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Conserved domains on  [gi|496341418|ref|WP_009050596|]
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MULTISPECIES: papain-like cysteine protease family protein [Pseudomonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C70 super family cl24120
Papain-like cysteine protease AvrRpt2; This is a family of cysteine proteases, found in ...
 53-156 1.21e-04

Papain-like cysteine protease AvrRpt2; This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.


The actual alignment was detected with superfamily member pfam12385:

Pssm-ID: 403550 [Multi-domain]  Cd Length: 143  Bit Score: 40.52  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496341418   53 QQTQTNWCWAALSASVGNYYRTGSWTQcGVANAQLGRNTCCNQPgpcnVYGYLDSALQTTRSFG--GMSQGSIQLSAIDN 130
Cdd:pfam12385  11 VQQAAMGCWAASASMIAGYRGQKPIDP-SEIAALVPGWSQYDTG----LNGPEDIALAEKWGLGnvPEPPQSYSIDALVK 85

                          90       100
                  ....*....|....*....|....*..
gi 496341418  131 QINMGRPVGLRCAWFGG-GAHFLAIYG 156
Cdd:pfam12385  86 LLRAYGPLWCAIAWPGGfVGHAIVLTG 112
 
Name Accession Description Interval E-value
Peptidase_C70 pfam12385
Papain-like cysteine protease AvrRpt2; This is a family of cysteine proteases, found in ...
 53-156 1.21e-04

Papain-like cysteine protease AvrRpt2; This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.


Pssm-ID: 403550 [Multi-domain]  Cd Length: 143  Bit Score: 40.52  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496341418   53 QQTQTNWCWAALSASVGNYYRTGSWTQcGVANAQLGRNTCCNQPgpcnVYGYLDSALQTTRSFG--GMSQGSIQLSAIDN 130
Cdd:pfam12385  11 VQQAAMGCWAASASMIAGYRGQKPIDP-SEIAALVPGWSQYDTG----LNGPEDIALAEKWGLGnvPEPPQSYSIDALVK 85

                          90       100
                  ....*....|....*....|....*..
gi 496341418  131 QINMGRPVGLRCAWFGG-GAHFLAIYG 156
Cdd:pfam12385  86 LLRAYGPLWCAIAWPGGfVGHAIVLTG 112
 
Name Accession Description Interval E-value
Peptidase_C70 pfam12385
Papain-like cysteine protease AvrRpt2; This is a family of cysteine proteases, found in ...
 53-156 1.21e-04

Papain-like cysteine protease AvrRpt2; This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.


Pssm-ID: 403550 [Multi-domain]  Cd Length: 143  Bit Score: 40.52  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496341418   53 QQTQTNWCWAALSASVGNYYRTGSWTQcGVANAQLGRNTCCNQPgpcnVYGYLDSALQTTRSFG--GMSQGSIQLSAIDN 130
Cdd:pfam12385  11 VQQAAMGCWAASASMIAGYRGQKPIDP-SEIAALVPGWSQYDTG----LNGPEDIALAEKWGLGnvPEPPQSYSIDALVK 85

                          90       100
                  ....*....|....*....|....*..
gi 496341418  131 QINMGRPVGLRCAWFGG-GAHFLAIYG 156
Cdd:pfam12385  86 LLRAYGPLWCAIAWPGGfVGHAIVLTG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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