|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
25-433 |
3.26e-132 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 386.69 E-value: 3.26e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 25 VVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFID 104
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 105 VFPlawagvSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVM 184
Cdd:TIGR00893 81 AYV------SLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 185 GIIGFVLTVIWVKFVHNPTDHPRMSAAELKYISEGGAVVDMDHKKETTqaagPKMDYIRQLLTNRMMLGVFFGQYFLNTI 264
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPST----PKKYQIKELLKDRRVWGLALGQFLVNIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 265 TWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLTFARKLPIVLGMLLASSIILCNYTA 344
Cdd:TIGR00893 231 LGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 345 STPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALIFVGGSALM 424
Cdd:TIGR00893 311 IPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALI 390
|
....*....
gi 496082092 425 MMVCYLFVV 433
Cdd:TIGR00893 391 GALSYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-432 |
1.46e-99 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 301.80 E-value: 1.46e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFidvfplAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFAL 175
Cdd:cd17319 81 FTALTGF------ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 176 GWEHVFTVMGIIGFVLTVIWVKFVhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqlltnRMMLGVF 255
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------------RQVWGLA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 256 FGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIgrgctlTFARKLPIVLGMLLAS 335
Cdd:cd17319 186 LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL------RGARRLVIIIGLLLAA 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 336 SIILCNYTASTP-LVITLMALAFFGKGFGALG-WPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNG 413
Cdd:cd17319 260 VGLLLAYLTTSPvVAVILLSLAGFGIGAASPVfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA 339
|
410
....*....|....*....
gi 496082092 414 ALIFVGGSALMMMVCYLFV 432
Cdd:cd17319 340 AFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-438 |
2.66e-64 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 210.88 E-value: 2.66e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 9 EKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSY 88
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 89 SLFFWSLFTFLQGFIDVFplawagVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLL 168
Cdd:COG2271 81 GLLLWGLATLLFGFATSF------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 169 GWLTFALGWEHVFTVMGIIGFVLTVIwvkfvhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqlltn 248
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 249 rMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfaRKLPIV 328
Cdd:COG2271 181 -RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLA 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 329 LGMLLAS-SIILCNYTASTPLVITLMALA-FFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVs 406
Cdd:COG2271 253 IGLLLAAlALLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL- 331
|
410 420 430
....*....|....*....|....*....|..
gi 496082092 407 ELHSFNGALIFVGGSALMMMVCYLFVVGDIKR 438
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
24-415 |
6.20e-55 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 187.20 E-value: 6.20e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 24 FVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFI 103
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 104 DVFPlawagvSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLG-WLTFALGWEHVFT 182
Cdd:TIGR00881 81 TSLW------VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 183 VMGIIGFVLTVIWVKFVHNPTDHPRMSAAELKYISEggavVDMDHKKEtTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLN 262
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE----PDGDAEKK-EEELTKKQIFLQYVLLNKVLWYISLGYVFVY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 263 TITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLI-GRGCTLTFARKLPIVLGMLlassIILCN 341
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFnGRRGPLAVFFMALIIVSLL----VYWLN 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082092 342 YTASTPLV-ITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVsELHSFNGAL 415
Cdd:TIGR00881 306 PAANPLMDlICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLA-DGFGWAGAF 379
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-432 |
3.30e-43 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 156.19 E-value: 3.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFAL 175
Cdd:COG2223 83 GLLLLALAVSYWL------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 176 GWEHVFTVMGIIGFVLTVIWVKFVHNPTDHPRmsaaelkyiseggavvdmdhkkettQAAGPKMDYIRQLLTNRMMLGVF 255
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------------------------AAAKASLRDQLEALRDPRFWLLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 256 FGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLtfarklpIVLGMLLAS 335
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL-------IVFALMALG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 336 SIILCNYTASTPLVITLMALAFFGKGFG-ALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGA 414
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAA 364
|
410
....*....|....*...
gi 496082092 415 LIFVGGSALMMMVCYLFV 432
Cdd:COG2223 365 FLVFAVLALVALVLTLLL 382
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
21-418 |
6.82e-43 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 154.63 E-value: 6.82e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 21 LMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLq 100
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 101 gfidvFPLA--WAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWE 178
Cdd:cd17380 81 -----TPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 179 HVFTVMGIIGFVLTVIWVKFVhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqlltnRMMLGVFFGQ 258
Cdd:cd17380 156 SVFYFFGLLGLLWALVWLIYL-------------------------------------------------PPVWAIIVAH 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 259 YFLNTITWFFLTWFPIYLvQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLTFARKLPIVLGMLL-ASSI 337
Cdd:cd17380 187 FCMNWGFYILLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGpALFL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 338 ILCNYTASTPLVITLMALAFFGKGFGALGWPV-ISDVAPKEiVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFngALI 416
Cdd:cd17380 266 LLLSHTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGSW--SLV 342
|
..
gi 496082092 417 FV 418
Cdd:cd17380 343 FV 344
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
21-433 |
7.68e-43 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 155.08 E-value: 7.68e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 21 LMIFVVTAVNYGDRATLSIA----------------------GTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLD 78
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAivamvnstathdnnntstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 79 KFGSKKVYSYSLFFWSLFTFLqgfidVFPLAWAGV-SMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQ 157
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLL-----TPLAARGGYgALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 158 YFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVhnptdhprmsaaelkyiseggavvdmdhkkettqaagp 237
Cdd:cd17318 157 QFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV-------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 238 kmdyirqlltnRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGC 317
Cdd:cd17318 199 -----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 318 -TLTFARKLPIVLGMLLASSIILC-NYTASTP-LVITLMALAFfgkGFGALGWPVIS----DVAPKeIVGLCGGVFNVFG 390
Cdd:cd17318 268 lSTTTVRKLFTSIGFLGPGVFLIAlGYLGSNAtLAVVFLTLSV---GLSGACYSGFLvnhlDLAPN-YAGTLMGITNTAA 343
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 496082092 391 NVASIATPLVIGYIVSELHSFNGALIFVGGSALMMMVCYLFVV 433
Cdd:cd17318 344 TIAGIISPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIFYL 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-423 |
4.76e-32 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 125.43 E-value: 4.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 47 ELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVsmffmrFMLGFSE 126
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL------FLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 127 APSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNPTDhp 206
Cdd:cd17475 99 GSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 207 rmsaaelkyiseggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILK 286
Cdd:cd17475 177 ---------------------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 287 VGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfARKLPIVLGMLLAS--SIILCNYTASTPLVitLMALAFFGKGFGA 364
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGG------RRRPVLVITAAIAAaaLLVLSLLSPGTPLW--LLVLLLILLGLFA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082092 365 LGW-----PVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALIFVGGSAL 423
Cdd:cd17475 308 IGWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLV 371
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
51-406 |
9.21e-32 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 126.40 E-value: 9.21e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 51 SAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLqgfidVFPLAWAGVSM-FFMRFMLGFSEAPS 129
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIV-----IPWAAGGGIALvVFCRVIQGLAQGSV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 130 FPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLT-FALGWEHVFTVMGIIGFVLTVIWVKFVH-NPTDHPR 207
Cdd:TIGR00894 149 SPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPAdDPSIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 208 MSAAELKYISEggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKV 287
Cdd:TIGR00894 229 ISKFEKKYINS---------SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKEN 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 288 GFVASIPALFGFAGGVLGGLFSDYLIGRGC-TLTFARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGK-GFGAL 365
Cdd:TIGR00894 300 GLLSSLPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAvSSGPL 379
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 496082092 366 GWPVIS--DVAPKeIVGLCGGVFNVFGNVASIATPLVIGYIVS 406
Cdd:TIGR00894 380 AGVLINslDLAPR-FLGFIKGITGLPGFIGGLIASTLAGNILS 421
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-394 |
5.15e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.53 E-value: 5.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 14 PTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFW 93
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 94 SLFTFLQGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTF 173
Cdd:COG2814 86 ALGSLLCALAPSLWL------LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 174 ALGWEHVFTVMGIIGFVLTVIWVKFVHNPTDHPRmsaaelkyiseggavvdmdhkkettqaaGPKMDYIRQLLTNRMMLG 253
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR----------------------------ARLRGSLRELLRRPRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIVLGMLL 333
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD---------RFGRRRLLLIGLLL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496082092 334 -ASSIILCNYTASTPLVITLMALAFFGKGF-GALGWPVISDVAPKEIVGLCGGVFNVFGNVAS 394
Cdd:COG2814 283 lALGLLLLALAGSLWLLLLALFLLGFGFGLlFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-398 |
6.07e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.28 E-value: 6.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 23 IFVVTAVNYGDRATLSIA-GTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQG 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 102 FIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVF 181
Cdd:pfam07690 81 FASSLWL------LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 182 TVMGIIGFVLTVIWVKFVHNPTDHPrmsaaelkyiseggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLgVFFGQYFL 261
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKR---------------------PKPAEEARLSLIVAWKALLRDPVLW-LLLALLLF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 262 NTITWFFLTWFPIYlVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfaRKLPIVLGMLLASSIILCN 341
Cdd:pfam07690 213 GFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLL 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 342 YTASTPLVITLMALAFFGKGFGALGWPV---ISDVAPKEIVGLCGGVFNVFGNVASIATP 398
Cdd:pfam07690 285 LSLTLSSLWLLLALLLLGFGFGLVFPALnalVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
45-433 |
6.31e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 113.83 E-value: 6.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLawagvsMFFMRFMLGF 124
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ------LLLARFLQGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 125 SEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNPtd 204
Cdd:cd17325 97 ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 205 hprmsaaelkyiseggavvdMDHKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSI 284
Cdd:cd17325 175 --------------------RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 285 LKVGFVASIPALFGFAGGVLGGLFSDYligrgctltFARKLPIVLGMLL-ASSIILCNYTASTPLVITLMALAFFGKGFG 363
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDR---------IGRKPLILIGLLLsAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496082092 364 ALGW-PVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVsELHSFNGALIFVGGSALMMMVCYLFVV 433
Cdd:cd17325 306 FPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY-DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-430 |
8.72e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 110.59 E-value: 8.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 23 IFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGF 102
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 103 IDVFPLAWAGvsmffmRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLT--FALGWEHV 180
Cdd:cd06174 81 APSFWLLLLG------RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 181 FTVMGIIGFVLTVIWVKFVHNPTDHPRmsaaelkyiseggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYF 260
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESAR--------------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 261 LNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfARKLPIVLGMLLASSIILC 340
Cdd:cd06174 215 VNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR------KPLLLIGLLLMALGLALLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 341 NYTASTPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALIFVGG 420
Cdd:cd06174 289 LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAV 368
|
410
....*....|
gi 496082092 421 SALMMMVCYL 430
Cdd:cd06174 369 LLLLAAILLL 378
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
16-432 |
2.44e-24 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 104.25 E-value: 2.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDvfplaWAGVS---MFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLT 172
Cdd:cd17345 81 INILIGFVP-----SATSSvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 173 FALG---WEHVFTVMGIIGFVLTVIWVKFVH-NPTDHPRMSAAELKyiseGGAVVDMDHKKETTQAAGPK--MDYIrqlL 246
Cdd:cd17345 156 AIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKdTPESEGLPPIEEYK----GDYPEEADGEEEEQELSAWEifVKYV---L 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 247 TNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDyLIGRGctltfaRKLP 326
Cdd:cd17345 229 KNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSD-KLFKG------RRAP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 327 IVLGMLLASSIILCNYTASTPLVITLMALAFFGK---------GFGALgwpvisDVAPKEIVGLCGGVFNVFGNV-ASIA 396
Cdd:cd17345 302 TGIIFMILVIVALIVYWLAPNVLVDLIALIALGFliygpvmliGLQAL------ELVPKKAAGTAAGLTGLFGYLgGSVL 375
|
410 420 430
....*....|....*....|....*....|....*.
gi 496082092 397 TPLVIGYIVsELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:cd17345 376 ATALIGIIV-DHFGWNGGFIVLLASCILAIIFLALV 410
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
20-434 |
3.15e-24 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 103.85 E-value: 3.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 20 LLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFL 99
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 100 QGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLT-FALGWE 178
Cdd:cd17328 81 SSFAPNFWQ------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 179 HVFTVMGIIGFVLTVIWVKFVHNPtdhPRMSAAElkyiseggavVDMDHKKETTQAAGpkmdyIRQLLTNRMMLGVFFGq 258
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFVREP---PRGAAEG----------GVMAKSTATSFLAD-----LKALAKNPSFILSTLG- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 259 YFLNTITWFFLT-WFPIYLVQDKGMSILKVGFVA----SIPALFGFAGGVLGGLFSDYLIGRGCTltfARKLPIVLGMLL 333
Cdd:cd17328 216 FTAVSFVTGALAfWAPTFFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRKTPR---ADPLVCAVGLLA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 334 ASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVISD----VAPKEIVGLCGGVFNVFGNV-ASIATPLVIGYIVSEL 408
Cdd:cd17328 293 AAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAillyVVIPTRRSTASAIQILLSHLlGDAGSPYLIGLISDLL 372
|
410 420
....*....|....*....|....*...
gi 496082092 409 HSFNGALI--FVGGSALMMMVCYLFVVG 434
Cdd:cd17328 373 RQNKDSPLaeAASLQYALLLCSFVLVLG 400
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
16-432 |
9.24e-22 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 96.19 E-value: 9.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFAL 175
Cdd:cd17312 81 ANIFMGFSTSLWF------FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 176 GWEHVFTVMGIIGFVLTVIWVKFVHNptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqllTNRMMLGVF 255
Cdd:cd17312 155 GWRAAFLVPGIVGLVVAIILFFFLRD---------------------------------------------SPPYVWVLS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 256 FGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfARKLPIVLGMLLAS 335
Cdd:cd17312 190 LAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGG------RRAPIAVIYMLLMT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 336 SIILCNYTASTPLVITLMALAFFGKGFGA----LGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSF 411
Cdd:cd17312 264 LSLALFWFFPHNKLLSIVLLFLIGFFVGGpinlIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWS 343
|
410 420
....*....|....*....|.
gi 496082092 412 NGALIFVGGSALMMMVCYLFV 432
Cdd:cd17312 344 TVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
17-398 |
1.18e-20 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 93.47 E-value: 1.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 17 YLILLMIFVVTAVNYGDRATLSIAGTEVAKE-LGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMKEdLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDVFPlawagvSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLAL-------FSPLL 168
Cdd:cd17327 84 LTLLTAAVKNFG------GLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFggllaygVFKIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 169 GWLTFAlGWEHVFTVMGIIGFVLTVIWVKFV-HNPTDHPRMSAAELKYISEggAVVDMDHKKETTQAagpKMDYIRQLLT 247
Cdd:cd17327 158 GVGGLA-GWRWLFIIEGLITIIIGLVIFFWLpDNPSKAWFLTEEEKELAVE--RLRANQTGKGDQKF---KWKQIKEAFK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 248 NRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGmSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLTFARKLPI 327
Cdd:cd17327 232 DPRTWLLFLFFFCSQITNNGISNFLPLILKSLGF-YSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLAL 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082092 328 V-LGMLLASSIILCNYTAstplviTLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATP 398
Cdd:cd17327 311 VgSIILLAAPNPPGAYFA------AYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
16-436 |
2.58e-19 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 89.32 E-value: 2.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFL-QGFIDVFPLAwagvsmfFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFA 174
Cdd:cd17343 81 TTVAfSGSSSVWVFS-------ILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 175 LGWEHVFTVMGIIGFVLTVIWVKFVHN-PTDhprmsaaelkyisEGGAVVDMDHKKETTQAAGPKMDYIRQLLTNRMMLG 253
Cdd:cd17343 154 YGWRSTLSISGTVAVVMSVVCLLFIKNePSD-------------VGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGR-GCTLTFARKLPIVLGML 332
Cdd:cd17343 221 LSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKhGSSSRGNPRMPLALVFM 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 333 LASSIILCNYT-----ASTPLVITLMALAFfgkGFGALGWPVISDV-----APKEIVGLCGGVFNVFGNVASIATPLVIG 402
Cdd:cd17343 301 AGLTVSLHLFRvhitsDSSELFILLLGFLI---GFSLYGPIAIFGVianesAPSHLCGTSHAIVALAANVGGVLAGLPFS 377
|
410 420 430
....*....|....*....|....*....|....
gi 496082092 403 YIVSElHSFNGALIfVGGSALMMMVCYLFVVGDI 436
Cdd:cd17343 378 YIAKH-YDWRTAFL-LLEILCAITVVILFLLRNI 409
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
11-405 |
7.72e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.02 E-value: 7.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 11 KGIPTRYLILLMI--FVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSY 88
Cdd:TIGR00895 8 KQPLSRYQWRAIIlsFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 89 SLFFWSLFTFLQGFidvfplAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLL 168
Cdd:TIGR00895 88 SILLFSVFTLLCAL------ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 169 GWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNPTD-----HPRMSAAELKYISEGGAVVDMDHKKETTQAAGPKMDYIR 243
Cdd:TIGR00895 162 GWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDflvskRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 244 QLLTNRMMLGVFF--GQYFLNTITWFFLT-WFPiYLVQDKGMSILKVGFVAsipALFGFaGGVLGGLFSDYLIGRgctlt 320
Cdd:TIGR00895 242 ALFQGKTARITVLlwLLYFMLLVGVYFLTnWLP-KLMVELGFSLSLAATGG---ALFNF-GGVIGSIIFGWLADR----- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 321 FARKLPIVLGMLLASSIILCNYTASTP-LVITLMALAFFGKGFGALGWPVIS-DVAPKEIVGLCGGVFNVFGNVASIATP 398
Cdd:TIGR00895 312 LGPRVTALLLLLGAVFAVLVGSTLFSPtLLLLLGAIAGFFVNGGQSGLYALMaLFYPTAIRATGVGWAIGIGRLGAIIGP 391
|
....*..
gi 496082092 399 LVIGYIV 405
Cdd:TIGR00895 392 ILAGYLL 398
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-432 |
3.13e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 79.92 E-value: 3.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 1 MILDSTLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKF 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 81 GSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGvsmffmRFMLGFSEAPSFPANARIVAAWFPAKeRGTASAIFNAAQYFS 160
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAG------TALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 161 LALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNPTDHPRMSAAELKyiseggavvdmdhkkettqaagpkmd 240
Cdd:COG2807 154 AALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS-------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 241 yIRQLLTNRM--MLGVFFGQYFLNTITWFflTWFPIYLvQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCT 318
Cdd:COG2807 208 -LRSLWRSPLawLLTLFFGLQSLLYYAVV--AWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 319 LTFArklpivLGMLLASSIILcnytASTPLVITLMALAFFGKGFGA---LGWPVISDVAP-KEIVGLCGGVFNVFGNVAS 394
Cdd:COG2807 284 LLLL------GLLGLAGLLGL----LLAPGSLPWLWAVLLGLGQGGlfpLALTLIGLRARtPAEAAALSGMAQSVGYLLA 353
|
410 420 430
....*....|....*....|....*....|....*...
gi 496082092 395 IATPLVIGYIVSELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:COG2807 354 ALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-430 |
3.45e-16 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 79.57 E-value: 3.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 20 LLMIFVVTAVNYGDRATLSIAGTEVAKE--LGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFT 97
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 98 FLQGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQY----FSLALFSPLLGWLTF 173
Cdd:cd17316 81 LLIGLLPTPIL------LLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 174 ALGWEHVFTVMGIIGFVLTVIWvkfvhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqlltnRMMLG 253
Cdd:cd17316 155 DWGWRILFLIGALPALLALLLR-----------------------------------------------------RRTLL 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYlIGRGCTLTFARKLPIVLGMLL 333
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGILALPL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 334 AssiiLCNYTASTPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNG 413
Cdd:cd17316 261 F----YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
410
....*....|....*..
gi 496082092 414 ALIFVGGSALMMMVCYL 430
Cdd:cd17316 337 PALILALLAIVALIVAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-432 |
3.62e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.90 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 14 PTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFW 93
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 94 SLFTFLQGFIDVFPlaWAGVSMFFMRFMLGFSEApsfPANARIVAAwfpakERGTASAIFNAAQ-YFSL-ALFSPLLGWL 171
Cdd:COG0738 84 ALGLLLFALAPSYP--LLLLALFLLGLGLGLLDV---AANPYVAAL-----GPETAASRLNLLHaFFSLgALLGPLLGGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 172 TFALG----WEHVFTVMGIIGFVLTVIWvkfvhnptdhprmsaaelkyiseggAVVDMDHKKETTQAAGPKMDYIRQLLT 247
Cdd:COG0738 154 LILLGlslsWHLPYLILAVLLLLLALLF-------------------------LRSKLPEIEEEEEEAAGSAASLKSLLK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 248 NRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYlIGRGCTLTFArklpI 327
Cdd:COG0738 209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLS----A 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 328 VLGMLLASSIILcnytaSTPLVITLMALAFFGKGFgALGWPVISDVAPKEI---VGLCGGVFNVFGNVASIATPLVIGYI 404
Cdd:COG0738 284 LLAAVGLLLALL-----APGPWLALIGLALVGLGL-SLMFPTIFSLALDGLgkrTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
410 420
....*....|....*....|....*...
gi 496082092 405 vSELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:COG0738 358 -ADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
52-404 |
3.82e-16 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 79.82 E-value: 3.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 52 AVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWagvsMFFMRFMLGFSEAPSFP 131
Cdd:cd17381 64 AETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGY----LIAVRALEGLGEGVTFP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 132 ANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNptdhprmsaa 211
Cdd:cd17381 140 AMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMP---------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 212 elkyiseggavvdmdhkkettqaagpkmdyirqlltnrmMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVA 291
Cdd:cd17381 210 ---------------------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 292 SIPALFGFAGGVLGGLFSDYLIGRGCTLTFA-RKLPIVLGM------LLASSIILCNYTastpLVITLMALAFFGKGFGA 364
Cdd:cd17381 251 ALPYLGCWLFMILSGQIADNLREKQNFSTVCvRKIFTLIGMigpavfLLAAGFTGCNYS----LAVAFLTISSTLGGFSA 326
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 496082092 365 LGWPVIS-DVAPKeIVGLCGGVFNVFGNVASIATPLVIGYI 404
Cdd:cd17381 327 SGFNINHlDIAPS-YAGILLGITNTFATIPGMVGPVIAKSL 366
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-430 |
8.91e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 8.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 42 TEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFidvfplAWAGVSMFFMRFM 121
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL------APSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 122 LGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHN 201
Cdd:cd17324 97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 202 PTDHPRMSAAELKyiseggavvdmdhkkettqaagpkmdYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKG 281
Cdd:cd17324 177 LPPKKPGSLGLLS--------------------------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 282 MSilkVGFVASIPALFGFAgGVLGGLFSDYLIGRGctltFARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGKG 361
Cdd:cd17324 231 FS---SSAIIGLLLLFGVA-GVVGSPLAGRLADRG----GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 362 FGALGWPV-ISDVAPkEIVGLCGGVFNVFGNVASIATPLVIGYIVSELhSFNGALIFVGGSALMMMVCYL 430
Cdd:cd17324 303 AAHSALQTrVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-309 |
1.29e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.00 E-value: 1.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGfidvfpLAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFAL 175
Cdd:COG0477 92 ASLLCG------LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 176 GWEHVFTVMGIIGFVLTVIWVKFvhnptdhPRMSAAELKYISEGGAVVDMDHKKETTQAAGPKMDYIRQLLTNRMMLGVF 255
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRL-------PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 496082092 256 FGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFS 309
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
42-432 |
1.50e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 1.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 42 TEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLawagvsMFFMRFM 121
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL------LLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 122 LGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALfSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHN 201
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 202 PtdhprmsaaelkyiseggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKG 281
Cdd:cd17474 176 P-------------------------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 282 MSILKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGKG 361
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLK---------KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082092 362 FGaLGWPVISD----VAPKEIVGLCGGVFNVFGNVASIATPLVIGYIvSELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:cd17474 302 LG-LNLPLLTTlvteLAPEEERGTASSLYNFVRFLGQAVGPLLFGLL-LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
56-404 |
2.03e-13 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 71.22 E-value: 2.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 56 GYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSlftFLQGFIDVFPLAWAGVSMfFMRFMLGFSEAPSFPANAR 135
Cdd:cd17382 52 GLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTS---TLNMLIPIAARVHYGCVI-FVRILQGLVEGVTYPACHG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 136 IVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVkfvhnptdhprmsaaelkY 215
Cdd:cd17382 128 IWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWM------------------L 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 216 ISeggavvdmdhkkettqaagpkMDYIRQLLTNrmmlgvffgqyFLNTITWFFLTWF-PIYLVQDKGMSILKVGFVASIP 294
Cdd:cd17382 190 VS---------------------MPVYAIIVAN-----------FCRSWTFYLLLISqPAYFKEVFGFDISKVGILSALP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 295 ALFGFAGGVLGGLFSDYLIGRGC-TLTFARKLPIVLGMLLASSIILC-NYTASTPLVITLMALAFFGKGFGALGWPVIS- 371
Cdd:cd17382 238 HLVMTIIVPIGGQLADYLRSRGIlSTTAVRKIFNCGGFGMEATFLLVvAFSHSPTVAISFLVLAVGFSGFAISGFNVNHl 317
|
330 340 350
....*....|....*....|....*....|...
gi 496082092 372 DVAPKeIVGLCGGVFNVFGNVASIATPLVIGYI 404
Cdd:cd17382 318 DIAPR-YASILMGISNGIGTLSGMVCPVIVGAL 349
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
74-432 |
4.12e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 70.29 E-value: 4.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 74 GWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIF 153
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYA------LLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 154 NAAQYFSLALFSPLLGWLTfALGWEHVFTVMGIiGFVLTVIWVKFVHNPTDHPRMSAAELKYISEGgavvdmdhkkettq 233
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLL-ALPVLILVLLFLPEPARKSKSAASPGAATAAA-------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 234 aagpkmdyirqlLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALfgfaGGVLGGLFSDYLI 313
Cdd:cd17473 194 ------------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASL----AGAIGALLFGRLK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 314 GRgctLTFARKLPIVLGmLLASSIILCNYTASTPLVItlMALAFFGKGFGALGWPV---ISDVAPKEIVGLCGGVFNVFG 390
Cdd:cd17473 258 RR---LGKRRLLAIGFA-LMALGFLLLALASGLWVVL--LGAILAGLGFGLLLPTLnswAMSLVPPELRGRAMGIVTSAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 496082092 391 NVASIATPLVIGYIVSELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:cd17473 332 FLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-199 |
4.82e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.30 E-value: 4.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 18 LILLMIFVVTAVNYGDRATLSIAGTEVakeLGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFT 97
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 98 FLQGFIDVFPLAWAGVsmffmrFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGW 177
Cdd:cd17325 280 LLLPLATSFWLLLLLL------ALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
170 180
....*....|....*....|..
gi 496082092 178 EHVFTVMGIIGFVLTVIWVKFV 199
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
47-431 |
2.22e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 68.10 E-value: 2.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 47 ELGLSAVSMGYIFS--AFGWAylLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFplawagVSMFFMRFMLGF 124
Cdd:cd17371 28 EFGLDEAEAGLLGTvtLAGGA--IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNY------WQLLILRALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 125 SEAPSFPANARIVAAWFPAKERGTASAIFNAAQY----FSLALFSPLLGWLTFALGWEHVFtVMGIIGFVLTVIWVKFVH 200
Cdd:cd17371 100 GFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRVLF-LLGALPALLVLFIRRFVK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 201 NPtdhPRMSAAElkyiseggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDK 280
Cdd:cd17371 179 EP---PQWQAAR---------------AARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 281 GMSILKVGFVASIPALFGFAGGVLGGLFSDYligrgctltFARKLPIVLGMLLASSIILcnYTASTPLVITLMALAFFGK 360
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISIL--LYFFLPLSPTLILILGFPL 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082092 361 GFGALG-----WPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALIFVGGSALMMMVCYLF 431
Cdd:cd17371 310 GFFASGpfsgmGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-394 |
2.51e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 67.97 E-value: 2.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 19 ILLMIFVVTAvnygDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTF 98
Cdd:cd17321 1 LLLAVFLAAL----DVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 99 LQGFidvfplAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWE 178
Cdd:cd17321 77 LCAL------APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 179 HVFTVMGIIGFVLTVIWVKFVhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqlLTNRMMLGVFFGQ 258
Cdd:cd17321 151 WIFLINVPIGLVALLLARTFS----------------------------------------------GAVLAAFLLGAAL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 259 YFLNTItwffltwFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfarkLPIVLGMLL--ASS 336
Cdd:cd17321 185 GGLLFL-------LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR---------LVLVAGLLLtaVGL 248
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496082092 337 IILCNYTASTPLVITLMALAFFGKGFGALGWP---VISDVAPKEIVGLCGGVFNVFGNVAS 394
Cdd:cd17321 249 LLLALLGADSSVWLLLPGLVLLGLGLGLFATPltnAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
45-404 |
1.08e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.04 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVsmffmrFMLGF 124
Cdd:cd17478 23 IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV------ALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 125 SEAPSFPANARIVAAwFPAKERGTASAIFNAAQYFSLALfSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNPTD 204
Cdd:cd17478 97 GSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 205 HPRmsaaelkyiseggavvdmDHKKETTQAAGPKMDYIRQLLtnRMMLGVFFGQYFLNTITwfflTWFPIYLVQdKGMSI 284
Cdd:cd17478 175 PEA------------------KKAAAKSSARSTLKGVWRALL--LLLIIVFLRSWVLSSLT----TFLPFYLVQ-RGYSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 285 LKVGFVASIPALFGFAGGVLGGLFSDYligrgctltFARKLPIVLGMLLAS-SIILCNYTASTPLVITLMALAFFGKGFG 363
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPLSDR---------FGRRRVIIASLLLAApFLLLFLLTPGIWSYILLVLAGFLLFASF 300
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 496082092 364 ALGWPVISDVAPkEIVGLCGGVFNVFGNVASIATPLVIGYI 404
Cdd:cd17478 301 PVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
37-433 |
2.64e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 64.97 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 37 LSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLqgfidvfpLAWAGVS-- 114
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA--------LALAVSSyw 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 115 -MFFMRFMLGFSEApSFPANARIVAAWFPAKERGTASAIF-------NAAQYFSLALFSPLLGWLTFALGWEHVFTVMGI 186
Cdd:cd17341 90 gLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIagagnmgVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 187 IGFVLTVIWVKFVHNPTDHPRMSAAELKyiseggavvdmdhkkettqaagPKMDYIRQLLTNRMML--GVFFGQYFLnti 264
Cdd:cd17341 169 LLAIAAVLVLLFGDDLPTGKASALEFLK----------------------VQLAVLKNYRTWILSLlyGVTFGSFVG--- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 265 twfFLTWFPIYLVQDKGMSILKVGFVAsipALFGFAGGV---LGGLFSDYLIGRGCTLtfarklpiVLGMLLASSIILCN 341
Cdd:cd17341 224 ---FSNVLPTYFKTRFGLPLVTAGILA---ALFPLAGALarpAGGWLSDRFGGRRRLW--------WLFIVMTIGAALLS 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 342 YT-----ASTPLVITLMALAFFGKGFG-ALGWPVISDVAPKEIvGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGAL 415
Cdd:cd17341 290 LSlptsgTNLVLFLALFVALGLGAGAGnGSVFRMVPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAF 368
|
410
....*....|....*...
gi 496082092 416 IFVGgsaLMMMVCYLFVV 433
Cdd:cd17341 369 SLFG---VLAVACTLLVW 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
45-433 |
3.47e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.46 E-value: 3.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLawagvsMFFMRFMLGF 124
Cdd:cd17489 23 AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL------LLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 125 SEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFV--LTVIWVKFVHNP 202
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLalLLVFLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 203 tdhprmsaaelkyiseggavvdmdHKKETTQAAGPKMDYIRQLLTnRMMLGVFFGQYFLNTITwfflTWFPIYlVQDKGM 282
Cdd:cd17489 177 ------------------------AAEEAEAGTRAFRRLVEKKVL-PPALILFLASIAYGAIS----TFLPLY-AAERGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 283 SilKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIVLGMLLASSIILCNYTASTPLVItLMALAFFGKGF 362
Cdd:cd17489 227 S--NAGLFFTVYAIALLLSRPFSGKLSD---------RKGPKTVIIPGLLLLALGLLLLSFAGSPWML-LLAAVLYGLGF 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082092 363 GAL---GWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELhSFNGALIFVGGSALMMMVCYLFVV 433
Cdd:cd17489 295 GLLfpaLQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
56-194 |
3.99e-10 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 61.23 E-value: 3.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 56 GYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMffmrfmLGFSEAPSFPANAR 135
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAAL------TGAGCSLIFPALGV 325
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082092 136 IVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGII---GFVLTVI 194
Cdd:PRK12382 326 EVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISavlGIIVTIL 387
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-423 |
5.87e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 60.75 E-value: 5.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 18 LILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFT 97
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 98 FLQGFID---VFPLAWaGVSMFFMRFMLgfseapSFPANArIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFA 174
Cdd:cd17355 83 VLLALATslwQLYLLW-GLLGGGGAGTL------AAVAFA-TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 175 LGWEHVFTVMGIIGFVLTVI-WVKFVHNPTDHPRMSAAELKYISEGGAVvdmdhkkettqaagpkmdyiRQLLTNRMMLG 253
Cdd:cd17355 155 FGWRTALLVLALLALLVLVPvLLLLRRRPADLALRAYDDASPASPGSTL--------------------KEALRSASFWL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLVqDKGMSILKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIVLGMLL 333
Cdd:cd17355 215 LALAFFLCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGD---------RYSPRRLLAASYAL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 334 ASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVISDVA---PKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHS 410
Cdd:cd17355 285 RALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAAryfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGS 364
|
410
....*....|...
gi 496082092 411 FNGALIFVGGSAL 423
Cdd:cd17355 365 YTAAWALAVALGL 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-406 |
9.26e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 9.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 47 ELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLD----KFGSKKVY------SYSLFFWSLFTFlQGFIDVFPLAWAGVSMF 116
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWiligaiPLALSFVLLFTA-PDLSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 117 FMRFMLGFSEAPSFPANARIVAawfPAKERGTASAIFNAAQYFSLALFSPLLGWL------TFALGWEHVFTVMGIIGFV 190
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTP---DYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 191 LTVIWVKFVHNPtdhprmsaaelkyiseggavvdmdhkKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLT 270
Cdd:COG2211 196 AFLLTFFGTKER--------------------------PVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 271 WFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYligrgctltFARKLPIVLGMLLASSIILCNY---TASTP 347
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FGKKKAFIIGLLLAALGLLLLFflgPGNLW 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 496082092 348 LVITLMALAFFGKG-FGALGWPVISDVAP-------KEIVGLCGGVFNVFGNVASIATPLVIGYIVS 406
Cdd:COG2211 321 LLLVLAALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-432 |
6.55e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 57.62 E-value: 6.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 19 ILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTF 98
Cdd:cd17353 4 LVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 99 LQGFIDVFPLAWagvsmFFMRFMLGFSEAPSFPANARIVAAWFPAKeRGTASAIFNAAQYFSLALFSPLLGWLTFALGWE 178
Cdd:cd17353 84 LSAFAISLPLLF-----LGYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 179 HVFTVMGIIGFVLTVIWVKFVHNPtdhprmsaaelkyiseggavVDMDHKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQ 258
Cdd:cd17353 158 TTFLILGIIFLIIIVIGAFLIRDP--------------------PKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 259 YFLntitWFFLTWFP---------IYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYlIGRGCTLTfarklpIVL 329
Cdd:cd17353 218 LWL----MFFLNATAglmligqakPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK-IGRKNTLS------IAF 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 330 GMLLASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVI-SDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSEl 408
Cdd:cd17353 287 LIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALtADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYT- 365
|
410 420
....*....|....*....|....
gi 496082092 409 HSFNGALIFVGGSALMMMVCYLFV 432
Cdd:cd17353 366 GGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
37-404 |
1.01e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.82 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 37 LSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGfidvfpLAWAGVSMF 116
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG------LAPNLASLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 117 FMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTV---MGIIGFVLtv 193
Cdd:cd17503 89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLL-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 194 iwvkfvhnptdhprmsaaelkyisegGAVVDMDHKKETTQAAGpkmdyirqLLTNRMMLGVFFGQYFLntitwffltwFP 273
Cdd:cd17503 167 --------------------------APLLDLRLFKDRNFTLG--------LLLSFLLGLGLFGAMFL----------LP 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 274 IYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRgctltfarkLPIVLGMLL--ASSIILCNYTASTPLVIT 351
Cdd:cd17503 203 LYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPR---------LLLLAGLLLlaLGTLLLAFLTPDTSLWLI 273
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 496082092 352 LMALAFFGKGFGALGWPV----ISDVAPKEIvGLCGGVFNVFGNVA-SIATPLVIGYI 404
Cdd:cd17503 274 ILPLFIRGLGMGLVFMPLntlaLNSLPPEQI-GDATALFNTIRQLGgSIGTALLATLL 330
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
39-366 |
1.39e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 56.51 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 39 IAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPlawagvSMFFM 118
Cdd:PRK11551 36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFP------SLLVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 119 RFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKF 198
Cdd:PRK11551 110 RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRW 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 199 VHNPTDHPRMSAAELKYISEGGAVVDMDHKKETtqaagpkmdyirqlltnrmmLGVFFGQYFLNTITWFFLTWFPIYLVq 278
Cdd:PRK11551 190 LPESRAFAQAAGAGKQRAPVLRALFGEGRATAT--------------------LLLWISYFFTLIVLYFLLNWLPSLLV- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 279 DKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLigrgctltfaRKLPIVLGMLLASSIILCNYTASTPLVitLMALAFF 358
Cdd:PRK11551 249 GQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL----------RPRRVVLLIYAGILASLAALAAAPSFA--GMLLAGF 316
|
....*...
gi 496082092 359 GKGFGALG 366
Cdd:PRK11551 317 AAGLFVVG 324
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-428 |
2.45e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.70 E-value: 2.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 19 ILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTF 98
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 99 LQGFIDVFPLAWAGVsmffmrFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALfSPLLGWLTFALGWE 178
Cdd:cd17329 81 LLGFAHSPWLFAIAL------VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGLLLLYSFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 179 HVFTVmGIIGFVLTVIWVKFVHNPTDHPRMSAAELKYISEggavvdmdhkkettqaagpkmdyIRQLLTNRMMLGVFFGQ 258
Cdd:cd17329 154 LLFLA-AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG-----------------------YKIVLRDRAFLLFLLAS 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 259 YFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGvlgglfsdYLIGRGcTLTFARKLPIVLGMLLASSII 338
Cdd:cd17329 210 FLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ--------FPVARL-VERFRLRKILMIGILLFAIGF 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 339 LCNYTASTPLVItLMALAFFGKGfGALGWP----VISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSelhSFNGA 414
Cdd:cd17329 281 AVLAFANTLAVL-ILAMIVLTLG-EMLVFPavqtLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD---LLGPG 355
|
410
....*....|....
gi 496082092 415 LIFVGGSALMMMVC 428
Cdd:cd17329 356 LPWLILAALGLIAA 369
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
16-191 |
3.21e-08 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 55.10 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDvfplawaGVSMFFMRFML-GFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFA 174
Cdd:cd17488 81 INILFGFSS-------SLWAFAVLWTLnAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALT 153
|
170
....*....|....*..
gi 496082092 175 LGWEHVFTVMGIIGFVL 191
Cdd:cd17488 154 YGWRAGMYVPGIIAILM 170
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
16-198 |
3.81e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 55.46 E-value: 3.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNygDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:TIGR00711 2 LLTIVLMLGTFMAVL--DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDVFPlawagvSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFAL 175
Cdd:TIGR00711 80 GSLLCGVAPNLE------LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY 153
|
170 180
....*....|....*....|....
gi 496082092 176 GWEHVFTVMGIIG-FVLTVIWVKF 198
Cdd:TIGR00711 154 HWRWIFLINVPIGiIVVVVAFFIL 177
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-198 |
1.45e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 18 LILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFT 97
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 98 FLQGFIDVFPLawagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGW 177
Cdd:cd06173 289 LVLGLSPSLWL------LLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|.
gi 496082092 178 EHVFTVMGIIGFVLTVIWVKF 198
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
16-438 |
1.98e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 53.17 E-value: 1.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKElGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSL 95
Cdd:PRK11273 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDvfplaWAGVS---MFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLlgwlt 172
Cdd:PRK11273 106 VMLFMGFVP-----WATSSiavMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLL----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 173 FALG------WEHVFTVMGIIGFVLTVIWVKFVHNPTDHPRMSAAElKYISEGGAVVDMDHKKETTQaagpKMDYIRQLL 246
Cdd:PRK11273 176 FLLGmawfndWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIE-EYKNDYPDDYNEKHEQELTA----KQIFMQYVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 247 TNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIgRGctltfARKLP 326
Cdd:PRK11273 251 PNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVF-RG-----NRGAT 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 327 IVLGMLLASSIILCNY--TASTPLV--ITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNV-ASIATPLVI 401
Cdd:PRK11273 325 GVFFMTLVTIATIVYWlnPAGNPTVdmACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIV 404
|
410 420 430
....*....|....*....|....*....|....*..
gi 496082092 402 GYIVSELHSFNGALIFVGGSALMMMVCYLFVVGDIKR 438
Cdd:PRK11273 405 GYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRH 441
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-194 |
4.31e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 4.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 12 GIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLF 91
Cdd:cd17316 172 ALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLI 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 92 FWSLFTFLQGFIDVFPLAWagvsMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWL 171
Cdd:cd17316 252 LSGILALPLFYLLSGSPTL----LLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
170 180
....*....|....*....|...
gi 496082092 172 TFALGWEHVFTVMGIIGFVLTVI 194
Cdd:cd17316 328 LASTGGTGVPALILALLAIVALI 350
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
15-420 |
5.00e-07 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 51.63 E-value: 5.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 15 TRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKkvysYSLFFWS 94
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLR----IGVLIGA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 95 LFTFLQGFIDVFPLAWAGVSMFFM--RFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLA---LFSPLLG 169
Cdd:cd17334 77 ALNALGSVLKCIPLGQQPKFALLVlgQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAigfLLPPVVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 170 WLT--FALGWEHVFTV-MGIIGFVLTVIWVKFVHNPTDHPRMSAAELKYISEGGAVVDmdhkkettqaagpkmDYIRQLL 246
Cdd:cd17334 157 PPPkgTKKEFGAVFYGeFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQ---------------KSISELL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 247 TNR--MMLGVFFGqyflnTITWFFLTWFPIY--LVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGC---TL 319
Cdd:cd17334 222 RNEpfVLLAVAFS-----IMMGVFAGFSSVLaqILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLiglII 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 320 TFARKLPIVLGMLLASSIILCNYTAStpLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPL 399
Cdd:cd17334 297 LALGTVVCTFFMLLVDRYGLPYVTLA--FYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLML 374
|
410 420
....*....|....*....|.
gi 496082092 400 VIGYIVSELHSFNGALIFVGG 420
Cdd:cd17334 375 VFSELLGPTPTESKYLLWFIL 395
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
16-194 |
1.80e-06 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 50.09 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKfgskkvySYSLFFWSL 95
Cdd:PRK11663 21 RRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDR-------SNARYFMGI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 96 FTFLQGFIDVFPLAWAGVSMFFMRFML-GFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFA 174
Cdd:PRK11663 94 GLIATGIINILFGFSSSLWAFALLWVLnAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALH 173
|
170 180
....*....|....*....|
gi 496082092 175 LGWEHVFTVMGIIGFVLTVI 194
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGLF 193
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-194 |
1.84e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 20 LLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFL 99
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 100 QGFidvfplAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEH 179
Cdd:cd17365 81 TAF------AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRS 154
|
170
....*....|....*
gi 496082092 180 VFTVMGIIGFVLTVI 194
Cdd:cd17365 155 VFLLGGVPPLILLPL 169
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-432 |
1.86e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 49.72 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLF-FWS 94
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGImVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 95 LFTFLQGFIDVFPLAWAGVSMFFMRFMLGFSEAPSfpanarIVAAWFPAKeRGTASAIFNAAQYFSLALFSPLLGWLTFA 174
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVL------VTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 175 LGWEHVFTVMGI-IGFVLTVIWVKFVHNPTDHPRMSAAELKYISEGGAVVDMdhkkettqaagpkmdyirqlltnrMMLG 253
Cdd:cd17314 154 YGLALVYTILGIlAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRD------------------------KVFW 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLV---QDKGMSILKVGFvaSIPALFGFAGGVLGGLFSDYLIGRgctltfARKLPIVLG 330
Cdd:cd17314 210 ILFIAIFLVLIGGFLFIANMASLVrslQLDAPSFVTKLM--SIYGLFNAFGRLLWGIVADFFGGR------LSTLSILLT 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 331 MLLASSIILCNYTASTPLVITLMALAFfgkGFGALGWPVISDVAPKEIVGL-----CGGVFNVFGNVASIATPLVIGYIV 405
Cdd:cd17314 282 ILGLGLCAFLFLLKMTPVGLVLTGSLL---GFSYGGLFTVYPATVSTVFGTesfatLYGILLFAPAIGSILGPMLGAKFY 358
|
410 420
....*....|....*....|....*..
gi 496082092 406 SELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:cd17314 359 DRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
17-432 |
7.60e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.93 E-value: 7.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 17 YLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLF 96
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 97 TFLQGFIDVFPlawagVSMFFMRFMLGFSEAPSFPANARIVAAWFpAKERGTASAIFNAAQYFSLALFSPLLGWLTFALG 176
Cdd:cd17352 82 LLLSSFATSLW-----QLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 177 WEHVFTVMGIIGFVLTViwvkfvhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkMDYIRQLLTNRMMLGVFF 256
Cdd:cd17352 156 WRGALLILGGLCLNLCV---------------------------------------------CGLLLRLLKDPTFVLLAL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 257 GQYFLNTITWFFLTWFPIYLvQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLTFArkLPIVLGMLLASS 336
Cdd:cd17352 191 GVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF--TLLILGLSLLAF 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 337 IILCNYTAstpLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELHSFNGALI 416
Cdd:cd17352 268 PLATTYVG---LIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFY 344
|
410
....*....|....*.
gi 496082092 417 FVGGSALMMMVCYLFV 432
Cdd:cd17352 345 FCGACLLLSGVLLFLL 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
272-435 |
8.37e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 8.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 272 FPIYlVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIVLGMLLASSIILCNYTASTPLVit 351
Cdd:cd17325 19 LPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD---------RFGRKRLLLLGLLLLAVSTLLFAFATSYWQ-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 352 LMALAFFGKGFGALGWPV----ISDVAPKEIVGLCGGVFNVFGNVASIATPlVIGYIVSELHSFNGALIFVGGSALMMMV 427
Cdd:cd17325 87 LLLARFLQGLASAAVWPAamalIADIAPPEERGRAMGIFSSAIGLGFLIGP-LLGGLLADALGYRAPFLVCAALALLALV 165
|
....*...
gi 496082092 428 CYLFVVGD 435
Cdd:cd17325 166 LALLLLPE 173
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-427 |
9.30e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 9.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSlFFWSLFTFLQGFIDVFPLAWAGVSMFFMRFMLGF 124
Cdd:cd06173 26 VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILA-DLLRALLAAVLALLALLGSLSLWLLLVLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 125 SEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVmGIIGFVLTVIWVKFVHNPTD 204
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI-NALSFLLSALLLLFIRRPPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 205 HPRmsaaelkyiseggavvdmdhKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKGMSI 284
Cdd:cd06173 184 AAP--------------------GESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 285 LKVGFVASIPALFGFAGGVLGGLFSDYLIgrgctltfARKLPIVLGMLLASSIILCNYTASTPLVITLMALAFFGKGFGA 364
Cdd:cd06173 244 AGYGLLLAAFGVGALLGALLLGRLSKRRR--------RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082092 365 LGW-PVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSelhSFNGALIFVGGSALMMMV 427
Cdd:cd06173 316 VPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD---ALGLSAVFLLAGALLLLA 376
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
19-363 |
1.26e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 19 ILLMIFVVTAVNYGDrATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTF 98
Cdd:cd17323 1 VFIISFLTFVVTFGS-SIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 99 lqgfidvfPLAWAGV--SMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQyFSLALFSPLLG-WLTFAL 175
Cdd:cd17323 80 --------GCALAPNiaMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGP-LLGPALGPIIGgFITQSL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 176 GWEHVFTVMGIIGFVLTVIWVKFvhnptdhprmsaaelkyiseggavvdmdhkkettqaagpkmdyirqlLTNRMMLGVF 255
Cdd:cd17323 151 GWRWIFWFLAIISGFCLILIFLF-----------------------------------------------LPIVLLLGLY 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 256 FGqyFLNTITWFFLTWFPIYLVQDKGMSILKVGfVASIPALFG-FAGGVLGGLFSDY-----LIGRGCTLTFARKLPIVL 329
Cdd:cd17323 184 VG--LVYAILYLFLTAFPYVFGEVYGFSPGEVG-LMYLPIGIGaLIGSIIGGRLSDYyyrrlKKKNGGKPEPEARLPPAF 260
|
330 340 350
....*....|....*....|....*....|....*...
gi 496082092 330 GMLLASSIILCNY----TASTPLVITLMALAFFGKGFG 363
Cdd:cd17323 261 IGAFLFPIGLFIFgwtiYPHIHWIVPIIGSAFFGFGLM 298
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-198 |
1.28e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 6 TLDEKKGIPTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDK-FGSKK 84
Cdd:cd17474 187 KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARR 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 85 VYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFfmrfmlGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALF 164
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVPSLALLLIAIVLF------GLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
170 180 190
....*....|....*....|....*....|....
gi 496082092 165 SPLLGWLTFALGWEHVFTVMGIIGFVLTVIWVKF 198
Cdd:cd17474 341 PLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
254-433 |
1.32e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYligrgctltFARKLPIVLGMLL 333
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 334 --ASSIILCNYTASTPLVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSeLHSF 411
Cdd:pfam07690 72 faLGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGW 150
|
170 180
....*....|....*....|..
gi 496082092 412 NGALIFVGGSALMMMVCYLFVV 433
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPR 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-171 |
2.19e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 14 PTRYLILLMIFVVTAVNygdrATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFW 93
Cdd:COG2211 229 PFLLLLLAYLLFFLALA----LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 94 SLFTFLQGFIDVFPLAWAGVSMFFMRFMLGFSEAPSFPANARIV---AAWFPAKERGTASAIFNAAQYFSLALFSPLLGW 170
Cdd:COG2211 305 ALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGL 384
|
.
gi 496082092 171 L 171
Cdd:COG2211 385 L 385
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
48-163 |
3.21e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 48 LGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDvfPLAWAGVSMFFMrFMLGFSEA 127
Cdd:cd17321 199 LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLG--ADSSVWLLLPGL-VLLGLGLG 275
|
90 100 110
....*....|....*....|....*....|....*.
gi 496082092 128 PSFPANARIVAAWFPAKERGTASAIFNAAQYFSLAL 163
Cdd:cd17321 276 LFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
9-196 |
1.24e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 9 EKKGIPTRYLILLMIFVVTAVNYGDRATLSIAgtevAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSY 88
Cdd:cd17370 194 SLKKLPKAFWLYLLAVALFALGNFSFAFLILR----AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 89 SLFFWSLFTFLQGFIDVFPLAWAGVSMFFMrfMLGFSEApSFPAnarIVAAWFPAKERGTASAIFNAAQYFSLALFSPLL 168
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGL--YMGAQES-IERA---AVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343
|
170 180
....*....|....*....|....*...
gi 496082092 169 GWLTFALGWEHVFTVMGIIGFVLTVIWV 196
Cdd:cd17370 344 GYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-165 |
1.87e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 20 LLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYsysLFFWSLFTFL 99
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL---LLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082092 100 QGFIDVFPLAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFS 165
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
43-362 |
2.72e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 43 EVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLawagvsMFFMRFML 122
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ------LLIARFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 123 GFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALfSPLLG-WLTFALGWEHVFTVMGIIGFVLTVIWVKFVhn 201
Cdd:cd17320 98 GLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPAL-APLLGgLLLLFFGWRAIFVFLALLGLLLLLLVLLFL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 202 PTDHPRmsaaelkyiseggavvdmdhkKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTITWFFLTWFPIYLVQDKG 281
Cdd:cd17320 175 PETLPE---------------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 282 MSILKVGFVASIPALFGFAGGVLGGLFSDY-----LIGRGCTLTFArklpIVLGMLLASSIILcnytASTPLVITLMALA 356
Cdd:cd17320 234 LSPAQFGLLFALNAIALILGSLLNGRLVRRfgprrLLRLGLLLLLA----AALVLLLAALLGG----LSLWPLVAPLFLI 305
|
....*.
gi 496082092 357 FFGKGF 362
Cdd:cd17320 306 FFGFGL 311
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
16-152 |
3.42e-04 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 42.61 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 16 RYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAV-----SMGYIFsafgwAYLLMQIPGGWLLDKFGSKKVYSYSL 90
Cdd:cd17398 2 RWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTavdwtSMIYML-----TYIPLIFPATWLLEKYGLRVTVLLGS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 496082092 91 FFWSLFTFLQGFI---DVFPLAWAGVSMFFMR--FMLGFSeapsfpanARIVAAWFPAKERGTASAI 152
Cdd:cd17398 77 FLNCLGAWLKLFSsspDLFWVAMAGQTICALAqvFILGIP--------PRLAAVWFGPDEVSTATAI 135
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
249-433 |
5.34e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 249 RMMLGVFFGQYFLNTITWFFLTWFPiYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIV 328
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 329 LGMLLASSIILCNYTASTP--LVITLMALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVs 406
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLwlLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA- 158
|
170 180
....*....|....*....|....*..
gi 496082092 407 ELHSFNGALIFVGGSALMMMVCYLFVV 433
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-202 |
5.79e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.90 E-value: 5.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 14 PTRYLILLMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKvySYSLFFW 93
Cdd:cd17371 206 PLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN--NFALFAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 94 ----SLFTFLQGFIDVFPLAWAGvsmffmrFMLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLG 169
Cdd:cd17371 284 gsaiSILLYFFLPLSPTLILILG-------FPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVG 356
|
170 180 190
....*....|....*....|....*....|...
gi 496082092 170 WLTFALGWEHVFTVMGIIGFVLTVIWVKFVHNP 202
Cdd:cd17371 357 FLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
21-432 |
6.38e-04 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 41.96 E-value: 6.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 21 LMIFVVTAVNYGDRATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQ 100
Cdd:PRK09556 32 LVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 101 GFIdvfpLAWAGVSMFFMRF---MLGFSEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGW 177
Cdd:PRK09556 112 GAS----LGSGSVSLGLMIAlwaLSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 178 EHV---FTVMGIIGFVLTVIWVKFVHN-PTDHPRMSAAELkyiseGGAVVDMDHKKETTQAAGPKMDYIRQLLTNRMMLG 253
Cdd:PRK09556 188 GHVigmFIFPSIIALIIGFIGLRYGSDsPEELGWGKAEEI-----FGEPISEEDKETESTDMTKWQIFVEYVLKNPVIWL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 254 VFFGQYFLNTITWFFLTWFPIYLVQDKGMSIlkvgfVASIPALFGF-AGGVLG----GLFSDYLIGRgctltfaRKLPIV 328
Cdd:PRK09556 263 LCFANIFLYIVRIGIDNWSPVYAFQELGFSK-----EDAINTFTLFeIGALVGsllwGWLSDLANGR-------RALVAC 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 329 LGMLLASSIILCNYTASTPLVI--TLMALAF--FGK----GFGALGWpvisdvAPKEIVGLCGGVFNVFGNV-------- 392
Cdd:PRK09556 331 IALALIIFTLGVYQHATSEYMYlaSLFALGFlvFGPqlliGVAAVGF------VPKKAIGVANGIKGTFAYLfgdsfakv 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 496082092 393 --ASIATPLVIGYIV--SELHSFNGALIFVGGSALMMMVCYLFV 432
Cdd:PRK09556 405 glGMIADPTKNGTPIfgYTLTGWAGTFAALDIAAIGCICLMAIV 448
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
45-363 |
7.33e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.52 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLffwslftfLQGFIDVFPLAWAGVS---MFFMRFM 121
Cdd:TIGR00886 29 KDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSL--------LLLAIPCLWAGLAVQSysvLLLIRLF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 122 LGFSEApSFPANARIVAAWFPAKERGTASAIF--------NAAQYFSLALFSPLL----GWLTFALGWEHVFTVMGIIGF 189
Cdd:TIGR00886 101 IGIAGG-SFASCMPWISFFFPKKIQGTALGLAagwgnmggGVAQFVMPPIIGSLIfgggQPAHLAWGWAFVIVPAGILLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 190 VLTVIWVkfvhNPTDHPrmsaaelkyiseggavvdMDHKKETTQAAGPKMDYIRQLLTNRMML------GVFFGqyflnt 263
Cdd:TIGR00886 180 PALLIFF----VGADTP------------------PGKPATGKLSFKEALKVFGNRHTWILALlysvtfGSFLG------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 264 itwfFLTWFPIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYLIGRGCTLTFARKLPIVLGMLLASSIILcnyt 343
Cdd:TIGR00886 232 ----VSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSD---- 303
|
330 340
....*....|....*....|
gi 496082092 344 ASTPLVITLMALAFFGKGFG 363
Cdd:TIGR00886 304 GSLAAFIVLFVALFFFAGAG 323
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-407 |
9.82e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 9.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 35 ATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLqgFIDVFPLAWAGVS 114
Cdd:cd17333 13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL--IFATPSIYLFVVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 115 MFFMRFMLGFSEApsfPANARIVAAWfpaKERGTASAIFNAAQYFSLALFSPLLG--WLTFALGWEHVFTVMGIIGFVLT 192
Cdd:cd17333 91 MFLAGLGAGILDT---GANTFVGALF---EESSATRLNVLHGFFGLGALIGPLIAtsLLTSELSWSWAYLIIGLIYLLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 193 VIWVKFVHNPTDHPRmsaaelkyiseggavvdmDHKKETTQAAGPKMDYIRQLLTNRMMLGVFFGQYFLNTitwfFLTWF 272
Cdd:cd17333 165 ILILLTLFPELPSAR------------------NPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETA----FSSWV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 273 PIYLVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDyligrgctlTFARKLPIVLGMLLASSIILCNYTASTPLVitl 352
Cdd:cd17333 223 PSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR---------RIKPHTLLVLSGSGALLGLLILLLAPTLVV--- 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 496082092 353 MALAFFGKGFGALG-WPVISDVAPKEI---VGLCGGVFNVFGNVASIATPLVIGYIVSE 407
Cdd:cd17333 291 GLVATALLGLFMAAlFPTILSLGISNLpyaKGKGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
70-433 |
9.96e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.11 E-value: 9.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 70 QIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSMFFMRFMLGFSEAPSFPANARIVAAWFPAKERGTA 149
Cdd:cd17364 56 QLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGAL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 150 SAIFNAAQYFSlalfspllgwltfalgwehvFTVMGIIGFVLTVIWvkfvhnptdhprmsaaelkyiseggavvdmdhKK 229
Cdd:cd17364 136 IAAVFAMQGFG--------------------ILAGAIVTLILSAIF--------------------------------EH 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 230 ETTQAAGPKMDYIRQLLtnrMMLGVFFG--------QYFLNTITWFFL--TWFPIYLVQ---------DKGMSILKVGFV 290
Cdd:cd17364 164 PLPAGTYHHADLVWRIV---LGLGAIPAlsvlyfrkHLLGTAGTWFLLdiAFYGQNLFQstiisaigfSKTMNAYQELFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 291 AS-----IPALFGFAGGVLGGLFSDyLIGRGCTLTFARKLPIVLGMLLASSIIlcNYTASTPLVITLMALAFFGKGFG-- 363
Cdd:cd17364 241 IAvgqliIALAGTVPGYWFTVFLID-RIGRKKIQMMGFFGMTIFLLILAGPYD--HWKISTIGFFVLYGLTFFFSNFGpn 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 364 ALGWPVISDVAPKEIVGLCGGVFNVFGNVASIATPLVIGYIVSELhSFNGALIFVGGSALMMMVCYLFVV 433
Cdd:cd17364 318 TTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNI-GVRNVLIILAGVALLGIILTLLFP 386
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
35-196 |
1.05e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.02 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 35 ATLSIAGTEVAKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFW---SLFTFLQGFIDVFPLAWA 111
Cdd:cd17320 219 AYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLlaaALVLLLAALLGGLSLWPL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 112 GVSMFFMRFMLGFseapSFPANARIVAAWFPaKERGTASAIFNAAQYFSLALFSPLLGWLtfalgWEHVFTVMGIIGFVL 191
Cdd:cd17320 299 VAPLFLIFFGFGL----IFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL-----PNGTALPMGLLILVL 368
|
....*
gi 496082092 192 TVIWV 196
Cdd:cd17320 369 GLLAL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-194 |
1.24e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 46 KELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFfwsLFTFLQGFIDVFPLAWAGVSMFFMRFMLGFS 125
Cdd:cd17478 223 VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLL---LAAPFLLLFLLTPGIWSYILLVLAGFLLFAS 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496082092 126 eapsFPANARIVAAWFPAKeRGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVI 194
Cdd:cd17478 300 ----FPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-195 |
2.27e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLAWAGVSmffmrFMLGF 124
Cdd:cd17477 215 GLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLL-----FLWGG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496082092 125 SEAPSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTVMGIIGFVLTVIW 195
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
45-362 |
5.97e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 45 AKELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVysyslfFWSLFTFLQGFIDVFPLAWAGVSMFFM-RFMLG 123
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKL------FIIIGLLFTVLASLIMILFPSPWGLLIaRFLSG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 124 FSEAPSFPANArIVAAWFPAKERGTASAIFNAAQYFSLALFSPLLGWLTFALGWEHVFTV---MGIIGFVLTViwvkFVH 200
Cdd:cd17490 97 IAAATWVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLaalAGVLGFILSL----FIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 201 NPTDHPRMSAAELKyiseggavvdmdhkkettqaagpkmdYIRQLLTNRMMLGV----FFGQYFLNTITWFFLtwfPIYL 276
Cdd:cd17490 172 EERREKKPVLTELK--------------------------ELLSVLKDKKLLFFsllaILQQMITFSTTFGFT---PLIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 277 vQDKGMSILKVGFVASIPALFGFAGGVLGG-LFSDYLIGRGCTLTFArklpivlgMLLASSIILCNYTASTPLVITLMAL 355
Cdd:cd17490 223 -KQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGF--------LLLGAYCFLIPFAPNLTLLYLLQAL 293
|
....*..
gi 496082092 356 AFFGKGF 362
Cdd:cd17490 294 NGFGTGI 300
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
47-212 |
6.26e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 6.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 47 ELGLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYSYSLFFWSLFTFLQGFIDVFPLawagvsMFFMRFMLGFSE 126
Cdd:cd06180 28 ELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAA------LLALRFLAGAAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082092 127 APSFPANARIVAAWFPAKERGTASAIFNAAQYFSLALFSPL-LGWLTFALGWEHVFTVMGIIGFVLTVI-WVKFVHNPTD 204
Cdd:cd06180 102 AFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLvPAGLGGGLSWRAGWLALALLSAVLLLLsFLLLRRGPSA 181
|
....*...
gi 496082092 205 HPRMSAAE 212
Cdd:cd06180 182 PTEASAAE 189
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
276-440 |
7.93e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.30 E-value: 7.93e-03
10 20 30 40 50 60 70 80
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gi 496082092 276 LVQDKGMSILKVGFVASIPALFGFAGGVLGGLFSDYligrgctltFARKLPIVLGMLLASSIILCNYTASTP--LVITLM 353
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDR---------IERRRLLLVLLLLFILGNLLAALAPSFalLLLARA 95
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90 100 110 120 130 140 150 160
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gi 496082092 354 ALAFFGKGFGALGWPVISDVAPKEIVGLCGGVFnVFGNVASIATPLVIGYIVSELHSFNGALIFVGGSALMMMVCYLFVV 433
Cdd:cd17324 96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL 174
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....*..
gi 496082092 434 GDIKRME 440
Cdd:cd17324 175 PSLPPKK 181
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