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Conserved domains on  [gi|496082738|ref|WP_008807245|]
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MULTISPECIES: carbon-phosphorus lyase complex subunit PhnI [Klebsiella]

Protein Classification

carbon-phosphorus lyase complex subunit PhnI( domain architecture ID 10007622)

carbon-phosphorus lyase complex subunit PhnI acts as a nucleosidase on ATP or GTP and is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate, together with PhnG, PhnH and PhnL

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PhnI COG3626
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion ...
1-350 0e+00

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion transport and metabolism];


:

Pssm-ID: 442844  Cd Length: 369  Bit Score: 662.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738   1 MYVAVKGGEKAILAAHALQEQKRRGDGRLPELSVDQIGDQLNLAVDRVMTEGGIADRELAALALKQASGDNVEAIFLLRA 80
Cdd:COG3626    1 MYVAVKGGERAIANAHRLLAERRRGDPAVPELSVDQIREQLRLAVDRVMAEGSLYDPELAALAIKQARGDLIEAIFLLRA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  81 YRTTLPRLAVSEPINTAEMRLERRISAVYKDIPGGQLLGPTYDYTHRLLDFTLLANGEAP-SVQQADGEAEPTPHVFSLL 159
Cdd:COG3626   81 YRTTLPRFGYSEPLDTAAMRVERRISATFKDLPGGQVLGPTFDYTHRLLDFALLAEGEPPfAPPEAEALPEPMPRVTDLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738 160 TQQGLAKAEED-RGTPPDDITRTPPVYPCSRSSRLQQLMRGDEGYLLALAYSTQRGYGRNHPFAGEIRSGYVQVEIVPEE 238
Cdd:COG3626  161 RAEGLIEPEPDaDDAEPFDITREPLVFPAPRSARLQALARGDEGFLLALAYSTQRGYGRNHPFAGEIRVGYVEVELVPPE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738 239 LGFSVNIGELLLTECEMVNGFVAPQDEPPHFTRGYGLTFGMSERKAMAMALVDRALQAPDYDEEIAGPAQDEEFVLAHAD 318
Cdd:COG3626  241 LGFAVEIGEILVTECEMVNQFKGSADEPPQFTRGYGLVFGHSERKAMSMALVDRALRAGELGEEVTAPAQDEEFVLSHSD 320
                        330       340       350
                 ....*....|....*....|....*....|..
gi 496082738 319 NVEAAGFVSHLKLPHYVDFQAELALLKRLQRE 350
Cdd:COG3626  321 NVEATGFVEHLKLPHYVDFQSELELLRRLRAE 352
 
Name Accession Description Interval E-value
PhnI COG3626
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion ...
1-350 0e+00

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion transport and metabolism];


Pssm-ID: 442844  Cd Length: 369  Bit Score: 662.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738   1 MYVAVKGGEKAILAAHALQEQKRRGDGRLPELSVDQIGDQLNLAVDRVMTEGGIADRELAALALKQASGDNVEAIFLLRA 80
Cdd:COG3626    1 MYVAVKGGERAIANAHRLLAERRRGDPAVPELSVDQIREQLRLAVDRVMAEGSLYDPELAALAIKQARGDLIEAIFLLRA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  81 YRTTLPRLAVSEPINTAEMRLERRISAVYKDIPGGQLLGPTYDYTHRLLDFTLLANGEAP-SVQQADGEAEPTPHVFSLL 159
Cdd:COG3626   81 YRTTLPRFGYSEPLDTAAMRVERRISATFKDLPGGQVLGPTFDYTHRLLDFALLAEGEPPfAPPEAEALPEPMPRVTDLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738 160 TQQGLAKAEED-RGTPPDDITRTPPVYPCSRSSRLQQLMRGDEGYLLALAYSTQRGYGRNHPFAGEIRSGYVQVEIVPEE 238
Cdd:COG3626  161 RAEGLIEPEPDaDDAEPFDITREPLVFPAPRSARLQALARGDEGFLLALAYSTQRGYGRNHPFAGEIRVGYVEVELVPPE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738 239 LGFSVNIGELLLTECEMVNGFVAPQDEPPHFTRGYGLTFGMSERKAMAMALVDRALQAPDYDEEIAGPAQDEEFVLAHAD 318
Cdd:COG3626  241 LGFAVEIGEILVTECEMVNQFKGSADEPPQFTRGYGLVFGHSERKAMSMALVDRALRAGELGEEVTAPAQDEEFVLSHSD 320
                        330       340       350
                 ....*....|....*....|....*....|..
gi 496082738 319 NVEAAGFVSHLKLPHYVDFQAELALLKRLQRE 350
Cdd:COG3626  321 NVEATGFVEHLKLPHYVDFQSELELLRRLRAE 352
PhnI pfam05861
Bacterial phosphonate metabolism protein (PhnI); This family consists of several ...
1-351 0e+00

Bacterial phosphonate metabolism protein (PhnI); This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organized in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex.


Pssm-ID: 428653  Cd Length: 346  Bit Score: 587.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738    1 MYVAVKGGEKAILAAHALQEQKRRGDGRLPELSVDQIGDQLNLAVDRVMTEGGIADRELAALALKQASGDNVEAIFLLRA 80
Cdd:pfam05861   1 MYVAVKGGEEAIENAHRLLAEERRGDESVPELSVEQIREQLRLAVDRVMSEGSLYDPELAALAIKQAQGDLLEAIFLLRA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738   81 YRTTLPRLAVSEPINTAEMRLERRISAVYKDIPGGQLLGPTYDYTHRLLDFTLLANGEAPSVqqadgeAEPTPHVFSLLT 160
Cdd:pfam05861  81 YRSTLPRFGYSQPVDTAAMRVERRISAAFKDIPGGQILGPTFDYTHRLLDFELAAEGEEFDA------PEPMPRVLDLLR 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  161 QQGL-AKAEEDRGTPPDDITRTPPVYPCSRSSRLQQLMRGDEGYLLALAYSTQRGYGRNHPFAGEIRSGYVQVEIVPEEL 239
Cdd:pfam05861 155 AEGLiPEPDPEDGEEPFDITREPLEFPAPRSARLQTLARGDEGFLLALAYSTQRGYGDVHPTVGELRVGYVPVEIPHPEL 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  240 GFSVNIGELLLTECEMVNGFVAPQDEPPHFTRGYGLTFGMSERKAMAMALVDRALQAPDYDEEIAGPAQDEEFVLAHADN 319
Cdd:pfam05861 235 GFAVEIGEIEVTECEMVNQFEGSADEPPQFTRGYGLCFGQNERKAIAMALLDRALRAGELGEDVEAPAQDEEFVLSHIDN 314
                         330       340       350
                  ....*....|....*....|....*....|..
gi 496082738  320 VEAAGFVSHLKLPHYVDFQAELALLKRLQREN 351
Cdd:pfam05861 315 VEATGFVSHLKLPHYVTFQSELDLVRRLRAEH 346
PhnG_redo TIGR03293
phosphonate C-P lyase system protein PhnG; PhnH is a component of the C-P lyase system ...
244-323 5.56e-03

phosphonate C-P lyase system protein PhnG; PhnH is a component of the C-P lyase system (GenProp0232) for the catabolism of phosphonate compounds. The specific function of this component is unknown. This model is based on pfam06754.2, and has been broadened to include sequences missed by that model which are clearly true positive hits based on genome context.


Pssm-ID: 274505  Cd Length: 144  Bit Score: 36.86  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  244 NIGELLLTECEMV--NGFVapqdepphftrGYGLTFGMSERKAMAMALVDRALQAPD-YDEEIAGPAQDEEFVLAHADNV 320
Cdd:TIGR03293  57 NLGEITVTRAAVRlnDGTE-----------GYAYVLGRDKRHAELLAVLDALLQAPLlHDELIADLIAPLAQRLAERRAR 125

                  ...
gi 496082738  321 EAA 323
Cdd:TIGR03293 126 RQA 128
 
Name Accession Description Interval E-value
PhnI COG3626
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion ...
1-350 0e+00

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion transport and metabolism];


Pssm-ID: 442844  Cd Length: 369  Bit Score: 662.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738   1 MYVAVKGGEKAILAAHALQEQKRRGDGRLPELSVDQIGDQLNLAVDRVMTEGGIADRELAALALKQASGDNVEAIFLLRA 80
Cdd:COG3626    1 MYVAVKGGERAIANAHRLLAERRRGDPAVPELSVDQIREQLRLAVDRVMAEGSLYDPELAALAIKQARGDLIEAIFLLRA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  81 YRTTLPRLAVSEPINTAEMRLERRISAVYKDIPGGQLLGPTYDYTHRLLDFTLLANGEAP-SVQQADGEAEPTPHVFSLL 159
Cdd:COG3626   81 YRTTLPRFGYSEPLDTAAMRVERRISATFKDLPGGQVLGPTFDYTHRLLDFALLAEGEPPfAPPEAEALPEPMPRVTDLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738 160 TQQGLAKAEED-RGTPPDDITRTPPVYPCSRSSRLQQLMRGDEGYLLALAYSTQRGYGRNHPFAGEIRSGYVQVEIVPEE 238
Cdd:COG3626  161 RAEGLIEPEPDaDDAEPFDITREPLVFPAPRSARLQALARGDEGFLLALAYSTQRGYGRNHPFAGEIRVGYVEVELVPPE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738 239 LGFSVNIGELLLTECEMVNGFVAPQDEPPHFTRGYGLTFGMSERKAMAMALVDRALQAPDYDEEIAGPAQDEEFVLAHAD 318
Cdd:COG3626  241 LGFAVEIGEILVTECEMVNQFKGSADEPPQFTRGYGLVFGHSERKAMSMALVDRALRAGELGEEVTAPAQDEEFVLSHSD 320
                        330       340       350
                 ....*....|....*....|....*....|..
gi 496082738 319 NVEAAGFVSHLKLPHYVDFQAELALLKRLQRE 350
Cdd:COG3626  321 NVEATGFVEHLKLPHYVDFQSELELLRRLRAE 352
PhnI pfam05861
Bacterial phosphonate metabolism protein (PhnI); This family consists of several ...
1-351 0e+00

Bacterial phosphonate metabolism protein (PhnI); This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organized in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex.


Pssm-ID: 428653  Cd Length: 346  Bit Score: 587.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738    1 MYVAVKGGEKAILAAHALQEQKRRGDGRLPELSVDQIGDQLNLAVDRVMTEGGIADRELAALALKQASGDNVEAIFLLRA 80
Cdd:pfam05861   1 MYVAVKGGEEAIENAHRLLAEERRGDESVPELSVEQIREQLRLAVDRVMSEGSLYDPELAALAIKQAQGDLLEAIFLLRA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738   81 YRTTLPRLAVSEPINTAEMRLERRISAVYKDIPGGQLLGPTYDYTHRLLDFTLLANGEAPSVqqadgeAEPTPHVFSLLT 160
Cdd:pfam05861  81 YRSTLPRFGYSQPVDTAAMRVERRISAAFKDIPGGQILGPTFDYTHRLLDFELAAEGEEFDA------PEPMPRVLDLLR 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  161 QQGL-AKAEEDRGTPPDDITRTPPVYPCSRSSRLQQLMRGDEGYLLALAYSTQRGYGRNHPFAGEIRSGYVQVEIVPEEL 239
Cdd:pfam05861 155 AEGLiPEPDPEDGEEPFDITREPLEFPAPRSARLQTLARGDEGFLLALAYSTQRGYGDVHPTVGELRVGYVPVEIPHPEL 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  240 GFSVNIGELLLTECEMVNGFVAPQDEPPHFTRGYGLTFGMSERKAMAMALVDRALQAPDYDEEIAGPAQDEEFVLAHADN 319
Cdd:pfam05861 235 GFAVEIGEIEVTECEMVNQFEGSADEPPQFTRGYGLCFGQNERKAIAMALLDRALRAGELGEDVEAPAQDEEFVLSHIDN 314
                         330       340       350
                  ....*....|....*....|....*....|..
gi 496082738  320 VEAAGFVSHLKLPHYVDFQAELALLKRLQREN 351
Cdd:pfam05861 315 VEATGFVSHLKLPHYVTFQSELDLVRRLRAEH 346
PhnG_redo TIGR03293
phosphonate C-P lyase system protein PhnG; PhnH is a component of the C-P lyase system ...
244-323 5.56e-03

phosphonate C-P lyase system protein PhnG; PhnH is a component of the C-P lyase system (GenProp0232) for the catabolism of phosphonate compounds. The specific function of this component is unknown. This model is based on pfam06754.2, and has been broadened to include sequences missed by that model which are clearly true positive hits based on genome context.


Pssm-ID: 274505  Cd Length: 144  Bit Score: 36.86  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496082738  244 NIGELLLTECEMV--NGFVapqdepphftrGYGLTFGMSERKAMAMALVDRALQAPD-YDEEIAGPAQDEEFVLAHADNV 320
Cdd:TIGR03293  57 NLGEITVTRAAVRlnDGTE-----------GYAYVLGRDKRHAELLAVLDALLQAPLlHDELIADLIAPLAQRLAERRAR 125

                  ...
gi 496082738  321 EAA 323
Cdd:TIGR03293 126 RQA 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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