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Conserved domains on  [gi|496573690|ref|WP_009274808|]
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MULTISPECIES: carbonic anhydrase [Parabacteroides]

Protein Classification

beta-class carbonic anhydrase( domain architecture ID 10130171)

beta-class carbonic anhydrase similar to carbonic anhydrase (CA) that catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton, and to carbon disulfide hydrolase that catalyzes the conversion of carbon disulfide into hydrogen sulfide and carbon dioxide, with carbonyl sulfide as an intermediate

Gene Ontology:  GO:0004089|GO:0008270

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-179 1.19e-63

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


:

Pssm-ID: 239474  Cd Length: 142  Bit Score: 192.47  E-value: 1.19e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  27 PDKKIAIVSCMDTRLTEllPASLGIKNGDVKIIKNAGAIISHpfgSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNSSE 106
Cdd:cd03379    1 PARKLAIVTCMDARLDP--EKALGLKLGDAKVIRNAGGRVTD---DAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496573690 107 MIEKMKERGIPQeridmiRYCGINFESWLRGFETSEASVHETVEQIRNHPLIPSDITVRGFVIDSVTGELTPV 179
Cdd:cd03379   76 LKEKMKERGIAE------AYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
 
Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-179 1.19e-63

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 192.47  E-value: 1.19e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  27 PDKKIAIVSCMDTRLTEllPASLGIKNGDVKIIKNAGAIISHpfgSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNSSE 106
Cdd:cd03379    1 PARKLAIVTCMDARLDP--EKALGLKLGDAKVIRNAGGRVTD---DAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496573690 107 MIEKMKERGIPQeridmiRYCGINFESWLRGFETSEASVHETVEQIRNHPLIPSDITVRGFVIDSVTGELTPV 179
Cdd:cd03379   76 LKEKMKERGIAE------AYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 25-179 6.24e-41

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 135.33  E-value: 6.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690    25 KYPDKKIAIVSCMDTRLTELLPasLGIKNGDVKIIKNAGAIISHPFGSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNS 104
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELI--FGLGPGDLFVIRNAGNIVPPYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAAL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496573690   105 SEM---IEKMKERGIPQERIDMiRYCGINFESWLRGFETSEASVHETVEqIRNHPLIPsDITVRGFVIDSVTGELTPV 179
Cdd:smart00947  80 DDEpglIDNWLERIRPARERAL-EELGDVDALEELNVRDQVENLRTSPA-IREAVAKG-KLKVHGWVYDIETGKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 31-176 3.57e-22

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 87.18  E-value: 3.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690   31 IAIVSCMDTRL-TELLpasLGIKNGDVKIIKNAGAIISHPFGSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNSSEMIE 109
Cdd:pfam00484   1 ALIIGCSDSRVpPELI---FDTGPGDLFVVRNAGNLVPPYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAAGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  110 KMKERGIPQ---------ERIDMIRYCGINFESWLRGFEtsEASVHETVEQIRNHPLIPS-----DITVRGFVIDSVTGE 175
Cdd:pfam00484  78 AELPGFIDNwlrhirpavERVAEELESLDDPEERDDALE--ELNVREQVENLRTFPIVREavakgKLKIHGWVYDLETGE 155


                  .
gi 496573690  176 L 176
Cdd:pfam00484 156 V 156
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-180 1.04e-12

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 63.26  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690   1 MIDELVSYNREFVKNKG------YEKYITNKYPdkKIAIVSCMDTRLT-ELLpASLGIknGDVKIIKNAGAIISHPFGSV 73
Cdd:COG0288    3 ALKRLLEGNRRFVAGKFpqdperFEELAKGQHP--FALVIGCSDSRVPpELI-FDQGP--GDLFVVRNAGNVVPPYDPGV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  74 IRSLIVAIYELGVVEVMIIGHTDCGA-----KHMNSSEM--IEKMKERGIPQERIDMIRYCGINFESWLRgfETSEASVH 146
Cdd:COG0288   78 LASIEYAVEVLGVKLIVVLGHSGCGAvkaalDGLELEELglIGNWLRHIRPAVERVRAELPAADGEERLD--RLVELNVR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 496573690 147 ETVEQIRNHPLIPS-----DITVRGFVIDSVTGELTPVE 180
Cdd:COG0288  156 EQVENLRTSPIVREavaagKLKVHGWVYDLATGRVEFLD 194
 
Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-179 1.19e-63

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 192.47  E-value: 1.19e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  27 PDKKIAIVSCMDTRLTEllPASLGIKNGDVKIIKNAGAIISHpfgSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNSSE 106
Cdd:cd03379    1 PARKLAIVTCMDARLDP--EKALGLKLGDAKVIRNAGGRVTD---DAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496573690 107 MIEKMKERGIPQeridmiRYCGINFESWLRGFETSEASVHETVEQIRNHPLIPSDITVRGFVIDSVTGELTPV 179
Cdd:cd03379   76 LKEKMKERGIAE------AYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 25-179 6.24e-41

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 135.33  E-value: 6.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690    25 KYPDKKIAIVSCMDTRLTELLPasLGIKNGDVKIIKNAGAIISHPFGSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNS 104
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELI--FGLGPGDLFVIRNAGNIVPPYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAAL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496573690   105 SEM---IEKMKERGIPQERIDMiRYCGINFESWLRGFETSEASVHETVEqIRNHPLIPsDITVRGFVIDSVTGELTPV 179
Cdd:smart00947  80 DDEpglIDNWLERIRPARERAL-EELGDVDALEELNVRDQVENLRTSPA-IREAVAKG-KLKVHGWVYDIETGKLEVL 154
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-179 3.24e-31

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 109.13  E-value: 3.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  27 PDKKIAIVSCMDTRLTELLpaSLGIKNGDVKIIKNAGAIISHPFGSVIRSLIVAIYELGVVEVMIIGHTDCGakhmnsse 106
Cdd:cd00382    1 QKPKALIIGCSDSRVPPEL--IFGLGPGDLFVVRNAGNLVPPYDLDVLASLEYAVEVLGVKHIIVCGHTDCG-------- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496573690 107 miekmkergipqeridMIRYCginfeswlrgfetSEASVHETVEQIRNHPLI-----PSDITVRGFVIDSVTGELTPV 179
Cdd:cd00382   71 ----------------AVKAL-------------VEENVREQVENLRSHPLIqeavaPGELKVHGWVYDIETGKLEVL 119
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 31-176 3.57e-22

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 87.18  E-value: 3.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690   31 IAIVSCMDTRL-TELLpasLGIKNGDVKIIKNAGAIISHPFGSVIRSLIVAIYELGVVEVMIIGHTDCGAKHMNSSEMIE 109
Cdd:pfam00484   1 ALIIGCSDSRVpPELI---FDTGPGDLFVVRNAGNLVPPYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAAGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  110 KMKERGIPQ---------ERIDMIRYCGINFESWLRGFEtsEASVHETVEQIRNHPLIPS-----DITVRGFVIDSVTGE 175
Cdd:pfam00484  78 AELPGFIDNwlrhirpavERVAEELESLDDPEERDDALE--ELNVREQVENLRTFPIVREavakgKLKIHGWVYDLETGE 155


                  .
gi 496573690  176 L 176
Cdd:pfam00484 156 V 156
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-180 1.04e-12

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 63.26  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690   1 MIDELVSYNREFVKNKG------YEKYITNKYPdkKIAIVSCMDTRLT-ELLpASLGIknGDVKIIKNAGAIISHPFGSV 73
Cdd:COG0288    3 ALKRLLEGNRRFVAGKFpqdperFEELAKGQHP--FALVIGCSDSRVPpELI-FDQGP--GDLFVVRNAGNVVPPYDPGV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  74 IRSLIVAIYELGVVEVMIIGHTDCGA-----KHMNSSEM--IEKMKERGIPQERIDMIRYCGINFESWLRgfETSEASVH 146
Cdd:COG0288   78 LASIEYAVEVLGVKLIVVLGHSGCGAvkaalDGLELEELglIGNWLRHIRPAVERVRAELPAADGEERLD--RLVELNVR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 496573690 147 ETVEQIRNHPLIPS-----DITVRGFVIDSVTGELTPVE 180
Cdd:COG0288  156 EQVENLRTSPIVREavaagKLKVHGWVYDLATGRVEFLD 194
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 32-99 8.43e-08

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 49.06  E-value: 8.43e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496573690  32 AIVSCMDTRLtellPASL----GIknGDVKIIKNAGAIIShpfGSVIRSLIVAIYELGVVEVMIIGHTDCGA 99
Cdd:cd03378   42 VILSCSDSRV----PPEIifdqGL--GDLFVVRVAGNIVD---DDVLGSLEYAVEVLGVPLVVVLGHESCGA 104
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 9-176 1.55e-06

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 46.00  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690   9 NREFVKNKG-YEKYITNKYPdkKIAIVSCMDTRLtelLPAS-LGIKNGDVKIIKNAGAII-----SHPFGSVIRSLIVAI 81
Cdd:cd00884    7 KEYFPEERElFEKLAKGQSP--KALFIACSDSRV---VPALiTQTQPGELFVVRNVGNLVppyepDGGFHGTSAAIEYAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496573690  82 YELGVVEVMIIGHTDCGA------KHMNSSEM--IEKMKERGIPQERIDMIRYCGINFESWLRGFEtsEASVHETVEQIR 153
Cdd:cd00884   82 AVLKVEHIVVCGHSDCGGirallsPEDLLDKLpfIGKWLRIAEPAKEVVLAELSHADFDDQLRALE--KENVLLSLENLL 159

                        170       180
                 ....*....|....*....|....*...
gi 496573690 154 NHPLIPS-----DITVRGFVIDSVTGEL 176
Cdd:cd00884  160 TYPFVRErleagTLSLHGWYYDIETGEL 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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