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Conserved domains on  [gi|496664227|ref|WP_009306720|]
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MULTISPECIES: rRNA adenine dimethyltransferase family protein [Eggerthella]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 18-345 2.28e-90

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 271.61  E-value: 2.28e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  18 EAHGLSTKYSLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPWsD 97
Cdd:COG0030    5 RRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAY-P 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  98 RFALLNKDALDlcsadfqsaepldaaasrgarsrgeaegsrtevrsaFALPTISGTTetladvagpmrllPNKLVANLPY 177
Cdd:COG0030   84 NLTVIEGDALK------------------------------------VDLPALAAGE-------------PLKVVGNLPY 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 178 AVAATVVLDYFEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNR 257
Cdd:COG0030  115 NISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTP 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 258 RPVFddqgvPLDADAIAAACTMAEAAFATRRKTLSNSCKTYFAGrgpqgaaviARLPQLFERAGIDPRLRGETLDLPEFV 337
Cdd:COG0030  195 RPEP-----LVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSK---------ERLEEALEAAGIDPTARAEELSVEEFA 260


                 ....*...
gi 496664227 338 RLGCAFQQ 345
Cdd:COG0030  261 RLANALKK 268
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 18-345 2.28e-90

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 271.61  E-value: 2.28e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  18 EAHGLSTKYSLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPWsD 97
Cdd:COG0030    5 RRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAY-P 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  98 RFALLNKDALDlcsadfqsaepldaaasrgarsrgeaegsrtevrsaFALPTISGTTetladvagpmrllPNKLVANLPY 177
Cdd:COG0030   84 NLTVIEGDALK------------------------------------VDLPALAAGE-------------PLKVVGNLPY 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 178 AVAATVVLDYFEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNR 257
Cdd:COG0030  115 NISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTP 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 258 RPVFddqgvPLDADAIAAACTMAEAAFATRRKTLSNSCKTYFAGrgpqgaaviARLPQLFERAGIDPRLRGETLDLPEFV 337
Cdd:COG0030  195 RPEP-----LVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSK---------ERLEEALEAAGIDPTARAEELSVEEFA 260


                 ....*...
gi 496664227 338 RLGCAFQQ 345
Cdd:COG0030  261 RLANALKK 268
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 27-339 1.73e-64

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 204.77  E-value: 1.73e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227   27 SLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLaPWSDRFALLNKDA 106
Cdd:TIGR00755   6 SLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLL-SLYNNLEIIEGDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  107 LDLcsaDFQSAEPLdaaasrgarsrgeaegsrtevrsafalptisgttetladvagpmrllPNKLVANLPYAVAATVVLD 186
Cdd:TIGR00755  85 LKF---DLNELAKD-----------------------------------------------LTKVVGNLPYNISSPLIFK 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  187 YFEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRPVFddqgv 266
Cdd:TIGR00755 115 LLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRK----- 189

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496664227  267 PLDADaIAAACTMAEAAFATRRKTLSNSCKTYFagrgpqgaaviARLPQLFERAGIDPRLRGETLDLPEFVRL 339
Cdd:TIGR00755 190 PSPKD-FALFEELLKAAFQQRRKTLRNNLKNLL-----------SELVELLEELGIDPDKRVEQLSPEDFLRL 250
rADc smart00650
Ribosomal RNA adenine dimethylases;
38-259 3.17e-49

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 162.68  E-value: 3.17e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227    38 ILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLApWSDRFALLNKDALDlcsadfqsa 117
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFA-AADNLTVIHGDALK--------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227   118 epldaaasrgarsrgeaegsrtevrsaFALPtisgttetladvagpmRLLPNKLVANLPYAVAATVVLDYFEQFASLESA 197
Cdd:smart00650  71 ---------------------------FDLP----------------KLQPYKVVGNLPYNISTPILFKLLEEPPAFRDA 107

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496664227   198 TVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRP 259
Cdd:smart00650 108 VLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKVDSAVVRLERRP 169
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
27-294 9.50e-46

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 156.60  E-value: 9.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  27 SLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPWsDRFALLNKDA 106
Cdd:PRK14896   6 KLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAA-GNVEIIEGDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 107 LDLcsadfqsaePLDAAasrgarsrgeaegsrtevrsafalptisgttetladvagpmrllpNKLVANLPYAVAATV--- 183
Cdd:PRK14896  85 LKV---------DLPEF---------------------------------------------NKVVSNLPYQISSPItfk 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 184 VLDYfeQFaslESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRP---- 259
Cdd:PRK14896 111 LLKH--GF---EPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREpkye 185

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 496664227 260 VFDDQGVPLDADAIaaactmaeaaFATRRKTLSNS 294
Cdd:PRK14896 186 VYDEDFFDDFVKAL----------FQHRRKTLRNA 210
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
21-302 1.38e-34

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 127.48  E-value: 1.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227   21 GLSTKYSLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPwSDRFA 100
Cdd:pfam00398   1 GNKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSL-DENLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  101 LLNKDALdlcsadfqsaepldaaasrgarsrgeaegsrtevrsafalptisgTTETLADVAGPMRllPNKLVANLPYAVA 180
Cdd:pfam00398  80 VIHQDFL---------------------------------------------KFEFPSLVTHIHQ--EFLVVGNLPYNIS 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  181 ATVVLDY-FEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRP 259
Cdd:pfam00398 113 TPIVKQLlFESRFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLERHD 192

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 496664227  260 VFddqgvPLDADAIAAACTMAEAAFATRRKTLSNSCKTYFAGR 302
Cdd:pfam00398 193 PD-----PHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGG 230
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 18-345 2.28e-90

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 271.61  E-value: 2.28e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  18 EAHGLSTKYSLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPWsD 97
Cdd:COG0030    5 RRYGLRPKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAY-P 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  98 RFALLNKDALDlcsadfqsaepldaaasrgarsrgeaegsrtevrsaFALPTISGTTetladvagpmrllPNKLVANLPY 177
Cdd:COG0030   84 NLTVIEGDALK------------------------------------VDLPALAAGE-------------PLKVVGNLPY 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 178 AVAATVVLDYFEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNR 257
Cdd:COG0030  115 NISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTP 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 258 RPVFddqgvPLDADAIAAACTMAEAAFATRRKTLSNSCKTYFAGrgpqgaaviARLPQLFERAGIDPRLRGETLDLPEFV 337
Cdd:COG0030  195 RPEP-----LVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSK---------ERLEEALEAAGIDPTARAEELSVEEFA 260


                 ....*...
gi 496664227 338 RLGCAFQQ 345
Cdd:COG0030  261 RLANALKK 268
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 27-339 1.73e-64

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 204.77  E-value: 1.73e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227   27 SLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLaPWSDRFALLNKDA 106
Cdd:TIGR00755   6 SLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLL-SLYNNLEIIEGDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  107 LDLcsaDFQSAEPLdaaasrgarsrgeaegsrtevrsafalptisgttetladvagpmrllPNKLVANLPYAVAATVVLD 186
Cdd:TIGR00755  85 LKF---DLNELAKD-----------------------------------------------LTKVVGNLPYNISSPLIFK 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  187 YFEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRPVFddqgv 266
Cdd:TIGR00755 115 LLKEKDAFKLAVLMVQKEVAERLVAKPGSKDYGRLSVLVQYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRK----- 189

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496664227  267 PLDADaIAAACTMAEAAFATRRKTLSNSCKTYFagrgpqgaaviARLPQLFERAGIDPRLRGETLDLPEFVRL 339
Cdd:TIGR00755 190 PSPKD-FALFEELLKAAFQQRRKTLRNNLKNLL-----------SELVELLEELGIDPDKRVEQLSPEDFLRL 250
rADc smart00650
Ribosomal RNA adenine dimethylases;
38-259 3.17e-49

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 162.68  E-value: 3.17e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227    38 ILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLApWSDRFALLNKDALDlcsadfqsa 117
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFA-AADNLTVIHGDALK--------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227   118 epldaaasrgarsrgeaegsrtevrsaFALPtisgttetladvagpmRLLPNKLVANLPYAVAATVVLDYFEQFASLESA 197
Cdd:smart00650  71 ---------------------------FDLP----------------KLQPYKVVGNLPYNISTPILFKLLEEPPAFRDA 107

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 496664227   198 TVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRP 259
Cdd:smart00650 108 VLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKVDSAVVRLERRP 169
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
27-294 9.50e-46

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 156.60  E-value: 9.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  27 SLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPWsDRFALLNKDA 106
Cdd:PRK14896   6 KLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAA-GNVEIIEGDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 107 LDLcsadfqsaePLDAAasrgarsrgeaegsrtevrsafalptisgttetladvagpmrllpNKLVANLPYAVAATV--- 183
Cdd:PRK14896  85 LKV---------DLPEF---------------------------------------------NKVVSNLPYQISSPItfk 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 184 VLDYfeQFaslESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRP---- 259
Cdd:PRK14896 111 LLKH--GF---EPAVLMYQKEFAERMVAKPGTKEYGRLSVMVQYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREpkye 185

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 496664227 260 VFDDQGVPLDADAIaaactmaeaaFATRRKTLSNS 294
Cdd:PRK14896 186 VYDEDFFDDFVKAL----------FQHRRKTLRNA 210
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
21-302 1.38e-34

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 127.48  E-value: 1.38e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227   21 GLSTKYSLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPwSDRFA 100
Cdd:pfam00398   1 GNKFRTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSL-DENLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  101 LLNKDALdlcsadfqsaepldaaasrgarsrgeaegsrtevrsafalptisgTTETLADVAGPMRllPNKLVANLPYAVA 180
Cdd:pfam00398  80 VIHQDFL---------------------------------------------KFEFPSLVTHIHQ--EFLVVGNLPYNIS 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  181 ATVVLDY-FEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRLNRRP 259
Cdd:pfam00398 113 TPIVKQLlFESRFGIVDMLLMLQKEFARRLLARPGSKLYSRLSVLRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLERHD 192

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 496664227  260 VFddqgvPLDADAIAAACTMAEAAFATRRKTLSNSCKTYFAGR 302
Cdd:pfam00398 193 PD-----PHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGG 230
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 27-262 9.07e-30

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 115.49  E-value: 9.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  27 SLGQNFLINDAILQKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLpavlvetlapwsdrFALLNKda 106
Cdd:PTZ00338  13 KFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRM--------------VAELKK-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 107 ldlcsadfqsaepldaaasrgaRSRGEAEGSRTEVRSAFALPTIsgttetladvagpmrlLP--NKLVANLPYAVAATVV 184
Cdd:PTZ00338  77 ----------------------RFQNSPLASKLEVIEGDALKTE----------------FPyfDVCVANVPYQISSPLV 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227 185 LDYFEQFASLESATVMVQKEVADRMAASPGTKNYGAYTVKLRLYAEPAGRFAVGPGNFFPPPRVESAVLRL---NRRPVF 261
Cdd:PTZ00338 119 FKLLAHRPLFRCAVLMFQKEFALRLLAQPGDELYCRLSVNTQLLCRVTHLMKVSKNSFNPPPKVESSVVRIepkNPPPDV 198


                 .
gi 496664227 262 D 262
Cdd:PTZ00338 199 D 199
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 42-83 2.95e-07

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 50.93  E-value: 2.95e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 496664227  42 IVALADLAPDDYVLEVGPGIGTLTIALL---KSAGRVLSVERDPD 83
Cdd:COG2519   83 IIARLDIFPGARVLEAGTGSGALTLALAravGPEGKVYSYERRED 127
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
35-109 7.67e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 46.57  E-value: 7.67e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496664227  35 NDAILQKIVALAdlAPDDYVLEVGPGIGTLT-IALLKSAGRVLSVERDPDLPAVLVETLA--PWSDRFALLNKDALDL 109
Cdd:COG4076   22 NDAFKAAIERVV--KPGDVVLDIGTGSGLLSmLAARAGAKKVYAVEVNPDIAAVARRIIAanGLSDRITVINADATDL 97
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 40-128 7.54e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 7.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  40 QKIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDLPAVLVETLAPWSDRFALLNKDALDLCSADfqsaEP 119
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPFPD----GS 87


                 ....*....
gi 496664227 120 LDAAASRGA 128
Cdd:COG2226   88 FDLVISSFV 96
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 38-84 1.02e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 42.77  E-value: 1.02e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 496664227  38 ILQ-KIVA----LADLAPDDYVLEVGPGIGTLTiALL-KSAGRVLSVERDPDL 84
Cdd:COG2518   49 ISQpYIVArmleALDLKPGDRVLEIGTGSGYQA-AVLaRLAGRVYSVERDPEL 100
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
40-109 1.55e-04

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 42.12  E-value: 1.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 496664227  40 QKIVALADLAPDDYVLEVGPGIGTLTIALLK---SAGRVLSVERDPDLPAVLVETLapwsDRFALLNKDALDL 109
Cdd:COG3963   35 RAMASEVDWSGAGPVVELGPGTGVFTRAILArgvPDARLLAVEINPEFAEHLRRRF----PRVTVVNGDAEDL 103
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 54-109 2.02e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 38.63  E-value: 2.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 496664227  54 VLEVGPGIGTLTIAL---LKSAGRVLSVERDPDLPAVLVETL--APWSDRFALLNKDALDL 109
Cdd:COG4122   20 ILEIGTGTGYSTLWLaraLPDDGRLTTIEIDPERAAIARENFarAGLADRIRLILGDALEV 80
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 36-109 3.94e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.20  E-value: 3.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496664227  36 DAILqkIVALADLAPDDYVLEVGPGIGTLTIALLK--SAGRVLSVERDPDLPAVLVETLA--PWSDRFALLNKDALDL 109
Cdd:COG4123   25 DAVL--LAAFAPVKKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEAAELARRNVAlnGLEDRITVIHGDLKEF 100
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
36-109 4.29e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 38.35  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664227  36 DAiLQKiVALADLAPDDYVLEVGPGIGTLTIALLK-SAGRVLSVERDPDlpAVLVETLAPWS-----DRFALLNKDALDL 109
Cdd:COG2521  120 DA-RRK-VKLVGVRRGDRVLDTCTGLGYTAIEALKrGAREVITVEKDPN--VLELAELNPWSrelanERIKIILGDASEV 195
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
41-84 5.07e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 37.88  E-value: 5.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 496664227  41 KIVALADLAPDDYVLEVGPGIGTLTIALLKSAGRVLSVERDPDL 84
Cdd:PRK00312  69 RMTELLELKPGDRVLEIGTGSGYQAAVLAHLVRRVFSVERIKTL 112
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 54-128 7.76e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 35.23  E-value: 7.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496664227   54 VLEVGPGIGTLTIALLKSAG-RVLSVERDPDLPAVLVETLAPWSDRFALLNKDALDLCSADfqsaEPLDAAASRGA 128
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGaRVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPD----GSFDLVVSSGV 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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