|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06955 |
PRK06955 |
biotin--[acetyl-CoA-carboxylase] ligase; |
1-292 |
2.57e-121 |
|
biotin--[acetyl-CoA-carboxylase] ligase;
Pssm-ID: 235896 [Multi-domain] Cd Length: 300 Bit Score: 349.46 E-value: 2.57e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 1 MSLAEPSAGWRLARERIQPSGPAAG--WPVDVVEATGSTNADLMAAVRDATWPAytatpahagnAPLVGARVLAAQRQTA 78
Cdd:PRK06955 6 PSSTPASGDWRIDRDRLDAHLAAAAraWPLEIVEETGSTNADLMARLKALPRSA----------DALPAPIVRVAYEQTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 79 GRGRQGRPWDGDHG--LTFSIACAFAGEPAQLGGLSLAVGVAVVEAVAGYAEARGgsgQALSLKWPNDVQIAGRKLAGIL 156
Cdd:PRK06955 76 GRGRQGRPWFAQPGnaLLFSVACVLPRPVAALAGLSLAVGVALAEALAALPAALG---QRIALKWPNDLLIAGRKLAGIL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 157 VETVRTAPGRTWTVIGIGLNLERPH----------VLETTLGRGLSGVEELV--DAPEANAVFSALLTSLGEHLQRFGLQ 224
Cdd:PRK06955 153 IETVWATPDATAVVIGIGLNVRRADavaaevdalrAREAALARGLPPVALAAacAGANLTDTLAAALNALAPALQAFGAD 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496532539 225 GLAPFVAPFAARDAFAGERVRLWQDGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRSADAEQ 292
Cdd:PRK06955 233 GLAPFAARWHALHAYAGREVVLLEDGAELARGVAHGIDETGQLLLDTPAGRQAIAAGDVSLREADAAR 300
|
|
| BirA2 |
COG0340 |
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA ... |
27-286 |
2.23e-56 |
|
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA carboxylase) ligase is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 440109 [Multi-domain] Cd Length: 241 Bit Score: 181.53 E-value: 2.23e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 27 PVDVVEATGSTNADLMAAVRdatwpaytatpahagnAPLVGARVLAAQRQTAGRGRQGRPWDGDHG--LTFSIACAFAGE 104
Cdd:COG0340 1 RIEVFDEVDSTNDEAKELAR----------------EGAPEGTVVVAEEQTAGRGRRGRSWVSPPGkgLYFSLLLRPDLP 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 105 PAQLGGLSLAVGVAVVeavagyaEA-RGGSGQALSLKWPNDVQIAGRKLAGILVETVRTAPGRTWTVIGIGLNLERPHVL 183
Cdd:COG0340 65 PARLPLLSLAAGLAVA-------EAlRELTGVDVGLKWPNDILLNGKKLAGILIEASGEGDGIDWVVIGIGINVNQPPFD 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 184 ETTLGRGLSGVEELVDAP-EANAVFSALLTSLGEHLQRFGLQGLAPFVAPFAARDAFAGERVRLWQDGSVVlEGVAHGID 262
Cdd:COG0340 138 PEELDQPATSLKEETGKEvDREELLAALLEELEELYDRFLEEGFAPILEEWRARLATLGRRVRVETGGETL-EGIAVGID 216
|
250 260
....*....|....*....|....*
gi 496532539 263 AQGRLAIE-SGGRVQWIHSGEVSLR 286
Cdd:COG0340 217 EDGALLLEtADGEIRAVAAGEVSLR 241
|
|
| birA_ligase |
TIGR00121 |
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the ... |
73-286 |
3.35e-35 |
|
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the biotin--acetyl-CoA-carboxylase ligase region of biotin--acetyl-CoA-carboxylase ligase. In Escherichia coli and some other species, this enzyme is part of a bifunction protein BirA that includes a small, N-terminal biotin operon repressor domain. Proteins identified by this model should not be called bifunctional unless they are also identified by birA_repr_reg (TIGR00122). The protein name suggests that this enzyme transfers biotin only to acetyl-CoA-carboxylase but it also transfers the biotin moiety to other proteins. The apparent orthologs among the eukaryotes are larger proteins that contain a single copy of this domain. [Protein fate, Protein modification and repair]
Pssm-ID: 272917 [Multi-domain] Cd Length: 237 Bit Score: 126.75 E-value: 3.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 73 AQRQTAGRGRQGRPWDGDHG-LTFSIACAFAGEPAQLGGLSLAVGVAVVeavagyaEARGGSGQALSLKWPNDVQIAGRK 151
Cdd:TIGR00121 31 AEYQTAGRGRRGRKWLSPEGgLYFSLILRPDLPKSPAPGLTLVAGIAIA-------EVLKELGDQVQVKWPNDILLKDKK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 152 LAGILVETVRTAPGRTWTVIGIGLNLERPHVLETTLGRGLSGVEELVDAPEANAVFSALLTSLGEHLQRFGLQGLAPFVA 231
Cdd:TIGR00121 104 LGGILTELTGKENRADYVVIGIGINVQNRKPAESLREQAISLSEEAGIDLDRGELIEGFLRNFEENLEWFEQEGIDEILS 183
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 496532539 232 PFAARDAFAGERVRLWQdGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLR 286
Cdd:TIGR00121 184 KWEKLSAHIGREVSLTT-GNGEIEGIARGIDKDGALLLEDGGGIKKIISGEISLR 237
|
|
| BPL |
cd16442 |
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an ... |
27-221 |
1.35e-30 |
|
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an activated form of biotin, biotinyl-5'-AMP, from substrates biotin and ATP followed by biotinylation of the biotin carboxyl carrier protein subunit of acetyl-CoA carboxylase. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine.
Pssm-ID: 319741 [Multi-domain] Cd Length: 173 Bit Score: 112.74 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 27 PVDVVEATGSTNADLMAAVRDATwPAYTatpahagnaplvgarVLAAQRQTAGRGRQGRPWDG--DHGLTFSIACAFAGE 104
Cdd:cd16442 1 KLIVLDEIDSTNDEAKELARSGA-PEGT---------------VVVAEEQTAGRGRRGRKWESpkGKGLYFSLLLRPDVP 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 105 PAQLGGLSLAVGVAVVeavagyaEA-RGGSGQALSLKWPNDVQIAGRKLAGILVETVRTAPGRTWTVIGIGLNLERPHvl 183
Cdd:cd16442 65 PAEAPLLTLLAAVAVA-------EAlEKLGGIPVQIKWPNDILVNGKKLAGILTEASAEGEGVAAVVIGIGINVNNTP-- 135
|
170 180 190
....*....|....*....|....*....|....*...
gi 496532539 184 ETTLGRGLSGVEELVDAPEANAVFSALLTSLGEHLQRF 221
Cdd:cd16442 136 PPEPLPDTSLATSLGKEVDRNELLEELLAALENRLELF 173
|
|
| BPL_LplA_LipB |
pfam03099 |
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, ... |
69-176 |
3.52e-11 |
|
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, lipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organizm probably has only one BPL. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LPLA) catalyzes the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor.
Pssm-ID: 427135 Cd Length: 132 Bit Score: 59.76 E-value: 3.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 69 RVLAAQRQTAGRGRQGRPW-DGDHGLTFSIACAFAGEPAQLGGLS-LAVGVAVVEAVAGYAEARGGSGQALSLKWPNDVQ 146
Cdd:pfam03099 24 GVVVVRRQTGGRGRGGNVWhSPKGCLTYSLLLSKEHPNVDPSVLEfYVLELVLAVLEALGLYKPGISGIPCFVKWPNDLY 103
|
90 100 110
....*....|....*....|....*....|
gi 496532539 147 IAGRKLAGILVETVRTAPGrTWTVIGIGLN 176
Cdd:pfam03099 104 VNGRKLAGILQRSTRGGTL-HHGVIGLGVN 132
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06955 |
PRK06955 |
biotin--[acetyl-CoA-carboxylase] ligase; |
1-292 |
2.57e-121 |
|
biotin--[acetyl-CoA-carboxylase] ligase;
Pssm-ID: 235896 [Multi-domain] Cd Length: 300 Bit Score: 349.46 E-value: 2.57e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 1 MSLAEPSAGWRLARERIQPSGPAAG--WPVDVVEATGSTNADLMAAVRDATWPAytatpahagnAPLVGARVLAAQRQTA 78
Cdd:PRK06955 6 PSSTPASGDWRIDRDRLDAHLAAAAraWPLEIVEETGSTNADLMARLKALPRSA----------DALPAPIVRVAYEQTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 79 GRGRQGRPWDGDHG--LTFSIACAFAGEPAQLGGLSLAVGVAVVEAVAGYAEARGgsgQALSLKWPNDVQIAGRKLAGIL 156
Cdd:PRK06955 76 GRGRQGRPWFAQPGnaLLFSVACVLPRPVAALAGLSLAVGVALAEALAALPAALG---QRIALKWPNDLLIAGRKLAGIL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 157 VETVRTAPGRTWTVIGIGLNLERPH----------VLETTLGRGLSGVEELV--DAPEANAVFSALLTSLGEHLQRFGLQ 224
Cdd:PRK06955 153 IETVWATPDATAVVIGIGLNVRRADavaaevdalrAREAALARGLPPVALAAacAGANLTDTLAAALNALAPALQAFGAD 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496532539 225 GLAPFVAPFAARDAFAGERVRLWQDGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRSADAEQ 292
Cdd:PRK06955 233 GLAPFAARWHALHAYAGREVVLLEDGAELARGVAHGIDETGQLLLDTPAGRQAIAAGDVSLREADAAR 300
|
|
| BirA2 |
COG0340 |
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA ... |
27-286 |
2.23e-56 |
|
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA carboxylase) ligase is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 440109 [Multi-domain] Cd Length: 241 Bit Score: 181.53 E-value: 2.23e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 27 PVDVVEATGSTNADLMAAVRdatwpaytatpahagnAPLVGARVLAAQRQTAGRGRQGRPWDGDHG--LTFSIACAFAGE 104
Cdd:COG0340 1 RIEVFDEVDSTNDEAKELAR----------------EGAPEGTVVVAEEQTAGRGRRGRSWVSPPGkgLYFSLLLRPDLP 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 105 PAQLGGLSLAVGVAVVeavagyaEA-RGGSGQALSLKWPNDVQIAGRKLAGILVETVRTAPGRTWTVIGIGLNLERPHVL 183
Cdd:COG0340 65 PARLPLLSLAAGLAVA-------EAlRELTGVDVGLKWPNDILLNGKKLAGILIEASGEGDGIDWVVIGIGINVNQPPFD 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 184 ETTLGRGLSGVEELVDAP-EANAVFSALLTSLGEHLQRFGLQGLAPFVAPFAARDAFAGERVRLWQDGSVVlEGVAHGID 262
Cdd:COG0340 138 PEELDQPATSLKEETGKEvDREELLAALLEELEELYDRFLEEGFAPILEEWRARLATLGRRVRVETGGETL-EGIAVGID 216
|
250 260
....*....|....*....|....*
gi 496532539 263 AQGRLAIE-SGGRVQWIHSGEVSLR 286
Cdd:COG0340 217 EDGALLLEtADGEIRAVAAGEVSLR 241
|
|
| PRK11886 |
PRK11886 |
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA; |
9-289 |
1.23e-45 |
|
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
Pssm-ID: 237010 [Multi-domain] Cd Length: 319 Bit Score: 156.49 E-value: 1.23e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 9 GWRLAR-------ERIQPSGPaaGWPVDVVEATGSTNADLMAAVrdatwpaytatpahagnAPLVGARVLAAQRQTAGRG 81
Cdd:PRK11886 56 GYRLAEpldlldpERISSQLP--PGRVTVLPVIDSTNQYLLDRI-----------------AELKSGDLCLAEYQTAGRG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 82 RQGRPW---DGdHGLTFSIACAFAGEPAQLGGLSLAVGVAVVeavagyaEA-RGGSGQALSLKWPNDVQIAGRKLAGILV 157
Cdd:PRK11886 117 RRGRQWfspFG-GNLYLSLYWRLNQGPAQAMGLSLVVGIAIA-------EAlRRLGAIDVGLKWPNDIYLNDRKLAGILV 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 158 ETVRTAPGRTWTVIGIGLNLERPHVLETTLGRGLSGVEELVDAPEANAVFSALLTSLGEHLQRFGLQGLAPFVAPFAARD 237
Cdd:PRK11886 189 ELSGETGDAAHVVIGIGINVAMPDFPEELIDQPWSDLQEAGPTIDRNQLAAELIKQLRAALELFEQEGLAPFLERWKKLD 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 496532539 238 AFAGERVRLwQDGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRSAD 289
Cdd:PRK11886 269 LFLGREVKL-IIGDKEISGIARGIDEQGALLLEDDGVEKPFNGGEISLRSWE 319
|
|
| birA_ligase |
TIGR00121 |
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the ... |
73-286 |
3.35e-35 |
|
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the biotin--acetyl-CoA-carboxylase ligase region of biotin--acetyl-CoA-carboxylase ligase. In Escherichia coli and some other species, this enzyme is part of a bifunction protein BirA that includes a small, N-terminal biotin operon repressor domain. Proteins identified by this model should not be called bifunctional unless they are also identified by birA_repr_reg (TIGR00122). The protein name suggests that this enzyme transfers biotin only to acetyl-CoA-carboxylase but it also transfers the biotin moiety to other proteins. The apparent orthologs among the eukaryotes are larger proteins that contain a single copy of this domain. [Protein fate, Protein modification and repair]
Pssm-ID: 272917 [Multi-domain] Cd Length: 237 Bit Score: 126.75 E-value: 3.35e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 73 AQRQTAGRGRQGRPWDGDHG-LTFSIACAFAGEPAQLGGLSLAVGVAVVeavagyaEARGGSGQALSLKWPNDVQIAGRK 151
Cdd:TIGR00121 31 AEYQTAGRGRRGRKWLSPEGgLYFSLILRPDLPKSPAPGLTLVAGIAIA-------EVLKELGDQVQVKWPNDILLKDKK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 152 LAGILVETVRTAPGRTWTVIGIGLNLERPHVLETTLGRGLSGVEELVDAPEANAVFSALLTSLGEHLQRFGLQGLAPFVA 231
Cdd:TIGR00121 104 LGGILTELTGKENRADYVVIGIGINVQNRKPAESLREQAISLSEEAGIDLDRGELIEGFLRNFEENLEWFEQEGIDEILS 183
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 496532539 232 PFAARDAFAGERVRLWQdGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLR 286
Cdd:TIGR00121 184 KWEKLSAHIGREVSLTT-GNGEIEGIARGIDKDGALLLEDGGGIKKIISGEISLR 237
|
|
| BPL |
cd16442 |
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an ... |
27-221 |
1.35e-30 |
|
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an activated form of biotin, biotinyl-5'-AMP, from substrates biotin and ATP followed by biotinylation of the biotin carboxyl carrier protein subunit of acetyl-CoA carboxylase. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine.
Pssm-ID: 319741 [Multi-domain] Cd Length: 173 Bit Score: 112.74 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 27 PVDVVEATGSTNADLMAAVRDATwPAYTatpahagnaplvgarVLAAQRQTAGRGRQGRPWDG--DHGLTFSIACAFAGE 104
Cdd:cd16442 1 KLIVLDEIDSTNDEAKELARSGA-PEGT---------------VVVAEEQTAGRGRRGRKWESpkGKGLYFSLLLRPDVP 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 105 PAQLGGLSLAVGVAVVeavagyaEA-RGGSGQALSLKWPNDVQIAGRKLAGILVETVRTAPGRTWTVIGIGLNLERPHvl 183
Cdd:cd16442 65 PAEAPLLTLLAAVAVA-------EAlEKLGGIPVQIKWPNDILVNGKKLAGILTEASAEGEGVAAVVIGIGINVNNTP-- 135
|
170 180 190
....*....|....*....|....*....|....*...
gi 496532539 184 ETTLGRGLSGVEELVDAPEANAVFSALLTSLGEHLQRF 221
Cdd:cd16442 136 PPEPLPDTSLATSLGKEVDRNELLEELLAALENRLELF 173
|
|
| PRK13325 |
PRK13325 |
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase; |
10-286 |
2.88e-26 |
|
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
Pssm-ID: 183976 [Multi-domain] Cd Length: 592 Bit Score: 108.26 E-value: 2.88e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 10 WRLAR-------ERIQPSGPAAGWPVDVVEATGSTNADLMAAVRDATWPAYTAtpahagnaplvgarVLAAQRQTAGRGR 82
Cdd:PRK13325 59 WRLVRplavfdaEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKT--------------ICVTHLQSKGRGR 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 83 QGRPWDGDHG--LTFSIACAFAGEPAQLGGLSlavgvavVEAVAGYAEARGGSGQALSLKWPNDVQIAGRKLAGILVETV 160
Cdd:PRK13325 125 QGRKWSHRLGecLMFSFGWVFDRPQYELGSLS-------PVAAVACRRALSRLGLKTQIKWPNDLVVGRDKLGGILIETV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 161 RtAPGRTWTVIGIGLNLERPHVLETTLG-RGLSGVEELVDAPEANAVFSALLTSLGEHLQRFGLQGLAPFVAPFAARDAF 239
Cdd:PRK13325 198 R-TGGKTVAVVGIGINFVLPKEVENAASvQSLFQTASRRGNADAAVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRD 276
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 496532539 240 AGERVRLWQDGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLR 286
Cdd:PRK13325 277 HGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVSGEISLR 323
|
|
| PRK08330 |
PRK08330 |
biotin--protein ligase; Provisional |
70-286 |
2.61e-24 |
|
biotin--protein ligase; Provisional
Pssm-ID: 169384 [Multi-domain] Cd Length: 236 Bit Score: 98.28 E-value: 2.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 70 VLAAQRQTAGRGRQGRPWDG-DHGLTFSIACAFAGEPAQLGGLS-LAVGVAVVEAVAGYAEARggsgqalsLKWPNDVQI 147
Cdd:PRK08330 30 VIVADRQTAGHGRKGRAWASpEGGLWMSVILKPKVSPEHLPKLVfLGALAVVDTLREFGIEGK--------IKWPNDVLV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 148 AGRKLAGILVEtvrtapGRT-WTVIGIGLNL--ERPHVLETTlgrGLSGVEELVDAPEANAVFSALLTSLgEHLQRFGLQ 224
Cdd:PRK08330 102 NYKKIAGVLVE------GKGdFVVLGIGLNVnnEIPDELRET---ATSMKEVLGREVPLIEVFKRLVENL-DRWYKLFLE 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496532539 225 GLAPFVAPFAARDAFAGERVRLWQDGSVVLEGVAHGIDAQGRLAIE-SGGRVQWIHSGEVSLR 286
Cdd:PRK08330 172 GPGEILEEVKGRSMILGKRVKIIGDGEILVEGIAEDIDEFGALILRlDDGTVKKVLYGDVSLR 234
|
|
| BPL_LplA_LipB |
pfam03099 |
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, ... |
69-176 |
3.52e-11 |
|
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, lipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organizm probably has only one BPL. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LPLA) catalyzes the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor.
Pssm-ID: 427135 Cd Length: 132 Bit Score: 59.76 E-value: 3.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 69 RVLAAQRQTAGRGRQGRPW-DGDHGLTFSIACAFAGEPAQLGGLS-LAVGVAVVEAVAGYAEARGGSGQALSLKWPNDVQ 146
Cdd:pfam03099 24 GVVVVRRQTGGRGRGGNVWhSPKGCLTYSLLLSKEHPNVDPSVLEfYVLELVLAVLEALGLYKPGISGIPCFVKWPNDLY 103
|
90 100 110
....*....|....*....|....*....|
gi 496532539 147 IAGRKLAGILVETVRTAPGrTWTVIGIGLN 176
Cdd:pfam03099 104 VNGRKLAGILQRSTRGGTL-HHGVIGLGVN 132
|
|
| BirA |
COG1654 |
Biotin operon repressor [Transcription]; |
11-287 |
2.13e-10 |
|
Biotin operon repressor [Transcription];
Pssm-ID: 441260 [Multi-domain] Cd Length: 324 Bit Score: 60.38 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 11 RLARERIQP--SGPAAGWPVDVVEATGSTNADLMAAvrdatwpaytatpAHAGNAPLVgarVLAAQRQTAGRGRQGRPWD 88
Cdd:COG1654 65 LLDPEEIRAglSTKRLGREILYVISSTSTNLLALEL-------------AAQGGDAGT---VVAAEQQRGGRGRRRRSWS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 89 G--DHGLTFSIACAFAGEPAQLGGLSLavgvavvEAVAGYAEARGGSGQALSLKWPNDVQIAGRKLAGILVETVRTAPGR 166
Cdd:COG1654 129 SpgGGGLLYSLLLRPPIAPALLSLLLL-------AAAVAVAAALAEGGGLVKWKKWPNDLLKKGKKILGILEEEGGDADG 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 167 TWTVIGIGLNLERPHVLETTLGRGLSGVEELVDAPEANAVfsALLTSLGEHLQRFGLQGLAPFVAPFAARDAFAGERVRL 246
Cdd:COG1654 202 VVIVVGGGGNNNNSNPEEEPQELAELATSLLLILRLRLLR--LLLLLLLLLLELLELLGFLEFFFLWERLDWELLRVLKL 279
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 496532539 247 WQDGSVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRS 287
Cdd:COG1654 280 VVVVVEIGGGGGGGGALGGGLLGLLLLGGGGGGGEGSLSAV 320
|
|
| PRK05935 |
PRK05935 |
biotin--protein ligase; Provisional |
31-220 |
2.49e-10 |
|
biotin--protein ligase; Provisional
Pssm-ID: 235649 [Multi-domain] Cd Length: 190 Bit Score: 58.68 E-value: 2.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 31 VEATGSTNAdlMAAVRDATWPAYTATpahagnaplvgarVLAAQRQTAGRGRQGRPW---DGDHGLTFsiaCAFAGE--- 104
Cdd:PRK05935 8 IAETPSTNT--TAKEGMHLWDPYALT-------------VISTREQTAGKGKFGKSWhssDQDLLASF---CFFITVlni 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 105 -PAQLGGLSlavgvavveavagyAEARGGSGQAL-----SLKWPNDVQIAGRKLAGILVETVrTAPGRTWTVIGIGLNle 178
Cdd:PRK05935 70 dVSLLFRLG--------------TEAVMRLGEDLgiteaVIKWPNDVLVHGEKLCGVLCETI-PVKGGLGVILGIGVN-- 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 496532539 179 rphvlettlgrGLSGVEEL--VDAPEanavfsallTSLGEHLQR 220
Cdd:PRK05935 133 -----------GNTTKDELlgIDQPA---------TSLQELLGH 156
|
|
| BPL_C |
pfam02237 |
Biotin protein ligase C terminal domain; The function of this structural domain is unknown. It ... |
239-286 |
7.56e-08 |
|
Biotin protein ligase C terminal domain; The function of this structural domain is unknown. It is found to the C terminus of the biotin protein ligase catalytic domain pfam01317.
Pssm-ID: 426672 [Multi-domain] Cd Length: 48 Bit Score: 47.84 E-value: 7.56e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 496532539 239 FAGERVRLWQDGSVVlEGVAHGIDAQGRLAIE-SGGRVQWIHSGEVSLR 286
Cdd:pfam02237 1 TLGREVRVLLGDGIV-EGIAVGIDDDGALLLEtDDGTIRDINSGEVSLR 48
|
|
| PTZ00276 |
PTZ00276 |
biotin/lipoate protein ligase; Provisional |
58-214 |
3.63e-07 |
|
biotin/lipoate protein ligase; Provisional
Pssm-ID: 140302 [Multi-domain] Cd Length: 245 Bit Score: 50.25 E-value: 3.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 58 AHAGNAPLVgarVLAAQrQTAGRGRQGRPWDGDHG-LTFSIACAFAGEPAQLGG-LSLAVGVAVVEAVAGYAEarggsGQ 135
Cdd:PTZ00276 27 AAAGGKPFA---VLAES-QTAGRGTGGRTWTSPKGnMYFTLCIPQKGVPPELVPvLPLITGLACRAAIMEVLH-----GA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 136 ALSLKWPNDVQIAGRKLAGILVEtvrtAPGRtWTVIGIGLNLE-RPHVleTTLGRGLSGVEELVDAPEANAVFSALLTSL 214
Cdd:PTZ00276 98 AVHTKWPNDIIYAGKKIGGSLIE----SEGE-YLIIGIGMNIEvAPPV--TDAGRESTMVNEIAEDLGVKSVTPQDLAEA 170
|
|
| PRK08477 |
PRK08477 |
biotin--[acetyl-CoA-carboxylase] ligase; |
73-180 |
7.23e-04 |
|
biotin--[acetyl-CoA-carboxylase] ligase;
Pssm-ID: 236273 [Multi-domain] Cd Length: 211 Bit Score: 39.94 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496532539 73 AQRQTAGRGRQGRPWDGDHG-LTFSIACAFAGEPA--QLGGLSLAVGVAVVeavagyaEARGGSGQALSLKWPNDVQIAG 149
Cdd:PRK08477 33 AKEQTAGIGSRGNSWEGKKGnLFFSFALKESDLPKdlPLQSSSIYFGFLLK-------EVLKELGSKVWLKWPNDLYLDD 105
|
90 100 110
....*....|....*....|....*....|.
gi 496532539 150 RKLAGILVETVrtapgRTWTVIGIGLNLERP 180
Cdd:PRK08477 106 KKIGGVITNKI-----KNFIVCGIGLNLKFS 131
|
|
| |
