EITNASALLFGAAAICFYPtnKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNF 327
Cdd:TIGR00792 238 FNIKNGVQVYYFTYVLGDPELfSYMGSIAIVAGLIGVLLFP--RLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLIL 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  328 GFVLFALIGIPLAGAAFIfppAMLSEISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGN 397
Cdd:TIGR00792 316 VLIILAGFGQNIVTGLVW---ALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIG 382
PRK11462 PRK11462
putative transporter; Provisional
 4-210 9.90e-20

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 91.15  E-value: 9.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   4 LTTKVQVLYALG--VSYAIVDQIFAqWILYFYLpsansslKPFMAPI-LVSIALAVSRFVDMITDPLVGFLSDKYNSKYG 80
Cdd:PRK11462   6 LSVKEKIGYGMGdaASHIIFDNVML-YMMFFYT-------DIFGIPAgFVGTMFLVARALDAISDPCMGLLADRTRSRWG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  81 RRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLS 160
Cdd:PRK11462  78 KFRPWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATA 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 496070619 161 YTAIAIIFPGILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRER 210
Cdd:PRK11462 158 GGMLSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKER 207
PRK10429 PRK10429
melibiose:sodium transporter MelB;
45-379 3.71e-16

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 80.53  E-value: 3.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  45 MAPILVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFT 124
Cdd:PRK10429  39 LSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILIGTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGM 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 125 FYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRlSYTAIAIIFPGIL-IKMIGGKDELFGIRGMIIFLCVIVFVGLAVT 203
Cdd:PRK10429 119 TYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFA-SLAGFVTAGFTLPfVNYVGGGDRGFGFQMFTLVLIAFFIVSTIIT 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 204 VFTVRERDYSTGEVS----KVSFKDTIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGYGKK-EITNASALL 278
Cdd:PRK10429 198 LRNVHEVYSSDNQVSaegsHLTLKDIVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLfPYYLSYAGA 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 279 FGAAAICFYPtnKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNFGFVLFALIGIPLAGAAFI-FPPAMLSEISTQ 357
Cdd:PRK10429 278 ANLVTLILFP--RLVKSLSRRILWAGASIFPVLSCGVLLLMGLAAPHNALLIVIAGILLNIGTALFWvLQVIMVADTVDY 355

                        330       340
                 ....*....|....*....|..
gi 496070619 358 ISEESGARIEGISFGIQGFFMK 379
Cdd:PRK10429 356 GEYKLGIRCESIAYSVQTMVVK 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 45-378 3.67e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 70.68  E-value: 3.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  45 MAPILVSIALAVSRFVDMITDPLVGFLSDKYnskyGRRIPFIAvGTIPLVLVTIAFFYppmsnekASFYYLMIVGSLFFT 124
Cdd:cd17325   28 ASVAQIGLIVAAYALAQLLFSPPAGRLSDRF----GRKRLLLL-GLLLLAVSTLLFAF-------ATSYWQLLLARFLQG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 125 FYT-IVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYtAIAIIFPGILIkmiggkdELFGIRGMIIFLCVIVFVGLAVT 203
Cdd:cd17325   96 LASaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGF-LIGPLLGGLLA-------DALGYRAPFLVCAALALLALVLA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 204 VFTVRERD--YSTGEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGYGKKEITNASALLFGA 281
Cdd:cd17325  168 LLLLPEPRppPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 282 AAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVnfgFVLFALIGIplaGAAFIFPPamlseISTQISEE 361
Cdd:cd17325  248 SALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL---LLLLALLGL---GLGLVFPA-----TLALLADI 316

                        330
                 ....*....|....*..
gi 496070619 362 SGARIEGISFGIQGFFM 378
Cdd:cd17325  317 VPPEGRGTAMGLFNTAF 333
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 49-408 1.43e-12

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 69.19  E-value: 1.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  49 LVSIALAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGtIPLVLVTIA-------FFYPPMSNEKASFYYLMIVGSL 121
Cdd:cd17313   35 LIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVG-APLAALGLIlipnaadIGLALGDGPRTWALVLFVLGIV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 122 FFTFYT-IVGAPYNALIPEIGRTPEERLNLStWQSVFRLSYTAIAIIFPGILIKMIGGKDELFGIRGMIIFLCVIVFVG- 199
Cdd:cd17313  114 LLDFAMnVCQGPVRALLPDLVPPEQRSKANG-IINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVc 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 200 LAVTVFTVRERDYST------GEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIGFnNLRAIMNYYVeDIMGYGKKEITN 273
Cdd:cd17313  193 VLVTLFFVKEPPLSPeagehsENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWI-AFFPFELFFT-DYMGEEVYHGTS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 274 ASALLFG---------------AAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVnfgFVLFALIGIP 338
Cdd:cd17313  271 AASSHYGagvrmgawgllifslAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVA---LVLFALGGIG 347

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 339 LAgAAFIFPPAMLSEISTQISEESGARIEGISFGIQgffmKTSFLISIVTLPIILVMGNGVSIISAITSG 408
Cdd:cd17313  348 WA-TININPYPLVSDYHSESGRGQGTDTGLLNLAIS----LAQILVSLLAGPIIDVKGYGTVFPVAAVAS 412
PRK09669 PRK09669
putative symporter YagG; Provisional
 1-379 2.56e-12

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 68.21  E-value: 2.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   1 MKKLTTKVQVLYALG-VSYAIVDQIFAQWILYFY-----LPSAnsslkpfmapILVSIALAVsRFVDMITDPLVGFLSDK 74
Cdd:PRK09669   3 TSQLTTKDKIGYGLGdTACNLVWQTVMLFLAYFYtdvfgLSAA----------IMGTMFLVV-RVLDAVTDPLMGALVDR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  75 YNSKYGRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQ 154
Cdd:PRK09669  72 TRTRHGQFRPYLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWR 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 155 svFRLSyTAIAIIFPGI---LIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERdYSTGEVSKVSFKDTIGIIIR 231
Cdd:PRK09669 152 --FALS-FIGGLIVSVIalpLVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKER-YTPEVDNSSSVWKDLKLLLG 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 232 NKNF-ILYLFGMMFFFIGFNNLRAIMnYYVEDIMGYGKKE----ITNASALLFGAaaicfYPTNKLSKKYGYRKIMLCCL 306
Cdd:PRK09669 228 NSQWrIMFIFNVVLLTAVVTRGGATL-YYVNYVLLRPDLAtlflVTGMIAGLFGA-----LLSERLLGKFDRVRAFKWTI 301

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496070619 307 AMLIVTTSMLFF-----LGKIFPVNFGFVLFALIGIPLAGaafifppAMLSEISTQISEESGARIEGISFGIQGFFMK 379
Cdd:PRK09669 302 VAFVILSALIFFippsnVWLIFALNILFNFIQNLTTPLQW-------SMFSDVVDYEEKRSGRRLDGLVFSTNLFAIK 372
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-402 6.09e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.60  E-value: 6.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  16 VSYAIVDQIFAQWILYFYLPSANSSLKpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYnskygRRIPFIAVGTIPLVL 95
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFG--LSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLFAL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  96 VTIAFFYPPmsnekaSFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPGILIKm 175
Cdd:cd06174   74 GALLFAFAP------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 176 iggkdELFGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEVSKV----SFKDTIGIIIRNKNFILYLFGMMFFFIGFNN 251
Cdd:cd06174  147 -----LGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEasskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 252 LRAIMNYYVEDIMGYGKKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLccLAMLIVTTSMLFFLGKIFPVNFGFVL 331
Cdd:cd06174  222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL--LIGLLLMALGLALLLLAPSLLLLLLL 299

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496070619 332 FALIGIPLAGAAFIfppamlseISTQISEESGARIEGISFGIQGFFMKTSFLISIVTLPIILVMGNGVSII 402
Cdd:cd06174  300 LLLLGFGLGGLLPL--------SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362
PRK09848 PRK09848
glucuronide transporter; Provisional
 54-380 4.06e-10

glucuronide transporter; Provisional


Pssm-ID: 182109 [Multi-domain]  Cd Length: 448  Bit Score: 61.34  E-value: 4.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  54 LAVSRFVDMITDPLVGFLSDKYNSKYGRRIPFIAVGTIPLVLVTIAFFYPPMS-NEKASFYYLMIVGSLFFTFYTIVGAP 132
Cdd:PRK09848  50 LLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLFGTAPLMIFSVLVFWVPTDwSHSSKVVYAYLTYMGLGLCYSLVNIP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 133 YNALIPEIGRTPEERLNLSTWQSVF-RLSYTAIAIIFpGILIKMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTVRERD 211
Cdd:PRK09848 130 YGSLATAMTQQPQSRARLGAARGIAaSLTFVCLAFLI-GPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENV 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 212 YStgEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGYGK--KEITNASALLFGAAAICFYPt 289
Cdd:PRK09848 209 VR--IVAQPSLKISLQTLKRNRPLFMLCIGALCVLISTFAVSASSLFYVRYVLNDTGlfTVLVLVQNLVGTVASAPLVP- 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 290 nKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKI-FPVNFGFVLFALIGIplaGAAFIFPPAMLSEISTQISEESGARIEG 368
Cdd:PRK09848 286 -GMVARIGKKNTFLIGALLGTCGYLLFFWVSVWsLPVALVALAIASIGQ---GVTMTVMWALEADTVEYGEYLTGVRIEG 361

                        330
                 ....*....|..
gi 496070619 369 ISFGIQGFFMKT 380
Cdd:PRK09848 362 LTYSLFSFTRKC 373
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
10-378 1.03e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.60  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  10 VLYALGVSYAIVdqIFAQWILYFYLPSANSSLKpfMAPILVSIALAVSRFVDMITDPLVGFLSDKYnskyGRRiPFIAVG 89
Cdd:COG2814   11 ALLALALGAFLS--GLGIGIVLPALPLIAADLG--ASPAQAGLVVTAYLLGAALGAPLAGRLADRF----GRR-RVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  90 TIPLVLVTIAFFYPPmsnekaSFYYLMIVGSLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSyTAIAIIFP 169
Cdd:COG2814   82 LLLFALGSLLCALAP------SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG-PALGPLLG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 170 GILIkmiggkdELFGIRGMIIFLCVIVFVGLAVTVFTVRErdysTGEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIGF 249
Cdd:COG2814  155 GLLA-------DLFGWRWVFLVNAVLALLALLLLLRLLPE----SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGF 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 250 NNLRAIMNYYVEDIMGYGKKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVnfgF 329
Cdd:COG2814  224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL---L 300

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 496070619 330 VLFALIGIplaGAAFIFPPAMlseisTQISEESGARIEGISFGIQGFFM 378
Cdd:COG2814  301 LALFLLGF---GFGLLFPLLQ-----ALVAELAPPEARGRASGLYNSAF 341
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 43-319 2.98e-09

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 58.63  E-value: 2.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  43 PFMAPILVSIALAVSRFVDMITDPLVGFLSDKYnskyGRRIPFIAVGTIPLVLVTIA-FFYPPMSNEKASFyyLMIVGSL 121
Cdd:COG2270   47 PAAATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFFTLLGVLATAAlFFVAPGGLWLGLL--LFVLANI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 122 FFTFYTIvgaPYNALIPEIGrTPEERLNLSTWQ-------SVFRLSYTAIAIIFPGILikmiGGKDELFGIRgMIIFLCV 194
Cdd:COG2270  121 GFEGSLV---FYNAFLPDIA-TPEEIGRVSGLGwalgylgGVLLLLINLALFLKPEAF----GLPDAGEAVR-ISFLLTA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 195 IVFVGLAV-TVFTVRERDYSTGEVSKVSF-------KDTIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGY 266
Cdd:COG2270  192 LWWLLFALpLFLFLPERPRPGPAPPRGAVragfrelRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGF 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 496070619 267 GKKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFL 319
Cdd:COG2270  272 STTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFL 324
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
 45-147 1.62e-07

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 53.24  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  45 MAPILVSIALAVSRFVDMITDPLVGFLSDKYN-SKYGRRIPFIaVGTIPLVLVTIAF--FYPPMSNekASFYYLMIVGSL 121
Cdd:cd17392   32 MGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWI-VFSTPLIILAYFFlwFLPPFTS--LSGLWYLTFYCL 108

                         90       100
                 ....*....|....*....|....*.
gi 496070619 122 FFTFYTIVGAPYNALIPEIGRTPEER 147
Cdd:cd17392  109 FETFMTCFHVPYSALTMFLGGCQRER 134
MFS_NLS1_MFSD2A cd17451
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ...
 47-211 2.81e-07

Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341009  Cd Length: 419  Bit Score: 52.51  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  47 PILVSIALAVSRFVDMITDPLVGFLSDKYN-SKYGRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVgSLFFTF 125
Cdd:cd17451   34 PFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFSTPFAVLSYFLIWFVPDFSQGKVMWYLLFY-CLFQTL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 126 YTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPGILIKMIGGKDELFGIRGMIIFLCVIVFVGlavtvf 205
Cdd:cd17451  113 QTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIVGMAAYMIAAGVICAIYVLCAIILFLG------ 186


                 ....*.
gi 496070619 206 tVRERD 211
Cdd:cd17451  187 -VREQR 191
MFS_1 pfam07690
Major Facilitator Superfamily;
45-378 3.98e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619   45 MAPILVSIALAVSRFVDMITDPLVGFLSDKYnskyGRRIPFIavgtIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFT 124
Cdd:pfam07690  29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRF----GRRRVLL----IGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  125 FYTIVGApynALIPEIGRTPEERLNLSTWQSVFRLSyTAIAIIFPGILIkmiggkdELFGIRGMIIFLCVIVFVGLAVTV 204
Cdd:pfam07690 101 ALFPAAL---ALIADWFPPEERGRALGLVSAGFGLG-AALGPLLGGLLA-------SLFGWRAAFLILAILSLLAAVLLL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  205 FTVRERDYSTGEVSKVSFKDTIGI--IIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDiMGYGKKEITNASALLFGAA 282
Cdd:pfam07690 170 LPRPPPESKRPKPAEEARLSLIVAwkALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  283 AICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNFGFVLFALIGIplaGAAFIFPPAMlseisTQISEES 362
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGF---GFGLVFPALN-----ALVSDLA 320

                         330
                  ....*....|....*.
gi 496070619  363 GARIEGISFGIQGFFM 378
Cdd:pfam07690 321 PKEERGTASGLYNTAG 336
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 49-336 3.67e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  49 LVSIALAVSRFVDMITDPLVGFLSDKYnskyGRRiPFIAVGTIPLVLVTIAFFYppmsneKASFYYLMIVGSLFFTFYTI 128
Cdd:cd17329   36 IVGLVLALSAVAGIVASLIGGRLADRF----GRK-PVMLAGLLLRALGFALLGF------AHSPWLFAIALVLTGFGGGL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 129 VGAPYNALIpeIGRTPEERLnlstwQSVFRLSYTAIAIifpGILI-KMIGGKDELFGIRGMIIFLCVIVFVGLAVTVFTV 207
Cdd:cd17329  105 FEPASEAMI--ADVTTPENR-----TRAFSLLYWAINL---GVAIgPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 208 RERDYSTGEVSKVSFKDTIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGYGKKEITNASALLFGAAAICFY 287
Cdd:cd17329  175 PETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQF 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 496070619 288 PTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFlGKIFPVNFGFVLFALIG 336
Cdd:cd17329  255 PVARLVERFRLRKILMIGILLFAIGFAVLAF-ANTLAVLILAMIVLTLG 302
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 62-100 9.12e-05

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 44.79  E-value: 9.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 496070619   62 MITDPLVGFLSDKYNSKYGRRIPFIAVGT--IPLVLVTIAF 100
Cdd:TIGR01301  53 LLVQPLVGYLSDRCTSRFGRRRPFIAAGAalVAFAVILIGF 93
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 47-211 1.38e-04

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 44.04  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  47 PILVSIALAVSRFVDMITDPLVGFLSDKYN-SKYGRRIPFIaVGTIPLVLVTIAF--FYPPMSNEKASFYylMIVGSLFF 123
Cdd:cd17452   34 PFQASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPWM-LGCTPFIVVSYFFlwFVPPFTTGRFLWY--LTFYCLFQ 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 124 TFYTIVGAPYNALIPEIGRTPEERLNLSTWQSVFRLSYTAIAIIFPGILIK---MIGGkdelfGIRGMIIFLCVIVFvgl 200
Cdd:cd17452  111 ALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIVAsayMIAA-----GVIGGLYLLCISVL--- 182

                        170
                 ....*....|.
gi 496070619 201 avtVFTVRERD 211
Cdd:cd17452  183 ---FLGVKERD 190
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 45-138 6.69e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 41.90  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  45 MAPILVSIALAVSRFVDMITDPLVGFLSDkynsKYGRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFT 124
Cdd:cd17367  256 FSKGDATWITTAALLVFMLLQPLGGRLSD----RIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLS 331

                         90
                 ....*....|....
gi 496070619 125 FYTIVGAPYNALIP 138
Cdd:cd17367  332 GYTSINAVVKAELF 345
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
32-350 7.83e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.40  E-value: 7.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  32 FYLPSANSSLKPFMAPIL------VSIALAVSRFVDMITDPLVGFLSDKYnskyGRRIPFIAVGTIPLVLVTIAFFYPPm 105
Cdd:COG2223   18 FGVWYLWSVLAPPLAEEFglsaaqLGLLFAIPVLVGALLRIPLGFLVDRF----GPRRVLLIGLLLLGIGLLLLALAVS- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 106 snekasfYYLMIVGSLFFTFytIVGAPYNALIPEIGR--TPEER-LNLSTWQSVFRLSYTAIAIIFPGILikmiggkdEL 182
Cdd:COG2223   93 -------YWLLLLLGLLLGI--GGGGSFAVGIALVSKwfPPDRRgLALGLAAGGGNLGAAVAAFLAPLLI--------AA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 183 FGIRGMIIFLCVIVFVGLAVTVFTVRERDYSTGEVSKVSFKDtIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVED 262
Cdd:COG2223  156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD-QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 263 IMGYGKKEITNASALLFGAAAICFYPTNKLSKKYGYRKIMLCCLAMLIVTTSMLFFLGKIFPVNF-GFVLFALIGIPLAG 341
Cdd:COG2223  235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNG 314


                 ....*....
gi 496070619 342 AAFIFPPAM 350
Cdd:COG2223  315 AVFALVPDI 323
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 48-168 1.13e-03

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 41.09  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  48 ILVSIALAVSRFVDMITDPLVGFLSDKYNS--KYGRRIPFIAVGTIpLVLVTIAF-FYPPM-----SNEKASFYYLMIVG 119
Cdd:cd17491   35 ALAGILLLIGQVADAISTPLVGYESDRTNGcgKYGRRKSWHLIGTI-CVLLSFPFiFNPCLgcsdsTSEWAKLVYYGPFI 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 496070619 120 SLFFTFYTIVGAPYNALIPEIGRTPEERLNLSTwqsvFRLSYTAIAIIF 168
Cdd:cd17491  114 IIFQFGWAAVQISHLSLIPELTSDEHERVELTA----LRYAFTVIANIT 158
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 53-202 1.30e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 40.97  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  53 ALAVSRFVDMITDPLVGFLSDKYnskyGRRIPFIaVGTIPLVLvtIAFFYPPMSNEKASFYYLMIVGSLFFTFYTIVGAP 132
Cdd:cd17369  269 AVLIASVVAAITIPLFGWLSDRV----GRRPVYL-AGALLAAL--FAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGP 341

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496070619 133 YNALIPEIGRTpeerlnlSTWQSVFRLSYTAIAIIF----PGILIKMIGGKDELFGIRGMIIFLCVIVFVGLAV 202
Cdd:cd17369  342 QAAFLAELFPT-------RVRYTGASLGYQLGAILGggfaPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 45-147 1.59e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 40.56  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  45 MAPILVSIALAVSRFVDMITdPLVGFLSDKYNSKYGRRIPFIAVGTIPLVL--VTIAFFYPPMSneKASFYYLMIVGSLF 122
Cdd:cd06176   33 LPATLVGLLIALHYLVAPLR-VWIGHRSDTHPLRGYRRTPYIWLGMLLLALglALAPFAALLLA--GAAFWLGLALAVLA 109

                         90       100
                 ....*....|....*....|....*....
gi 496070619 123 FTFY----TIVGAPYNALIPEigRTPEER 147
Cdd:cd06176  110 FLLYgigvGAAGTAFLALLAD--LTPEER 136
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
62-396 2.49e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  62 MITDPLVGFLSDKYNSKYGrripfIAVGtipLVLVTIAFFYPPMSnekASFYYLMIVGSLFFTFYTIVGAPYNALIPEIG 141
Cdd:COG0738   57 LLASLPAGRLIDRFGYKRG-----LLLG---LLLMALGLLLFALA---PSYPLLLLALFLLGLGLGLLDVAANPYVAALG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 142 RTpEERLNLSTWQSVFRLSytaiAIIFPGILIKMIGGKDELFGIRGMIIFLcvIVFVGLAVTVFTVRERDYSTGEVSKVS 221
Cdd:COG0738  126 PE-TAASRLNLLHAFFSLG----ALLGPLLGGLLILLGLSLSWHLPYLILA--VLLLLLALLFLRSKLPEIEEEEEEAAG 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 222 FKDTIGIIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGYGKKEITNASALLFGAAAICFYPTNKLSKKYGYRKI 301
Cdd:COG0738  199 SAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 302 MLCCLAMLIVTTSMLFFLGkifPVNFGFVLFALIGIplaGAAFIFpPAMLSEISTQISEESGARIEGISF---------- 371
Cdd:COG0738  279 LRLSALLAAVGLLLALLAP---GPWLALIGLALVGL---GLSLMF-PTIFSLALDGLGKRTAAAVSAVLImgivggaigp 351

                        330       340       350
                 ....*....|....*....|....*....|
gi 496070619 372 GIQGFF-----MKTSFLISIVTLPIILVMG 396
Cdd:COG0738  352 PLIGFLadafgLRAAFLVPLVCYLLILLLA 381
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 47-405 2.72e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619  47 PILVSIALAVSRFVDMITDPLVGFLSDKYNSkygRRIPFIAVGTIPLVLVTIAFFYPPMSNEKASFYYLMIVGSLFFTFY 126
Cdd:cd06173   33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDR---RRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 127 TIVgapYNALIPEIgrTPEERLnlSTWQSVFRLSYTAIAIIFP---GILIKmiggkdeLFGIRGMIIFLCVIVFVGLAVT 203
Cdd:cd06173  110 GPA---RQALLPEL--VPKEQL--VRANALNSLATQLARIIGPalgGLLVA-------LLGPGGAFAINALSFLLSALLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 204 VFTVRERDYSTGEVSKVSFKDTIG---IIIRNKNFILYLFGMMFFFIGFNNLRAIMNYYVEDIMGYGKKEITNASALLFG 280
Cdd:cd06173  176 LFIRRPPPAAPGESSSLLLRDLREglrYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496070619 281 AAAICFYPTNKLSKKYGYRKIMLCCLAMLivttsMLFFLGKIFPVNFGFVLFALIGIPLAGAAFIfpPAMLSEISTQISE 360
Cdd:cd06173  256 GALLGALLLGRLSKRRRRGRLLLIGALLL-----GLALLVLGLSPSLWLLLAALFLLGLAGGLFN--VPLNTLLQLRVPD 328

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 496070619 361 ESGARIEGISFGIQGFFMK-----TSFLISIVTLPIILVMGNGVSIISAI 405
Cdd:cd06173  329 ELRGRVFSVYNALNSGAMPlgallAGLLADALGLSAVFLLAGALLLLAAL 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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