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Conserved domains on  [gi|496522779|ref|WP_009231062|]
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glycosyl transferase [Prevotella sp. oral taxon 317]

Protein Classification

glycosyltransferase family 25 protein( domain architecture ID 3353)

glycosyltransferase family 25 protein may be involved in lipopolysaccharide (LPS) biosynthesis, facilitating the transfer of one of a variety of sugars onto a growing LPS chain

CAZY:  GT25
Gene Ontology:  GO:1901271
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3306 super family cl47316
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 10-101 2.90e-09

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3306:

Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 55.39  E-value: 2.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779  10 LPVYVINLEERTERRQHIEEQFS------------DRTEFELTWIKAVKHPIGAVGLWKSM-----------VQAIRKAE 66
Cdd:COG3306    1 MKIFVINLDRSTERREHIEAQLArlgldfeffdavDGRDLSEEELARYDRAKALRRYGRPLtpgeigcflshRKAWQKIV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 496522779  67 ENEDDIIVICEDDHTFTPAynreylFRNILEAEAQ 101
Cdd:COG3306   81 ESGLPYALILEDDVILSPD------FAEVLEALAW 109
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 10-101 2.90e-09

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 55.39  E-value: 2.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779  10 LPVYVINLEERTERRQHIEEQFS------------DRTEFELTWIKAVKHPIGAVGLWKSM-----------VQAIRKAE 66
Cdd:COG3306    1 MKIFVINLDRSTERREHIEAQLArlgldfeffdavDGRDLSEEELARYDRAKALRRYGRPLtpgeigcflshRKAWQKIV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 496522779  67 ENEDDIIVICEDDHTFTPAynreylFRNILEAEAQ 101
Cdd:COG3306   81 ESGLPYALILEDDVILSPD------FAEVLEALAW 109
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
 11-84 2.09e-08

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 51.06  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779  11 PVYVINLEERTERRQHIEEQFsDRTEFELTWIKAV------KHPI------------------GAVGLWKSMVQAIRKAE 66
Cdd:cd06532    1 KIFVINLDRSTDRRERMEAQL-AALGLDFEFFDAVdgkdlsEEELaalydalflprygrpltpGEIGCFLSHYKLWQKIV 79

                         90
                 ....*....|....*...
gi 496522779  67 ENEDDIIVICEDDHTFTP 84
Cdd:cd06532   80 ESNLEYALILEDDAILDP 97
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
 10-99 1.73e-04

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 41.27  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779   10 LPVYVINLEERTERRQHIEEQFSDRT-EFELtwIKAV------KHPI-------------------GAVG-------LWK 56
Cdd:pfam01755   2 IKIYVISLKRATERREHIQKEFGKLNiPFQF--FDAIdgkelpNHLLfklynfllrskyagrpltlGEIGcflshysLWQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 496522779   57 SMVqairkaeENEDDIIVICEDDHTFTP--AYNREYLFRNILEAE 99
Cdd:pfam01755  80 KCV-------ELNLEYIIILEDDVILSEnfKAILQFLLKEINELE 117
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 10-101 2.90e-09

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 55.39  E-value: 2.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779  10 LPVYVINLEERTERRQHIEEQFS------------DRTEFELTWIKAVKHPIGAVGLWKSM-----------VQAIRKAE 66
Cdd:COG3306    1 MKIFVINLDRSTERREHIEAQLArlgldfeffdavDGRDLSEEELARYDRAKALRRYGRPLtpgeigcflshRKAWQKIV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 496522779  67 ENEDDIIVICEDDHTFTPAynreylFRNILEAEAQ 101
Cdd:COG3306   81 ESGLPYALILEDDVILSPD------FAEVLEALAW 109
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
 11-84 2.09e-08

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 51.06  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779  11 PVYVINLEERTERRQHIEEQFsDRTEFELTWIKAV------KHPI------------------GAVGLWKSMVQAIRKAE 66
Cdd:cd06532    1 KIFVINLDRSTDRRERMEAQL-AALGLDFEFFDAVdgkdlsEEELaalydalflprygrpltpGEIGCFLSHYKLWQKIV 79

                         90
                 ....*....|....*...
gi 496522779  67 ENEDDIIVICEDDHTFTP 84
Cdd:cd06532   80 ESNLEYALILEDDAILDP 97
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
 10-99 1.73e-04

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 41.27  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496522779   10 LPVYVINLEERTERRQHIEEQFSDRT-EFELtwIKAV------KHPI-------------------GAVG-------LWK 56
Cdd:pfam01755   2 IKIYVISLKRATERREHIQKEFGKLNiPFQF--FDAIdgkelpNHLLfklynfllrskyagrpltlGEIGcflshysLWQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 496522779   57 SMVqairkaeENEDDIIVICEDDHTFTP--AYNREYLFRNILEAE 99
Cdd:pfam01755  80 KCV-------ELNLEYIIILEDDVILSEnfKAILQFLLKEINELE 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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