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Conserved domains on  [gi|496222383|ref|WP_008936418|]
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MULTISPECIES: lysophospholipid acyltransferase family protein [Brucella]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10005341)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; similar to Rickettsia prowazekii uncharacterized protein RP090

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG2121 COG2121
Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily ...
26-258 3.89e-84

Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily [Function unknown];


:

Pssm-ID: 441724 [Multi-domain]  Cd Length: 225  Bit Score: 250.57  E-value: 3.89e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383  26 RIRGPLARSAAVKSILVWLIASYLKLVHATNP-RLKDSASSEDIVHDFAPFIVTFWHGQHLMGPFLRpKGLELVAMFSRS 104
Cdd:COG2121    2 KLLKKLARSPLLLRLLGWLLAGYLRLLFRTLRvEVEGEEALDRLLASGKPFILAFWHGQLLMAPFLF-RGKKIAVLVSRS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383 105 ADAELNARVAEKLGLLTVRGSGGRGtranpekgGARALLTLKNALRKGQSTSMIADIAHGEAREAGEGIILLAKLSGRPI 184
Cdd:COG2121   81 RDGELIARVLERLGFGTVRGSSSRG--------GAAALREMLRALKEGYSVAITPDGPRGPRRVVKPGIIYLARKSGAPI 152
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496222383 185 IPLAYAFSRNHVLeKTWDKTTIPLPFGRSTIVRGDPVWVDADADDVQLEEKRVELTRQLNRATDRAYAALEKAK 258
Cdd:COG2121  153 VPVAVAASRRWRL-KSWDRFVLPLPFSRVVIVYGEPIYVPPDADEEELEALRLELEAALNALTARADALLGRAP 225
 
Name Accession Description Interval E-value
COG2121 COG2121
Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily ...
26-258 3.89e-84

Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily [Function unknown];


Pssm-ID: 441724 [Multi-domain]  Cd Length: 225  Bit Score: 250.57  E-value: 3.89e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383  26 RIRGPLARSAAVKSILVWLIASYLKLVHATNP-RLKDSASSEDIVHDFAPFIVTFWHGQHLMGPFLRpKGLELVAMFSRS 104
Cdd:COG2121    2 KLLKKLARSPLLLRLLGWLLAGYLRLLFRTLRvEVEGEEALDRLLASGKPFILAFWHGQLLMAPFLF-RGKKIAVLVSRS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383 105 ADAELNARVAEKLGLLTVRGSGGRGtranpekgGARALLTLKNALRKGQSTSMIADIAHGEAREAGEGIILLAKLSGRPI 184
Cdd:COG2121   81 RDGELIARVLERLGFGTVRGSSSRG--------GAAALREMLRALKEGYSVAITPDGPRGPRRVVKPGIIYLARKSGAPI 152
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496222383 185 IPLAYAFSRNHVLeKTWDKTTIPLPFGRSTIVRGDPVWVDADADDVQLEEKRVELTRQLNRATDRAYAALEKAK 258
Cdd:COG2121  153 VPVAVAASRRWRL-KSWDRFVLPLPFSRVVIVYGEPIYVPPDADEEELEALRLELEAALNALTARADALLGRAP 225
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
49-245 8.49e-59

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 184.72  E-value: 8.49e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383  49 LKLVHATNP-RLKDSASSEDIVHDFAPFIVTFWHGQHLMGPFLRPKGLELVAMFSRSADAELNARVAEKLGLLTVRGSGG 127
Cdd:cd07983    1 LRLLYLTLRwRVIGDESADALIAQGEPVILAFWHGRLLLMPYLFRRRKRIAALISRSKDGEIIARVLERLGIRVVRGSSS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383 128 RgtranpekGGARALLTLKNALRKGQSTSMIADIAHGEAREAGEGIILLAKLSGRPIIPLAYAFSRNHVLeKTWDKTTIP 207
Cdd:cd07983   81 R--------GGAAALREMLRALKDGYNIAITPDGPRGPRYKVKPGVILLARKSGAPIVPVAIAASRAWRL-KSWDRFIIP 151
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 496222383 208 LPFGRSTIVRGDPVWVDADADDVQLEEKRVELTRQLNR 245
Cdd:cd07983  152 KPFSRVVIVFGEPIHVPPDADEEELEEYRLELEAALNA 189
DUF374 pfam04028
Domain of unknown function (DUF374); Bacterial domain of unknown function.
90-164 3.10e-16

Domain of unknown function (DUF374); Bacterial domain of unknown function.


Pssm-ID: 461136  Cd Length: 69  Bit Score: 70.98  E-value: 3.10e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496222383   90 LRPKGLELVAMFSRSADAELNARVAEKLGLLTVRGSGGRgtranpekGGARALLTLKNALRKGQSTSMIADIAHG 164
Cdd:pfam04028   1 YRFRKKRIAALVSRSRDGELIARVLERFGFKTIRGSSSR--------GGARALREMLRALKDGYSIAITPDGPRG 67
 
Name Accession Description Interval E-value
COG2121 COG2121
Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily ...
26-258 3.89e-84

Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily [Function unknown];


Pssm-ID: 441724 [Multi-domain]  Cd Length: 225  Bit Score: 250.57  E-value: 3.89e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383  26 RIRGPLARSAAVKSILVWLIASYLKLVHATNP-RLKDSASSEDIVHDFAPFIVTFWHGQHLMGPFLRpKGLELVAMFSRS 104
Cdd:COG2121    2 KLLKKLARSPLLLRLLGWLLAGYLRLLFRTLRvEVEGEEALDRLLASGKPFILAFWHGQLLMAPFLF-RGKKIAVLVSRS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383 105 ADAELNARVAEKLGLLTVRGSGGRGtranpekgGARALLTLKNALRKGQSTSMIADIAHGEAREAGEGIILLAKLSGRPI 184
Cdd:COG2121   81 RDGELIARVLERLGFGTVRGSSSRG--------GAAALREMLRALKEGYSVAITPDGPRGPRRVVKPGIIYLARKSGAPI 152
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496222383 185 IPLAYAFSRNHVLeKTWDKTTIPLPFGRSTIVRGDPVWVDADADDVQLEEKRVELTRQLNRATDRAYAALEKAK 258
Cdd:COG2121  153 VPVAVAASRRWRL-KSWDRFVLPLPFSRVVIVYGEPIYVPPDADEEELEALRLELEAALNALTARADALLGRAP 225
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
49-245 8.49e-59

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 184.72  E-value: 8.49e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383  49 LKLVHATNP-RLKDSASSEDIVHDFAPFIVTFWHGQHLMGPFLRPKGLELVAMFSRSADAELNARVAEKLGLLTVRGSGG 127
Cdd:cd07983    1 LRLLYLTLRwRVIGDESADALIAQGEPVILAFWHGRLLLMPYLFRRRKRIAALISRSKDGEIIARVLERLGIRVVRGSSS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383 128 RgtranpekGGARALLTLKNALRKGQSTSMIADIAHGEAREAGEGIILLAKLSGRPIIPLAYAFSRNHVLeKTWDKTTIP 207
Cdd:cd07983   81 R--------GGAAALREMLRALKDGYNIAITPDGPRGPRYKVKPGVILLARKSGAPIVPVAIAASRAWRL-KSWDRFIIP 151
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 496222383 208 LPFGRSTIVRGDPVWVDADADDVQLEEKRVELTRQLNR 245
Cdd:cd07983  152 KPFSRVVIVFGEPIHVPPDADEEELEEYRLELEAALNA 189
DUF374 pfam04028
Domain of unknown function (DUF374); Bacterial domain of unknown function.
90-164 3.10e-16

Domain of unknown function (DUF374); Bacterial domain of unknown function.


Pssm-ID: 461136  Cd Length: 69  Bit Score: 70.98  E-value: 3.10e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496222383   90 LRPKGLELVAMFSRSADAELNARVAEKLGLLTVRGSGGRgtranpekGGARALLTLKNALRKGQSTSMIADIAHG 164
Cdd:pfam04028   1 YRFRKKRIAALVSRSRDGELIARVLERFGFKTIRGSSSR--------GGARALREMLRALKDGYSIAITPDGPRG 67
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
85-246 2.10e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 37.96  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383  85 LMGPFLRPKGLELVAMFSRSADAELNARVAeklglltvRGSGGRGTRANPEKGGARALLtlkNALRKGQSTSMIADIAHG 164
Cdd:cd07984   34 LAGLALALLGYPVTVVYRPLKNPLLDRLIT--------RGRERFGARLIPRGGGLRELI---RALKKGEIVGILPDQDPG 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496222383 165 EAREA-----GE------GIILLAKLSGRPIIPLayafsrnhvlektwdkTTIPLPFGRSTIVRGDPVWVDADADDvqle 233
Cdd:cd07984  103 RKGGVfvpffGRpaatptGPARLALKTGAPVVPA----------------FAYRLPGGGYRIEFEPPLENPPSEDV---- 162
                        170
                 ....*....|...
gi 496222383 234 ekrVELTRQLNRA 246
Cdd:cd07984  163 ---EEDTQRLNDA 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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