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Conserved domains on  [gi|496663804|ref|WP_009306297|]
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MULTISPECIES: DNA-deoxyinosine glycosylase [Eggerthella]

Protein Classification

uracil-DNA glycosylase family protein( domain architecture ID 10178247)

uracil-DNA glycosylase family protein; uracil-DNA glycosylase is a DNA repair enzyme that catalyzes the removal of mismatched uracil from DNA to initiate DNA base excision repair pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UDG-F6_HDG cd10032
Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; ...
 8-147 8.35e-65

Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


:

Pssm-ID: 381682  Cd Length: 141  Bit Score: 195.11  E-value: 8.35e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   8 HPLEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEP-EPLGIEGRTAFLYAHGIALWDVLSSCAIVG 86
Cdd:cd10032    1 HGFPPVVDENSRVLILGSFPSVKSLEAQFYYGHPRNRFWRILGALFGEDlKALDYEERKAFLLEHGIALWDVLASCRRKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496663804  87 ASDASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFgAPQLPGLAHTGLPSTSPANA 147
Cdd:cd10032   81 SLDSAIRNVEPNDIAGLLAKAPnIKAIIFNGKKAARLFKKY-VAPLRGIETLRLPSTSPANA 141
 
Name Accession Description Interval E-value
UDG-F6_HDG cd10032
Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; ...
 8-147 8.35e-65

Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381682  Cd Length: 141  Bit Score: 195.11  E-value: 8.35e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   8 HPLEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEP-EPLGIEGRTAFLYAHGIALWDVLSSCAIVG 86
Cdd:cd10032    1 HGFPPVVDENSRVLILGSFPSVKSLEAQFYYGHPRNRFWRILGALFGEDlKALDYEERKAFLLEHGIALWDVLASCRRKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496663804  87 ASDASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFgAPQLPGLAHTGLPSTSPANA 147
Cdd:cd10032   81 SLDSAIRNVEPNDIAGLLAKAPnIKAIIFNGKKAARLFKKY-VAPLRGIETLRLPSTSPANA 141
Mug COG3663
G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];
10-158 2.26e-61

G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 442880  Cd Length: 157  Bit Score: 186.91  E-value: 2.26e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804  10 LEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEPEPLGIEGRTAFLYAHGIALWDVLSSC-AIVGAS 88
Cdd:COG3663    1 LPPVLAPGLRVLILGSNPGLASLAAGFYYAHPRNRFWPILGAAGGTDPRLDYPERKAFLLEHGIGLWDVVARCtRRAGSL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496663804  89 DASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFGAPQLPGLAHT---GLPSTSPANARMRLDDLVKAY 158
Cdd:COG3663   81 DSAIRNAGPNDLAALLRYRPrIKTVAFNGKTAYRLFFKLVAPQPETIGGIelwVLPSPSPANARFSLEEKLAAW 154
hypoxanDNAglyco TIGR04274
hypoxanthine-DNA glycosylase; Members of this protein family represent family 6 of the ...
 10-152 1.18e-42

hypoxanthine-DNA glycosylase; Members of this protein family represent family 6 of the uracil-DNA glycosylase superfamily, where the five previously described families all act as uracil-DNA glycosylase (EC 3.2.2.27) per se. This family, instead, acts as a hypoxanthine-DNA glycosylase, where hypoxanthine results from deamination of adenine. Activity was shown directly for members from Methanosarcina barkeri and Methanosarcina acetivorans.


Pssm-ID: 211997  Cd Length: 150  Bit Score: 139.06  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   10 LEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEPEPLGIEGRTAFLYAHGIALWDVLSSCAIVGASD 89
Cdd:TIGR04274   2 FPPVLPSDPRILILGSLPGNLSLRKQQYYAHPGNQFWRIIESLIGEPHSLNYPTRIELLKRHGIALWDVCAACEREGSLD 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496663804   90 ASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFgAPQLPGLAHTGLPSTSPANARMRLD 152
Cdd:TIGR04274  82 SNIKDEVPNDINELVEMHPtIKLILFNGQKAGKLFKKH-FRDIPGIETIILPSTSPANARLSFE 144
UDG smart00986
Uracil DNA glycosylase superfamily;
17-150 1.52e-10

Uracil DNA glycosylase superfamily;


Pssm-ID: 214956  Cd Length: 156  Bit Score: 56.63  E-value: 1.52e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804    17 DSRVLVLGTMPSPKSREI-GFYYGHPQNRFWKVMGALFDEPEPlgiegrtaFLYAHGIALWDVLSSCAIVGASDASIVDP 95
Cdd:smart00986   7 NAKVLIVGQAPGASEEDRgGPFVGAAGLLLSVMLGVAGLPRLP--------PYLTNIVKCRPPDAGNRRPTSWELQGCLL 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496663804    96 VAnnLSRIAEAAPLEAVFTTGSKATALYRRFGAPQLPGLAHTG-------------LPSTSPANARMR 150
Cdd:smart00986  79 PW--LTVELALARPHLILLLGKFAAQALLGLLRRPLVFGLRGRvaqlkgkghrvlpLPHPSPLNRNFF 144
UDG pfam03167
Uracil DNA glycosylase superfamily;
17-162 8.65e-06

Uracil DNA glycosylase superfamily;


Pssm-ID: 397331  Cd Length: 154  Bit Score: 43.49  E-value: 8.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   17 DSRVLVLGTMPSPKSREIGFYY-GHPQNRFWKVMGAlfdepepLGIEGRTafLYAHGIALWD-VLSSCAIVGASDASIVD 94
Cdd:pfam03167   7 NAKVLIVGEAPGADEDATGLPFvGRAGNLLWKLLNA-------AGLTRDL--FSPQGVYITNvVKCRPGNRRKPTSHEID 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 496663804   95 PVANNLSRIAEAAPLEAVFTTGSKATALYRRFGAP--------QLPGLAHTGLPSTSPANAR-MRLDDLVKAYLSIR 162
Cdd:pfam03167  78 ACWPYLEAEIELLRPRVIVLLGKTAAKALLGLKKItklrgkliDLKGIPVLPTPHPSPLLRNkLNPFLKANAWEDLK 154
PRK10201 PRK10201
G/U mismatch-specific DNA glycosylase;
13-49 7.75e-05

G/U mismatch-specific DNA glycosylase;


Pssm-ID: 182301  Cd Length: 168  Bit Score: 40.88  E-value: 7.75e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 496663804  13 IYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVM 49
Cdd:PRK10201   5 ILAPGLRVVFCGINPGLSSAHTGFPFAHPANRFWKVI 41
 
Name Accession Description Interval E-value
UDG-F6_HDG cd10032
Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; ...
 8-147 8.35e-65

Uracil DNA glycosylase family 6, includes hypoxanthine-DNA glycosylase and similar proteins; Uracil DNA glycosylase family 6 hypoxanthine-DNA glycosylase (HDG) lacks any detectable UDG activity; it excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Uracil-DNA glycosylase (UDGs) initiates repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.


Pssm-ID: 381682  Cd Length: 141  Bit Score: 195.11  E-value: 8.35e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   8 HPLEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEP-EPLGIEGRTAFLYAHGIALWDVLSSCAIVG 86
Cdd:cd10032    1 HGFPPVVDENSRVLILGSFPSVKSLEAQFYYGHPRNRFWRILGALFGEDlKALDYEERKAFLLEHGIALWDVLASCRRKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496663804  87 ASDASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFgAPQLPGLAHTGLPSTSPANA 147
Cdd:cd10032   81 SLDSAIRNVEPNDIAGLLAKAPnIKAIIFNGKKAARLFKKY-VAPLRGIETLRLPSTSPANA 141
Mug COG3663
G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];
10-158 2.26e-61

G:T/U-mismatch repair DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 442880  Cd Length: 157  Bit Score: 186.91  E-value: 2.26e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804  10 LEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEPEPLGIEGRTAFLYAHGIALWDVLSSC-AIVGAS 88
Cdd:COG3663    1 LPPVLAPGLRVLILGSNPGLASLAAGFYYAHPRNRFWPILGAAGGTDPRLDYPERKAFLLEHGIGLWDVVARCtRRAGSL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496663804  89 DASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFGAPQLPGLAHT---GLPSTSPANARMRLDDLVKAY 158
Cdd:COG3663   81 DSAIRNAGPNDLAALLRYRPrIKTVAFNGKTAYRLFFKLVAPQPETIGGIelwVLPSPSPANARFSLEEKLAAW 154
hypoxanDNAglyco TIGR04274
hypoxanthine-DNA glycosylase; Members of this protein family represent family 6 of the ...
 10-152 1.18e-42

hypoxanthine-DNA glycosylase; Members of this protein family represent family 6 of the uracil-DNA glycosylase superfamily, where the five previously described families all act as uracil-DNA glycosylase (EC 3.2.2.27) per se. This family, instead, acts as a hypoxanthine-DNA glycosylase, where hypoxanthine results from deamination of adenine. Activity was shown directly for members from Methanosarcina barkeri and Methanosarcina acetivorans.


Pssm-ID: 211997  Cd Length: 150  Bit Score: 139.06  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   10 LEPIYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVMGALFDEPEPLGIEGRTAFLYAHGIALWDVLSSCAIVGASD 89
Cdd:TIGR04274   2 FPPVLPSDPRILILGSLPGNLSLRKQQYYAHPGNQFWRIIESLIGEPHSLNYPTRIELLKRHGIALWDVCAACEREGSLD 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 496663804   90 ASIVDPVANNLSRIAEAAP-LEAVFTTGSKATALYRRFgAPQLPGLAHTGLPSTSPANARMRLD 152
Cdd:TIGR04274  82 SNIKDEVPNDINELVEMHPtIKLILFNGQKAGKLFKKH-FRDIPGIETIILPSTSPANARLSFE 144
UDG-F2_TDG_MUG cd10028
Uracil DNA glycosylase family 2, includes thymine DNA glycosylase, mismatch-specific uracil ...
 19-158 9.91e-11

Uracil DNA glycosylase family 2, includes thymine DNA glycosylase, mismatch-specific uracil DNA glycosylase and similar proteins; Uracil DNA glycosylase family 2 consists of thymine DNA glycosylase (TDG), which removes uracil and thymine from G:U and G:T mismatches in double-stranded DNA. It includes mismatch-specific uracil DNA glycosylase (MUG), the prokaryotic homolog of TDG. Escherichia coli MUG is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other..


Pssm-ID: 381679  Cd Length: 163  Bit Score: 57.10  E-value: 9.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804  19 RVLVLGTMPSPKSREIGFYYGHPQNRFWKvmgALFDE---PEPLGI-EGRTafLYAHGIALWDVlssCAIVGASDASIVD 94
Cdd:cd10028   10 DVLFCGINPGLRSAAVGHHYAHPGNRFWP---LLHESgltPRLLTPeEDRR--LPEYGIGLTNL---VKRPTASAAELSK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804  95 P-----VANNLSRIAEAAPLEAVFTtgSK--ATALYRRFGAPQLPGL-AHTG--------LPSTSPANARMRLDDLVKAY 158
Cdd:cd10028   82 AelragVPRLLAKIARYRPRVVAFV--GKgaYRAFFGRLKKKAAYGLqPETGiggtrvfvLPSTSGLNAHYSLEDKLEPW 159
UDG smart00986
Uracil DNA glycosylase superfamily;
17-150 1.52e-10

Uracil DNA glycosylase superfamily;


Pssm-ID: 214956  Cd Length: 156  Bit Score: 56.63  E-value: 1.52e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804    17 DSRVLVLGTMPSPKSREI-GFYYGHPQNRFWKVMGALFDEPEPlgiegrtaFLYAHGIALWDVLSSCAIVGASDASIVDP 95
Cdd:smart00986   7 NAKVLIVGQAPGASEEDRgGPFVGAAGLLLSVMLGVAGLPRLP--------PYLTNIVKCRPPDAGNRRPTSWELQGCLL 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496663804    96 VAnnLSRIAEAAPLEAVFTTGSKATALYRRFGAPQLPGLAHTG-------------LPSTSPANARMR 150
Cdd:smart00986  79 PW--LTVELALARPHLILLLGKFAAQALLGLLRRPLVFGLRGRvaqlkgkghrvlpLPHPSPLNRNFF 144
UDG-like cd09593
uracil-DNA glycosylases (UDG) and related enzymes; Uracil-DNA glycosylases (UDGs) initiate ...
 20-147 9.09e-08

uracil-DNA glycosylases (UDG) and related enzymes; Uracil-DNA glycosylases (UDGs) initiate repair of uracils in DNA. Uracil may arise from misincorporation of dUMP residues by DNA polymerase or via deamination of cytosine. Uracil in DNA mispaired with guanine is one of the major pro-mutagenic events, causing G:C->A:T mutations; thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other. UDG family 1 is the most efficient uracil-DNA glycosylase (UDG, also known as UNG) and shows a specificity for uracil in DNA. UDG family 2 includes thymine DNA glycosylase which removes uracil and thymine from G:U and G:T mismatches, and mismatch-specific uracil DNA glycosylase (MUG) which in Escherichia coli is highly specific to G:U mismatches, but also repairs G:T mismatches at high enzyme concentration. UDG family 3 includes Human SMUG1 which can remove uracil and its oxidized pyrimidine derivatives from, single-stranded DNA and double-stranded DNA with a preference for single-stranded DNA. Pedobacter heparinus SMUG2, which is UDG family 3 SMUG1-like, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG family 4 includes Thermotoga maritima TTUDGA, a robust UDG which like family 1, acts on double-stranded and single-stranded uracil-containing DNA. UDG family 5 (UDGb) includes Thermus thermophilus HB8 TTUDGB which acts on double-stranded uracil-containing DNA; it is a hypoxanthine DNA glycosylase acting on double-stranded hypoxanthine-containing DNA except for the C/I base pair, as well as a xanthine DNA glycosylase which acts on both double-stranded and single-stranded xanthine-containing DNA. UDG family 6 hypoxanthine-DNA glycosylase lacks any detectable UDG activity; it excises hypoxanthine. Other UDG families include one represented by Bradyrhizobium diazoefficiens Blr0248 which prefers single-stranded DNA and removes uracil, 5-hydroxymethyl-uracil or xanthine from it.


Pssm-ID: 381677  Cd Length: 125  Bit Score: 48.54  E-value: 9.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804  20 VLVLGTMPSPKS-REIGFYYGHPQNRFWKVMGALFDEPEPlgiegrtaFLYahGIALWDV--LSSCAIVGASDASIVDPV 96
Cdd:cd09593    1 VLIVGQNPGPHGaRAGGVPPGPSGNRLWRLLAAAGGTPRL--------FRY--GVGLTNTvpRGPPGAAAGSEKKELRFC 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 496663804  97 ANNLSRIAEAAPLEAVFTTGSKATALYR--RFGAPQLPGLAHT--GLPSTSPANA 147
Cdd:cd09593   71 GRWLRKLLELLNPRVVVLLGKKAQEAYLavLTSSKGAPGKGTEvlVLPHPSPRNR 125
UDG pfam03167
Uracil DNA glycosylase superfamily;
17-162 8.65e-06

Uracil DNA glycosylase superfamily;


Pssm-ID: 397331  Cd Length: 154  Bit Score: 43.49  E-value: 8.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496663804   17 DSRVLVLGTMPSPKSREIGFYY-GHPQNRFWKVMGAlfdepepLGIEGRTafLYAHGIALWD-VLSSCAIVGASDASIVD 94
Cdd:pfam03167   7 NAKVLIVGEAPGADEDATGLPFvGRAGNLLWKLLNA-------AGLTRDL--FSPQGVYITNvVKCRPGNRRKPTSHEID 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 496663804   95 PVANNLSRIAEAAPLEAVFTTGSKATALYRRFGAP--------QLPGLAHTGLPSTSPANAR-MRLDDLVKAYLSIR 162
Cdd:pfam03167  78 ACWPYLEAEIELLRPRVIVLLGKTAAKALLGLKKItklrgkliDLKGIPVLPTPHPSPLLRNkLNPFLKANAWEDLK 154
PRK10201 PRK10201
G/U mismatch-specific DNA glycosylase;
13-49 7.75e-05

G/U mismatch-specific DNA glycosylase;


Pssm-ID: 182301  Cd Length: 168  Bit Score: 40.88  E-value: 7.75e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 496663804  13 IYAVDSRVLVLGTMPSPKSREIGFYYGHPQNRFWKVM 49
Cdd:PRK10201   5 ILAPGLRVVFCGINPGLSSAHTGFPFAHPANRFWKVI 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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