|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
10-426 |
7.51e-87 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 270.96 E-value: 7.51e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 10 IDLKSFYASVECKERNrDPLTTNLVVADQSRTEktiCLAVSPSLKSYGIPGRPRLFEVVQKIKEVNntrrwkalnrtftg 89
Cdd:cd01700 3 VDCNSFYASCERVFRP-LLLGRPLVVLSNNDGC---VIARSPEAKALGIKMGSPYFKVPDLLERHG-------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 90 ssddstelnanpalkvdYIVAPPRMEYYLEYSSKIYNIYLKYiaPEDIFPYSIDEVFIDATDYLNtyQMTARELAMTMIR 169
Cdd:cd01700 65 -----------------VAVFSSNYALYGDMSRRIMSILERF--SPDVEVYSIDESFLDLTGSLR--FGDLEELARKIRR 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 170 DVLKTTGITATAGIGTNMYLCKIAMDIVAKHikPDKDGVRIAELDEMsyRRKLWNHRPLTDFWRVGKGYAKKLEEHGLFS 249
Cdd:cd01700 124 RILQETGIPVTVGIGPTKTLAKLANDLAKKK--NPYGGVVDLTDEEV--RDKLLKILPVGDVWGIGRRTAKKLNAMGIHT 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 250 MGDVARCsvgkpnefhNEELLYKMFGINAELLIDHAWGyEPCTmeQVKAYKPETNSVCSGQVLHCPY-DFDKAKLVVKEM 328
Cdd:cd01700 200 AGDLAQA---------DPDLLRKKFGVVGERLVRELNG-IDCL--PLEEYPPPKKSIGSSRSFGRDVtDLDELKQALAEY 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 329 TDLMTLDLVDKRLVTDQIVLTVGYdienltdpdryrkykgsvtiDRYGRKVPKHAHGTTnLKKKTSSTMLITDAVMELYD 408
Cdd:cd01700 268 AERAAEKLRRQKSVARTISVFIGT--------------------SGFSRQPKYYSATNT-LPYPTNDTREIVKAALRLLY 326
|
410
....*....|....*...
gi 496559828 409 RIVDKNLLIRRINITANK 426
Cdd:cd01700 327 AIYRPGYAYRKAGVMLSD 344
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
10-506 |
3.39e-42 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 155.16 E-value: 3.39e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 10 IDLKSFYASVEckeRNRDPLTTN--LVVADQSRTEKTICLAVSPSLKSYGIPGRPRLFEVVQKIKevnntrrwkalnrtf 87
Cdd:PRK03103 8 VDMQSFYASVE---KAANPELKGrpVIVSGDPERRSGVVLAACPLAKAYGVKTAERLWEAQQKCP--------------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 88 tgssddstelnanpalkvDYIVAPPRMEYYLEYSSKIYNIYLKYiaPEDIFPYSIDEVFIDATDYLNTYQmTARELAMTM 167
Cdd:PRK03103 70 ------------------DLVVVKPRMQRYIDVSLQITRILEDF--TDLVEPFSIDEQFLDVTGSQKLFG-SPLEIAQKI 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 168 IRDVLKTTGITATAGIGTNMYLCKIAMDIVAKHiKPDKdgvrIAELDEMSYRRKLWNhRPLTDFWRVGKGYAKKLEEHGL 247
Cdd:PRK03103 129 QQRIMRETGVYARVGIGPNKLLAKMACDNFAKK-NPDG----LFTLDKEDVPADLWP-LPVRKLFGVGSRMEKHLRRMGI 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 248 FSMGDVARCSVgkpnefhneELLYKMFGINAELLIDHAWGYE-----PCTMEQVKAYkpetnsvcsGQVLHCPYDFDKA- 321
Cdd:PRK03103 203 RTIGQLANTPL---------ERLKKRWGINGEVLWRTANGIDyspvtPHSLDRQKAI---------GHQMTLPRDYRGFe 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 322 --KLVVKEMTDLMTLDLVDKRLVTDQIVLTV-GYDIENLTDPDRYRKykgsvtidrygrkvpkhahgttnLKKKTSSTML 398
Cdd:PRK03103 265 eiKVVLLELCEEVCRRARAKGYMGRTVSVSLrGADFDWPTGFSRQMT-----------------------LPEPTNLAME 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 399 ITDAVMELYDRIVDkNLLIRRINITANKLVdesfskeEETYEQLDLFTDYtvkeqeqaeeeavlEREKRMQQTMLTIKKK 478
Cdd:PRK03103 322 VYEAACKLFHRHWD-GKPVRRVGVTLSNLV-------SDDVWQLSLFGDR--------------ERKRSLGYVMDDIKNR 379
|
490 500
....*....|....*....|....*...
gi 496559828 479 FGKNAILKGMNLQEGATAKDRNEQIGGH 506
Cdd:PRK03103 380 FGPTAILRASSLTEAGQAFERAAKIGGH 407
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
7-424 |
1.29e-41 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 151.84 E-value: 1.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 7 YIAIDLKSFYASVEckeRNRDPLTTN--LVVAdqSRTEKTICLAVSPSLKSYGIP-GRPrLFEVVQKIKEVnntrrwkal 83
Cdd:COG0389 3 ILHVDMDAFYASVE---QRDRPELRGkpVAVG--GDNNRGVVAAASYEARAFGVRsGMP-LFQARRLCPDL--------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 84 nrtftgssddstelnanpalkvdyIVAPPRMEYYLEYSSKIYNIYLKYiAPEdIFPYSIDEVFIDATDYLNTYQmTAREL 163
Cdd:COG0389 68 ------------------------VVLPPDFELYRDVSRRVMAILERY-TPL-VEPLSIDEAFLDVTGSARLFG-SAEAI 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 164 AMTMIRDVLKTTGITATAGIGTNMYLCKIAmdivAKHIKPdkDGVRIAELDEMsyRRKLWnHRPLTDFWRVGKGYAKKLE 243
Cdd:COG0389 121 ARRIRRRIRRETGLTVSVGIAPNKFLAKIA----SDLAKP--DGLTVIPPGEV--AAFLA-PLPVEKLWGVGPKTAEKLA 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 244 EHGLFSMGDVARCSvgkpnefhnEELLYKMFGINAELLIDHAWGYEPctmEQVKAYKPETnSVCSGQVLHCP-YDFDKAK 322
Cdd:COG0389 192 RLGIRTIGDLAALP---------RAELRRRFGKVGERLYRLARGIDP---RPVEPRRPRK-SIGVERTFGEDlTDLEELE 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 323 LVVKEMTDLMTLDLVDKRLVTDQIVLTVGYdienltdpDRYRKYKGSVTIDRYgrkvpkhahgttnlkkkTSSTMLITDA 402
Cdd:COG0389 259 AALRRLAERLAERLRRQGLGARTVTVKLRT--------SDFRTTTRSRTLPEP-----------------TDDTAELLRA 313
|
410 420
....*....|....*....|..
gi 496559828 403 VMELYDRIVDKNLLIRRINITA 424
Cdd:COG0389 314 ARELLERIYRPGRPVRLLGVRL 335
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
10-195 |
1.67e-29 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 113.05 E-value: 1.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 10 IDLKSFYASVEckeRNRDPLTTNLVVADQSRTEKTICLAVSPSLKSYGIPGRPRLFEVVQKIKEVnntrrwkalnrtftg 89
Cdd:pfam00817 1 IDMDAFFASVE---LLRDPELKGKPVAVGGGNGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNL--------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 90 ssddstelnanpalkvdyIVAPPRMEYYLEYSSKIYNIYLKYIAPeDIFPYSIDEVFIDATDYLNTYQmTARELAMTMIR 169
Cdd:pfam00817 63 ------------------IVVPPDLELYRRASRKIFEILRRFSTP-KVEQASIDEAFLDLTGLEKLFG-AEEALAKRLRR 122
|
170 180
....*....|....*....|....*.
gi 496559828 170 DVLKTTGITATAGIGTNMYLCKIAMD 195
Cdd:pfam00817 123 EIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
108-287 |
5.44e-28 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 114.16 E-value: 5.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 108 IVAPPRMEYYLEYSSKIYNIYLKYIapEDIFPYSIDEVFIDATDYLNTYqMTARELAMTMIRDVLKTTGITATAGIGTNM 187
Cdd:cd03586 65 IFVPPRFDKYREVSRQIMEILREYT--PLVEPLSIDEAYLDVTDYVRLF-GSATEIAKEIRARIREETGLTASAGIAPNK 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 188 YLCKIAMDIvakhIKPdkDGVRIAELDEMsyRRKLWnHRPLTDFWRVGKGYAKKLEEHGLFSMGDVARCSvgkpnefhnE 267
Cdd:cd03586 142 FLAKIASDL----NKP--NGLTVIPPEDV--EEFLA-PLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLD---------V 203
|
170 180
....*....|....*....|
gi 496559828 268 ELLYKMFGINAELLIDHAWG 287
Cdd:cd03586 204 ELLKKLFGKSGRRLYELARG 223
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
10-492 |
1.93e-23 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 102.42 E-value: 1.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 10 IDLKSFYASVECKernRDPLTTN--LVVADQSRTEKTICLAVSPSLKSYGIPGRPRLfevvqkikevnntrrWKALNRTf 87
Cdd:PRK01810 10 VDMNSFFASVEIA---YDPSLQGkpLAVAGNEKERKGIIVTCSYEARAYGIRTTMPL---------------WEAKRLC- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 88 tgssddstelnanPALkvdyIVAPPRMEYYLEYSSKIYNIYLKYiaPEDIFPYSIDEVFIDATDYlnTYQMTARELAMTM 167
Cdd:PRK01810 71 -------------PQL----IVRRPNFDRYREASRQMFQILSEF--TPLVQPVSIDEGYLDITDC--YALGSPLEIAKMI 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 168 IRDVLKTTGITATAGIGTNMYLCKIAMDIvakhikpdKDGVRIAELDEMSYRRKLWNhRPLTDFWRVGKGYAKKLEEHGL 247
Cdd:PRK01810 130 QQRLLTELQLPCSIGIAPNKFLAKMASDM--------KKPLGITVLRKRDVPEMLWP-LPVGEMHGIGEKTAEKLKDIGI 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 248 FSMGDVARCsvgkpnefhNEELLYKMFGINAELLIDHAWGYEPCTMEQVKAYkpETNSVCSGQVLhcPYDFDKAKL---V 324
Cdd:PRK01810 201 QTIGDLAKA---------DEHILRAKLGINGVRLQRRANGIDDRPVDPEAIY--QFKSVGNSTTL--SHDMDEEKElldV 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 325 VKEMTDLMTLDLVDKRLVTDQIVLTVgydienltdpdRYRKYKgsvTIDRygrkvpkhahgTTNLKKKTSSTMLITDAVM 404
Cdd:PRK01810 268 LRRLSKSVSKRLQKKTVVSYNVQIMI-----------RYHDRR---TITR-----------SKTLKNPIWEKRDIFQAAS 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 405 ELYDRIVDKNLlIRRINITANKLVDEsfskeEETYEQLDLFtDYTVKeqeqaeeeavlEREKRMQQTMLTIKKKFGKNAI 484
Cdd:PRK01810 323 RLFKQHWNGDP-VRLLGVTATDLEWK-----TEAVKQLDLF-SFEED-----------AKEEPLLAVIDQINDKYGMPLL 384
|
....*...
gi 496559828 485 LKGMNLQE 492
Cdd:PRK01810 385 QRGSQLLR 392
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
10-290 |
4.91e-21 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 94.35 E-value: 4.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 10 IDLKSFYASVE---CKERNRDPLttnlVVAdQSRTEKTICLAVSPSLKSYGIPgrprlfeVVQKIKEVnntrrwkalnrt 86
Cdd:cd00424 3 IDFDNFFASVEqlaRPELKGRPV----VVV-PFNSDSTCVIACSYEARKYGVK-------RGMPVREA------------ 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 87 ftgssddsteLNANPALkvdyIVAPPRMEYYLEYSSKIYNiYLKYIAPEdIFPYSIDEVFIDATDYLNTYQMtARELAMT 166
Cdd:cd00424 59 ----------RKMCPNL----ILVPARLDLYRRLSERLLS-ELEEVAPL-VEVASIDELFLDLTGSARLLGL-GSEVALR 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 167 MIRDVLKTTG-ITATAGIGTNMYLCKIAmdivAKHIKPdkDGVRIAELDEMSYRrklWNHRPLTDFWRVGKGYAKKLEEH 245
Cdd:cd00424 122 IKRHIAEQLGgITASIGIASNKLLAKLA----AKYAKP--DGLTILDPEDLPGF---LSKLPLTDLPGIGAVTAKRLEAV 192
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 496559828 246 GLFSMGDVARCSvgkpnefhNEELLYKMFGINAELLIDHAWGYEP 290
Cdd:cd00424 193 GINPIGDLLAAS--------PDALLALWGGVSGERLWYALRGIDD 229
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
102-287 |
2.35e-18 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 86.33 E-value: 2.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 102 ALKV--DYIVAPPRMEYYLEYSSKIYNIYLKYIapEDIFPYSIDEVFIDATDylNTYQM-TARELAMTMIRDVLKTTGIT 178
Cdd:PRK02406 54 ALKLcpDLIFVPGRFDVYKEVSRQIREIFRRYT--DLIEPLSLDEAYLDVTD--NKLCIgSATLIAQEIRQDIFEELGLT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 179 ATAGIGTNMYLCKIAMDI-------VakhIKPDKDGVRIAELdemsyrrklwnhrPLTDFWRVGKGYAKKLEEHGLFSMG 251
Cdd:PRK02406 130 ASAGVAPNKFLAKIASDWnkpnglfV---ITPEEVDAFLATL-------------PVEKIPGVGKVTAEKLHALGIYTCA 193
|
170 180 190
....*....|....*....|....*....|....*.
gi 496559828 252 DVARCSvgkpnefhnEELLYKMFGINAELLIDHAWG 287
Cdd:PRK02406 194 DLQKYD---------LAELIRHFGKFGRRLYERARG 220
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
106-427 |
3.91e-13 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 71.19 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 106 DYIVAPPRMEYYLEYSSKIYNIYLKYIapEDIFPYSIDEVFIDATDYLNTYQMTARELAMTMIRDVLKTTGITATAGIGT 185
Cdd:cd01701 113 QLVTLPYDFEAYEEVSLTFYEILASYT--DNIEAVSCDEALIDITSLLEETYELPEELAEAIRNEIRETTGCSASVGIGP 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 186 NMYLCKIAMdivaKHIKPDKDGVRIAELDEmsyrrKLWNHRPLTDFWRVGKGYAKKLEEHGLFSMGDVARCSVGKPNefh 265
Cdd:cd01701 191 NILLARLAT----RKAKPDGQYHLSAEKVE-----EFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKEK--- 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 266 neelLYKMFG-INAELLIDHAWGYEpctMEQVKAYKPETNSVCSGQVLHCPYDFDKAKLVVKEMTDLMTLDLVDKRLVTD 344
Cdd:cd01701 259 ----LQKVLGpKTGEKLYDYCRGID---DRPVTGEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGR 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 345 QIVLTVGydIENLTDPDRYRKYKGSVTIDRYGRkvpkhahgTTNLKKKTSSTMLITDAVMELYDRIVDKNLLIRRINITA 424
Cdd:cd01701 332 QITLKLM--KRAPGAPIEPPKYMGHGICDSFSK--------SSTLGVATDDSGVIGTEAKKLFRDLSIPPEELRGVGIQV 401
|
...
gi 496559828 425 NKL 427
Cdd:cd01701 402 TKL 404
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
106-260 |
1.27e-12 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 69.05 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 106 DYIVAPPRMEYYLEYSSKIYNIYLKYiaPEDIFPYSIDEVFIDATDYLNTYQmTARELAMTMIRDVLKTTGITATAGIGT 185
Cdd:PRK01216 70 NAVYLPMRKEVYQQVSNRIMKLLREY--SEKIEIASIDEAYLDISDKVKNYQ-DAYNLGLEIKNKILEKEKITVTVGISK 146
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 496559828 186 NMYLCKIAMDIVakhiKPdkDGVRIAELDEMsyrRKLWNHRPLTDFWRVGKGYAKKLEEHGLFSMGDVARCSVGK 260
Cdd:PRK01216 147 NKVFAKIAADMA----KP--NGIKVIDDEEV---KRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDE 212
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
11-275 |
4.98e-12 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 67.70 E-value: 4.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 11 DLKSFYASVECKE----RNRDPLTTNLVVadqsrtekticLAVSPSLKSYGI----PGRprlfevvqkikevnntrrwKA 82
Cdd:PRK03858 10 DLDSFYASVEQRDdpalRGRPVIVGGGVV-----------LAASYEAKAYGVrtamGGR-------------------QA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 83 LnrtftgssddstelnanpALKVDYIVAPPRMEYYLEYSSKIYNIYlkyiapEDIFPY----SIDEVFIDATDyLNTYQM 158
Cdd:PRK03858 60 R------------------RLCPQAVVVPPRMSAYSRASKAVFEVF------RDTTPLveglSIDEAFLDVGG-LRRISG 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 159 TARELAMTMIRDVLKTTGITATAGIGTNMYLCKIAMDiVAKhikPDkdGVRIAELD-EMSYRRKLwnhrPLTDFWRVGKG 237
Cdd:PRK03858 115 TPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQ-VAK---PD--GLLVVPPDrELAFLHPL----PVRRLWGVGPV 184
|
250 260 270
....*....|....*....|....*....|....*...
gi 496559828 238 YAKKLEEHGLFSMGDVARcsvgkpnefHNEELLYKMFG 275
Cdd:PRK03858 185 TAAKLRAHGITTVGDVAE---------LPESALVSLLG 213
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
102-287 |
1.05e-10 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 63.41 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 102 ALKV--DYIVAPPRMEYYLEYSSKIYNIYLKyIAPeDIFPYSIDEVFID--ATDYLNTyQMTARELAmTMIRDVLKTTGI 177
Cdd:PRK02794 94 ALKLcpDAVVIKPDMEKYVRVGREVRAMMQA-LTP-LVEPLSIDEAFLDlsGTERLHG-APPAVVLA-RFARRVEREIGI 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 178 TATAGIGTNMYLCKIAMDIVakhiKPDKDGVrIAELDEMSYRRKlwnhRPLTDFWRVGKGYAKKLEEHGLFSMGDVARCs 257
Cdd:PRK02794 170 TVSVGLSYNKFLAKIASDLD----KPRGFSV-IGRAEALAFLAP----KPVGIIWGVGPATAARLARDGIRTIGDLQRA- 239
|
170 180 190
....*....|....*....|....*....|
gi 496559828 258 vgkpnefhNEELLYKMFGINAELLIDHAWG 287
Cdd:PRK02794 240 --------DEADLMRRFGSMGLRLWRLARG 261
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
108-257 |
1.27e-08 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 57.25 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 108 IVAPPRMEYYLEYSSKIYNIyLKYIAP--EdifPYSIDEVFIDATDYLNTYQMTARELAMTMIRDVLKTTGITATAGIGT 185
Cdd:PRK03348 73 VVLPPRFVVYRAASRRVFDT-LRELSPvvE---QLSFDEAFVEPAELAGASAEEVEAFAERLRARVREETGLPASVGAGS 148
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496559828 186 NMYLCKIAMDIVakhiKPdkDGVRIAELDEmsyRRKLWNHRPLTDFWRVGKGYAKKLEEHGLFSMGDVARCS 257
Cdd:PRK03348 149 GKQIAKIASGLA----KP--DGIRVVPPGE---ERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALS 211
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
305-431 |
1.31e-08 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 52.56 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 305 SVCSGQVLHCPY-DFDKAKLVVKEMTDLMTLDLVDKRLVTDQIVLTVGYDienltdpdRYRKYKGSVTIDRYgrkvpkha 383
Cdd:pfam11799 3 SIGAERTFGRDLtDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS--------DFRTITRSVTLPSP-------- 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 496559828 384 hgttnlkkkTSSTMLITDAVMELYDRIVDkNLLIRRINITANKLVDES 431
Cdd:pfam11799 67 ---------TDDTDEIYRAALRLLRRLYR-GRPVRLLGVSLSNLVPEG 104
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
115-255 |
3.64e-08 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 55.54 E-value: 3.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 115 EYYLEYSSKIYNIyLKYIAPEdIFPYSIDEVFIDATDYLNTYQMT--ARELAMTmirdVLKTTGITATAGIGTNMYLCKI 192
Cdd:PRK03609 75 ELYADMSNRVMST-LEELSPR-VEIYSIDEAFCDLTGVRNCRDLTdfGREIRAT----VLQRTHLTVGVGIAQTKTLAKL 148
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496559828 193 AmDIVAKHIKPDKDGVriAELDEMSYRRKLWNHRPLTDFWRVGKGYAKKLEEHGLFSMGDVAR 255
Cdd:PRK03609 149 A-NHAAKKWQRQTGGV--VDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLAD 208
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
10-279 |
1.32e-05 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 47.31 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 10 IDLKSFYASVECKernRDPLTTNL-VVADQSrteKTIcLAVSPSLKSYGIpGRprlFEVVQKIKE------VNNTRRWKA 82
Cdd:cd01702 3 IDMDAFFAQVEQV---RLGLLRNDpVAVVQW---NSI-IAVSYAARAFGV-TR---FMTIDEAKKkcpdliLAHVATYKK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 83 lnrtftGSSDDSTELNANPAL-KVDyivapprMEYYLEYSSKIYNIyLKYIAPEdIFPYSIDEVFIDatdylntyqmTAR 161
Cdd:cd01702 72 ------GEDEADYHENPSPARhKVS-------LDPYRRASRKILNI-LKRFGDV-VEKASIDEAYLD----------LGS 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 162 ELAMTMIRDVLKTTGITATAGIGTNMYLCKIAmdivAKHIKPDKDG-VRIAELDEmsyrrkLWNHRPLTDFWRVGKGYAK 240
Cdd:cd01702 127 RIVEEIRQQVYDELGYTCSAGIAHNKMLAKLA----SGMNKPNAQTiLRNDAVAS------FLSSLPITSIRGLGGKLGE 196
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 496559828 241 KL-EEHGLFSMGDVA--RCSVGKPNEFHNEEL---LYKMF-GINAE 279
Cdd:cd01702 197 EIiDLLGLPTEGDVAgfRSSESDLQEHFGEKLgewLYNLLrGIDHE 242
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
116-258 |
3.64e-05 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 45.92 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 116 YYLEYSSKIYNIYLKYIAPEDIFPYSIDEVFIDATDylnTYQMTARELAMTMIRDVLKTTGITATAGIGTNMYLCKiamd 195
Cdd:cd01703 71 PFRDMSKKVYRLLRSYSWNDRVERLGFDENFMDVTE---MRLLVASHIAYEMRERIENELGLTCCAGIASNKLLAK---- 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496559828 196 IVAKHIKPDKDGVRIAEldemsYRRKLWNHRPLTDFWRV-GKGY--AKKLEEHGLFSMGDVARCSV 258
Cdd:cd01703 144 LVGSVNKPNQQTTLLPP-----SCADLMDFMDLHDLRKIpGIGYktAAKLEAHGISSVRDLQEFSN 204
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
7-253 |
8.68e-05 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 45.01 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 7 YIAIDLKSFYASVECKeRNRDPLTTNLVVADQSRTEKTICLAVSPSLKSyGIPGrprlfevvqkikevnntrrwkalnrt 86
Cdd:PTZ00205 135 YIHLDMDMFYAAVEIK-KHPEYAAIPLAIGTMTMLQTANYVARGRGIRQ-GMPG-------------------------- 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 87 FTGssddsteLNANPALkvdyIVAPPRMEYYLEYSSKIYNIYLKYiaPEDIFPYSIDEVFIDATDYLNTYQ--MTARELA 164
Cdd:PTZ00205 187 FLA-------LKICPNL----LILPPDFDAYNEESNTVRRIVAEY--DPNYISFGLDELTLEVSAYIERFEgtKTAEDVA 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 165 MTMIRDVLKTTGITATAGIGTNMYLCKIAMDIVakhiKPD--KDGVRIAELDEMSYRRKLwnhrPLTDFWRVGKGYAKKL 242
Cdd:PTZ00205 254 SELRVRVFGETKLTASAGIGPTAALAKIASNIN----KPNgqHDLNLHTRGDVMTYVRDL----GLRSVPGVGKVTEALL 325
|
250
....*....|.
gi 496559828 243 EEHGLFSMGDV 253
Cdd:PTZ00205 326 KGLGITTLSDI 336
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
143-255 |
1.72e-04 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 43.86 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496559828 143 DEVFI--DATDylntyqmtARELAMTMIRDVLKTTGITATAGIGTNMYLCKIAMDIVakhiKPDkdGV-RIAELDEMSyr 219
Cdd:PRK03352 109 DEAFLgvDTDD--------PEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFA----KPA--GVfRLTDANWMA-- 172
|
90 100 110
....*....|....*....|....*....|....*.
gi 496559828 220 rkLWNHRPLTDFWRVGKGYAKKLEEHGLFSMGDVAR 255
Cdd:PRK03352 173 --VMGDRPTDALWGVGPKTAKRLAALGITTVADLAA 206
|
|
| |
