NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|496513579|ref|WP_009221862|]
View 

tRNA (cytidine(34)-2'-O)-methyltransferase [Peptoniphilus sp. oral taxon 386]

Protein Classification

tRNA (cytidine(34)-2'-O)-methyltransferase( domain architecture ID 10000715)

tRNA (cytidine(34)-2'-O)-methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine to the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA)

EC:  2.1.1.207
Gene Ontology:  GO:0003723|GO:0008173|GO:1904047|GO:0141098|GO:0001510
SCOP:  4002340

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 1-159 4.90e-93

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 439989  Cd Length: 153  Bit Score: 266.13  E-value: 4.90e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNedemkDGASL 80
Cdd:COG0219    1 MLHIVLYEPEIPQNTGNIIRLCAATGARLHLIEPLGFSLDDKKLKRAGLDYWELVDLTVHDSWEAFLEAL-----PGGRL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496513579  81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQLDFLGLE 159
Cdd:COG0219   76 FLFTTKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAAPADQRLRIPMRPG-VRSLNLSNAVAIVLYEALRQLGFPGLV 153
 
Name Accession Description Interval E-value
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 1-159 4.90e-93

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 266.13  E-value: 4.90e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNedemkDGASL 80
Cdd:COG0219    1 MLHIVLYEPEIPQNTGNIIRLCAATGARLHLIEPLGFSLDDKKLKRAGLDYWELVDLTVHDSWEAFLEAL-----PGGRL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496513579  81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQLDFLGLE 159
Cdd:COG0219   76 FLFTTKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAAPADQRLRIPMRPG-VRSLNLSNAVAIVLYEALRQLGFPGLV 153
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 3-153 8.00e-82

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 237.74  E-value: 8.00e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   3 NIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNedemkDGASLYF 82
Cdd:cd18094    1 NIVLYEPEIPQNTGNIARTCAATGARLHLIEPLGFSLDDKRLKRAGLDYWDHVDLTVHDSWEAFLEAL-----PPGRLFL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496513579  83 ATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQL 153
Cdd:cd18094   76 FTTKGTKPYTDFDFKPGDYLVFGRESTGLPEEILDAFPDRRLRIPMRPK-VRSLNLSNSVAIVLYEALRQL 145
tRNA_yibK_trmL TIGR00185
tRNA (cytidine(34)-2'-O)-methyltransferase; TrmL (previously YibK) is responsible for 2 ...
 1-158 2.26e-65

tRNA (cytidine(34)-2'-O)-methyltransferase; TrmL (previously YibK) is responsible for 2'-O-methylation at tRNA(Leu) position 34. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 211559  Cd Length: 153  Bit Score: 196.48  E-value: 2.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579    1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEdemkdGASL 80
Cdd:TIGR00185   1 MLNIVLYEPEIPPNTGNIARTCAATGTRLHLIEPLGFFLDDKRLKRAGLDYWEFVQVFYHKSWEEFLEAEK-----PQKL 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496513579   81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDYgRSLNLSNSANIILFEALRQLDFLGL 158
Cdd:TIGR00185  76 FALTKKGTPAHSAVTYQDGDYLMFGPETRGLPQSILDNLMEQKIRIPMTNDV-RSLNLSNAVAIVVYEAWRQLGYPGL 152
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 1-157 3.94e-51

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 160.55  E-value: 3.94e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEDEmkdgaSL 80
Cdd:PRK10358   1 MLNIVLFEPEIPPNTGNIIRLCANTGFRLHIIEPMGFAWDDKRLRRAGLDYHEFTAVTRHHDYAAFLEAENPQ-----RL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496513579  81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFN-DIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQLDFLG 157
Cdd:PRK10358  76 FALTTKGTPAHSAVSYQDGDYLMFGPETRGLPASILDAlPAEQKIRIPMMPD-SRSMNLSNAVSVVVYEAWRQLGYPG 152
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 1-147 8.94e-39

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 128.42  E-value: 8.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579    1 MLNIVFYEPEIPFNTGAIARTC---GLTKtrLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEDEmkdG 77
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAaafGADG--LILVEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEA---G 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   78 ASLYFATTKAeQKYTDVKFKDGDYIMFGPETRGIPESILfNDIEHCIKIPMLKDYgRSLNLSNSANIILF 147
Cdd:pfam00588  76 YAVVATSLGG-KSLYEIDFPKKVALVFGNEGTGLSNEVL-ELCDRLVRIPMSGDV-ESLNVAVAAAIALY 142
 
Name Accession Description Interval E-value
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 1-159 4.90e-93

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 266.13  E-value: 4.90e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNedemkDGASL 80
Cdd:COG0219    1 MLHIVLYEPEIPQNTGNIIRLCAATGARLHLIEPLGFSLDDKKLKRAGLDYWELVDLTVHDSWEAFLEAL-----PGGRL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496513579  81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQLDFLGLE 159
Cdd:COG0219   76 FLFTTKGTKPYTDVDYQPGDVLLFGRETAGLPEEVLAAPADQRLRIPMRPG-VRSLNLSNAVAIVLYEALRQLGFPGLV 153
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 3-153 8.00e-82

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 237.74  E-value: 8.00e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   3 NIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNedemkDGASLYF 82
Cdd:cd18094    1 NIVLYEPEIPQNTGNIARTCAATGARLHLIEPLGFSLDDKRLKRAGLDYWDHVDLTVHDSWEAFLEAL-----PPGRLFL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496513579  83 ATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQL 153
Cdd:cd18094   76 FTTKGTKPYTDFDFKPGDYLVFGRESTGLPEEILDAFPDRRLRIPMRPK-VRSLNLSNSVAIVLYEALRQL 145
tRNA_yibK_trmL TIGR00185
tRNA (cytidine(34)-2'-O)-methyltransferase; TrmL (previously YibK) is responsible for 2 ...
 1-158 2.26e-65

tRNA (cytidine(34)-2'-O)-methyltransferase; TrmL (previously YibK) is responsible for 2'-O-methylation at tRNA(Leu) position 34. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 211559  Cd Length: 153  Bit Score: 196.48  E-value: 2.26e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579    1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEdemkdGASL 80
Cdd:TIGR00185   1 MLNIVLYEPEIPPNTGNIARTCAATGTRLHLIEPLGFFLDDKRLKRAGLDYWEFVQVFYHKSWEEFLEAEK-----PQKL 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496513579   81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHCIKIPMLKDYgRSLNLSNSANIILFEALRQLDFLGL 158
Cdd:TIGR00185  76 FALTKKGTPAHSAVTYQDGDYLMFGPETRGLPQSILDNLMEQKIRIPMTNDV-RSLNLSNAVAIVVYEAWRQLGYPGL 152
PRK10358 PRK10358
tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase ...
 1-157 3.94e-51

tRNA (uridine(34)/cytosine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL;


Pssm-ID: 182406  Cd Length: 157  Bit Score: 160.55  E-value: 3.94e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   1 MLNIVFYEPEIPFNTGAIARTCGLTKTRLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEDEmkdgaSL 80
Cdd:PRK10358   1 MLNIVLFEPEIPPNTGNIIRLCANTGFRLHIIEPMGFAWDDKRLRRAGLDYHEFTAVTRHHDYAAFLEAENPQ-----RL 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496513579  81 YFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFN-DIEHCIKIPMLKDyGRSLNLSNSANIILFEALRQLDFLG 157
Cdd:PRK10358  76 FALTTKGTPAHSAVSYQDGDYLMFGPETRGLPASILDAlPAEQKIRIPMMPD-SRSMNLSNAVSVVVYEAWRQLGYPG 152
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 1-147 8.94e-39

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 128.42  E-value: 8.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579    1 MLNIVFYEPEIPFNTGAIARTC---GLTKtrLHLIEPLGFSVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEDEmkdG 77
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAaafGADG--LILVEPRSADPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEA---G 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   78 ASLYFATTKAeQKYTDVKFKDGDYIMFGPETRGIPESILfNDIEHCIKIPMLKDYgRSLNLSNSANIILF 147
Cdd:pfam00588  76 YAVVATSLGG-KSLYEIDFPKKVALVFGNEGTGLSNEVL-ELCDRLVRIPMSGDV-ESLNVAVAAAIALY 142
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 4-149 3.57e-26

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 96.53  E-value: 3.57e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   4 IVFYEPEIPFNTGAIARTC---GLTKtrLHLIEPLGFsVDSSHLKRAGLDYWHLVDINYYKSYDDFLEKNEDEmkDGASL 80
Cdd:cd18082    2 LVLDNIRSPGNIGSIFRTAdafGVEK--IYLVGPTAD-IFDPKAKRTSRGTHFSVPYERVDNFEEYLKSLKEE--GYPLI 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496513579  81 YFATTKAEQKYTDVKFKD--GDYIMFGPETRGIPESILfNDIEHCIKIPMLKDYgRSLNLSNSANIILFEA 149
Cdd:cd18082   77 GLELTDGSIPLSEFKFKKpkKIALIFGNERSGLSPELL-ALCDYTVHIPMSGKN-SSLNVSVATGIALYEF 145
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 12-153 2.71e-13

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 63.64  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  12 PFNTGAIARTC---GLTKtrLHLIEPL-GFSVDSSHLKRAglDYWhlVDINYYKSYDDFLEKnedeMK-DGASLYFATTK 86
Cdd:cd18092   27 PHNASAVLRTCdafGVQD--VHVIEPKnKFKKNRGVAMGA--DKW--LDVHRHDSTEECLAA----LKeQGYRIVATSLS 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496513579  87 AEqkytDVKFKDGDY-----IMFGPETRGIPESILfNDIEHCIKIPMlkdYG--RSLNLSNSANIILFEALRQL 153
Cdd:cd18092   97 PD----AVPLDELDYtrptaLVFGNEKDGVSEEAL-AAADERVYIPM---YGfvESLNVSVAAAIILYELQRQR 162
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 2-148 2.70e-12

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 60.59  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   2 LNIVFYEPEIPFNTGAIARTC---GLtkTRLHLIEPLGFSVDSSHLKRAgldyWHLVDI--NyYKSYDDFlekneDEMKD 76
Cdd:cd18093    1 IRVVLVEPQHPGNIGAVARAMknfGL--SDLRLVNPRCDDPEEAARALA----SGAEDVleN-AKVYDTL-----EEALA 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  77 GASLYFATT-----------KAEQKYTDVKFKDGDY---IMFGPETRGipesiLFND-IEHC---IKIPMLKDYGrSLNL 138
Cdd:cd18093   69 DCDLVVATTarprglrrpllTPRELAELLKEHAAGGkvaLVFGREDSG-----LTNEeLALCdllVTIPTNPEYP-SLNL 142

                        170
                 ....*....|
gi 496513579 139 SNSANIILFE 148
Cdd:cd18093  143 AQAVAIVLYE 152
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 83-152 4.08e-12

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 59.90  E-value: 4.08e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496513579  83 ATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILFNDIEHcIKIPMlkdYGR--SLNLSNSANIILFEALRQ 152
Cdd:cd18104   78 TTPKAEKLYYEADLRGPIAIVVGSESEGLSEFWLKAADER-VRIPM---AGQadSLNVSVAAAILLYEALRQ 145
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 72-152 2.77e-10

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 56.74  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  72 DEMKD-GASLYFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILfndiEHC---IKIPMlkdYGR--SLNLSNSANII 145
Cdd:COG0566  182 EELKEaGFWVVGTDLDGEASLYEVDLPGPVALVLGNEGKGLSRLVL----EACdelVRIPM---AGGveSLNVAVAAAIL 254


                 ....*..
gi 496513579 146 LFEALRQ 152
Cdd:COG0566  255 LYEAARQ 261
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 72-149 2.51e-09

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 52.39  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  72 DEMKD-GASLYFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILfndiEHC---IKIPMLKDYGrSLNLSNSANIILF 147
Cdd:cd18103   67 EELKEaGFWIYGADGEAEKSLYDVDLTGPLALVLGSEGKGLRRLVL----KNCdflVKIPMAGKVD-SLNVSVAAGIILY 141


                 ..
gi 496513579 148 EA 149
Cdd:cd18103  142 EI 143
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 4-153 6.09e-08

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 50.12  E-value: 6.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579   4 IVFYEPEIPFNTGAIAR---TCGLTktRLHLIEPLGFSVD-----SSH----LKRAgldywhlvdinyyKSYDDFlekne 71
Cdd:COG0565    6 VVLVEPQHPGNIGAAARamkNFGLS--DLRLVNPRGWPDEearamASGaddvLENA-------------RVVDTL----- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  72 DEMKDGASLYFATT-----------KAEQKYTDVKFKDGDY---IMFGPETRGipesiLFND-IEHC---IKIPMLKDYG 133
Cdd:COG0565   66 EEALADCDLVVGTTarprelrkpvlTPREAAEELLARAAGGkvaLVFGRERSG-----LTNEeLALCdalVTIPTNPEYP 140

                        170       180
                 ....*....|....*....|
gi 496513579 134 rSLNLSNSANIILFEaLRQL 153
Cdd:COG0565  141 -SLNLAQAVQVVAYE-LRKA 158
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 55-149 1.79e-07

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 47.42  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  55 VDINYYKSYDDFLekneDEMKD-GASLYFATTKAEQKYTDVKFKDGDYIMFGPETRGIPESILfNDIEHCIKIPMlkdYG 133
Cdd:cd18095   54 LPIIRVDDLEELL----EELKEaGYKVVAADLDGGSSLYDLDLPKPVALVLGNEGNGLSDELL-ELCDKRVTIPM---SG 125

                         90
                 ....*....|....*...
gi 496513579 134 R--SLNLSNSANIILFEA 149
Cdd:cd18095  126 GveSLNVAVAAAILLYEL 143
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 12-152 3.76e-05

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 42.29  E-value: 3.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496513579  12 PFNTGAIARTC---GLTKtrLHLIEP---LGFSVDSShlkrAGLDYWhlVDINYYKSYDDFLEknedEMKDGASLYFATT 85
Cdd:PRK11081  30 PHNVSAIIRTAdavGVHE--VHAVWPgsrMRTMGSTA----AGSNSW--VQVKTHRTIGDAVA----HLKGQGMQILATH 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496513579  86 KAEqkyTDVKFKDGDY-----IMFGPETRGI-PESILFNDiEHCIkIPMLkdyG--RSLNLSNSANIILFEALRQ 152
Cdd:PRK11081  98 LSD---TAVDFREIDYtrptcILMGQEKTGIsQEALALAD-QDII-IPMI---GmvQSLNVSVASALILYEAQRQ 164
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
121-152 2.21e-03

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 36.87  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 496513579 121 EHC---IKIPMLKDYGrSLNLSNSANIILFEALRQ 152
Cdd:PRK11181 208 EHCdelISIPMAGSVS-SLNVSVATGICLFEAVRQ 241
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 76-149 6.19e-03

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 35.30  E-value: 6.19e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 496513579  76 DGASLYFATTKAE-QKYTDVKFKDGDYIMF-GPETRGI-PESILFNDIE--HCIKIPMLKDyGRSLNLSNSANIILFEA 149
Cdd:cd18106   71 DDSKVFLADNNLPvQPYDSIDYCSGPIVLViGGETHGVsPEAYKLAHSTggSRVHIPLANG-VDSLNSAVAASILLFEM 148
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 91-148 7.11e-03

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 34.82  E-value: 7.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 496513579  91 YTDVKFKDGDYIMFGPETRGIPESILFNdIEHCIKIPMLKDYGRSLNLSNSANIILFE 148
Cdd:cd18109   84 LYEFTLPEKGILVMGNEGHGISPEVLKL-LTHRLTIPRYGKGAESLNVAVATAILLSE 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH