|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09369 |
PRK09369 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated |
6-439 |
0e+00 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
Pssm-ID: 236486 Cd Length: 417 Bit Score: 541.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQrEGVLQLDSSKVESA 85
Cdd:PRK09369 4 LVIEGGKPLSGEVTISGAKNAALPILAASLLAEEPVTLTNVPDLSDVRTMIELLRSLGAKVEFDG-NGTVTIDASNINNT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HmADIDAhAGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTAPDGLNGTVIEL 165
Cdd:PRK09369 83 E-APYEL-VKKMRASILVLGPLLARFGEAKVSLPGGCAIGARPVDLHLKGLEALGAEIEIEHGYVEAKADGRLKGAHIVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASW 245
Cdd:PRK09369 161 DFPSVGATENILMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKISGAGTDTITIEGVERLHGAEHTVIPDRIEAGTF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 246 ASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPgGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQ 325
Cdd:PRK09369 241 LVAAAITGGDVTIRGARPEHLEAVLAKLREAGAEIEEGEDGIRVDMP-GRLKAVDIKTAPYPGFPTDMQAQFMALLTQAE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 326 GLSIVHETVYENRFGFTGALRKMGATIQvyreCLGgtecrfgqrnfyHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALT 405
Cdd:PRK09369 320 GTSVITETIFENRFMHVPELIRMGADIE----VDG------------HTAVVRGVEKLSGAPVMATDLRASASLVLAGLV 383
|
410 420 430
....*....|....*....|....*....|....
gi 496525348 406 AEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTRL 439
Cdd:PRK09369 384 AEGTTIVDRIYHLDRGYERIEEKLRALGADIERV 417
|
|
| MurA |
COG0766 |
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ... |
6-438 |
0e+00 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440529 Cd Length: 416 Bit Score: 526.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQrEGVLQLDSSKVESA 85
Cdd:COG0766 4 LIIEGGKPLSGEVRISGAKNAALPILAAALLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDD-GGTLTIDASNINST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HMADidAHAGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTApDGLNGTVIEL 165
Cdd:COG0766 83 EAPY--ELVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPIDLHLKGLEALGAEIEIEHGYIEARA-GRLKGARIYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASW 245
Cdd:COG0766 160 DFPSVGATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNAMGAKIEGAGTDTITIEGVEKLHGAEHTVIPDRIEAGTF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 246 ASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPgGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQ 325
Cdd:COG0766 240 LVAAAITGGDVTVKNVIPEHLEAVLAKLREAGVEIEEGDDGIRVRGP-GRLKAVDIKTAPYPGFPTDLQAQFMALLTQAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 326 GLSIVHETVYENRFGFTGALRKMGATIQVYreclggtecrfgqrnfYHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALT 405
Cdd:COG0766 319 GTSVITETVFENRFMHVDELNRMGADIKLD----------------GHTAIVRGVTKLSGAPVMATDLRAGAALVLAGLA 382
|
410 420 430
....*....|....*....|....*....|...
gi 496525348 406 AEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTR 438
Cdd:COG0766 383 AEGETVIDNIYHIDRGYENLEEKLRALGADIER 415
|
|
| UdpNAET |
cd01555 |
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ... |
14-432 |
2.35e-165 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.
Pssm-ID: 238796 Cd Length: 400 Bit Score: 470.80 E-value: 2.35e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 14 LTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQrEGVLQLDSSKVESAHMadIDAH 93
Cdd:cd01555 1 LSGEVRISGAKNAALPILAAALLTDEPVTLRNVPDLLDVETMIELLRSLGAKVEFEG-ENTLVIDASNINSTEA--PYEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 94 AGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTAPDGLNGTVIELPYPSVGAT 173
Cdd:cd01555 78 VRKMRASILVLGPLLARFGEARVSLPGGCAIGARPVDLHLKGLEALGAKIEIEDGYVEAKAAGRLKGARIYLDFPSVGAT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 174 EQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASWASAALATR 253
Cdd:cd01555 158 ENIMMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKIEGAGTDTIRIEGVERLHGAEHTVIPDRIEAGTFLVAAAITG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 254 GDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPGGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQGLSIVHET 333
Cdd:cd01555 238 GDITVENVIPEHLEAVLAKLREMGAKIEIGEDGIRVDGDGGRLKAVDIETAPYPGFPTDLQAQFMALLTQAEGTSVITET 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 334 VYENRFGFTGALRKMGATIQVYReclggtecrfgqrnfyHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALTAEGTSRVE 413
Cdd:cd01555 318 IFENRFMHVDELNRMGADIKVEG----------------NTAIIRGVTKLSGAPVMATDLRAGAALVLAGLAAEGETIIS 381
|
410
....*....|....*....
gi 496525348 414 GVNLIDRGYEHFMSKLESL 432
Cdd:cd01555 382 NIYHIDRGYERIEEKLRAL 400
|
|
| murA |
TIGR01072 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and ... |
6-438 |
8.54e-141 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 162190 [Multi-domain] Cd Length: 416 Bit Score: 408.93 E-value: 8.54e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQREgvLQLDSSKVESA 85
Cdd:TIGR01072 4 LVVEGGKPLSGEVTISGAKNAALPIIAATLLTDEPVTLTNVPDLSDVKTTLDLLRNLGARVERDNNT--LEINTPNINST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HmADIDAhAGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTAPDGLNGTVIEL 165
Cdd:TIGR01072 82 E-APYEL-VRKMRASILVLGPLLARFGKAVVSLPGGCAIGARPVDLHLKGLKALGAEIVIEDGYVYASAKGRLVGAHIVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASW 245
Cdd:TIGR01072 160 DKVSVGATENIIMAAVLAEGTTVIENAAREPEIVDLCEFLNKMGAKITGAGSNTITIEGVEKLHGTEHSVIPDRIEAGTF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 246 ASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPGGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQ 325
Cdd:TIGR01072 240 LVAAAITGGEITIKNVRPDHLRAVLAKLREIGAEVEVDENGIRVDMRQKRLKAVDIETLPYPGFPTDLQAQFMALLSQAE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 326 GLSIVHETVYENRFGFTGALRKMGATIQVyreclggtecrfgqrnFYHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALT 405
Cdd:TIGR01072 320 GTSVITETVFENRFMHVDELIRMGANIKL----------------EGNTAVIHGVEQLSGAEVMATDLRAGAALVLAGLV 383
|
410 420 430
....*....|....*....|....*....|...
gi 496525348 406 AEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTR 438
Cdd:TIGR01072 384 AEGETIVHNVYHLDRGYEDLEEKLRALGAKIER 416
|
|
| EPSP_synthase |
pfam00275 |
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); |
9-429 |
9.07e-51 |
|
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
Pssm-ID: 395213 Cd Length: 415 Bit Score: 176.72 E-value: 9.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 9 EGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQREGVLQLDSSKVESahma 88
Cdd:pfam00275 1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIIKLDDEKSVVIVEGLGGS---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 89 dIDAHAGSsripILFCG-------PLLHRLGEAFIPDL--GGCRIGDRPIDFHLEILRQFGASVDKQEQGIrlTAP---D 156
Cdd:pfam00275 77 -FEAPEDL----VLDMGnsgtalrPLTGRLALQSGEVVlpGDCSIGKRPMDRLLDALRQLGAEIEGREGYN--YAPlkvR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 157 GLNGTVIE--LPYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVD-TDRTIHVEGVDELCGYTH 233
Cdd:pfam00275 150 GLRLGGIHidGDVSSQFVTSLLMLAALLAEGTTTIENLASEPYIDDTENMLKKFGAKIEGSgTELSITVKGGEKLPGQEY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 234 SALPDRIEAASWASAALATRGDVFVRGAHQSHMTTF---LNTFRKVGGAFDVTD-EGIRFYHPGGDLRSIVVETNVHPGF 309
Cdd:pfam00275 230 RVEGDRSSAAYFLVAAAITGGTVTVENVGINSLQGDealLEILEKMGAEITQEEdADIVVGPPGLRGKAVDIRTAPDPAP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 310 MTDWQQPLVVALTQAQGLSIVHETVYENRFGFTGALRKMGATIQVYREclgGTECRFGQRNFYHSAVVSgptplsgadiv 389
Cdd:pfam00275 310 TTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPD---GLIIIPAVKELKGAEVDS----------- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 496525348 390 VPDLRGGFSHLIAALTAEGTSRVEGVNLIDRGYEHFMSKL 429
Cdd:pfam00275 376 YGDHRIAMALALAGLVAEGETIIDDIECTDRSFPDFEEKL 415
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09369 |
PRK09369 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated |
6-439 |
0e+00 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
Pssm-ID: 236486 Cd Length: 417 Bit Score: 541.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQrEGVLQLDSSKVESA 85
Cdd:PRK09369 4 LVIEGGKPLSGEVTISGAKNAALPILAASLLAEEPVTLTNVPDLSDVRTMIELLRSLGAKVEFDG-NGTVTIDASNINNT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HmADIDAhAGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTAPDGLNGTVIEL 165
Cdd:PRK09369 83 E-APYEL-VKKMRASILVLGPLLARFGEAKVSLPGGCAIGARPVDLHLKGLEALGAEIEIEHGYVEAKADGRLKGAHIVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASW 245
Cdd:PRK09369 161 DFPSVGATENILMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKISGAGTDTITIEGVERLHGAEHTVIPDRIEAGTF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 246 ASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPgGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQ 325
Cdd:PRK09369 241 LVAAAITGGDVTIRGARPEHLEAVLAKLREAGAEIEEGEDGIRVDMP-GRLKAVDIKTAPYPGFPTDMQAQFMALLTQAE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 326 GLSIVHETVYENRFGFTGALRKMGATIQvyreCLGgtecrfgqrnfyHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALT 405
Cdd:PRK09369 320 GTSVITETIFENRFMHVPELIRMGADIE----VDG------------HTAVVRGVEKLSGAPVMATDLRASASLVLAGLV 383
|
410 420 430
....*....|....*....|....*....|....
gi 496525348 406 AEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTRL 439
Cdd:PRK09369 384 AEGTTIVDRIYHLDRGYERIEEKLRALGADIERV 417
|
|
| MurA |
COG0766 |
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ... |
6-438 |
0e+00 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440529 Cd Length: 416 Bit Score: 526.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQrEGVLQLDSSKVESA 85
Cdd:COG0766 4 LIIEGGKPLSGEVRISGAKNAALPILAAALLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDD-GGTLTIDASNINST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HMADidAHAGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTApDGLNGTVIEL 165
Cdd:COG0766 83 EAPY--ELVRKMRASILVLGPLLARFGEARVSLPGGCAIGARPIDLHLKGLEALGAEIEIEHGYIEARA-GRLKGARIYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASW 245
Cdd:COG0766 160 DFPSVGATENIMMAAVLAEGTTVIENAAREPEIVDLANFLNAMGAKIEGAGTDTITIEGVEKLHGAEHTVIPDRIEAGTF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 246 ASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPgGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQ 325
Cdd:COG0766 240 LVAAAITGGDVTVKNVIPEHLEAVLAKLREAGVEIEEGDDGIRVRGP-GRLKAVDIKTAPYPGFPTDLQAQFMALLTQAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 326 GLSIVHETVYENRFGFTGALRKMGATIQVYreclggtecrfgqrnfYHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALT 405
Cdd:COG0766 319 GTSVITETVFENRFMHVDELNRMGADIKLD----------------GHTAIVRGVTKLSGAPVMATDLRAGAALVLAGLA 382
|
410 420 430
....*....|....*....|....*....|...
gi 496525348 406 AEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTR 438
Cdd:COG0766 383 AEGETVIDNIYHIDRGYENLEEKLRALGADIER 415
|
|
| UdpNAET |
cd01555 |
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ... |
14-432 |
2.35e-165 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.
Pssm-ID: 238796 Cd Length: 400 Bit Score: 470.80 E-value: 2.35e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 14 LTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQrEGVLQLDSSKVESAHMadIDAH 93
Cdd:cd01555 1 LSGEVRISGAKNAALPILAAALLTDEPVTLRNVPDLLDVETMIELLRSLGAKVEFEG-ENTLVIDASNINSTEA--PYEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 94 AGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTAPDGLNGTVIELPYPSVGAT 173
Cdd:cd01555 78 VRKMRASILVLGPLLARFGEARVSLPGGCAIGARPVDLHLKGLEALGAKIEIEDGYVEAKAAGRLKGARIYLDFPSVGAT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 174 EQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASWASAALATR 253
Cdd:cd01555 158 ENIMMAAVLAEGTTVIENAAREPEIVDLANFLNKMGAKIEGAGTDTIRIEGVERLHGAEHTVIPDRIEAGTFLVAAAITG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 254 GDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPGGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQGLSIVHET 333
Cdd:cd01555 238 GDITVENVIPEHLEAVLAKLREMGAKIEIGEDGIRVDGDGGRLKAVDIETAPYPGFPTDLQAQFMALLTQAEGTSVITET 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 334 VYENRFGFTGALRKMGATIQVYReclggtecrfgqrnfyHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALTAEGTSRVE 413
Cdd:cd01555 318 IFENRFMHVDELNRMGADIKVEG----------------NTAIIRGVTKLSGAPVMATDLRAGAALVLAGLAAEGETIIS 381
|
410
....*....|....*....
gi 496525348 414 GVNLIDRGYEHFMSKLESL 432
Cdd:cd01555 382 NIYHIDRGYERIEEKLRAL 400
|
|
| murA |
TIGR01072 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and ... |
6-438 |
8.54e-141 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 162190 [Multi-domain] Cd Length: 416 Bit Score: 408.93 E-value: 8.54e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQREgvLQLDSSKVESA 85
Cdd:TIGR01072 4 LVVEGGKPLSGEVTISGAKNAALPIIAATLLTDEPVTLTNVPDLSDVKTTLDLLRNLGARVERDNNT--LEINTPNINST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HmADIDAhAGSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTAPDGLNGTVIEL 165
Cdd:TIGR01072 82 E-APYEL-VRKMRASILVLGPLLARFGKAVVSLPGGCAIGARPVDLHLKGLKALGAEIVIEDGYVYASAKGRLVGAHIVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAASW 245
Cdd:TIGR01072 160 DKVSVGATENIIMAAVLAEGTTVIENAAREPEIVDLCEFLNKMGAKITGAGSNTITIEGVEKLHGTEHSVIPDRIEAGTF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 246 ASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIRFYHPGGDLRSIVVETNVHPGFMTDWQQPLVVALTQAQ 325
Cdd:TIGR01072 240 LVAAAITGGEITIKNVRPDHLRAVLAKLREIGAEVEVDENGIRVDMRQKRLKAVDIETLPYPGFPTDLQAQFMALLSQAE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 326 GLSIVHETVYENRFGFTGALRKMGATIQVyreclggtecrfgqrnFYHSAVVSGPTPLSGADIVVPDLRGGFSHLIAALT 405
Cdd:TIGR01072 320 GTSVITETVFENRFMHVDELIRMGANIKL----------------EGNTAVIHGVEQLSGAEVMATDLRAGAALVLAGLV 383
|
410 420 430
....*....|....*....|....*....|...
gi 496525348 406 AEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTR 438
Cdd:TIGR01072 384 AEGETIVHNVYHLDRGYEDLEEKLRALGAKIER 416
|
|
| PRK12830 |
PRK12830 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed |
6-438 |
2.45e-96 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed
Pssm-ID: 183779 Cd Length: 417 Bit Score: 295.61 E-value: 2.45e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDqrEGVLQLDSSKVESA 85
Cdd:PRK12830 4 IVINGGKPLSGEVTISGAKNSAVALIPAAILADGPVTLDGVPDISDVHSLVDILEELGGKVKRD--GDTLEIDPTGIQSM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 86 HMADIDAHagSSRIPILFCGPLLHRLGEAFIPDLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIRLTApDGLNGTVIEL 165
Cdd:PRK12830 82 PLPNGKVK--SLRASYYFMGALLGRFKKAVVGLPGGCDLGPRPIDQHIKGFEALGAEVTNEGGAIYLKA-DELKGAHIYL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 166 PYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAII-SVDTDrTIHVEGVDELCGYTHSALPDRIEAAS 244
Cdd:PRK12830 159 DVVSVGATINIMLAAVKAKGRTVIENAAKEPEIIDVATLLNNMGANIkGAGTD-VIRIEGVDELHGCRHTVIPDRIEAGT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 245 WASAALATRGDVFVRGAHQSHMTTFLNTFRKVGGAFDVTDEGIrFYHPGGDLRSIVVETNVHPGFMTDWQQPLVVALTQA 324
Cdd:PRK12830 238 YMILAAACGGGVTINNVIPEHLESFIAKLEEMGVRVEVNEDSI-FVEKQGNLKAVDIKTLPYPGFATDLQQPLTPLLLKA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 325 QGLSIVHETVYENRFGFTGALRKMGATIQVyrecLGGTecrfgqrnfyhsAVVSGPTPLSGADIVVPDLRGGFSHLIAAL 404
Cdd:PRK12830 317 NGRSVVTDTIYEKRFKHVDELKRMGANIKV----EGRS------------AIITGPSKLTGAKVKATDLRAGAALVIAGL 380
|
410 420 430
....*....|....*....|....*....|....
gi 496525348 405 TAEGTSRVEGVNLIDRGYEHFMSKLESLNAAVTR 438
Cdd:PRK12830 381 MAEGVTEITNIEHIDRGYSNIIEKLKALGADIWR 414
|
|
| EPT-like |
cd01554 |
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ... |
14-432 |
2.18e-53 |
|
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.
Pssm-ID: 238795 Cd Length: 408 Bit Score: 183.57 E-value: 2.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 14 LTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSidYDQREGVLQLDSSKVeSAHMADIDA- 92
Cdd:cd01554 1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVE--IEDKDGVITIQGVGM-AGLKAPQNAl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 93 ---HAGSSRIPILfcGPLLHRLGEAFIPdlGGCRIGDRPIDFHLEILRQFGASVDKQEQgiRLTAPDGLNG-----TVIE 164
Cdd:cd01554 78 nlgNSGTAIRLIS--GVLAGADFEVELF--GDDSLSKRPMDRVTLPLKKMGASISGQEE--RDLPPLLKGGknlgpIHYE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 165 LPYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAAS 244
Cdd:cd01554 152 DPIASAQVKSALMFAALLAKGETVIIEAAKEPTINHTENMLQTFGGHISVQGTKKIVVQGPQKLTGQKYVVPGDISSAAF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 245 WASAALATRGDVFVRGAH-QSHMTTFLNTFRKVGGAFDVTDEGIRFyhPGGDLRSIVVETNVHPgFMTDWQQPLVVALTQ 323
Cdd:cd01554 232 FLVAAAIAPGRLVLQNVGiNETRTGIIDVLRAMGAKIEIGEDTISV--ESSDLKATEICGALIP-RLIDELPIIALLALQ 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 324 AQGLSIVHETVY------ENRFGFTGALRKMGATIQVYRECLggtecrfgqrnfyhsaVVSGPTPLSGADIVV-PDLRGG 396
Cdd:cd01554 309 AQGTTVIKDAEElkvketDRIFVVADELNSMGADIEPTADGM----------------IIKGKEKLHGARVNTfGDHRIG 372
|
410 420 430
....*....|....*....|....*....|....*.
gi 496525348 397 FSHLIAALTAEGTSRVEGVNLIDRGYEHFMSKLESL 432
Cdd:cd01554 373 MMTALAALVADGEVELDRAEAINTSYPSFFDDLESL 408
|
|
| EPSP_synthase |
pfam00275 |
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); |
9-429 |
9.07e-51 |
|
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
Pssm-ID: 395213 Cd Length: 415 Bit Score: 176.72 E-value: 9.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 9 EGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQREGVLQLDSSKVESahma 88
Cdd:pfam00275 1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIIKLDDEKSVVIVEGLGGS---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 89 dIDAHAGSsripILFCG-------PLLHRLGEAFIPDL--GGCRIGDRPIDFHLEILRQFGASVDKQEQGIrlTAP---D 156
Cdd:pfam00275 77 -FEAPEDL----VLDMGnsgtalrPLTGRLALQSGEVVlpGDCSIGKRPMDRLLDALRQLGAEIEGREGYN--YAPlkvR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 157 GLNGTVIE--LPYPSVGATEQTLLTAVRACGLTELRGAAVEPEIMDLVDVLQKMGAIISVD-TDRTIHVEGVDELCGYTH 233
Cdd:pfam00275 150 GLRLGGIHidGDVSSQFVTSLLMLAALLAEGTTTIENLASEPYIDDTENMLKKFGAKIEGSgTELSITVKGGEKLPGQEY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 234 SALPDRIEAASWASAALATRGDVFVRGAHQSHMTTF---LNTFRKVGGAFDVTD-EGIRFYHPGGDLRSIVVETNVHPGF 309
Cdd:pfam00275 230 RVEGDRSSAAYFLVAAAITGGTVTVENVGINSLQGDealLEILEKMGAEITQEEdADIVVGPPGLRGKAVDIRTAPDPAP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 310 MTDWQQPLVVALTQAQGLSIVHETVYENRFGFTGALRKMGATIQVYREclgGTECRFGQRNFYHSAVVSgptplsgadiv 389
Cdd:pfam00275 310 TTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPD---GLIIIPAVKELKGAEVDS----------- 375
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 496525348 390 VPDLRGGFSHLIAALTAEGTSRVEGVNLIDRGYEHFMSKL 429
Cdd:pfam00275 376 YGDHRIAMALALAGLVAEGETIIDDIECTDRSFPDFEEKL 415
|
|
| EPSP_synthase |
cd01556 |
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ... |
14-432 |
3.79e-14 |
|
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.
Pssm-ID: 238797 Cd Length: 409 Bit Score: 73.75 E-value: 3.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 14 LTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIDYDQREGVLQLDSSKVESAHmADIDA- 92
Cdd:cd01556 1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVEIVGGGGLGLPPE-AVLDCg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 93 HAGSS-RipiLFCGPLLHRLGEAFIpdLGGCRIGDRPIDFHLEILRQFGASVDKQEQGIR--LTAPDGLNGTVIELPyps 169
Cdd:cd01556 80 NSGTTmR---LLTGLLALQGGDSVL--TGDESLRKRPMGRLVDALRQLGAEIEGREGGGYppLIGGGGLKGGEVEIP--- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 170 VGATEQ----TLLTAVRACGLTELRGAAVEPEIM-DL-VDVLQKMGAIISVDTDRTIHVEGVDELCGYTH-------SA- 235
Cdd:cd01556 152 GAVSSQfksaLLLAAPLAEGPTTIIIGELESKPYiDHtERMLRAFGAEVEVDGYRTITVKGGQKYKGPEYtvegdasSAa 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 236 --------LPDRIEAASWASAALATRgdvfvrgahqshmttFLNTFRKVGGAFDVTDEGIRFYHPGGDLRSIVVETNVhp 307
Cdd:cd01556 232 fflaaaaiTGSEIVIKNVGLNSGDTG---------------IIDVLKEMGADIEIGNEDTVVVESGGKLKGIDIDGND-- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 308 gfMTDWQQPLVVALTQAQGLSI--------VHETvyeNRF-GFTGALRKMGATIQVYRECLggtecrfgqrnfyhsAVVS 378
Cdd:cd01556 295 --IPDEAPTLAVLAAFAEGPTRirnaaelrVKES---DRIaAMATELRKLGADVEETEDGL---------------IIEG 354
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 496525348 379 GPTPLSGADI-VVPDLRGGFSHLIAALTAEGTSRVEGVNLIDRGYEHFMSKLESL 432
Cdd:cd01556 355 GPLKGAGVEVyTYGDHRIAMSFAIAGLVAEGGVTIEDPECVAKSFPNFFEDLESL 409
|
|
| AroA |
COG0128 |
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ... |
6-432 |
9.86e-13 |
|
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439898 Cd Length: 421 Bit Score: 69.35 E-value: 9.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDV-VSGLLSLhGVSIDYDQREGVL------QLD 78
Cdd:COG0128 4 LTIAPPSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLAtLEALRAL-GAEIEELDGGTLRvtgvggGLK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 79 SSKvesahmADIDAH-AGSS-RipiLFCGPLLHRLGEAFIpdlggcrIGD-----RPIDFHLEILRQFGASVDKQEQG-- 149
Cdd:COG0128 83 EPD------AVLDCGnSGTTmR---LLTGLLALQPGEVVL-------TGDeslrkRPMGRLLDPLRQLGARIESRGGGyl 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 150 -IRLTAPdGLNGTVIELPypsVGATEQ----TLLTAVRA-CGL-TELRGAAVEPEIMDL-VDVLQKMGAIISVDTDRTIH 221
Cdd:COG0128 147 pLTIRGG-PLKGGEYEIP---GSASSQfksaLLLAGPLAeGGLeITVTGELESKPYRDHtERMLRAFGVEVEVEGYRRFT 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 222 VEGVDELCGYTHS---------------ALpdrieaaswasaalaTRGDVFVRGAHQSHM---TTFLNTFRKVGGAFDVT 283
Cdd:COG0128 223 VPGGQRYRPGDYTvpgdissaafflaaaAI---------------TGSEVTVEGVGLNSTqgdTGILDILKEMGADIEIE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 284 DEGIRFYhpGGDLRSIVVETNVHPG-FMTdwqqpLVVALTQAQGLSI--------VHET-----VYENrfgftgaLRKMG 349
Cdd:COG0128 288 NDGITVR--GSPLKGIDIDLSDIPDeAPT-----LAVLAAFAEGTTRirgaaelrVKESdriaaMATE-------LRKLG 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 350 ATIQVYRECLggtecrfgqrnfyhsaVVSGPTPLSGADIVV-PDLRGGFSHLIAALTAEGTSRVEGVNLIDRGYEHFMSK 428
Cdd:COG0128 354 ADVEETEDGL----------------IIEGGPKLKGAEVDSyGDHRIAMAFAVAGLRAEGPVTIDDAECVAKSFPDFFEL 417
|
....
gi 496525348 429 LESL 432
Cdd:COG0128 418 LESL 421
|
|
| aroA |
TIGR01356 |
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ... |
16-434 |
8.17e-08 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273574 Cd Length: 409 Bit Score: 54.20 E-value: 8.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 16 GEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDVVSGLLSLHGVSIdydQREGvlqlDSSKVESAHMADIDA--H 93
Cdd:TIGR01356 1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKI---EDGG----EVAVIEGVGGKEPQAelD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 94 AGSSRIPILFCGPLLHRLGEAFIPDlGGCRIGDRPIDFHLEILRQFGASVDKQEQG----IRLTAPdgLNGTVIELPyPS 169
Cdd:TIGR01356 74 LGNSGTTARLLTGVLALADGEVVLT-GDESLRKRPMGRLVDALRQLGAEISSLEGGgslpLTISGP--LPGGIVYIS-GS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 170 VGATEQT----LLTAVRACGLTELRGAAVE-PEIMDLVDVLQKMGAIISVDTDRTIHVEGVDELCGYTHSALPDRIEAAS 244
Cdd:TIGR01356 150 ASSQYKSalllAAPALQAVGITIVGEPLKSrPYIEITLDLLGSFGVEVERSDGRKIVVPGGQKYGPQGYDVPGDYSSAAF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 245 WASAALATRGDVFVRGAHQSHMTT---FLNTFRKVGGAFDVTDEGIRFYHPGGdLRSIVVETNVhpgfMTDWQQPLVVAL 321
Cdd:TIGR01356 230 FLAAAAITGGRVTLENLGINPTQGdkaIIIVLEEMGADIEVEEDDLIVEGASG-LKGIKIDMDD----MIDELPTLAVLA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 322 TQAQGLSI--------VHETvyeNRF-GFTGALRKMGATIQVyreclggtecrfgqrnFYHSAVVSGPTPLSGADI-VVP 391
Cdd:TIGR01356 305 AFAEGVTRitgaeelrVKES---DRIaAIAEELRKLGVDVEE----------------FEDGLYIRGKKELKGAVVdTFG 365
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 496525348 392 DLRGGFSHLIAALTAEGTSRVEGVNLIDRGYEHFMSKLESLNA 434
Cdd:TIGR01356 366 DHRIAMAFAVAGLVAEGEVLIDDPECVAKSFPSFFDVLERLGA 408
|
|
| EPT_RTPC-like |
cd01553 |
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate ... |
237-432 |
5.07e-03 |
|
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a 4th slightly different domain inserted between the 2nd and 3rd repeat. They evidently share the same active site location, although the catalytic residues differ.
Pssm-ID: 238794 Cd Length: 211 Bit Score: 38.03 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 237 PDRIEAASWASAALATRGDVFVRGAHQSHMT--------TFLNTFRKVGGAfdvTDEGIRF------YHPGGdLRSIVVE 302
Cdd:cd01553 8 GGGQILRSFLVLAAISGGPITVTGIRPDRAKpgllrqhlTFLKALEKICGA---TVEGGELgsdrisFRPGT-VRGGDVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 303 TNVHP-GFMTDWQQPLVVALTQAQGLSIVHETVY----------ENRFGFTGALRKMGATIQVyreclggTECRFGQRnf 371
Cdd:cd01553 84 FAIGSaGSCTDVLQTILPLLLFAKGPTRLTVTGGtdnpsappadFIRFVLEPELAKIGAHQEE-------TLLRHGFY-- 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496525348 372 yhsavvsGPTPLSGADIVVPDLRGGFSHLIAALT---AEGTSRVEGVNLIDRGYEHFMSKLESL 432
Cdd:cd01553 155 -------PAGGGVVATEVSPVEKLNTAQLRQLVLpmlLASGAVEFTVAHPSCHLLTNFAVLEAL 211
|
|
| PRK02427 |
PRK02427 |
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
127-226 |
5.22e-03 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 235037 [Multi-domain] Cd Length: 435 Bit Score: 38.97 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 127 RP-IDFHLEILRQFGASVDKQE----QGIRLTAPDGLNGTVIELP-------YPSVGAteqtLLTA-----VRACGLTEL 189
Cdd:PRK02427 195 RPhTEITLRMLRAFGVEVENVEgwgyRRIVIKGGQRLRGQDITVPgdpssaaFFLAAA----AITGgsevtITNVGLNST 270
|
90 100 110
....*....|....*....|....*....|....*..
gi 496525348 190 RGAAVepeimdLVDVLQKMGAIISVDTDRTIHVEGVD 226
Cdd:PRK02427 271 QGGKA------IIDVLEKMGADIEIENEREGGEPVGD 301
|
|
| PRK02427 |
PRK02427 |
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
6-224 |
5.70e-03 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 235037 [Multi-domain] Cd Length: 435 Bit Score: 38.97 E-value: 5.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 6 LQVEGGRPLTGEITVRGAKNLVPKAMVAALLGSSPSVLRNVPLIRDVDV-VSGLLSLhGVSIDYDQREgvlqldsskVES 84
Cdd:PRK02427 5 LLIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLAtLNALRAL-GVEIEDDEVV---------VEG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 85 AHMADIDAHAGssripILFCG----------PLLhrlgeAFIPDL----GGCRIGDRPIDFHLEILRQFGASVDKQEQG- 149
Cdd:PRK02427 75 VGGGGLKEPED-----VLDCGnsgttmrlltGLL-----ALQPGEvvltGDESLRKRPMGRLLDPLRQMGAKIEGRDEGy 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496525348 150 --IRLTAPDGLNGTVIELPYPSvgateQ-----TLLTAVRACGLTELRgaAVEPE-----IMDLVDVLQKMGAIISVDTD 217
Cdd:PRK02427 145 lpLTIRGGKKGGPIEYDGPVSS-----QfvkslLLLAPLFAEGDTETT--VIEPLpsrphTEITLRMLRAFGVEVENVEG 217
|
250
....*....|
gi 496525348 218 ---RTIHVEG 224
Cdd:PRK02427 218 wgyRRIVIKG 227
|
|
| |
