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Conserved domains on  [gi|496082245|ref|WP_008806752|]
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MULTISPECIES: GntR family transcriptional regulator [Klebsiella]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
2-232 4.80e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 230.13  E-value: 4.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  82 EVLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLE-GSKFDY 160
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLEtGSLYEL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082245 161 IEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQVDYHLRR 232
Cdd:COG2188  166 LEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
2-232 4.80e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 230.13  E-value: 4.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  82 EVLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLE-GSKFDY 160
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLEtGSLYEL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082245 161 IEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQVDYHLRR 232
Cdd:COG2188  166 LEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
PRK09764 PRK09764
GntR family transcriptional regulator;
3-236 1.05e-47

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 158.07  E-value: 1.05e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   3 YKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLAE 82
Cdd:PRK09764   7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  83 VLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLEGSKFDYIE 162
Cdd:PRK09764  87 KLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIE 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082245 163 KECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQVDYHLRRVQAQ 236
Cdd:PRK09764 167 EVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR 240
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 87-225 1.55e-35

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 123.56  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245    87 QGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLEGSKFDYIEKECG 166
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLG 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082245   167 IIIS---GNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQ 225
Cdd:smart00866  82 LKIVrstRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 87-225 2.70e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 115.00  E-value: 2.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   87 QGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHL-EGSKFDYIEKEC 165
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEERY 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  166 GIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQ 225
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 2-216 1.04e-30

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 113.73  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245    2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   82 EVLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLE-GSKFDY 160
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAAsGSITDA 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 496082245  161 IEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSV 216
Cdd:TIGR02325 169 LREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSV 224
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 2-66 3.06e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 81.34  E-value: 3.06e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVA 66
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
2-232 4.80e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 230.13  E-value: 4.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  82 EVLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLE-GSKFDY 160
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLEtGSLYEL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082245 161 IEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQVDYHLRR 232
Cdd:COG2188  166 LEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
PRK09764 PRK09764
GntR family transcriptional regulator;
3-236 1.05e-47

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 158.07  E-value: 1.05e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   3 YKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLAE 82
Cdd:PRK09764   7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  83 VLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLEGSKFDYIE 162
Cdd:PRK09764  87 KLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIE 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082245 163 KECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQVDYHLRRVQAQ 236
Cdd:PRK09764 167 EVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRKSSR 240
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 87-225 1.55e-35

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 123.56  E-value: 1.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245    87 QGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLEGSKFDYIEKECG 166
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLG 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082245   167 IIIS---GNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQ 225
Cdd:smart00866  82 LKIVrstRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 87-225 2.70e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 115.00  E-value: 2.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   87 QGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHL-EGSKFDYIEKEC 165
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEERY 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  166 GIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNASEYQ 225
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 2-216 1.04e-30

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 113.73  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245    2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   82 EVLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLE-GSKFDY 160
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAAsGSITDA 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 496082245  161 IEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSV 216
Cdd:TIGR02325 169 LREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSV 224
PRK11402 PRK11402
transcriptional regulator PhoB;
2-221 3.78e-29

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 109.92  E-value: 3.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:PRK11402  10 LYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  82 EVLRKQGKEVVSQVLAFEVmPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLEG-SKFDY 160
Cdd:PRK11402  90 DFGVSQGKATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsSTYQL 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496082245 161 IEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSDSGEFLNYSVMFRNA 221
Cdd:PRK11402 169 FQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRA 229
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 2-170 2.70e-24

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 96.66  E-value: 2.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245    2 IYKSIADRLrlrlNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFV-ARKDVHHETSNLTGL 80
Cdd:TIGR02404   5 IYQDLEQKI----TKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   81 AEVLRKQGKEVVSQVLAFEV-MPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPVKLFRNLSLSHLEGSKFD 159
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQ 160

                         170
                  ....*....|.
gi 496082245  160 YIEKECGIIIS 170
Cdd:TIGR02404 161 YLENELGLAIS 171
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 3-216 8.44e-22

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 90.22  E-value: 8.44e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   3 YKSIADRLRLRLNSAdFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLAE 82
Cdd:PRK10079  14 YQEIAAKLEQELRQH-YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  83 VLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMPvklfrNLSL-SHLE----GSK 157
Cdd:PRK10079  93 NLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFA-----DLTWwPTLQrfdsGSL 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245 158 FDYIEKECGIIISGNYETLTPVLADKQLARSMNVPEQTPLLRITSLSYSD-SGEFLNYSV 216
Cdd:PRK10079 168 HDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTLNHRDgESSPAEYSV 227
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 2-200 2.18e-21

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 88.91  E-value: 2.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245    2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGLA 81
Cdd:TIGR02018   2 LYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNIA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   82 EVLRKQGKEVVSQVLAFEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLEDSYMpvklfrNLSLSHlegskfDYI 161
Cdd:TIGR02018  82 DEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLV------NAAAVP------DYL 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 496082245  162 EKECGIIISGNY-----------ETLTPVLADKQLARSMNVPEQTPLLRI 200
Cdd:TIGR02018 150 KQDFTQTTPGAYlsqaaplteaeHRIEAISADPEEARLLAIDAGEPCLLI 199
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 3-65 2.85e-21

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 83.82  E-value: 2.85e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496082245    3 YKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFV 65
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 2-66 3.06e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 81.34  E-value: 3.06e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVA 66
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
6-65 7.51e-19

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 77.62  E-value: 7.51e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245     6 IADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFV 65
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
2-78 2.75e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 78.05  E-value: 2.75e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLT 78
Cdd:COG2186    8 LAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPLA 84
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 2-67 4.04e-15

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 74.09  E-value: 4.04e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVAR 67
Cdd:COG1167   13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
PRK14999 PRK14999
histidine utilization repressor; Provisional
 25-137 1.22e-11

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 62.64  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245  25 LPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVArkdvhhETSNLTGLAEVlRKQGKEVVS-------QVLA 97
Cdd:PRK14999  36 IPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVA------EPKGQSALFEV-RSIAEEIAArrhqhrcEVLT 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 496082245  98 FEVMPAPPAIASLLRIKIDERIYFSRRVRYVDGKPLMLED 137
Cdd:PRK14999 109 LERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIED 148
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-71 6.54e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 54.54  E-value: 6.54e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082245   6 IADRLRLRLNSADFAIGSPLPgEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVH 71
Cdd:COG1802   16 VYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPE 80
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 6-65 1.38e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 54.00  E-value: 1.38e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   6 IADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFV 65
Cdd:PRK10421   7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
22-65 1.05e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 48.48  E-value: 1.05e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 496082245  22 GSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFV 65
Cdd:PRK09464  31 GEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV 74
PRK11523 PRK11523
transcriptional regulator ExuR;
2-65 1.25e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 48.30  E-value: 1.25e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082245   2 IYKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFV 65
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 8-67 6.23e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 46.17  E-value: 6.23e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082245   8 DRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVAR 67
Cdd:PRK03837  20 ERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSR 79
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 22-80 7.26e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 42.83  E-value: 7.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 496082245  22 GSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHETSNLTGL 80
Cdd:PRK09990  28 GQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDASPLMHL 86
PRK10225 PRK10225
Uxu operon transcriptional regulator;
3-74 1.34e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 42.31  E-value: 1.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082245   3 YKSIADRLRLRLNSADFAIGSPLPGEKKLAEEFGVARMTIRKAIDLLVDWGLVVRRHGSGTFVARKDVHHET 74
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNT 82
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 31-60 1.70e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 41.66  E-value: 1.70e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 496082245  31 LAEEFGVARMTIRKAIDLLVDWGLVVRRHG 60
Cdd:COG1349   25 LAERLGVSEETIRRDLAELEEQGLLRRVHG 54
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
29-60 2.24e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 35.31  E-value: 2.24e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 496082245   29 KKLAEEFGVARMTIRKAIDLLVDWGLVVRRHG 60
Cdd:pfam08220  18 EELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
29-60 2.93e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 34.89  E-value: 2.93e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 496082245    29 KKLAEEFGVARMTIRKAIDLLVDWGLVVRRHG 60
Cdd:smart00420  18 EELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 23-56 3.95e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 34.72  E-value: 3.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 496082245   23 SPLPGeKKLAEEFGVARMTIRKAIDLLVDWGLVV 56
Cdd:pfam08279  12 GPISG-QELAEKLGVSRRTIRRDIKILEELGVPI 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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