|
Name |
Accession |
Description |
Interval |
E-value |
| lacY |
PRK09528 |
galactoside permease; Reviewed |
4-410 |
7.40e-162 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 461.67 E-value: 7.40e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 4 SNKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIII 83
Cdd:PRK09528 8 KNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWIISGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 84 TLFAPYWIYVFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIGAAIGTFAAGKLYGI 163
Cdd:PRK09528 88 VLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFIAGILFNI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 164 DQNMIFWLASGAGVCLLVI--VWKMQISAHPQQG-LLSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFA 240
Cdd:PRK09528 168 NPQINFWLGSGSALILLVLlfFAKPDAPSTAKVAnALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYDVFDQQFP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 241 IYYSHFFESKARGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGF 320
Cdd:PRK09528 248 NFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSILKLLHAF 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 321 ESSVLLVAALKYITANFNPLLSATVYLIGFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISFITL--DK 398
Cdd:PRK09528 328 EVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISVFTLsgDR 407
|
410
....*....|..
gi 496082652 399 ARVFASQPVPAN 410
Cdd:PRK09528 408 ELSLLRRQVPEA 419
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
8-396 |
2.16e-151 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 433.58 E-value: 2.16e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 8 YFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFA 87
Cdd:cd06172 1 YWKFSLFFFLFFFIWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 88 PYWIYVFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIGAAIGTFAAGKLYGIDQNM 167
Cdd:cd06172 81 PFFIFVYGPLLQSNILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 168 IFWLASGAGVCLLVIVWKMQISAHPQQGLLSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFF 247
Cdd:cd06172 161 NFWLGSGFALILLLLLLFAKPEDSDTAAAAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 248 ESKARGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFESSVLLV 327
Cdd:cd06172 241 ATPEQGNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496082652 328 AALKYITANFNPLLSATVYLIGFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISFITL 396
Cdd:cd06172 321 SIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
5-409 |
1.30e-131 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 384.50 E-value: 1.30e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 5 NKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIIT 84
Cdd:pfam01306 6 NTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCITGLLV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 85 LFAPYWIYVFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIGAAIGTFAAGKLYGID 164
Cdd:pfam01306 86 LFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGILFSID 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 165 QNMIFWLASGAGVCLLVIVWKMQISAhPQQGL----LSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFA 240
Cdd:pfam01306 166 PQIVFWLGSGFALILALLLMFAKPDK-SSSAIvadaLGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFDQQFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 241 IYYSHFFESKARGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGF 320
Cdd:pfam01306 245 NFFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKMLHMF 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 321 ESSVLLVAALKYITANFNPLLSATVYLIGFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISFITLDKAR 400
Cdd:pfam01306 325 EVPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTLSGSG 404
|
....*....
gi 496082652 401 VFASQPVPA 409
Cdd:pfam01306 405 PQILLPRPV 413
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
5-396 |
9.66e-131 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 381.40 E-value: 9.66e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 5 NKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIIT 84
Cdd:TIGR00882 1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 85 LFAPYWIYVFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIGAAIGTFAAGKLYGID 164
Cdd:TIGR00882 81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 165 QNMIFWLASGAGVCLLVIVWKMQISAHPQQGL---LSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAI 241
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVanaLGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 242 YYSHFFESKARGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFE 321
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082652 322 SSVLLVAALKYITANFNPLLSATVYLIGFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISFITL 396
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTL 395
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
10-394 |
3.13e-22 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 97.27 E-value: 3.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 10 ISCLFFLFFFIGWGCCYPYLSLWLTEtIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWM---LAIIITLF 86
Cdd:cd17335 1 RLKLFYFFFFAALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLsllAAVLFFLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 87 APYWIYVFAPLLKInVFLGAlagglyigMAYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIGAAIGTFAAGKL-----Y 161
Cdd:cd17335 80 LFFVAQIFWLLLLL-VILGA--------FFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILidrssT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 162 GIDQNMIFWLASGAGVCLLVIVWKMQISAHPQQgllsgkaSPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAI 241
Cdd:cd17335 151 YKNYTIAFYVFAVLMLLALLLALKFPFRPKHPE-------PNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 242 YYSHFFESKArgaeVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFE 321
Cdd:cd17335 224 HLQDLGGSKT----LIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLT 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 322 SSVLLVAALKYITANFNPLLSATVYLIgfqfsksFSSIFLSTGI-------GHMYQSMGFTSSYIVLGGIALCFTLISFI 394
Cdd:cd17335 300 FALVWAAAVSYASAAAPPGLRATAQGL-------LQGLYFGLGGglgsligGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-400 |
1.49e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.47 E-value: 1.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 15 FLFFFIGWGCCY--PYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKnlmWMLAIIITLFAPYWIY 92
Cdd:COG2223 11 TLAFFLAFGVWYlwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 93 VFAPLLkINVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRAssFEFGRARMFGGIGAAIGTFAAGKLYG-IDQNMIFWL 171
Cdd:COG2223 88 ALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG--LALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 172 ASGAGVCLLVIVWKMQISAHPQQGllsgKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFeskA 251
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAA----AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF---G 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 252 RGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLI-KLLHGFESSVLLVAAL 330
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVlFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496082652 331 KYITANFNPLLSATVYLIGFqFSKSFSSIFLSTGIGHMYQSMG-FTSSYIVLGGIALCFTLISFITLDKAR 400
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-393 |
5.11e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.60 E-value: 5.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 12 CLFFLFFFIGWGCCYPYLSLWLTEtIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFAPYWI 91
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 92 YVfapllkinVFLGALAGGLYIGMAYGAGCGVCEAYIDKVS--RASSFEFGRARMFGGIGAAIGTFAAGKLYGID----Q 165
Cdd:cd06174 81 AP--------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASSLgfgwR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 166 NMIFWLASGAGVCLLVIVWKMQISAHPQQGLLSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYdqqFAIYYSH 245
Cdd:cd06174 153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF---STLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 246 FFESKARGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLI-MSLRIIGSAWAIGPVSISLIKLLHGFESSV 324
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496082652 325 LLVAALKYITANFNPLLSATVYLIGFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISF 393
Cdd:cd06174 310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
14-344 |
7.97e-11 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 63.03 E-value: 7.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 14 FFLFFFIGWGCCYPYLSLWLtETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFapyWIYV 93
Cdd:pfam12832 7 FYFFYFAALGCLLPYWGLYL-RSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVL---FLSV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 94 FAPLLKINVFLGALAGGLYIGMaYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIGAAIGTFAAGKLygIDQNMIFWLAS 173
Cdd:pfam12832 83 LFIPISLTFWWLALLVVLFSFF-WNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGAL--FDHYSVGLLPS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 174 gAGVCLLVIVWKMQISAHPQQGLLSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFESKarg 253
Cdd:pfam12832 160 -VLFYLFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASN--- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 254 aEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIG-SAWAIGPVSISLIKLLHGFESSVLLVAALKY 332
Cdd:pfam12832 236 -TLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAISFGLTHAAAIEY 314
|
330
....*....|..
gi 496082652 333 ITANFNPLLSAT 344
Cdd:pfam12832 315 VRRIFPGSLQGT 326
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
16-311 |
1.17e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 62.63 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 16 LFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFAPYWIYVFA 95
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 96 PLLKINVFLGALAGGLYIgmaygagcGVCEAYIDKVSRASSFEFGRA--RMFGGIGAAIGTFAAGKLYGIDQNMIFWLAS 173
Cdd:cd17329 89 WLFAIALVLTGFGGGLFE--------PASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 174 GAGVCLLVIVW----KMQISAHPQQGLLSGKASPVTLRDAvsllkikkfwFFALYVIGVGAVYETYDQQFAIYYSHFFES 249
Cdd:cd17329 161 VLFLLAALVLLfllpETRPKRRAAEKTEILRGYKIVLRDR----------AFLLFLLASFLISLIYFQLESTLPVYVVEI 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496082652 250 KARGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSI 311
Cdd:cd17329 231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVL 292
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-394 |
6.21e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.28 E-value: 6.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 12 CLFFLFFFIGWGCCYPYLSLWLTEtIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFAPYWI 91
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 92 YVFAPLLKINVFLGALAGGLYIgmaygagcGVCEAYIDKVSRASSF--EFGRARMFGGIGAAIGTFAAGKLYG-IDQNMI 168
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVW--------PAAMALIADIAPPEERgrAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 169 FWLASGAGVCLLVIVWKMqISAHPQQGLLSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFE 248
Cdd:cd17325 153 FLVCAALALLALVLALLL-LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 249 SkarGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFESSVLLVA 328
Cdd:cd17325 232 L---SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496082652 329 ALKYITANFNPLLSATVYLIgFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISFI 394
Cdd:cd17325 309 TLALLADIVPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-314 |
6.70e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.69 E-value: 6.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 4 SNKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYR--KNLMWMLAI 81
Cdd:COG2211 8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 82 IITLFAPYWIYVFAPLLKINVFLGALAGGLYI-GMAYGAGCGVCEAYI-------DKVSRASSFefgrARMFGGIGAAIG 153
Cdd:COG2211 88 AIPLALSFVLLFTAPDLSPTGKLIYALVTYLLlGLAYTLVNIPYSALGaeltpdyEERTRLSSW----RFAFAGLGGLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 154 TFAAGKLY----GIDQNMIFWLASGAGVCLLVIVWKMQISAHpqqGLLSGKASPVTLRDAV-SLLKIKKFWFFALYVIGV 228
Cdd:COG2211 164 SVLPPPLVaafgGDAALGYRLTALIFAVLGLLAFLLTFFGTK---ERPVPEEEKVSLKESLkALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 229 GAVYETYDQQFAIYYSHFFEskaRGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGsAWAIGP 308
Cdd:COG2211 241 FLALALVAALLLYYFKYVLG---LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL-LFFLGP 316
|
....*.
gi 496082652 309 VSISLI 314
Cdd:COG2211 317 GNLWLL 322
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-186 |
6.20e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 6.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 1 MITSNKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMW-ML 79
Cdd:cd17325 194 LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIgLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 80 AIIITLFAPYWIYVFAPLLKINVFLGALAGGLYIGMAygagcgvceAYIDKVSRASSFE--FGRARMFGGIGAAIGTFAA 157
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATL---------ALLADIVPPEGRGtaMGLFNTAFSLGMVLGPLLG 344
|
170 180 190
....*....|....*....|....*....|
gi 496082652 158 GKLYG-IDQNMIFWLASGAGVCLLVIVWKM 186
Cdd:cd17325 345 GFLYDaFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-339 |
8.79e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 8.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 9 FISCLFFLFFFIGWGCCYPYLSlWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFAP 88
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 89 YWIYVFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAyiDKVSRAssfeFGRARMFGGIGAAIGTFAAGKLYG-IDQNM 167
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPP--ERRGRA----LGLLGAGLGLGPALGPLLGGLLADlFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 168 IFWLASGAGVCLLVIVWKMQISAHPQqgllsgkASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFF 247
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPA-------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 248 EskaRGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFESSVLLV 327
Cdd:COG2814 239 G---LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315
|
330
....*....|..
gi 496082652 328 AALKYITANFNP 339
Cdd:COG2814 316 LLQALVAELAPP 327
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-314 |
2.41e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 12 CLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKnlMWMLAIIITLFAPYWI 91
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR--VLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 92 YVFAPLLkiNVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRASSfeFGRARMFGGIGAAIGTFAAGKLYG-IDQNMIFW 170
Cdd:pfam07690 80 LFASSLW--LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRA--LGLVSAGFGLGAALGPLLGGLLASlFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 171 LASGAGVCLLVIVWKMqISAHPQQGLLSGKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFESK 250
Cdd:pfam07690 156 ILAILSLLAAVLLLLP-RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082652 251 ARGAEVFGYLttgqIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLI 314
Cdd:pfam07690 235 LLAGLLLGLG----GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
11-289 |
3.11e-06 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 48.78 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 11 SCLFFLFFFIgWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAII--ITLFAP 88
Cdd:cd06177 3 SVMMFLQFFI-WGAWLVTLGGYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRFFAAEKVLAVLHLIgaAALFYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 89 YWIYVFAPLlkinvFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRassfEFGRARMFGGIGAAIGTFAAGKLYGIDQNMI 168
Cdd:cd06177 82 ATVTDFSVF-----FWVMLLYSLCYMPTLALTNSIAFSNLEDPVK----DFPPIRVWGTIGWIAAGWPVGFLGWEASNLQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 169 FWLASGAGVCLLVIVWKMQISAHPQQGLLSGKASPVTLrDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFfe 248
Cdd:cd06177 153 FYIAAGASLLLGLYSLTLPHTPPKKAGKGVSKRSLLGL-DAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDF-- 229
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 496082652 249 sKARGAEVFGYLTTGQIfLDAIVMFFAPWFVNKIGPKNALL 289
Cdd:cd06177 230 -GMIVKNPAGIMSLGQI-SEILFMLAIPFFLKRLGIKKVML 268
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-184 |
2.06e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 12 CLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFApYWI 91
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA-LLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 92 YVFAPLLKINVFLGALAGGLyIGMAYGAGCGVCEAYIDKVSRASSfeFGRARMFGGIGAAIGTFAAGKLYGI-DQNMIFW 170
Cdd:COG2271 265 LALLPSPALAIALLFLAGFG-LGGAFGLLWALAAELFPKKARGTA--SGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFL 341
|
170
....*....|....
gi 496082652 171 LASGAGVCLLVIVW 184
Cdd:COG2271 342 LLAALALLAALLAL 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
1-184 |
3.75e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.64 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 1 MITSNKNYFISCLFFLFFFIGWGCCYpYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLA 80
Cdd:COG2223 201 ALRDPRFWLLSLLYFGTFGSFIGFSS-WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 81 IIItlfapywIYVFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAYIDKV--SRASSFEFGRARMFGGIGAAIGTFAAG 158
Cdd:COG2223 280 LMA-------LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIfpTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
|
170 180
....*....|....*....|....*...
gi 496082652 159 KLYGIDQN--MIFWLASGAGVCLLVIVW 184
Cdd:COG2223 353 ALLDATGSytAAFLVFAVLALVALVLTL 380
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
28-295 |
4.50e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 45.38 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 28 YLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYR--KNLMWMLAIIITLfAPYWIYVFAPLLKINVFLG 105
Cdd:pfam13347 19 YLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRwgRRRPWLLLSAIIL-AVSFILLFTPPELGRAPLF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 106 ALAGGLYIGMAYGAGCGVCEAYIDKVSRASSFE-----FGRARMFGGIGAAIGTFAAGKLYGID-------QNMIFWLAS 173
Cdd:pfam13347 98 IWLLATYILLRIAYTFFEIPYWSLGPELTRDYDertslTSYRSFFSVGGGLLAAALAFPLVLILggtglerKGYRIFALI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 174 GAGVCLLVI---VWKMQISAHPQQGLLSGKASPVTLRDAV-SLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFES 249
Cdd:pfam13347 178 GAVLMLLGViitAAGTKERVSMRSKEDTGQKEAGSLLDMLkEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 496082652 250 KARGAEVFGYLTTGQIfldaIVMFFAPWFVNKIGPKNALLYCGLIM 295
Cdd:pfam13347 258 GFAASAFPLVFTIGAL----LGIPLWPPLAKRIGKKNTYILGALIT 299
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-117 |
7.35e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 7.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 4 SNKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIII 83
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110
....*....|....*....|....*....|....
gi 496082652 84 TLFAPYWIYVFAPLLKINVFLGALAGGLYIGMAY 117
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-158 |
8.69e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 8.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 1 MITSNKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKnlMWMLA 80
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK--AFIIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 81 IIITLFAPYWIYVFAPLlkiNVFLGALAGGLyIGMAYGAGCGVCEAYIDKVSRASSFEFGRAR---------MFGGIGAA 151
Cdd:COG2211 301 LLLAALGLLLLFFLGPG---NLWLLLVLAAL-AGIGLGAILVLPWAMLADVVDYDEWKTGRRReglyfgiftFAIKLGQA 376
|
....*..
gi 496082652 152 IGTFAAG 158
Cdd:COG2211 377 LAGALAG 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-391 |
1.41e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 12 CLFFLFFFIGWGCCYPYLSLWLtETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFAPYwI 91
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY-L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 92 YVFAPLLkinVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRASSfeFGRARMFGGIGAAIGTFAAGKLYG-IDQNMIFW 170
Cdd:cd17489 80 LATSVAL---LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEG--IGYYGLATTLAMALGPALGLFLYQhLGFAVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 171 LASGAGVCLLVIVWKMQISAHPQqgllsgKASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHffesk 250
Cdd:cd17489 155 VAAVLALLALLLVFLVKDPPPVA------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE----- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 251 aRGAEVFGYLTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFESSVLLVAAL 330
Cdd:cd17489 224 -RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496082652 331 KYITANFNPLLSAT---VYLIGFQFSKSFSSIFLstgiGHMYQSMGFTSSYIVLGGIALCFTLI 391
Cdd:cd17489 303 ALAVDLVPPHRRGAangTFFIFFDLGIGLGGLLL----GLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-396 |
1.53e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 1 MITSNKNYFISCLFFLFFFIG-----WGCCYPYLSlwltETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNL 75
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGfatalWGPLIPALK----DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 76 MWMLAIIITLFApywIYVFAPllkinVFLGALAGGLYIGMAYGAGCGVCEAYIDKVSRassfEFGRARM--------FGG 147
Cdd:COG0738 77 LLGLLLMALGLL---LFALAP-----SYPLLLLALFLLGLGLGLLDVAANPYVAALGP----ETAASRLnllhaffsLGA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 148 -IGAAIGTFAAGKLYGIDQNMIFWLASGAGVCLLVIVWKMQISAHPQQGllsgKASPVTLRDAVSLLKIKKFWFFALYVI 226
Cdd:COG0738 145 lLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE----EEAAGSAASLKSLLKNPRLLLGGLAIF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 227 GVGAVYETYDQQFAIYYSHFFE-SKARGAEVFGYLTTGQifldAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWA 305
Cdd:COG0738 221 LYVGAEGAIGDWLPLYLKDVLGlSEATAALGLSLFWGGM----TIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 306 IGPVSISLIKLLHGFESSVLLVAALKYITANFNPLLSATVYLIGfqFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLggiA 385
Cdd:COG0738 297 PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL--IMGIVGGAIGPPLIGFLADAFGLRAAFLVP---L 371
|
410
....*....|.
gi 496082652 386 LCFTLISFITL 396
Cdd:COG0738 372 VCYLLILLLAL 382
|
|
| MFS_unc93_like |
cd17338 |
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ... |
273-393 |
6.90e-04 |
|
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340896 [Multi-domain] Cd Length: 388 Bit Score: 41.56 E-value: 6.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 273 FFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSIsLIKLLHGFESSVLLVAALKYITANFNP----LLSATVYLI 348
Cdd:cd17338 47 FIAPLLVKLLGEKITLVLGGLGYAIFIASNIFPIWGTLV-PASIILGFAAAILWTAQGTYITRISDEsnigRNFGIFWSI 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 496082652 349 gFQFSKSFSSIFLSTGIGHMYQSMGFTSSYIVLGGIALCFTLISF 393
Cdd:cd17338 126 -FQLSQVFGNLISLALLNHSKGSSGTTILFIVFMAIMLVGIILLF 169
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
42-394 |
7.26e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 42 TDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAI-IITLFAPYWIYVFAPLLKINVFLGALAGGLY-IGMAYGA 119
Cdd:cd17473 35 LLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLyGIGGVAGLFLDSLYALLASRALLGIGVAGIMtLATALIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 120 gcgvceAYIDKVSRASSFefGRARMFGGIGAAIGTFAAGKLYGIDQNMIFWLASGAGVCLLVIVWKMQISAHPQqgllsg 199
Cdd:cd17473 115 ------DYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKS------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 200 KASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFESkarGAEVFGYLTTGQIFLDAIVMFFAPWFV 279
Cdd:cd17473 181 KSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGG---SAALIGLALAIASLAGAIGALLFGRLK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 280 NKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFESSVLLVAALKYITANFNPLLS--ATVYLIGFQFSKSFS 357
Cdd:cd17473 258 RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRgrAMGIVTSAFFLGQFL 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 496082652 358 SIFLSTGIGHMYqsMGFTSSYIVLGGIALCFTLISFI 394
Cdd:cd17473 338 SPLVLGPLVNLT--GGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
5-183 |
1.12e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 5 NKNYFISCLFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIIT 84
Cdd:cd17329 199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 85 LFAPYWIYVFAPLLKINVFLGALAGGLYIGMAYGAGcgvcEAYIDKVSRASSfeFGRARMFGGIGAAIGTFAAGKLYGID 164
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV----AALAPPDKRGSY--MGFYALAWGLGRAIGPLVGGLLLDLL 352
|
170
....*....|....*....
gi 496082652 165 QNMIFWLAsGAGVCLLVIV 183
Cdd:cd17329 353 GPGLPWLI-LAALGLIAAA 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-183 |
1.58e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.28 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 13 LFFLFFFIGWGCCYPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAIIITLFAPYWiY 92
Cdd:cd17316 184 LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF-Y 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 93 VFAPLLKINVFLGALAGGLYIGMAYGAGCGVCEAYIDKV-SRASSFEFGRARMFGGIGAAIGTFAAGKLYGIdQNMIFWL 171
Cdd:cd17316 263 LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGT-GVPALIL 341
|
170
....*....|..
gi 496082652 172 ASGAGVCLLVIV 183
Cdd:cd17316 342 ALLAIVALIVAL 353
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-333 |
3.22e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 26 YPYLSLWLTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMW--MLAIIITLFAPYWIYVFAPLLKINVF 103
Cdd:cd17471 16 LPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILlaLLAGALGYLLFAFLRNYWVLLLVGVV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 104 LGALAGGLY-IGMAYGAgcgvceAYIDKVS-RASSFEFGRARMFGGIGAAIG-TFAAGKLYGIDQNMIFWLASGAGVCLL 180
Cdd:cd17471 96 LLSLGAAAFpQLFALAR------EYADRSSgRDATLFNSVLRAAFSLAWVIGpPLAFLLLDVLGFTGLFLLAALLYLVVA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 181 VIVWKMQISAHPQQgllsgkASPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFeskARGAEVFGYL 260
Cdd:cd17471 170 LLVLFLLPSVKPPA------QKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNEL---GGSESWVGLL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496082652 261 TTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLLHGFESSVLLVAALKYI 333
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYF 313
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
10-317 |
4.08e-03 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 38.98 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 10 ISCLFFLFFFIgWGCCYPYLSLWLTETiGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKNLMWMLAII--ITLFA 87
Cdd:pfam03825 7 LKVMMFLQFFI-WGAWLVTLGSYMFVT-GFDGASIGAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIgaITLFM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 88 PYWIYVFAPLLKINvflgalaggLYIGMAYGAGCGVCEAYIDKVSRASSFEFGRARMFGGIG----AAIGTFAAGKLYGI 163
Cdd:pfam03825 85 AAQVTTFEAFFLVI---------LVNSLAYMPTLALTNSIAFANLQDPVTDFPPIRVWGTIGwimaSWPFVMWVVSLAGF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 164 DQ-NMIFWLASGAGVCLLVIVWKMQISAHPQQGLLSGKAspVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDqQFAIY 242
Cdd:pfam03825 156 ELsHMQLLIAAGLSALLVLFALTLPHTPAKQKANQSWTT--LLGLDAFALLKNKRMAVFFIFSFLLGAELQIYN-VFANT 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496082652 243 YSHFFeSKARGAEVFGYLTTGQiFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLIKLL 317
Cdd:pfam03825 233 FLTSF-DKFIVKHASIIMSLGQ-ISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGADPTPFGTALLL 305
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-314 |
7.45e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 7.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 33 LTETIGINYTDVGLVYSFTAIVAVCVQPLFGFISDKLVYRKN-----LMWMLAIIITLFAP-YWIYVFApllkinVFLGA 106
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLlplgpLLTGLGLSLLGFAPnYWLLLLL------VALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 107 LAGGLY--IGMAYGAgcgvcEAYIDKVSRASSF-----EFGRArmfggIGAAIGTFAAGKLYGIDqnmIFWLASGAGVCL 179
Cdd:cd17478 96 IGSAAFhpEGARLAS-----QAAGGRRGLAMSIfsvggNLGFA-----LGPLIAAALVALFGGLG---LLILLIIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082652 180 LVIVWKMQISAHPQQgllsgkasPVTLRDAVSLLKIKKFWFFALYVIGVGAVYETYDQQFAIYYSHFFESKARGAEVFGY 259
Cdd:cd17478 163 ALLLLRLRPLKKPEA--------KKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 496082652 260 LTTGQIFLDAIVMFFAPWFVNKIGPKNALLYCGLIMSLRIIGSAWAIGPVSISLI 314
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL 289
|
|
| |
