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Conserved domains on  [gi|496306738|ref|WP_009015916|]
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flippase [Acidaminococcus intestini]

Protein Classification

flippase( domain architecture ID 10192054)

flippase assists in the membrane translocation of lipopolysaccharides including those containing O-antigens; similar to Escherichia coli O-antigen transporter

Gene Ontology:  GO:0140327|GO:0016020
PubMed:  14670712|8606190

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 2-397 5.65e-41

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


:

Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 151.16  E-value: 5.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   2 KNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIAyrQDDPKGRSKTFFELT 81
Cdd:cd13128    3 KNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIA--RYRKEKIREIISTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  82 LLRLVL--MLLSLTAYSTFVVPRMYHRAIFMLQGLNIAATFFDIT----WFFQGLEEFGKIAARNVLLRFITVASFFLFI 155
Cdd:cd13128   81 VLKLILgiLALLLLFLFAFLIAFYDPELVLLLYILALSLPFSALNslfrGIFQGFEKMKYIVIARIIESVLSLILALILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 156 HSPEDLGLYIGLLAGLSLVTNLSLWFFLPRYLVRVPKEELH---IVRHLSPLIALFIPQIAVNLYTLMDRTMIGlAAAST 232
Cdd:cd13128  161 LLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFDlklAKELLRFSIPLALSGIFSLIYTRIDTIMLG-YFLGD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 233 LQNGYYEQAEKTVRITLTIVTSLIPVMIPRMAYAFArKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPN 312
Cdd:cd13128  240 AAVGIYNAAYRIAELLLFIPSAISTALFPRISELYK-NDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 313 YLPVIPLVRILSLIVIAIGLSNVTGnQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQ 392
Cdd:cd13128  319 YLPAALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILL 397


                 ....*
gi 496306738 393 FYLVR 397
Cdd:cd13128  398 LYLLK 402
 
Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 2-397 5.65e-41

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 151.16  E-value: 5.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   2 KNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIAyrQDDPKGRSKTFFELT 81
Cdd:cd13128    3 KNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIA--RYRKEKIREIISTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  82 LLRLVL--MLLSLTAYSTFVVPRMYHRAIFMLQGLNIAATFFDIT----WFFQGLEEFGKIAARNVLLRFITVASFFLFI 155
Cdd:cd13128   81 VLKLILgiLALLLLFLFAFLIAFYDPELVLLLYILALSLPFSALNslfrGIFQGFEKMKYIVIARIIESVLSLILALILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 156 HSPEDLGLYIGLLAGLSLVTNLSLWFFLPRYLVRVPKEELH---IVRHLSPLIALFIPQIAVNLYTLMDRTMIGlAAAST 232
Cdd:cd13128  161 LLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFDlklAKELLRFSIPLALSGIFSLIYTRIDTIMLG-YFLGD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 233 LQNGYYEQAEKTVRITLTIVTSLIPVMIPRMAYAFArKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPN 312
Cdd:cd13128  240 AAVGIYNAAYRIAELLLFIPSAISTALFPRISELYK-NDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 313 YLPVIPLVRILSLIVIAIGLSNVTGnQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQ 392
Cdd:cd13128  319 YLPAALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILL 397


                 ....*
gi 496306738 393 FYLVR 397
Cdd:cd13128  398 LYLLK 402
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 1-393 1.44e-30

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 121.59  E-value: 1.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   1 MKNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIAYRQDDPKGRSKTFFEL 80
Cdd:COG2244    5 LKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSTALL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  81 TLLRLVLMLLSLTAYSTFVVPRMYH----RAIFMLQGLNIAATFFD--ITWFFQGLEEFGKIAARNVLLRFITVASFFLF 154
Cdd:COG2244   85 LRLLLSLLLALLLLLLAPFIAALLGepelALLLLLLALALLLSALSavLLALLRGLERFKLLALINILSSLLSLLLALLL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 155 IHSPEDLGLYIgllaglslvtnlslwfflprylvrvpkeelhivrhLSPLIALFIPQIAVNLYTLMDRTMIGLAAASTlQ 234
Cdd:COG2244  165 ALLGLGLWGLV-----------------------------------LKYSLPLLLSGLLGLLLTNLDRLLLGALLGPA-A 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 235 NGYYEQAEKTVRITLTIVTSLIPVMIPRMAYAFARKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPNYL 314
Cdd:COG2244  209 VGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYA 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496306738 315 PVIPLVRILSLIVIAIGLSNVTGnQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQF 393
Cdd:COG2244  289 EAAPVLPILALGALFLALSGVLS-NLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 319-448 1.07e-09

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 56.81  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  319 LVRILSLIVIAIGLSNVTgNQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQFYLVRC 398
Cdd:pfam14667   1 VLQILALSIIFLSLSTVL-TSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 496306738  399 ALPLRDILLGSRTHLFASLIMFGLVT---FAAGSLSPSLVHTALLVLLGGASY 448
Cdd:pfam14667  80 YLGLRLLLRRLLKPLLAALVMGIVVYlllLLLGLLLGLALALLLAVLVGALVY 132
PRK10459 PRK10459
MOP flippase family protein;
254-338 1.19e-07

MOP flippase family protein;


Pssm-ID: 236697 [Multi-domain]  Cd Length: 492  Bit Score: 53.88  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 254 SLIPVM-----IPRMAY-AFAR--KDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPNYLPVIPLVRILSL 325
Cdd:PRK10459 253 ATVPPMkinpiITRVAFpVFAKiqDDTEKLRVGFLKLLSVLGIINFPLLLGLMVVSNNFVPLVFGEKWNSAIPILQLLCI 332

                         90
                 ....*....|...
gi 496306738 326 iviaIGLSNVTGN 338
Cdd:PRK10459 333 ----VGLLRSVGN 341
 
Name Accession Description Interval E-value
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 2-397 5.65e-41

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 151.16  E-value: 5.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   2 KNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIAyrQDDPKGRSKTFFELT 81
Cdd:cd13128    3 KNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIA--RYRKEKIREIISTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  82 LLRLVL--MLLSLTAYSTFVVPRMYHRAIFMLQGLNIAATFFDIT----WFFQGLEEFGKIAARNVLLRFITVASFFLFI 155
Cdd:cd13128   81 VLKLILgiLALLLLFLFAFLIAFYDPELVLLLYILALSLPFSALNslfrGIFQGFEKMKYIVIARIIESVLSLILALILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 156 HSPEDLGLYIGLLAGLSLVTNLSLWFFLPRYLVRVPKEELH---IVRHLSPLIALFIPQIAVNLYTLMDRTMIGlAAAST 232
Cdd:cd13128  161 LLGGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFDlklAKELLRFSIPLALSGIFSLIYTRIDTIMLG-YFLGD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 233 LQNGYYEQAEKTVRITLTIVTSLIPVMIPRMAYAFArKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPN 312
Cdd:cd13128  240 AAVGIYNAAYRIAELLLFIPSAISTALFPRISELYK-NDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 313 YLPVIPLVRILSLIVIAIGLSNVTGnQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQ 392
Cdd:cd13128  319 YLPAALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILL 397


                 ....*
gi 496306738 393 FYLVR 397
Cdd:cd13128  398 LYLLK 402
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 1-393 1.44e-30

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 121.59  E-value: 1.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   1 MKNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIAYRQDDPKGRSKTFFEL 80
Cdd:COG2244    5 LKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSTALL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  81 TLLRLVLMLLSLTAYSTFVVPRMYH----RAIFMLQGLNIAATFFD--ITWFFQGLEEFGKIAARNVLLRFITVASFFLF 154
Cdd:COG2244   85 LRLLLSLLLALLLLLLAPFIAALLGepelALLLLLLALALLLSALSavLLALLRGLERFKLLALINILSSLLSLLLALLL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 155 IHSPEDLGLYIgllaglslvtnlslwfflprylvrvpkeelhivrhLSPLIALFIPQIAVNLYTLMDRTMIGLAAASTlQ 234
Cdd:COG2244  165 ALLGLGLWGLV-----------------------------------LKYSLPLLLSGLLGLLLTNLDRLLLGALLGPA-A 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 235 NGYYEQAEKTVRITLTIVTSLIPVMIPRMAYAFARKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPNYL 314
Cdd:COG2244  209 VGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYA 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496306738 315 PVIPLVRILSLIVIAIGLSNVTGnQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQF 393
Cdd:COG2244  289 EAAPVLPILALGALFLALSGVLS-NLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLLL 366
MATE_tuaB_like cd13127
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 11-403 6.77e-14

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240532 [Multi-domain]  Cd Length: 406  Bit Score: 73.29  E-value: 6.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  11 QILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYgqreIAYRQDDPKGRSKTFFeLTLLRLVLMLL 90
Cdd:cd13127   12 QVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSA----LIQRKDLTEEDLSTVF-WLNLLLGLLLY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  91 SLTAYSTFVVPRMYH--RAIFMLQGLNIaatffdiTWFFQGLE-----------EFGKIAARNVLLRFI--TVASFFLFI 155
Cdd:cd13127   87 LLLFLLAPLIAAFYNepELIPLLRVLSL-------SFLLSGLGsvprallqrelRFKKLAIIELISTLVsgVVAIVLALL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 156 HspedLGLY---IGLLAGlSLVTNLSLWFFLPRYLVRVPKeelhiVRHLSPLIA----LFIPQIAVNLYTLMDRTMIG-L 227
Cdd:cd13127  160 G----FGVWalvAQQLVG-ALVSTVLLWILSRWRPRLSFS-----LASLKELLSfgskLLGSNLLNYFSRNLDNLIIGkF 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 228 AAASTLqnGYYEQAEktvRITLTIVTSLIPVMIPRMAYAFAR--KDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFV 305
Cdd:cd13127  230 LGAAAL--GYYSRAY---RLALLPVQNITGPITRVLFPALSRlqDDPERLRRAYLKALRLLALITFPLMVGLALLAEPLV 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 306 PWFFGPNYLPVIPLVRILSLIVIAIGLSNVTGNQYLVpTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAAsVLTE 385
Cdd:cd13127  305 LLLLGEKWLPAVPILQILALAGLFQPLSSLNGSLLLA-LGRTDLLLKLGLIKAVLTVLALLIGIPYGIIGVAIAY-VIAS 382

                        410
                 ....*....|....*...
gi 496306738 386 LIVMGVQFYLVRCALPLR 403
Cdd:cd13127  383 LLSFPLNLYLAGRLIGIS 400
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 126-371 9.05e-11

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 63.64  E-value: 9.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 126 FFQGLEEFGKIAARNVLLRFITVAS--FFLFIHSPEDLGLY-------IGLLAGlSLVTNLSLWFFLPRYLVRVPKEELH 196
Cdd:cd13124  133 YFQGLQNMTPTAVSQVIEQIVRVIVilVLAYLLLPVGGGLYyaaagatFGAVIG-ALAGLLVLLYYYRKKRRELKRLLRK 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 197 IVRH-------LSPLIALFIP----QIAVNLYTLMDRTMI--GLAAA------STLQNGYYE-QAEKTVRITLTIVTSLI 256
Cdd:cd13124  212 SPRSkistkeiLKELLSYAIPitlsSLILPLLQLIDSFTVprRLQAAglseseATALYGILTgRAQPLVQLPTVIATALS 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 257 PVMIPRMAYAFARKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGpnYLPVIPLVRILSLIVIAIGLSNVT 336
Cdd:cd13124  292 TSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFG--DSEGGLILQILAPSILFLSLQQVT 369

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 496306738 337 gNQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPY 371
Cdd:cd13124  370 -AAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPI 403
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 319-448 1.07e-09

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 56.81  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  319 LVRILSLIVIAIGLSNVTgNQYLVPTNKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMGVQFYLVRC 398
Cdd:pfam14667   1 VLQILALSIIFLSLSTVL-TSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 496306738  399 ALPLRDILLGSRTHLFASLIMFGLVT---FAAGSLSPSLVHTALLVLLGGASY 448
Cdd:pfam14667  80 YLGLRLLLRRLLKPLLAALVMGIVVYlllLLLGLLLGLALALLLAVLVGALVY 132
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 2-264 1.30e-09

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 58.85  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738    2 KNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIA----YRQDDPKGRSKTF 77
Cdd:pfam01943   3 KNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAkyreKYELVSLYWLNAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   78 FELTLLRLVLMLLSLTAYSTFVVPRMYHRAIFMLQGLNIAATFFDITWFFQGLEEFGKIAARNVLLRFITVASFFLFIHS 157
Cdd:pfam01943  83 LVKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIAVFL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  158 PEDLGLYIGLLAGLSLVTNL-SLWFFLPRYLVRVPKEELHIVRHL-SPLIALFIPQIAVNLYTLMDRTMIGLAAASTLQN 235
Cdd:pfam01943 163 PGDIVAALLYQVLAALVGGIiALAVLRKIFRPRFVFPSLKLVRKLlSFGAPLFISSLAISLYTYIDSILLGLLLGAGAVG 242

                         250       260
                  ....*....|....*....|....*....
gi 496306738  236 GYYEQAEKTVRITLTIVTSLIPVMIPRMA 264
Cdd:pfam01943 243 IYNAAYQLLVAIQGLLNPIVTAVLFPVFS 271
PRK10459 PRK10459
MOP flippase family protein;
254-338 1.19e-07

MOP flippase family protein;


Pssm-ID: 236697 [Multi-domain]  Cd Length: 492  Bit Score: 53.88  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 254 SLIPVM-----IPRMAY-AFAR--KDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPNYLPVIPLVRILSL 325
Cdd:PRK10459 253 ATVPPMkinpiITRVAFpVFAKiqDDTEKLRVGFLKLLSVLGIINFPLLLGLMVVSNNFVPLVFGEKWNSAIPILQLLCI 332

                         90
                 ....*....|...
gi 496306738 326 iviaIGLSNVTGN 338
Cdd:PRK10459 333 ----VGLLRSVGN 341
Polysacc_synt_3 pfam13440
Polysaccharide biosynthesis protein;
25-318 8.09e-06

Polysaccharide biosynthesis protein;


Pssm-ID: 404342 [Multi-domain]  Cd Length: 293  Bit Score: 47.59  E-value: 8.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   25 LARVLGPESIGLASFSSSIVSYFSLFASLGIGlygqREIAYRQDDPKGRSKTFFeLTLLRLVLMLLSLTAYSTFVVPRMY 104
Cdd:pfam13440   2 LARLLSPEDFGVVAIATVVISFANIFVDMGFS----SALIQKKDITETDYSTVF-TFNLIFGALIYLILFALAPLIASFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  105 HRAIfMLQGLNIAAtffdITWFFQGLE-----------EFGKIAARNVLLRFITVASFF---LFIHSPEdlGLYIGLLAG 170
Cdd:pfam13440  77 NQPE-LVPVLRVLA----LVLILNGLSsvqtallrrdlRFKKLFKITLTSSVIGGIVGIvlaYLGFGVW--ALVIGTLAQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  171 LSLVTNLSLWFFLPRYLVRVPKEelHIVRHLSPLIALFIPQIAVNLYTLMDRTMIGLaAASTLQNGYYEQAEKTVRITLT 250
Cdd:pfam13440 150 QLLSLVLLWLASDWRPRLTFSLK--VIKELFSFGSWLLLSNLLNYLARNLDNLIIGK-VLGTAALGLYSVAYRLALLPTA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496306738  251 IVTSLI-PVMIPrmAYAFARKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPNFVPWFFGPNYLPVIP 318
Cdd:pfam13440 227 NITSVItKVLFP--ALSRIQDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLLGSQWLESVP 293
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
 251-463 1.96e-05

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 47.07  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 251 IVTSLIPVMIPRMAYAFARKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAPnfvpwffgpnylpviPLVRIL------- 323
Cdd:COG0728  274 FGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAE---------------PIVRLLfergaft 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 324 ---------SLIVIAIGLSNVTGNQYLVPT----NKQAILTKSVLVGAVCNFILNLLFIPYAMAAGAAAASVLTELIVMG 390
Cdd:COG0728  339 aedtaltalALAAYALGLPAFALVKVLARAfyarQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNAL 418

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 391 VQFYLVR---CALPLRDILLGSRTHLFASLIM--------FGLVTFAAGSLSPSLVHTALLVLLGGASYFLLLLLFKDDM 459
Cdd:COG0728  419 LLLVLLRrrlGGLPLRGILRTLLKLLLASLVMgavlwlllRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGVRL 498


                 ....
gi 496306738 460 THLV 463
Cdd:COG0728  499 RDLL 502
MATE_like_10 cd13125
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 2-322 4.24e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240530 [Multi-domain]  Cd Length: 409  Bit Score: 39.45  E-value: 4.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738   2 KNYFYNLSYQILVVLTPFITIPYLARVLGPESIGLASFSSSIVSYFSLFASLGIGLYGQREIAYRQDDPKGRSKTFFELT 81
Cdd:cd13125    1 KVSSLSGISTLIKILAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGINNGVVKYTAEYKDDEEKLARVWSTAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738  82 LLRLVLMLLSLTA-------YSTFVVPRMYHRAIFMLQGLNIAATFFD--ITWFFQGLEEFGKIAARNVLLRFITVASFF 152
Cdd:cd13125   81 RITLILSILGGLLlllfskpLSSLLFGDIDYSWVFILLGLALPLFALNnlLLAILNGLKEIKRYALINIISSLIGLLVSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 153 LFIHSPEDLGLYIGLLAGLSLVTNLSLWFFLPRYLVRVP----KEELHIVRHLSPLIALFI-PQIAVNLYTLMDRTMI-- 225
Cdd:cd13125  161 LLVYFYGLKGALLALVLNQSLIFLVTLIYSRKQPWFKLKylwgRLDKDIIKKLLKFSLMALvSALSLPLSQIIVRNILir 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496306738 226 --GLAAAstlqnGYYEQAEKTVRITLTIVTSLIPV-MIPRMAyafARKDHEKVIQGMKLSYQFVSLLSFPICFGLMAVAP 302
Cdd:cd13125  241 qlGWEAA-----GYWQAVWKISDVYLGFITTALSTyYLPRLS---AIKDNKELKREVNKQLKVILPLVAIGALLIYLLRD 312

                        330       340
                 ....*....|....*....|
gi 496306738 303 NFVPWFFGPNYLPVIPLVRI 322
Cdd:cd13125  313 LIIQILFSEEFLPARELFLW 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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