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Conserved domains on  [gi|497293784|ref|WP_009608001|]
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MULTISPECIES: carbonic anhydrase [Eggerthella]

Protein Classification

beta-class carbonic anhydrase( domain architecture ID 10130171)

beta-class carbonic anhydrase similar to carbonic anhydrase (CA) that catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton, and to carbon disulfide hydrolase that catalyzes the conversion of carbon disulfide into hydrogen sulfide and carbon dioxide, with carbonyl sulfide as an intermediate

Gene Ontology:  GO:0004089|GO:0008270

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-189 1.71e-46

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


:

Pssm-ID: 239474  Cd Length: 142  Bit Score: 149.32  E-value: 1.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  37 PDKKLAIVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHpfgSVMRSLLIAVCELGVEDIMIVAHTNCGAQHMSGKE 116
Cdd:cd03379    1 PARKLAIVTCMDARLDPEKALGL--KLGDAKVIRNAGGRVTD---DAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497293784 117 MVANMERLGVSAeriefaRHCGIDFDKWLAGFGDTEEAVRKSVDMVANHPVMPPHVRVIGFIMDSDTGKLSVV 189
Cdd:cd03379   76 LKEKMKERGIAE------AYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
 
Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-189 1.71e-46

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 149.32  E-value: 1.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  37 PDKKLAIVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHpfgSVMRSLLIAVCELGVEDIMIVAHTNCGAQHMSGKE 116
Cdd:cd03379    1 PARKLAIVTCMDARLDPEKALGL--KLGDAKVIRNAGGRVTD---DAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497293784 117 MVANMERLGVSAeriefaRHCGIDFDKWLAGFGDTEEAVRKSVDMVANHPVMPPHVRVIGFIMDSDTGKLSVV 189
Cdd:cd03379   76 LKEKMKERGIAE------AYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 35-189 3.77e-31

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 110.67  E-value: 3.77e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784    35 KYPDKKLAIVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHPFGSVMRSLLIAVCELGVEDIMIVAHTNCGAQHMSG 114
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGL--GPGDLFVIRNAGNIVPPYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAAL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497293784   115 KEM---VANMERLGVSAERIEfARHCGIDFDKWLAGFGDTEEAVRKSVDmVANHPVMpPHVRVIGFIMDSDTGKLSVV 189
Cdd:smart00947  80 DDEpglIDNWLERIRPARERA-LEELGDVDALEELNVRDQVENLRTSPA-IREAVAK-GKLKVHGWVYDIETGKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 43-186 1.03e-16

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 73.31  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784   43 IVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHPFGSVMRSLLIAVCELGVEDIMIVAHTNCGA-----QHMSGKEM 117
Cdd:pfam00484   3 IIGCSDSRVPPELIFDT--GPGDLFVVRNAGNLVPPYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAvkaalDAAGPAEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497293784  118 VAN----MERLGVSAERIEFARHCGIDFDKWLAGFgdTEEAVRKSVDMVANHPVMPP-----HVRVIGFIMDSDTGKL 186
Cdd:pfam00484  81 PGFidnwLRHIRPAVERVAEELESLDDPEERDDAL--EELNVREQVENLRTFPIVREavakgKLKIHGWVYDLETGEV 156
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
12-189 2.16e-10

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 57.48  E-value: 2.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  12 IDGILAHNRAFVERR------DFERYTTDKYPdkKLAIVSCMDTRLTAlllaalglkN-------GDAKIIKVAGAEVAH 78
Cdd:COG0288    4 LKRLLEGNRRFVAGKfpqdpeRFEELAKGQHP--FALVIGCSDSRVPP---------ElifdqgpGDLFVVRNAGNVVPP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  79 PFGSVMRSLLIAVCELGVEDIMIVAHTNCGA-----QHMSGKEM--VAN-MERLGVSAERIEfARHCGIDFDKWLAGFgd 150
Cdd:COG0288   73 YDPGVLASIEYAVEVLGVKLIVVLGHSGCGAvkaalDGLELEELglIGNwLRHIRPAVERVR-AELPAADGEERLDRL-- 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 497293784 151 TEEAVRKSVDMVANHPVMPPHV-----RVIGFIMDSDTGKLSVV 189
Cdd:COG0288  150 VELNVREQVENLRTSPIVREAVaagklKVHGWVYDLATGRVEFL 193
 
Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-189 1.71e-46

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 149.32  E-value: 1.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  37 PDKKLAIVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHpfgSVMRSLLIAVCELGVEDIMIVAHTNCGAQHMSGKE 116
Cdd:cd03379    1 PARKLAIVTCMDARLDPEKALGL--KLGDAKVIRNAGGRVTD---DAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497293784 117 MVANMERLGVSAeriefaRHCGIDFDKWLAGFGDTEEAVRKSVDMVANHPVMPPHVRVIGFIMDSDTGKLSVV 189
Cdd:cd03379   76 LKEKMKERGIAE------AYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 35-189 3.77e-31

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 110.67  E-value: 3.77e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784    35 KYPDKKLAIVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHPFGSVMRSLLIAVCELGVEDIMIVAHTNCGAQHMSG 114
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGL--GPGDLFVIRNAGNIVPPYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAAL 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497293784   115 KEM---VANMERLGVSAERIEfARHCGIDFDKWLAGFGDTEEAVRKSVDmVANHPVMpPHVRVIGFIMDSDTGKLSVV 189
Cdd:smart00947  80 DDEpglIDNWLERIRPARERA-LEELGDVDALEELNVRDQVENLRTSPA-IREAVAK-GKLKVHGWVYDIETGKLEVL 154
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-189 1.22e-21

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 84.86  E-value: 1.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  37 PDKKLAIVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHPFGSVMRSLLIAVCELGVEDIMIVAHTNCGAqhmsgke 116
Cdd:cd00382    1 QKPKALIIGCSDSRVPPELIFGL--GPGDLFVVRNAGNLVPPYDLDVLASLEYAVEVLGVKHIIVCGHTDCGA------- 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497293784 117 mvanmerlgVSAeriefarhcgidfdkwlagfgDTEEAVRKSVDMVANHPVM-----PPHVRVIGFIMDSDTGKLSVV 189
Cdd:cd00382   72 ---------VKA---------------------LVEENVREQVENLRSHPLIqeavaPGELKVHGWVYDIETGKLEVL 119
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 43-186 1.03e-16

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 73.31  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784   43 IVSCMDTRLTALLLAALglKNGDAKIIKVAGAEVAHPFGSVMRSLLIAVCELGVEDIMIVAHTNCGA-----QHMSGKEM 117
Cdd:pfam00484   3 IIGCSDSRVPPELIFDT--GPGDLFVVRNAGNLVPPYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAvkaalDAAGPAEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497293784  118 VAN----MERLGVSAERIEFARHCGIDFDKWLAGFgdTEEAVRKSVDMVANHPVMPP-----HVRVIGFIMDSDTGKL 186
Cdd:pfam00484  81 PGFidnwLRHIRPAVERVAEELESLDDPEERDDAL--EELNVREQVENLRTFPIVREavakgKLKIHGWVYDLETGEV 156
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
12-189 2.16e-10

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 57.48  E-value: 2.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  12 IDGILAHNRAFVERR------DFERYTTDKYPdkKLAIVSCMDTRLTAlllaalglkN-------GDAKIIKVAGAEVAH 78
Cdd:COG0288    4 LKRLLEGNRRFVAGKfpqdpeRFEELAKGQHP--FALVIGCSDSRVPP---------ElifdqgpGDLFVVRNAGNVVPP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497293784  79 PFGSVMRSLLIAVCELGVEDIMIVAHTNCGA-----QHMSGKEM--VAN-MERLGVSAERIEfARHCGIDFDKWLAGFgd 150
Cdd:COG0288   73 YDPGVLASIEYAVEVLGVKLIVVLGHSGCGAvkaalDGLELEELglIGNwLRHIRPAVERVR-AELPAADGEERLDRL-- 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 497293784 151 TEEAVRKSVDMVANHPVMPPHV-----RVIGFIMDSDTGKLSVV 189
Cdd:COG0288  150 VELNVREQVENLRTSPIVREAVaagklKVHGWVYDLATGRVEFL 193
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 42-109 5.59e-03

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 35.96  E-value: 5.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497293784  42 AIVSCMDTRLTALLLAALGLknGDAKIIKVAGaEVAHPfgSVMRSLLIAVCELGVEDIMIVAHTNCGA 109
Cdd:cd03378   42 VILSCSDSRVPPEIIFDQGL--GDLFVVRVAG-NIVDD--DVLGSLEYAVEVLGVPLVVVLGHESCGA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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