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Conserved domains on  [gi|497336312|ref|WP_009650525|]
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MULTISPECIES: ferredoxin-type protein NapG [Campylobacter]

Protein Classification

ferredoxin-type protein NapG( domain architecture ID 11484276)

ferredoxin-type protein NapG is required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
 1-255 1.49e-150

quinol dehydrogenase periplasmic component; Provisional


:

Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 419.80  E-value: 1.49e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312   1 MQNLDLKNRREVLKFGLKALALAAGGGFVWRQATQAAPL--VLLRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLG 78
Cdd:PRK09476   3 RSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQQQARAsgVALRPPGALNENDFLSACIRCGLCVQACPYDTLKLATLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  79 DGISAGTPFFRPREIPCYMCEDIPCVPVCPTGALDVNLVstdgklDIEKAKMGVAV-VDMKNCVAYWGIQCDACYRACPL 157
Cdd:PRK09476  83 SGLSAGTPYFVARDIPCEMCEDIPCVKACPSGALDRELV------DIDDARMGLAVlVDQENCLNFQGLRCDVCYRVCPL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 158 LDKALYLEYKRNERTQKHAFLLPIVDSDVCTGCGVCERACITQKPAIVVLNREVALGAVGDNYVKGWVKEDERRVDEADS 237
Cdd:PRK09476 157 IDKAITLELERNERTGKHAFFLPTVHSDACTGCGKCEKACVLEKAAIKVLPRSLAKGKLGHHYRKGWLEKDEGRSSNAGE 236

                        250
                 ....*....|....*...
gi 497336312 238 TIKLDSKKATDYLNGGEL 255
Cdd:PRK09476 237 IKKLDTKKAEDYLNSGEL 254
 
Name Accession Description Interval E-value
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
 1-255 1.49e-150

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 419.80  E-value: 1.49e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312   1 MQNLDLKNRREVLKFGLKALALAAGGGFVWRQATQAAPL--VLLRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLG 78
Cdd:PRK09476   3 RSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQQQARAsgVALRPPGALNENDFLSACIRCGLCVQACPYDTLKLATLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  79 DGISAGTPFFRPREIPCYMCEDIPCVPVCPTGALDVNLVstdgklDIEKAKMGVAV-VDMKNCVAYWGIQCDACYRACPL 157
Cdd:PRK09476  83 SGLSAGTPYFVARDIPCEMCEDIPCVKACPSGALDRELV------DIDDARMGLAVlVDQENCLNFQGLRCDVCYRVCPL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 158 LDKALYLEYKRNERTQKHAFLLPIVDSDVCTGCGVCERACITQKPAIVVLNREVALGAVGDNYVKGWVKEDERRVDEADS 237
Cdd:PRK09476 157 IDKAITLELERNERTGKHAFFLPTVHSDACTGCGKCEKACVLEKAAIKVLPRSLAKGKLGHHYRKGWLEKDEGRSSNAGE 236

                        250
                 ....*....|....*...
gi 497336312 238 TIKLDSKKATDYLNGGEL 255
Cdd:PRK09476 237 IKKLDTKKAEDYLNSGEL 254
mauM_napG TIGR00397
MauM/NapG family ferredoxin-type protein; MauM is involved in methylamine utilization. NapG is ...
 9-221 7.07e-64

MauM/NapG family ferredoxin-type protein; MauM is involved in methylamine utilization. NapG is associated with nitrate reductase activity. The two proteins are highly similar. [Energy metabolism, Electron transport]


Pssm-ID: 129492 [Multi-domain]  Cd Length: 213  Bit Score: 198.60  E-value: 7.07e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312    9 RREVLKFGLKALALAAGGGFVWRQATQAAPLV---LLRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLGDGISAGT 85
Cdd:TIGR00397   4 RRDAFADAARAVGVACVGGFFGAALLRSRPAVaarVLRPPGALPEQDFLAACVRCGLCVEACPYDILSLASWSDPAPLGT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312   86 PFFRPREIPCYMCEDIPCVPVCPTGALDVNLVstdgklDIEKAKMGVAV-VDMKNCVAYWGIQCDACYRACPLLDKALYL 164
Cdd:TIGR00397  84 PFFTPREVPCRMCKDIPCARACPTGALDPLLT------DIRKADMGVAVlVGHETCLNYKGLNCSICVRVCPIRGEAISL 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497336312  165 EYKRNERTQkhaFLLPIVDSDVCTGCGVCERACITQKPAIVVLNREVALGAVGDNYV 221
Cdd:TIGR00397 158 KPIENERGR---LQIPTVDSAKCTGCGTCEKHCVLSEAAIRVLPRELGLGVPGANSA 211
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 42-206 4.73e-57

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 178.99  E-value: 4.73e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  42 LRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLGDGISAG-TPFFRPREIPCYMCEDIpCVPVCPTGALDvnlvstD 120
Cdd:cd16373    1 LRPPGALDEEEFLALCIRCGLCVEACPTGVIQPAGLEDGLEGGrTPYLDPREGPCDLCCDA-CVEVCPTGALR------P 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 121 GKLDIEKAKMGVAVVDMKNCVAYWG-IQCDACYRACPLLDKALYLEykrnertqkHAFLLPIVDSDVCTGCGVCERACIT 199
Cdd:cd16373   74 LDLEEQKVKMGVAVIDKDRCLAWQGgTDCGVCVEACPTEAIAIVLE---------DDVLRPVVDEDKCVGCGLCEYVCPV 144


                 ....*...
gi 497336312 200 QKP-AIVV 206
Cdd:cd16373  145 EPPkAIVV 152
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 57-156 5.36e-07

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 48.40  E-value: 5.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQAC------PFD-TLSLAKLGDGISAGTPFFRPREIPCYMCEDIPCVPVCPTGAldvnlvstdgkldIEKAK 129
Cdd:COG0437   15 CIGCRACVVACkeennlPVGvTWRRVRRYEEGEFPNVEWLFVPVLCNHCDDPPCVKVCPTGA-------------TYKRE 81

                         90       100
                 ....*....|....*....|....*..
gi 497336312 130 MGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:COG0437   82 DGIVLVDYDKCIG-----CRYCVAACP 103
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 57-111 3.05e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 43.28  E-value: 3.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 497336312   57 CIRCGLCVQACPFDTLSLAKLGDGISAGTPFFRPREipCYMCEDipCVPVCPTGA 111
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTVVIDPER--CVGCGA--CVAVCPTGA 51
 
Name Accession Description Interval E-value
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
 1-255 1.49e-150

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 419.80  E-value: 1.49e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312   1 MQNLDLKNRREVLKFGLKALALAAGGGFVWRQATQAAPL--VLLRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLG 78
Cdd:PRK09476   3 RSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQQQARAsgVALRPPGALNENDFLSACIRCGLCVQACPYDTLKLATLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  79 DGISAGTPFFRPREIPCYMCEDIPCVPVCPTGALDVNLVstdgklDIEKAKMGVAV-VDMKNCVAYWGIQCDACYRACPL 157
Cdd:PRK09476  83 SGLSAGTPYFVARDIPCEMCEDIPCVKACPSGALDRELV------DIDDARMGLAVlVDQENCLNFQGLRCDVCYRVCPL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 158 LDKALYLEYKRNERTQKHAFLLPIVDSDVCTGCGVCERACITQKPAIVVLNREVALGAVGDNYVKGWVKEDERRVDEADS 237
Cdd:PRK09476 157 IDKAITLELERNERTGKHAFFLPTVHSDACTGCGKCEKACVLEKAAIKVLPRSLAKGKLGHHYRKGWLEKDEGRSSNAGE 236

                        250
                 ....*....|....*...
gi 497336312 238 TIKLDSKKATDYLNGGEL 255
Cdd:PRK09476 237 IKKLDTKKAEDYLNSGEL 254
mauM_napG TIGR00397
MauM/NapG family ferredoxin-type protein; MauM is involved in methylamine utilization. NapG is ...
 9-221 7.07e-64

MauM/NapG family ferredoxin-type protein; MauM is involved in methylamine utilization. NapG is associated with nitrate reductase activity. The two proteins are highly similar. [Energy metabolism, Electron transport]


Pssm-ID: 129492 [Multi-domain]  Cd Length: 213  Bit Score: 198.60  E-value: 7.07e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312    9 RREVLKFGLKALALAAGGGFVWRQATQAAPLV---LLRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLGDGISAGT 85
Cdd:TIGR00397   4 RRDAFADAARAVGVACVGGFFGAALLRSRPAVaarVLRPPGALPEQDFLAACVRCGLCVEACPYDILSLASWSDPAPLGT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312   86 PFFRPREIPCYMCEDIPCVPVCPTGALDVNLVstdgklDIEKAKMGVAV-VDMKNCVAYWGIQCDACYRACPLLDKALYL 164
Cdd:TIGR00397  84 PFFTPREVPCRMCKDIPCARACPTGALDPLLT------DIRKADMGVAVlVGHETCLNYKGLNCSICVRVCPIRGEAISL 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497336312  165 EYKRNERTQkhaFLLPIVDSDVCTGCGVCERACITQKPAIVVLNREVALGAVGDNYV 221
Cdd:TIGR00397 158 KPIENERGR---LQIPTVDSAKCTGCGTCEKHCVLSEAAIRVLPRELGLGVPGANSA 211
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 42-206 4.73e-57

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 178.99  E-value: 4.73e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  42 LRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAKLGDGISAG-TPFFRPREIPCYMCEDIpCVPVCPTGALDvnlvstD 120
Cdd:cd16373    1 LRPPGALDEEEFLALCIRCGLCVEACPTGVIQPAGLEDGLEGGrTPYLDPREGPCDLCCDA-CVEVCPTGALR------P 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 121 GKLDIEKAKMGVAVVDMKNCVAYWG-IQCDACYRACPLLDKALYLEykrnertqkHAFLLPIVDSDVCTGCGVCERACIT 199
Cdd:cd16373   74 LDLEEQKVKMGVAVIDKDRCLAWQGgTDCGVCVEACPTEAIAIVLE---------DDVLRPVVDEDKCVGCGLCEYVCPV 144


                 ....*...
gi 497336312 200 QKP-AIVV 206
Cdd:cd16373  145 EPPkAIVV 152
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 43-197 1.75e-17

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 76.51  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  43 RPPAAKPEKEFIASCIRCGLCVQACPFDTLslaKLGDGisaGTPFFRPREIPCYMCEDipCVPVCPTGALDvnlvstdgk 122
Cdd:cd10564    1 RPPWAVDEALFLDLCTRCGDCVEACPEGII---VRGDG---GFPELDFSRGECTFCGA--CAEACPEGALD--------- 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497336312 123 LDIEKAKMGVAVVDMkNCVAYWGIQCDACYRACPllDKALYLeykrneRTQKHAFLLPIVDSDVCTGCGVCERAC 197
Cdd:cd10564   64 PAREAPWPLRAEIGD-SCLALQGVECRSCQDACP--TQAIRF------RPRLGGIALPELDADACTGCGACVSVC 129
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 57-197 9.31e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 66.27  E-value: 9.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlGDGISAGTPFFRPREIPCYMCEDipcvpVCPTGALDVnlvstDGKLDIEKAKMGVAVVD 136
Cdd:cd10549    8 CIGCGICVKACPTDAIELGP-NGAIARGPEIDEDKCVFCGACVE-----VCPTGAIEL-----TPEGKEYVPKEKEAEID 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497336312 137 MKNCvaywgIQCDACYRACPLldKALYLEykrnertqkhAFLLPIVDSDVCTGCGVCERAC 197
Cdd:cd10549   77 EEKC-----IGCGLCVKVCPV--DAITLE----------DELEIVIDKEKCIGCGICAEVC 120
PRK10194 PRK10194
ferredoxin-type protein NapF;
30-197 4.13e-10

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 56.96  E-value: 4.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  30 WRQATQAaplvlLRPPAAKPEKEFIASCIRCGLCVQACPFDTLSLAklgdgiSAGTPFFRPREIPCYMCEDipCVPVCP- 108
Cdd:PRK10194  14 WRKASNG-----IRPPWSGDESHFLTHCTRCDACINACENNILQRG------AGGYPSVNFKNNECSFCYA--CAQACPe 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 109 -------TGALDVNLVSTDgkldiekakmgvavvdmkNCVAYWGIQCDACYRACPLLDKALyleykrneRTQKHAFLLPI 181
Cdd:PRK10194  81 slfsprhTRAWDLQFTIGD------------------ACLAYQSVECRRCQDSCEPMAIIF--------RPTLSGIYQPQ 134

                        170
                 ....*....|....*.
gi 497336312 182 VDSDVCTGCGVCERAC 197
Cdd:PRK10194 135 LNSQLCNGCGACAASC 150
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 57-156 2.29e-09

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 54.32  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACPFD-TLSLAKLGDGISA---GTPFFRPREIPCYMCEDIPCVPVCPTGAldvnlvstdgkldIEKAKMGV 132
Cdd:cd04410    8 CIGCGTCEVACKQEhGLRPGPDWSRIKViegGGLERAFLPVSCMHCEDPPCVKACPTGA-------------IYKDEDGI 74

                         90       100
                 ....*....|....*....|....
gi 497336312 133 AVVDMKNCVAywgiqCDACYRACP 156
Cdd:cd04410   75 VLIDEDKCIG-----CGSCVEACP 93
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 56-156 1.27e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 49.32  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  56 SCIRCGLCVQACPFDTLslaKLGDGISAGTPFFRPREIPCYMCedIP---CVPVCPTGALDVNLVstdgkldiekakmGV 132
Cdd:cd10549   41 KCVFCGACVEVCPTGAI---ELTPEGKEYVPKEKEAEIDEEKC--IGcglCVKVCPVDAITLEDE-------------LE 102

                         90       100
                 ....*....|....*....|....
gi 497336312 133 AVVDMKNCvaywgIQCDACYRACP 156
Cdd:cd10549  103 IVIDKEKC-----IGCGICAEVCP 121
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 84-156 2.21e-07

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 48.90  E-value: 2.21e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497336312  84 GTPFFRPREIPCYMCEDIPCVPVCPTGALdvnlvstdgkldIEKAKMGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:cd10553   47 GKPRLKFVYMSCFHCENPWCVKACPTGAM------------QKREKDGIVYVDQELCIG-----CKACIEACP 102
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 57-112 3.84e-07

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 48.41  E-value: 3.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACPFDTLSLAKLGDGISAGTPFFRPREIPCYMC---EDIP-CVPVCPTGAL 112
Cdd:cd10554   87 CIGCKLCVLACPFGAIEMAPTTVPGVDWERGPRAVAVKCDLCagrEGGPaCVEACPTKAL 146
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-156 4.58e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 47.57  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACpfdtlSLAKLGDG------ISAGTPFFRPREIP--CYMCEDIPCVPVCPTGALDVNlvstdgkldiekA 128
Cdd:cd10550    8 CTGCRTCELAC-----SLKHEGVFnpslsrIRVVRFEPEGLDVPvvCRQCEDAPCVEACPVGAISRD------------E 70

                         90       100
                 ....*....|....*....|....*...
gi 497336312 129 KMGVAVVDMKNCvaywgIQCDACYRACP 156
Cdd:cd10550   71 ETGAVVVDEDKC-----IGCGMCVEACP 93
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 57-156 5.36e-07

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 48.40  E-value: 5.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQAC------PFD-TLSLAKLGDGISAGTPFFRPREIPCYMCEDIPCVPVCPTGAldvnlvstdgkldIEKAK 129
Cdd:COG0437   15 CIGCRACVVACkeennlPVGvTWRRVRRYEEGEFPNVEWLFVPVLCNHCDDPPCVKVCPTGA-------------TYKRE 81

                         90       100
                 ....*....|....*....|....*..
gi 497336312 130 MGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:COG0437   82 DGIVLVDYDKCIG-----CRYCVAACP 103
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 29-112 6.01e-07

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 46.86  E-value: 6.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312   29 VWRQATQAAPLVLLRPPAAKPEKEFIASCIRCGLCVQACPFDTLslaKLGDGisaGTPFFRPREIPCYMCEdiPCVPVCP 108
Cdd:TIGR00402   8 VFPATSSTIEKTQIRPPWSARESLFSAVCTRCGECASACENNIL---QLGQQ---GQPTVEFDNAECDFCG--KCAEACP 79


                  ....
gi 497336312  109 TGAL 112
Cdd:TIGR00402  80 TNAF 83
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 57-156 7.80e-07

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 47.91  E-value: 7.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQAC------PFDTLSLAKL---GDGISAGTPFFRPReiPCYMCEDIPCVPVCPTGAldvnlvstdgkldIEK 127
Cdd:cd10551    8 CIGCGACVVACkaennvPPGVFRNRVLeyeVGEYPNVKRTFLPV--LCNHCENPPCVKVCPTGA-------------TYK 72

                         90       100
                 ....*....|....*....|....*....
gi 497336312 128 AKMGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:cd10551   73 REDGIVLVDYDKCIG-----CRYCMAACP 96
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 54-197 1.83e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 46.11  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  54 IASCIRCGLCVQACP---FDTLSLAKLGDGISAGTPFFRPREIP-CYMCEDIPCVPVCPTGALdvnlvstdgkldiEKAK 129
Cdd:cd16370    8 MERCIGCYSCMLACSrrvHKSASLSKSAIRVRTRGGLEGGFTVVvCRACEDPPCAEACPTGAL-------------EPRK 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312 130 MGVAVVDMKNCvaywgIQCDACYRACPLldKALYLEYKRNErtqkhafllPIvdsdVCTGCGVCERAC 197
Cdd:cd16370   75 GGGVVLDKEKC-----IGCGNCVKACIV--GAIFWDEETNK---------PI----ICIHCGYCARYC 122
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-156 1.95e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 46.02  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQAC----------PFDTLSLAKLGDGISAGTPFFrprEIPCYMCEDIPCVPVCPTGAldvnlvstdgkldIE 126
Cdd:cd16371    9 CIGCKACEIACkdkndlppgvNWRRVYEYEGGEFPEVFAYFL---SMSCNHCENPACVKVCPTGA-------------IT 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 497336312 127 KAKMGVAVVDMKNCvaywgIQCDACYRACP 156
Cdd:cd16371   73 KREDGIVVVDQDKC-----IGCGYCVWACP 97
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 57-111 3.05e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 43.28  E-value: 3.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 497336312   57 CIRCGLCVQACPFDTLSLAKLGDGISAGTPFFRPREipCYMCEDipCVPVCPTGA 111
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTVVIDPER--CVGCGA--CVAVCPTGA 51
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 146-212 6.48e-06

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 42.81  E-value: 6.48e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497336312 146 IQCDACYRACPllDKALYLEYKRNERTqkhafllPIVDSDVCTGCGVCERACITQkpAIVVLNREVA 212
Cdd:COG1143    5 IGCGLCVRVCP--VDAITIEDGEPGKV-------YVIDPDKCIGCGLCVEVCPTG--AISMTPFELA 60
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 57-203 7.52e-06

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 45.76  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlgDGIsagtpffrPREIP--CYMCEDipCVPVCPTGALDvnLVSTDGKLDIEKAKMGVAV 134
Cdd:COG2878  139 CIGCGDCIKACPFDAIVGAA--KGM--------HTVDEdkCTGCGL--CVEACPVDCIE--MVPVSPTVVVSSWDKGKAV 204

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497336312 135 VDMKNCVaywGIQCDACYRACPLLDKAlyleykrnertqkhafLLPIVDSDVCTGCGVCERACITQKPA 203
Cdd:COG2878  205 RKVVGCI---GLCCKKCCPAAAITVNN----------------LAAIIDYKKCTCCGCCEKCCPTAIIA 254
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 57-112 2.05e-05

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 43.45  E-value: 2.05e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497336312  57 CIRCGLCVQACPFDTLSLAKLGDGISAgtpffrpreipCYMCED------IP-CVPVCPTGAL 112
Cdd:cd10562  102 CIGCGYCVAACPFDVPRYDETTNKITK-----------CTLCFDriengmQPaCVKTCPTGAL 153
PRK09898 PRK09898
ferredoxin-like protein;
95-199 2.30e-05

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 44.06  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  95 CYMCEDIPCVPVCPTGALDVNlvstdgkldiekAKMGVAVVDMKNCvaywgIQCDACYRACPLLDKALYLEYKRnertqk 174
Cdd:PRK09898 123 CRQCKEPQCMNVCPIGAITWQ------------QKEGCITVDHKRC-----IGCSACTTACPWMMATVNTESKK------ 179

                         90       100
                 ....*....|....*....|....*
gi 497336312 175 hafllpivdSDVCTGCGVCERACIT 199
Cdd:PRK09898 180 ---------SSKCVLCGECANACPT 195
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
57-112 2.83e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 42.72  E-value: 2.83e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACPFDTlslaklgdgISAGTPFFRPREIPCYMCEDIP----CVPVCPTGAL 112
Cdd:COG1142   83 CIGCGLCVLACPFGA---------ITMVGEKSRAVAVKCDLCGGREggpaCVEACPTGAL 133
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 95-156 3.34e-05

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 43.06  E-value: 3.34e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497336312  95 CYMCEDIPCVPVCPTGALDvnlvstdgkldieKAKMGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:cd10562   70 CMHCTDAACVKVCPTGALY-------------KTENGAVVVDEDKCIG-----CGYCVAACP 113
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-114 3.50e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 42.18  E-value: 3.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497336312  57 CIRCGLCVQACPFdtlslaklgdgisaGTPFFRPRE---IPCYMCEDIP-CVPVCPTGALDV 114
Cdd:cd10550   82 CIGCGMCVEACPF--------------GAIRVDPETgkaIKCDLCGGDPaCVKVCPTGALEF 129
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 84-156 3.55e-05

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 42.77  E-value: 3.55e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497336312  84 GTPFFRPREIPCYMCEDIPCVPVCPTGAldvnlvstdgkldIEKAKMGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:cd16366   59 GDLSWLFRKDQCMHCTDAGCLAACPTGA-------------IIRTETGTVVVDPETCIG-----CGYCVNACP 113
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 129-211 4.42e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 40.48  E-value: 4.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 129 KMGVAVVDMKNCvaywgIQCDACYRACPLldKALYLEYKRNertqkhafllPIVDSDVCTGCGVCERACITQkpAIVVLN 208
Cdd:COG1149    2 KRKIPVIDEEKC-----IGCGLCVEVCPE--GAIKLDDGGA----------PVVDPDLCTGCGACVGVCPTG--AITLEE 62


                 ...
gi 497336312 209 REV 211
Cdd:COG1149   63 REA 65
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 57-114 4.69e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 40.48  E-value: 4.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlgdgisAGTPFFRPREipCYMCEDipCVPVCPTGALDV 114
Cdd:COG1149   13 CIGCGLCVEVCPEGAIKLDD------GGAPVVDPDL--CTGCGA--CVGVCPTGAITL 60
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 57-114 5.07e-05

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 40.46  E-value: 5.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlgdgisAGTPFFRPREIPCYMCEdiPCVPVCPTGALDV 114
Cdd:COG1146   10 CIGCGACVEVCPVDVLELDE------EGKKALVINPEECIGCG--ACELVCPVGAITV 59
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 132-197 7.51e-05

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 40.42  E-value: 7.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312 132 VAVVDMKNCvaywgIQCDACYRACPllDKALYLEYKRNertqkhafllPIVDSDVCTGCGVCERAC 197
Cdd:COG1144   24 RPVVDEDKC-----IGCGLCWIVCP--DGAIRVDDGKY----------YGIDYDYCKGCGICAEVC 72
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 57-112 8.65e-05

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 41.62  E-value: 8.65e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497336312  57 CIRCGLCVQACPFDTLSLAKLgdgisagtpffRPREIPCYMCED------IP-CVPVCPTGAL 112
Cdd:cd16366  102 CIGCGYCVNACPFDIPRFDEE-----------TGRVAKCTLCYDrisnglQPaCVKTCPTGAL 153
Fer4_9 pfam13187
4Fe-4S dicluster domain;
57-112 2.49e-04

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 37.92  E-value: 2.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312   57 CIRCGLCVQACPFDTLSLAKLGdgisaGTPFFRPREIPCYMCEDipCVPVCPTGAL 112
Cdd:pfam13187   2 CTGCGACVAACPAGAIVPDLVG-----QTIRGDIAGLACIGCGA--CVDACPRGAI 50
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 57-114 2.64e-04

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 38.19  E-value: 2.64e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497336312  57 CIRCGLCVQACPFDTLslaKLGDGISAGTPFFRPRE-IPCYMCEDipcvpVCPTGALDV 114
Cdd:COG1143    4 CIGCGLCVRVCPVDAI---TIEDGEPGKVYVIDPDKcIGCGLCVE-----VCPTGAISM 54
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 146-211 3.12e-04

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 39.24  E-value: 3.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312 146 IQCDACYRACPllDKALYLEYKRnertqkhaflLPIVDSDVCTGCGVCERACITQKpaiVVLNREV 211
Cdd:PRK09624  54 VRCYLCYIYCP--EPAIYLDEEG----------YPVFDYDYCKGCGICANECPTKA---IEMVRET 104
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-112 3.51e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 39.57  E-value: 3.51e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312  57 CIRCGLCVQACPFdtlslaklgdgisaGTPFFRPRE---IPCYMCED------IP-CVPVCPTGAL 112
Cdd:cd16374   75 CIGCGMCAMACPF--------------GVPRFDPSLkvaVKCDLCIDrrregkLPaCVEACPTGAL 126
NapF COG1145
Ferredoxin [Energy production and conversion];
57-114 5.71e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 40.09  E-value: 5.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlgdgisaGTPFFRPREIPCYMCEDipCVPVCPTGALDV 114
Cdd:COG1145  184 CIGCGLCVKVCPTGAIRLKD-------GKPQIVVDPDKCIGCGA--CVKVCPVGAISL 232
PLN00071 PLN00071
photosystem I subunit VII; Provisional
 56-114 5.85e-04

photosystem I subunit VII; Provisional


Pssm-ID: 177700 [Multi-domain]  Cd Length: 81  Bit Score: 37.62  E-value: 5.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497336312  56 SCIRCGLCVQACPFDTLSLAKlGDGISAGTPFFRPREIPCYMCEDipCVPVCPTGALDV 114
Cdd:PLN00071  10 TCIGCTQCVRACPTDVLEMIP-WDGCKAKQIASAPRTEDCVGCKR--CESACPTDFLSV 65
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 133-206 6.53e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 37.38  E-value: 6.53e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497336312 133 AVVDMKNCvaywgIQCDACYRACPllDKALYLEYKRnertqKHAFllpIVDSDVCTGCGVCERACITQkpAIVV 206
Cdd:COG1146    3 PVIDTDKC-----IGCGACVEVCP--VDVLELDEEG-----KKAL---VINPEECIGCGACELVCPVG--AITV 59
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
57-156 7.15e-04

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 40.39  E-value: 7.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACPFDTLSLAKLGDGISAGTPFFRPREIPCYmcediPCVPVCPTGALDVNlvstdgkldiekakMGVAVVD 136
Cdd:COG4624   58 CCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCY-----PCVRACPVKAIKVD--------------DGKAEID 118

                         90       100
                 ....*....|....*....|
gi 497336312 137 MKNCvaywgIQCDACYRACP 156
Cdd:COG4624  119 EEKC-----ISCGQCVAVCP 133
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
56-197 7.17e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 39.92  E-value: 7.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  56 SCIRCGLCVQACPFDTLSlakLGDGIsagtpffrPREIP--CYMCEdiPCVPVCPTGALDvnlvstdgkLDIEKAKMGVA 133
Cdd:PRK07118 140 GCLGLGSCVAACPFDAIH---IENGL--------PVVDEdkCTGCG--ACVKACPRNVIE---------LIPKSARVFVA 197

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 134 VV------DMKNCVAYWGIQCDACYRACPllDKALYLEYKrnertqkhaflLPIVDSDVCTGCGVCERAC 197
Cdd:PRK07118 198 CNskdkgkAVKKVCEVGCIGCGKCVKACP--AGAITMENN-----------LAVIDQEKCTSCGKCVEKC 254
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 146-197 8.05e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 38.33  E-value: 8.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 497336312 146 IQCD--ACYRACPLldKALYLEYKRNERtqkhafllpIVDSDVCTGCGVCERAC 197
Cdd:cd10550   50 RQCEdaPCVEACPV--GAISRDEETGAV---------VVDEDKCIGCGMCVEAC 92
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
95-156 8.14e-04

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 39.86  E-value: 8.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497336312  95 CYMCEDIPCVPVCPTGAldvnlvstdgkldIEKAKMGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:PRK14993 100 CNHCDNPPCVPVCPVQA-------------TFQREDGIVVVDNKRCVG-----CAYCVQACP 143
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 146-197 8.22e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 36.74  E-value: 8.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 497336312  146 IQCDACYRACPllDKALYLEYKRNERTQKHafllPIVDSDVCTGCGVCERAC 197
Cdd:pfam12838   2 IGCGACVAACP--VGAITLDEVGEKKGTKT----VVIDPERCVGCGACVAVC 47
NapF COG1145
Ferredoxin [Energy production and conversion];
10-197 9.81e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 39.71  E-value: 9.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  10 REVLKFGLKALALAAGGGFVWRQATQAAPLVLLRPPAAKPEKEFIASCIRCGLCVQAcpFDTLSLAKLGDGISAGTPFFR 89
Cdd:COG1145   56 KEAFDALKDVLGILGAIVIGIGAGEIVRVGIAAADLNLKAVALVLLLALAVAGAAKR--LIISAVKLVAGLVVAAGEVLL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  90 PREIPCYMCEDIPCVPVCPTGALDVNLVSTDGKLDIEKAKMGVAVVDMKNCvaywgIQCDACYRACPLldKALYLEYKRN 169
Cdd:COG1145  134 VIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKC-----IGCGLCVKVCPT--GAIRLKDGKP 206

                        170       180
                 ....*....|....*....|....*...
gi 497336312 170 ErtqkhafllPIVDSDVCTGCGVCERAC 197
Cdd:COG1145  207 Q---------IVVDPDKCIGCGACVKVC 225
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 55-156 1.01e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 38.44  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  55 ASCIRCGLCVQACpfdtlslAKLGDGISA---GTPFFRPREIP--CYMCEDIPCVPVCPTGALDVNlvsTDGKLDIEKak 129
Cdd:cd16367   19 DRCIRCDNCEKAC-------ADTHDGHSRldrNGLRFGNLLVPtaCRHCVDPVCMIGCPTGAIHRD---DGGEVVISD-- 86

                         90       100
                 ....*....|....*....|....*..
gi 497336312 130 mgvavvdmkncvayWGIQCDACYRACP 156
Cdd:cd16367   87 --------------ACCGCGNCASACP 99
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 134-199 1.25e-03

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 39.60  E-value: 1.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312 134 VVDMKNCvaywgIQCDACYRACPllDKALYLEYKRNERTQKHAFLLPIVDSD--VCTGCGVCERACIT 199
Cdd:PRK14028 243 VIDHSKC-----IMCRKCWLYCP--DDAIIEAWREAEGPRGRKFRMKMIDFDyqYCKGCGVCAEVCPT 303
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 55-183 1.27e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 39.62  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  55 ASCIRCGLCVQACpfdtlSLAKLGDGISAGTPFFRPR-----------EIPCYMCEDIPCVPVCPTGALDV--NLVSTDG 121
Cdd:PRK12809  10 AECIGCHACEIAC-----AVAHNQENWPLSHSDFRPRihvvgkgqaanPVACHHCNNAPCVTACPVNALTFqsDSVQLDE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312 122 KLDIEKAKMGVA----VVDMKNCVAYwgiQCD----------ACYRACP-----LLDKALYLEYKRnERTQKHAFLLPIV 182
Cdd:PRK12809  85 QKCIGCKRCAIAcpfgVVEMVDTIAQ---KCDlcnqrssgtqACIEVCPtqalrLMDDKGLQQIKV-ARQRKTAAGKASS 160


                 .
gi 497336312 183 D 183
Cdd:PRK12809 161 D 161
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 56-156 1.53e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 39.73  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  56 SCIRCGLCVQACpfdtlsLAKLGDGISAGTP-FFRPR-----------EIPCYMCEDIPCVPVCPTGAldvnlvstdgkl 123
Cdd:PRK12769  11 QCLGCHACEIAC------VMAHNDEQHVLSQhHFHPRitvikhqqqrsAVTCHHCEDAPCARSCPNGA------------ 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 497336312 124 dIEKAKMGVAVVDMKnCvaywgIQCDACYRACP 156
Cdd:PRK12769  73 -ISHVDDSIQVNQQK-C-----IGCKSCVVACP 98
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 57-112 1.62e-03

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 38.52  E-value: 1.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497336312  57 CIRCGLCVQACPFDTLSLAKLGDgisagtpffrpREIPCYMCED-------IPCVPVCPTGAL 112
Cdd:cd10558  103 CIGCGYCIKGCPFDIPRISKDDN-----------KMYKCTLCSDrvsvglePACVKTCPTGAL 154
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-114 1.78e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 37.54  E-value: 1.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312  57 CIRCGLCVQACPFdtlslaklgdgisaGTPFFRPRE---IPCYMCED------IP-CVPVCPTGALDV 114
Cdd:cd16371   86 CIGCGYCVWACPY--------------GAPQYNPETgkmDKCDMCVDrldegeKPaCVAACPTRALDF 139
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 57-156 1.84e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 37.62  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  57 CIRCGLCVQACpfdtlSLAKLGDGI----SAGTPFfRPR-----------EIPCYMCEDIPCVPVCPTGALDVnlvstdg 121
Cdd:cd10554    9 CIGCRTCEVAC-----AAAHSGKGIfeagTDGLPF-LPRlrvvktgevtaPVQCRQCEDAPCANVCPVGAISQ------- 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 497336312 122 kldiekaKMGVAVVDMKNCVAywgiqCDACYRACP 156
Cdd:cd10554   76 -------EDGVVQVDEERCIG-----CKLCVLACP 98
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
57-115 2.22e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 35.86  E-value: 2.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlgdgisaGTPFFRPREipCYMCEDipCVPVCPTGALDVN 115
Cdd:COG2768   13 CIGCGACVKVCPVGAISIED-------GKAVIDPEK--CIGCGA--CIEVCPVGAIKIE 60
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
57-120 2.38e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 39.07  E-value: 2.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497336312  57 CIRCGLCVQACPFDTLSLAKlgDGISagtpffRPREIPCYMCEDipCVPVCPTGALDVNLVSTD 120
Cdd:COG1148  498 CTGCGRCVEVCPYGAISIDE--KGVA------EVNPALCKGCGT--CAAACPSGAISLKGFTDD 551
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 45-68 2.81e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 38.78  E-value: 2.81e-03
                         10        20
                 ....*....|....*....|....
gi 497336312  45 PAAKPEKefiaSCIRCGLCVQACP 68
Cdd:PRK05035 364 PPPPPEQ----PCIRCGACADACP 383
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
124-197 2.92e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 38.69  E-value: 2.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312 124 DIEKAKMG----VAVVDMKNCvaywgIQCDACYRACPLldKALYLEYKRNertqkhafllPIVDSDVCTGCGVCERAC 197
Cdd:COG1148  478 LLSKGELGvepsVAEVDPEKC-----TGCGRCVEVCPY--GAISIDEKGV----------AEVNPALCKGCGTCAAAC 538
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
57-112 3.07e-03

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 38.12  E-value: 3.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312  57 CIRCGLCVQACPFdtlslaklgdGISAGTPFFRPREipCYMCEDipCVPVCPTGAL 112
Cdd:COG0348  212 CIDCGLCVKVCPM----------GIDIRKGEINQSE--CINCGR--CIDACPKDAI 253
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
54-197 3.51e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 38.47  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  54 IASCIRCGLCVQACPFDTLSLAKLG-DGISAGTPFFRPREIPCYMCEDIPCVPVCPTGALDVNLVSTDGKLDIEKAKMGV 132
Cdd:COG4624    6 RACCCCCIEEGDELLLLEEAERVLRiIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPS 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497336312 133 AVVDMKNCvaywgIQCDACYRACPLldKALYLEYKRNErtqkhafllpiVDSDVCTGCGVCERAC 197
Cdd:COG4624   86 IIRDKEKC-----KNCYPCVRACPV--KAIKVDDGKAE-----------IDEEKCISCGQCVAVC 132
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 103-169 5.58e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 34.64  E-value: 5.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497336312 103 CVPVCPTGALDVNlvstDGKLdiekakmgvaVVDMKNCvaywgIQCDACYRACPllDKALYLEYKRN 169
Cdd:COG2221   23 CVAVCPTGAISLD----DGKL----------VIDEEKC-----IGCGACIRVCP--TGAIKGEKPKK 68
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 57-112 5.60e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 36.60  E-value: 5.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312  57 CIRCGLCVQACPFdtlslaklgdgisaGTPFFRPRE---IPCYMCED-----IP--CVPVCPTGAL 112
Cdd:cd16369   84 CIGCSNCVNACPF--------------GVPKYDEERnlmMKCDMCYDrtsvgKApmCASVCPSGAL 135
PsaC COG5703
Photosystem I reaction center iron-sulfur center subunit VII, PsaC [Energy production and ...
 57-115 5.75e-03

Photosystem I reaction center iron-sulfur center subunit VII, PsaC [Energy production and conversion]; Photosystem I reaction center iron-sulfur center subunit VII, PsaC is part of the Pathway/BioSystem: Photosystem I


Pssm-ID: 444413 [Multi-domain]  Cd Length: 82  Bit Score: 35.18  E-value: 5.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497336312  57 CIRCGLCVQACPFDTLSLAKLGDGISAGTPFFRPRE--IPCYMCEdipcvPVCPTGALDVN 115
Cdd:COG5703   11 CIGCTQCVRACPTDVLEMVPWDGCKAGQIAASPRTEdcVGCKRCE-----TACPTDFLSIR 66
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 36-135 7.21e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 36.98  E-value: 7.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  36 AAPLVLLRPPAAKPEKEFIAS---------CIRCGLCVQACPFDTLSlaklgdgisagtPFFRPREIPCYMCEDI-PCVP 105
Cdd:cd03110   36 APNLHLLLGPEPEEEEDFVGGkkafidqekCIRCGNCERVCKFGAIL------------EFFQKLIVDESLCEGCgACVI 103

                         90       100       110
                 ....*....|....*....|....*....|
gi 497336312 106 VCPTGALDVNLVSTdGKLDIEKAKMGVAVV 135
Cdd:cd03110  104 ICPRGAIYLKDRDT-GKIFISSSDGGPLVH 132
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 56-112 7.34e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 35.75  E-value: 7.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497336312  56 SCIRCGLCVQACPFDTLSLAklgdgisagtpffrpREIPCYMCE---DIPCVPVCPTGAL 112
Cdd:cd16367   87 ACCGCGNCASACPYGAIQMV---------------RAVKCDLCAgyaGPACVSACPTGAA 131
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
57-112 7.55e-03

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 36.01  E-value: 7.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497336312  57 CIRCGLCVQACPFD--TLSLAKLGDGISAGTPFfrP----REIPCYMCEDipcvpVCPTGAL 112
Cdd:PRK05888  60 CIACKLCAAICPADaiTIEAAEREDGRRRTTRY--DinfgRCIFCGFCEE-----ACPTDAI 114
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 57-68 7.73e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 37.04  E-value: 7.73e-03
                         10
                 ....*....|..
gi 497336312  57 CIRCGLCVQACP 68
Cdd:COG4656  366 CIRCGRCVDACP 377
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 132-197 9.00e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 36.51  E-value: 9.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312 132 VAVVDMKNCVAYWGIQCDACYRACPLldKALYLEYKRnertqkhaflLPIVDSDVCTGCGVCERAC 197
Cdd:COG2878  126 AAVIGGPKGCEYGCIGCGDCIKACPF--DAIVGAAKG----------MHTVDEDKCTGCGLCVEAC 179
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 57-129 9.14e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 37.03  E-value: 9.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497336312  57 CIRCGLCVQACPFDTLSLAklgdgISAGTP-FFRPREIPCYMCEDIP----CVPVCPTGALdvNLVSTDGKLDIEKAK 129
Cdd:PRK12769  87 CIGCKSCVVACPFGTMQIV-----LTPVAAgKVKATAHKCDLCAGREngpaCVENCPADAL--QLVTEQALSGMAKSR 157
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 122-197 9.31e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 34.25  E-value: 9.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497336312 122 KLDIEKAKMgVAVVDMKNCvaywgIQCDACYRACPLldKALYLEYKRnertqkhafllPIVDSDVCTGCGVCERAC 197
Cdd:COG4231    7 ILDNRTTAM-RYVIDEDKC-----TGCGACVKVCPA--DAIEEGDGK-----------AVIDPDLCIGCGSCVQVC 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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