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Conserved domains on  [gi|496539131|ref|WP_009245279|]
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metal-dependent transcriptional regulator [Mediterraneibacter gnavus]

Protein Classification

metal-dependent transcriptional regulator( domain architecture ID 11442477)

metal-dependent transcriptional regulator may be activated by one or more from a variety of metal ions such as Mn, Cd, Co, Ni, and Fe, among others, and may function as an activator or repressor of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-119 1.44e-41

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


:

Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 133.79  E-value: 1.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131   1 MKTNESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKL 80
Cdd:COG1321    2 MMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 496539131  81 LTAWLTQ-LGVDEAIAAEDACRMEHIISKESFEAIKNHIE 119
Cdd:COG1321   82 LERFLVEvLGVDWDEAHEEAERLEHVLSDETIERLDAFLG 121
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-119 1.44e-41

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 133.79  E-value: 1.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131   1 MKTNESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKL 80
Cdd:COG1321    2 MMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 496539131  81 LTAWLTQ-LGVDEAIAAEDACRMEHIISKESFEAIKNHIE 119
Cdd:COG1321   82 LERFLVEvLGVDWDEAHEEAERLEHVLSDETIERLDAFLG 121
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 28-116 2.39e-18

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 73.79  E-value: 2.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131    28 DIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKLLTAWLTQ-LGVDEAIAAEDACRMEHII 106
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDvLGVDEEEVHEEAERLEHVL 82

                           90
                   ....*....|
gi 496539131   107 SKESFEAIKN 116
Cdd:smart00529  83 SDELEDRLDR 92
PRK03902 PRK03902
transcriptional regulator MntR;
1-116 8.03e-16

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 68.48  E-value: 8.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131   1 MKTnESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKL 80
Cdd:PRK03902   1 MPT-PSMEDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHEL 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 496539131  81 LTAWLTQLGVDEAIAAEDACRMEHIISKESFEAIKN 116
Cdd:PRK03902  80 LEQFLRIIGVDESKIYNDVEGIEHHLSWNAIDRIGD 115
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-119 4.57e-12

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 56.71  E-value: 4.57e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 496539131   64 TESGKAIADMIYERHKLLTAWLTQ-LGVDEAIAAEDACRMEHIISKESFEAIKNHIE 119
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVDvLGVDWDEVHEEAERLEHALSDELIDRLDEFLG 57
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-119 1.44e-41

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 133.79  E-value: 1.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131   1 MKTNESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKL 80
Cdd:COG1321    2 MMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 496539131  81 LTAWLTQ-LGVDEAIAAEDACRMEHIISKESFEAIKNHIE 119
Cdd:COG1321   82 LERFLVEvLGVDWDEAHEEAERLEHVLSDETIERLDAFLG 121
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 28-116 2.39e-18

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 73.79  E-value: 2.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131    28 DIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKLLTAWLTQ-LGVDEAIAAEDACRMEHII 106
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDvLGVDEEEVHEEAERLEHVL 82

                           90
                   ....*....|
gi 496539131   107 SKESFEAIKN 116
Cdd:smart00529  83 SDELEDRLDR 92
PRK03902 PRK03902
transcriptional regulator MntR;
1-116 8.03e-16

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 68.48  E-value: 8.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131   1 MKTnESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKL 80
Cdd:PRK03902   1 MPT-PSMEDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHEL 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 496539131  81 LTAWLTQLGVDEAIAAEDACRMEHIISKESFEAIKN 116
Cdd:PRK03902  80 LEQFLRIIGVDESKIYNDVEGIEHHLSWNAIDRIGD 115
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-122 3.68e-13

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 61.95  E-value: 3.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131   4 NESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEGFIYLTESGKAIADMIYERHKLLTA 83
Cdd:PRK11050  32 RELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVEN 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 496539131  84 WLTQLGVDEAIAAEDACRMEHIISKESFEAIKNHIESHS 122
Cdd:PRK11050 112 FLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHG 150
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 64-119 4.57e-12

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 56.71  E-value: 4.57e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 496539131   64 TESGKAIADMIYERHKLLTAWLTQ-LGVDEAIAAEDACRMEHIISKESFEAIKNHIE 119
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVDvLGVDWDEVHEEAERLEHALSDELIDRLDEFLG 57
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 5-49 7.30e-07

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 43.13  E-value: 7.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 496539131    5 ESAENYLETILILSQKRPVVRSVDIAEELGFKKSSVSVAMKNLRE 49
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEK 45
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-101 5.51e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 37.26  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496539131  13 TILILSQKRPVvRSVDIAEELGFKKSSVSVAMKNLREKEHITVTKEG------FIYLTESGKAIADMIYERH-KLLTAWL 85
Cdd:COG1846   43 VLAALAEAGGL-TQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPedrravLVRLTEKGRALLEEARPALeALLAELL 121

                         90
                 ....*....|....*.
gi 496539131  86 TQLGVDEAIAAEDACR 101
Cdd:COG1846  122 AGLSEEELEALLRLLR 137
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
11-79 3.72e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 34.49  E-value: 3.72e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496539131    11 LETILILSQKRPVVRSvDIAEELGFKKSSVSVAMKNLREKEHITVTK------EGFIYLTESGKAIADMIYERHK 79
Cdd:smart00347  13 FLVLRILYEEGPLSVS-ELAKRLGVSPSTVTRVLDRLEKKGLVRREPspedrrSVLVSLTEEGRELIEQLLEARS 86
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 21-56 8.94e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 32.56  E-value: 8.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 496539131   21 RPVVRSVDIAEELGFKKSSVSVAMKNLREKEHITVT 56
Cdd:pfam12802  17 NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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