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Conserved domains on  [gi|496082174|ref|WP_008806681|]
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MULTISPECIES: barstar family protein [Klebsiella]

Protein Classification

barstar family protein( domain architecture ID 10006576)

barstar family protein similar to Bacillus amyloliquefaciens Barstar, an intracellular inhibitor of the extracellular ribonuclease barnase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BarS COG2732
Barstar, RNAse (barnase) inhibitor [Transcription];
3-90 8.77e-21

Barstar, RNAse (barnase) inhibitor [Transcription];


:

Pssm-ID: 442038  Cd Length: 90  Bit Score: 78.43  E-value: 8.77e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082174  3 TYTFDFDEIAEQQDFYREFSRTFELAQDKVNNLDSLWDAVTGGlLPLPLDIEFIHLNDKQRRR---FGALILLFDEAEEE 79
Cdd:COG2732   1 TVVIDGSEIRDEEDFYRQLARALDFPDYFGRNLDALWDCLTGG-VELPVELVWKNAEASRRRLgedFEALIEVLEEAEEE 79

                        90
                ....*....|.
gi 496082174 80 LEGELRFNARH 90
Cdd:COG2732  80 LEGDLRFNLRD 90
 
Name Accession Description Interval E-value
BarS COG2732
Barstar, RNAse (barnase) inhibitor [Transcription];
3-90 8.77e-21

Barstar, RNAse (barnase) inhibitor [Transcription];


Pssm-ID: 442038  Cd Length: 90  Bit Score: 78.43  E-value: 8.77e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082174  3 TYTFDFDEIAEQQDFYREFSRTFELAQDKVNNLDSLWDAVTGGlLPLPLDIEFIHLNDKQRRR---FGALILLFDEAEEE 79
Cdd:COG2732   1 TVVIDGSEIRDEEDFYRQLARALDFPDYFGRNLDALWDCLTGG-VELPVELVWKNAEASRRRLgedFEALIEVLEEAEEE 79

                        90
                ....*....|.
gi 496082174 80 LEGELRFNARH 90
Cdd:COG2732  80 LEGDLRFNLRD 90
Barstar cd05142
Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus ...
 4-74 4.37e-19

Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.


Pssm-ID: 240165  Cd Length: 87  Bit Score: 73.90  E-value: 4.37e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082174  4 YTFDFDEIAEQQDFYREFSRTFELAQDKVNNLDSLWDAVTGGLLpLPLDIEFIHLND-KQRRRFGALILLFD 74
Cdd:cd05142   2 VVIDGEEIRSIEDLHQILKKELALPEYYGENLDALWDCLTGWVE-LPLTIEWKNFEQsKQRLGNYAESLLQV 72
 
Name Accession Description Interval E-value
BarS COG2732
Barstar, RNAse (barnase) inhibitor [Transcription];
3-90 8.77e-21

Barstar, RNAse (barnase) inhibitor [Transcription];


Pssm-ID: 442038  Cd Length: 90  Bit Score: 78.43  E-value: 8.77e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082174  3 TYTFDFDEIAEQQDFYREFSRTFELAQDKVNNLDSLWDAVTGGlLPLPLDIEFIHLNDKQRRR---FGALILLFDEAEEE 79
Cdd:COG2732   1 TVVIDGSEIRDEEDFYRQLARALDFPDYFGRNLDALWDCLTGG-VELPVELVWKNAEASRRRLgedFEALIEVLEEAEEE 79

                        90
                ....*....|.
gi 496082174 80 LEGELRFNARH 90
Cdd:COG2732  80 LEGDLRFNLRD 90
Barstar cd05142
Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus ...
 4-74 4.37e-19

Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.


Pssm-ID: 240165  Cd Length: 87  Bit Score: 73.90  E-value: 4.37e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082174  4 YTFDFDEIAEQQDFYREFSRTFELAQDKVNNLDSLWDAVTGGLLpLPLDIEFIHLND-KQRRRFGALILLFD 74
Cdd:cd05142   2 VVIDGEEIRSIEDLHQILKKELALPEYYGENLDALWDCLTGWVE-LPLTIEWKNFEQsKQRLGNYAESLLQV 72
Barstar_like cd00489
Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus ...
 7-64 9.24e-03

Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.


Pssm-ID: 238273  Cd Length: 85  Bit Score: 32.32  E-value: 9.24e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 496082174  7 DFDEIAEQQDFYREFSRTFELAQDKVNNLDSLWDAVTgGLLPLPLDIEFIHLNDKQRR 64
Cdd:cd00489   4 DGEDIADWEDFHARLKKKLGFPDYYGHNLDALWDCLT-GLVEEPLVLRWRNLEHLKRL 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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