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Conserved domains on  [gi|496664275|ref|WP_009306768|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Eggerthella]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442335)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-97 6.41e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 54.90  E-value: 6.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664275   9 QQVKDRLLAALIDFAGRKDWSKVTVTELVEQAGVARASFYRNFSSVEDLVDYGIRQVTQRYHEGMPTTDGNPRSRERIEY 88
Cdd:COG1309    5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRA 84


                 ....*....
gi 496664275  89 QFRFYQEHA 97
Cdd:COG1309   85 LLRAYLEFL 93
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 139-173 1.53e-08

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


:

Pssm-ID: 464123  Cd Length: 103  Bit Score: 49.93  E-value: 1.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 496664275  139 FYAGAFYNVLICWLESGMKESPAAMADEFARMLHG 173
Cdd:pfam14278  69 FYSYGFVGLILDWLENGMKESPEEIAELLSRLING 103
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-97 6.41e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 54.90  E-value: 6.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664275   9 QQVKDRLLAALIDFAGRKDWSKVTVTELVEQAGVARASFYRNFSSVEDLVDYGIRQVTQRYHEGMPTTDGNPRSRERIEY 88
Cdd:COG1309    5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRA 84


                 ....*....
gi 496664275  89 QFRFYQEHA 97
Cdd:COG1309   85 LLRAYLEFL 93
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 139-173 1.53e-08

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 49.93  E-value: 1.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 496664275  139 FYAGAFYNVLICWLESGMKESPAAMADEFARMLHG 173
Cdd:pfam14278  69 FYSYGFVGLILDWLENGMKESPEEIAELLSRLING 103
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
15-59 2.30e-05

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 40.08  E-value: 2.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 496664275   15 LLAALIDFAGRKDWSKVTVTELVEQAGVARASFYRNFSSVEDLVD 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-97 6.41e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 54.90  E-value: 6.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496664275   9 QQVKDRLLAALIDFAGRKDWSKVTVTELVEQAGVARASFYRNFSSVEDLVDYGIRQVTQRYHEGMPTTDGNPRSRERIEY 88
Cdd:COG1309    5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRA 84


                 ....*....
gi 496664275  89 QFRFYQEHA 97
Cdd:COG1309   85 LLRAYLEFL 93
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 139-173 1.53e-08

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 49.93  E-value: 1.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 496664275  139 FYAGAFYNVLICWLESGMKESPAAMADEFARMLHG 173
Cdd:pfam14278  69 FYSYGFVGLILDWLENGMKESPEEIAELLSRLING 103
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
15-59 2.30e-05

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 40.08  E-value: 2.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 496664275   15 LLAALIDFAGRKDWSKVTVTELVEQAGVARASFYRNFSSVEDLVD 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
DUF6262 pfam19776
Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, ...
 30-50 2.54e-03

Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, is found in bacteria. Proteins in this family are typically between 124 and 143 amino acids in length. Some members included in this family are hypothetical transposases, associated with transposon Tn554. There is a conserved sequence GV/LSR/K and a highly conserved tyrosine residue.


Pssm-ID: 466180 [Multi-domain]  Cd Length: 110  Bit Score: 36.06  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|.
gi 496664275   30 KVTVTELVEQAGVARASFYRN 50
Cdd:pfam19776  33 KITVPELVKRTGLSRGFFYKN 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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