NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|496526457|ref|WP_009234740|]
View 

MULTISPECIES: MoxR family ATPase [Actinomyces]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 18-303 3.45e-129

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 369.88  E-value: 3.45e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  18 IVNNVGQALLDKDDVIKLALTTMLSEGHLLLEDAPGTGKTALARALAASVQGTHSRIQFTPDLLPSDITGVTIYDQKTGS 97
Cdd:COG0714    6 LRAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  98 WDFHAGPIFSSIVLADEINRASPKTQSALLEVMEESQVTVDGVRHTTERPFMVIATQNPIEQAGTYRLPEAQLDRFLMKA 177
Cdd:COG0714   86 FEFRPGPLFANVLLADEINRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457 178 SVGYPGREALTRILSSSAHPDRSKnLSAVVASSVVASMADLAATNHIENSVLDYIGALVEATRDAEETRMGVSTRGAIGM 257
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRHLAE-VEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPDLRKGPSPRASIAL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 496526457 258 ARAARVWAAAQGRNFVLPDDVKDLAEVVWAHRLVMDPDAEFTGATA 303
Cdd:COG0714  245 LRAARALALLDGRDYVTPDDVKAVAGPVLKHRLILSPEADAEGVTA 290
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 18-303 3.45e-129

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 369.88  E-value: 3.45e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  18 IVNNVGQALLDKDDVIKLALTTMLSEGHLLLEDAPGTGKTALARALAASVQGTHSRIQFTPDLLPSDITGVTIYDQKTGS 97
Cdd:COG0714    6 LRAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  98 WDFHAGPIFSSIVLADEINRASPKTQSALLEVMEESQVTVDGVRHTTERPFMVIATQNPIEQAGTYRLPEAQLDRFLMKA 177
Cdd:COG0714   86 FEFRPGPLFANVLLADEINRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457 178 SVGYPGREALTRILSSSAHPDRSKnLSAVVASSVVASMADLAATNHIENSVLDYIGALVEATRDAEETRMGVSTRGAIGM 257
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRHLAE-VEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPDLRKGPSPRASIAL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 496526457 258 ARAARVWAAAQGRNFVLPDDVKDLAEVVWAHRLVMDPDAEFTGATA 303
Cdd:COG0714  245 LRAARALALLDGRDYVTPDDVKAVAGPVLKHRLILSPEADAEGVTA 290
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 45-175 6.58e-84

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 249.01  E-value: 6.58e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457   45 HLLLEDAPGTGKTALARALAASVQGTHSRIQFTPDLLPSDITGVTIYDQKTGSWDFHAGPIFSSIVLADEINRASPKTQS 124
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGTEVFDQKTREFEFRPGPVFANVLLADEINRAPPKTQS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 496526457  125 ALLEVMEESQVTVDGVRHTTERPFMVIATQNPIEQAGTYRLPEAQLDRFLM 175
Cdd:pfam07726  81 ALLEAMQERQVTIDGETHPLPEPFFVLATQNPIEQEGTYPLPEAQLDRFLM 131
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-181 7.61e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 50.99  E-value: 7.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  44 GHLLLEDAPGTGKTALARALAASVQGTHSRIQFtpdLLPSDITGVTIYDQKTGSWDFHAGPIFS-----SIVLADEINRA 118
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELFRPGAPFLY---LNASDLLEGLVVAELFGHFLVRLLFELAekakpGVLFIDEIDSL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496526457 119 SPKTQSALLEVMEESQVTVDGVRHtterpFMVIATQNPIEQAgtyRLPEAQLDRFLMKASVGY 181
Cdd:cd00009   97 SRGAQNALLRVLETLNDLRIDREN-----VRVIGATNRPLLG---DLDRALYDRLDIRIVIPL 151
MCM smart00350
minichromosome maintenance proteins;
33-173 3.60e-03

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 38.78  E-value: 3.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457    33 IKLALTTML--------SEGH--------LLLEDaPGTGKTALARAlaasVQGTHSRIQFTPDLLPSDItGVTIY---DQ 93
Cdd:smart00350 211 IKKAILLLLfggvhknlPDGMkirgdiniLLCGD-PGTAKSQLLKY----VEKTAPRAVYTTGKGSSAV-GLTAAvtrDP 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457    94 KTGSWDFHAGPIFSS---IVLADEINRASPKTQSALLEVMEESQVTVD--GVRHTTERPFMVIATQNPIEqaGTY----- 163
Cdd:smart00350 285 ETREFTLEAGALVLAdngVCCIDEFDKMDDSDRTAIHEAMEQQTISIAkaGITTTLNARCSVLAAANPIG--GRYdpklt 362

                          170
                   ....*....|....*
gi 496526457   164 -----RLPEAQLDRF 173
Cdd:smart00350 363 peeniDLPAPILSRF 377
44 PHA02544
clamp loader, small subunit; Provisional
 46-132 5.99e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 38.05  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  46 LLLEDAPGTGKTALARALAAS-------VQGTHSRIQFTPDLLPSDITGVTiydqktgswdFHAGPifsSIVLADEINRA 118
Cdd:PHA02544  46 LLHSPSPGTGKTTVAKALCNEvgaevlfVNGSDCRIDFVRNRLTRFASTVS----------LTGGG---KVIIIDEFDRL 112

                         90
                 ....*....|....*
gi 496526457 119 S-PKTQSALLEVMEE 132
Cdd:PHA02544 113 GlADAQRHLRSFMEA 127
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 18-303 3.45e-129

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 369.88  E-value: 3.45e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  18 IVNNVGQALLDKDDVIKLALTTMLSEGHLLLEDAPGTGKTALARALAASVQGTHSRIQFTPDLLPSDITGVTIYDQKTGS 97
Cdd:COG0714    6 LRAEIGKVYVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  98 WDFHAGPIFSSIVLADEINRASPKTQSALLEVMEESQVTVDGVRHTTERPFMVIATQNPIEQAGTYRLPEAQLDRFLMKA 177
Cdd:COG0714   86 FEFRPGPLFANVLLADEINRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457 178 SVGYPGREALTRILSSSAHPDRSKnLSAVVASSVVASMADLAATNHIENSVLDYIGALVEATRDAEETRMGVSTRGAIGM 257
Cdd:COG0714  166 YIGYPDAEEEREILRRHTGRHLAE-VEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPDLRKGPSPRASIAL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 496526457 258 ARAARVWAAAQGRNFVLPDDVKDLAEVVWAHRLVMDPDAEFTGATA 303
Cdd:COG0714  245 LRAARALALLDGRDYVTPDDVKAVAGPVLKHRLILSPEADAEGVTA 290
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 45-175 6.58e-84

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 249.01  E-value: 6.58e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457   45 HLLLEDAPGTGKTALARALAASVQGTHSRIQFTPDLLPSDITGVTIYDQKTGSWDFHAGPIFSSIVLADEINRASPKTQS 124
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGTEVFDQKTREFEFRPGPVFANVLLADEINRAPPKTQS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 496526457  125 ALLEVMEESQVTVDGVRHTTERPFMVIATQNPIEQAGTYRLPEAQLDRFLM 175
Cdd:pfam07726  81 ALLEAMQERQVTIDGETHPLPEPFFVLATQNPIEQEGTYPLPEAQLDRFLM 131
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 45-173 3.37e-15

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 71.17  E-value: 3.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457   45 HLLLEDAPGTGKTALARALAASVQGTHSR-IQFTPDLLPSDITGVTIYDQKTGSWdfHAGPIF-----SSIVLADEINRA 118
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFyVQLTRDTTEEDLFGRRNIDPGGASW--VDGPLVraareGEIAVLDEINRA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 496526457  119 SPKTQSALLEVMEESQVTV-DGVRHTTERP--FMVIATQNPIEQAGTyRLPEAQLDRF 173
Cdd:pfam07728  79 NPDVLNSLLSLLDERRLLLpDGGELVKAAPdgFRLIATMNPLDRGLN-ELSPALRSRF 135
AAA_lid_2 pfam17863
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 237-297 5.34e-08

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465538 [Multi-domain]  Cd Length: 73  Bit Score: 49.14  E-value: 5.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496526457  237 EATRDAEETRMGVST-RGAIGMARAARVWAAAQGRNFVLPDDVKDLAEVVWAHRLVMDPDAE 297
Cdd:pfam17863   1 LATRAHLAIALGVSPrRADLALLRAARALAALEGRDYVTPEDVKEAAPLVLAHRLRREPEAE 62
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-181 7.61e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 50.99  E-value: 7.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  44 GHLLLEDAPGTGKTALARALAASVQGTHSRIQFtpdLLPSDITGVTIYDQKTGSWDFHAGPIFS-----SIVLADEINRA 118
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELFRPGAPFLY---LNASDLLEGLVVAELFGHFLVRLLFELAekakpGVLFIDEIDSL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496526457 119 SPKTQSALLEVMEESQVTVDGVRHtterpFMVIATQNPIEQAgtyRLPEAQLDRFLMKASVGY 181
Cdd:cd00009   97 SRGAQNALLRVLETLNDLRIDREN-----VRVIGATNRPLLG---DLDRALYDRLDIRIVIPL 151
bpMoxR pfam20030
MoxR domain in the MoxR-vWA-beta-propeller ternary systems; Core MoxR component domain of the ...
 17-191 5.20e-07

MoxR domain in the MoxR-vWA-beta-propeller ternary systems; Core MoxR component domain of the MoxR-vWA-beta-propeller ternary systems, a class of NTP-dependent biological conflict systems.


Pssm-ID: 437862 [Multi-domain]  Cd Length: 205  Bit Score: 49.55  E-value: 5.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457   17 TIVNNVGQALLDKDDVIKLALTTMLSEGHLLLEDAPGTGKTALARALAASVQGTHSRIQFTPDLLPSDITG-VTIYDQKT 95
Cdd:pfam20030   5 EVLRPLKTGFVGKDEIIDLLGLALVARENLFLLGPPGTAKSALVRRLAARLGGRYFEYLLTRFTEPNELFGpFDIRKLRE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457   96 GSWDFHAGPIF--SSIVLADEINRASPKTQSALLEVMEEsQVTVDGvRHTTERP-FMVIATQNpieqagtyRLPE----- 167
Cdd:pfam20030  85 GELVTNTEGMLpeASLVFLDELFNANSAILNSLLMVLNE-RIFRRG-KETRKLPaLMFVGASN--------HLPEdeala 154

                         170       180
                  ....*....|....*....|....
gi 496526457  168 AQLDRFLMKASVGYPGREALTRIL 191
Cdd:pfam20030 155 ALFDRFLLRVKCDNVPPDQLEAVL 178
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 30-173 7.13e-07

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 50.03  E-value: 7.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  30 DDVIKLALTTMLSEG---------------HLLLEDAPGTGKTAL--------ARALAASVQGTHSriqftpdllpSDIT 86
Cdd:cd17706   13 HEDVKKAVLLQLFGGvqkiledgtrirgdiHILLVGDPGTAKSQIlkyvlkiaPRGVYTSGKGSSG----------AGLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  87 GVTIYDQKTGSWDFHAGpifsSIVLA-------DEINRASPKTQSALLEVMEESQVTVD--GVRHTTERPFMVIATQNPI 157
Cdd:cd17706   83 AAVVRDSETGEWYLEAG----ALVLAdggvcciDEFDKMKELDRTALHEAMEQQTISIAkaGIVTTLNARCSILAAANPK 158

                        170       180
                 ....*....|....*....|....
gi 496526457 158 EQ--------AGTYRLPEAQLDRF 173
Cdd:cd17706  159 GGrynpklspIENINLPSPLLSRF 182
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 53-132 1.93e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 41.39  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  53 GTGKTALARALAASV-QGTHSRIQFTPDLLPSDITGVTIYDQKTGSWDFHAGPIFS--------SIVLADEINRASPKTQ 123
Cdd:cd19499   51 GVGKTELAKALAELLfGDEDNLIRIDMSEYMEKHSVSRLIGAPPGYVGYTEGGQLTeavrrkpySVVLLDEIEKAHPDVQ 130


                 ....*....
gi 496526457 124 SALLEVMEE 132
Cdd:cd19499  131 NLLLQVLDD 139
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 45-156 1.94e-04

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 42.44  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  45 HLLLEDAPGTGKTALARalaaSVQGTHSRIQFTP--DLLPSDITGVTIYDQKTGSWDFHAGPIF---SSIVLADEINRAS 119
Cdd:cd17761   44 HILLVGDPGTAKSQLLK----YVSKVAPRAVYTTgkGSTAAGLTAAVVRDEGTGEWYLEAGALVladKGIAVVDEIDKMR 119

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 496526457 120 PKTQSALLEVMEESQVTVD--GVRHTTERPFMVIATQNP 156
Cdd:cd17761  120 KEDRSALHEAMEQQTISIAkaGIVATLNARAAVLAAANP 158
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 30-118 3.60e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 42.06  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  30 DDVIKLALTTMLSEGHLLLEDAPGTGKTALARALAASVQGTHS----RIQFTPDL-LPSDITGvtIYDQ-KTGSWDFHAG 103
Cdd:COG1401  208 EETLEAFLAALKTKKNVILAGPPGTGKTYLARRLAEALGGEDNgrieFVQFHPSWsYEDFLLG--YRPSlDEGKYEPTPG 285

                         90       100
                 ....*....|....*....|....*..
gi 496526457 104 PIFSSIVLA------------DEINRA 118
Cdd:COG1401  286 IFLRFCLKAeknpdkpyvliiDEINRA 312
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 43-136 3.79e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 40.64  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457   43 EGHLLLEDAPGTGKTALARALAASVQGTHS---RIQFTPDLLPSDIT-------GVTIYDQKtGSWDFHAGPIFSSIVLA 112
Cdd:pfam07724   3 IGSFLFLGPTGVGKTELAKALAELLFGDERaliRIDMSEYMEEHSVSrligappGYVGYEEG-GQLTEAVRRKPYSIVLI 81

                          90       100
                  ....*....|....*....|....
gi 496526457  113 DEINRASPKTQSALLEVMEESQVT 136
Cdd:pfam07724  82 DEIEKAHPGVQNDLLQILEGGTLT 105
MCM smart00350
minichromosome maintenance proteins;
33-173 3.60e-03

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 38.78  E-value: 3.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457    33 IKLALTTML--------SEGH--------LLLEDaPGTGKTALARAlaasVQGTHSRIQFTPDLLPSDItGVTIY---DQ 93
Cdd:smart00350 211 IKKAILLLLfggvhknlPDGMkirgdiniLLCGD-PGTAKSQLLKY----VEKTAPRAVYTTGKGSSAV-GLTAAvtrDP 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457    94 KTGSWDFHAGPIFSS---IVLADEINRASPKTQSALLEVMEESQVTVD--GVRHTTERPFMVIATQNPIEqaGTY----- 163
Cdd:smart00350 285 ETREFTLEAGALVLAdngVCCIDEFDKMDDSDRTAIHEAMEQQTISIAkaGITTTLNARCSVLAAANPIG--GRYdpklt 362

                          170
                   ....*....|....*
gi 496526457   164 -----RLPEAQLDRF 173
Cdd:smart00350 363 peeniDLPAPILSRF 377
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
15-68 3.65e-03

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 38.63  E-value: 3.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 496526457  15 FSTIVnnvGQalldkdDVIKLALTTMLSEGHL----LLEDAPGTGKTALARALAASVQ 68
Cdd:COG2812    9 FDDVV---GQ------EHVVRTLKNALASGRLahayLFTGPRGVGKTTLARILAKALN 57
44 PHA02544
clamp loader, small subunit; Provisional
 46-132 5.99e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 38.05  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496526457  46 LLLEDAPGTGKTALARALAAS-------VQGTHSRIQFTPDLLPSDITGVTiydqktgswdFHAGPifsSIVLADEINRA 118
Cdd:PHA02544  46 LLHSPSPGTGKTTVAKALCNEvgaevlfVNGSDCRIDFVRNRLTRFASTVS----------LTGGG---KVIIIDEFDRL 112

                         90
                 ....*....|....*
gi 496526457 119 S-PKTQSALLEVMEE 132
Cdd:PHA02544 113 GlADAQRHLRSFMEA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH