|
Name |
Accession |
Description |
Interval |
E-value |
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
44-517 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 583.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 44 GATLRAQDAGAGYLFAALPGDRTHGANYAAQARAAGAAGVLTDPAGlalireDPEAADVTVLVHARPREVLGAVSARIYG 123
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPG------ALLAAGVPVIVVPDPRAALALLAAAFYG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 124 DPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVVPSSLTTPEAPDLQRMFAVMAERGVDTVVME 203
Cdd:COG0769 75 HPSQKLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVTHVVME 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 204 VSSHALALGRVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEagSPTRARQAAVCVDDVWGRRAADVAAQGAatp 283
Cdd:COG0769 155 VSSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFD--QLGPGGAAVINADDPYGRRLAAAAPARV--- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 284 ITVSTTGPADWSvVRTVRTDAGSQTVLIAGPDGaETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAHV-AVPG 362
Cdd:COG0769 230 ITYGLKADADLR-ATDIELSADGTRFTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLkGVPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 363 RLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTRGRLAVVLGAGGDRDTEKRPLMGAAAARGADLVIVTDDNPRSEPP 442
Cdd:COG0769 308 RMERVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDP 387
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497364317 443 ADIRAAVLAGARSVDaargEIREIGDRRDAIAAAVDWARPGDVVLIAGKGHEKGQEIDGVKHPFDDRQVLGELLS 517
Cdd:COG0769 388 AAIIADILAGIPGAG----KVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDREVAREALA 458
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
38-519 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 552.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 38 DDRDVSGATLRAQDAGAGYLFAALPGDRTHGANYAAQARAAGAAGVLTDPAGlaliredPEAADVTVLVHARPREVLGAV 117
Cdd:PRK00139 11 APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADG-------EAGTGVPVIIVPDLRKALALL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 118 SARIYGDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVVPSSLTTPEAPDLQRMFAVMAERGV 197
Cdd:PRK00139 84 AAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQRLLAELVDAGV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 198 DTVVMEVSSHALALGRVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEagspTRARQAAVCVDDVWGRRAADVAA 277
Cdd:PRK00139 164 TYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFS----ELGLAAVINADDEVGRRLLALPD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 278 QgaatpITVSTTgPADWSVVRTVRTDAGSQTVLiagpdgaETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAH 357
Cdd:PRK00139 240 A-----YAVSMA-GADLRATDVEYTDSGQTFTL-------VTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 358 V-AVPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTRGRLAVVLGAGGDRDTEKRPLMGAAAARGADLVIVTDDN 436
Cdd:PRK00139 307 LqGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVTSDN 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 437 PRSEPPADIRAAVLAGARsvdaargeiREIGDRRDAIAAAVDWARPGDVVLIAGKGHEKGQEIDGVKHPFDDRQVLGELL 516
Cdd:PRK00139 387 PRSEDPAAIIADILAGIY---------DVIEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIPFDDREVAREAL 457
|
...
gi 497364317 517 SDR 519
Cdd:PRK00139 458 AER 460
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
39-509 |
1.04e-152 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 450.61 E-value: 1.04e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 39 DRDVSGATLRAQDAGAGYLFAALPGDRTHGANYAAQARAAGAAGVLTDPAGlalireDPEAADVTVLVHARPREVLGAVS 118
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDV------DFYVAPVPVIIVPDLRHALSSLA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 119 ARIYGDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDG---TVVPSSLTTPEAPDLQRMFAVMAER 195
Cdd:TIGR01085 75 AAFYGHPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGndlIKNPAALTTPEALTLQSTLAEMVEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 196 GVDTVVMEVSSHALALGRVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAGSptRARQAAVCVDDVWGRRAADV 275
Cdd:TIGR01085 155 GAQYAVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELG--LKRFAVINLDDEYGAQFVKR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 276 AAQgaatPITVS-TTGPADWSV----VRTVRTDAGSQTVLIAGPDGaETEMTVPLPGAYNVANALLAVAMTVAAG-TDVD 349
Cdd:TIGR01085 233 LPK----DITVSaITQPADGRAqdikITDSGYSFEGQQFTFETPAG-EGHLHTPLIGRFNVYNLLAALATLLHLGgIDLE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 350 TAVAGLAHV-AVPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTRGRLAVVLGAGGDRDTEKRPLMGAAAARGAD 428
Cdd:TIGR01085 308 DIVAALEKFrGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLAD 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 429 LVIVTDDNPRSEPPADIRAAVLAGARsvdaARGEIREIGDRRDAIAAAVDWARPGDVVLIAGKGHEKGQEIDGVKHPFDD 508
Cdd:TIGR01085 388 LVILTSDNPRGEDPEQIIADILAGIS----EKEKVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGETIPFDD 463
|
.
gi 497364317 509 R 509
Cdd:TIGR01085 464 R 464
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
34-549 |
4.20e-124 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 392.14 E-value: 4.20e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 34 ELHGDDRDVSGATLRAQDAGAGYLFAALPGDRTHGANYAAQARAAGAAGVLTDPAGlalirEDPE-AADVTVLVHARPRE 112
Cdd:PRK11929 21 WLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEG-----EDQVaAADALVLPVADLRK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 113 VLGAVSARIYGDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVVPSSLTTPEAPDLQRMFAVM 192
Cdd:PRK11929 96 ALGELAARWYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGRLIPGSLTTPDAIILHRILARM 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 193 AERGVDTVVMEVSSHALALGRVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAGSPtraRQAAVC-VDDVWGRR 271
Cdd:PRK11929 176 RAAGADAVAMEASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPG---LGAAVInADDPAAAR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 272 AADVAAQGAATPITVSTTGpADWSvVRTVRTDAGSQTVLIAGPDGaETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTA 351
Cdd:PRK11929 253 LLAALPRGLKVGYSPQNAG-ADVQ-ARDLRATAHGQVFTLATPDG-SYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 352 VAGLAHVA-VPGRLEKV---ERGQEFLAVVDYAHKPAAVEAVLATLG---AQTRGRLAVVLGAGGDRDTEKRPLMGAAAA 424
Cdd:PRK11929 330 ARALAAVSpVPGRMERVgptAGAQGPLVVVDYAHTPDALAKALTALRpvaQARNGRLVCVFGCGGDRDKGKRPEMGRIAA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 425 RGADLVIVTDDNPRSEPPADIRAAVLAGARSVDAArgeiREIGDRRDAIAAAVDWARPGDVVLIAGKGHEKGQEIDGVKH 504
Cdd:PRK11929 410 ELADRVVVTSDNPRSEAPEAIIDQILAGIPAGARV----FVISDRAEAIRQAIWMAAPGDVILIAGKGHETYQEIGGRKL 485
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 497364317 505 PFDDRQVLGELLSDRAAAPSTALRVLIADPAAGVDEARRAVRDLV 549
Cdd:PRK11929 486 FFDDREWARRALLARISSTLIKLRAAKGGSNSLQINSLPHAGAVS 530
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
88-506 |
6.10e-66 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 225.30 E-value: 6.10e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 88 AGLALI-REDPEAADVTVLVHARPREVLGAVSARIYGDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEI 166
Cdd:PRK14022 68 QGLKLYvSEKDYEVGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTT 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 167 RVDGTVVPSSLTTPEAPDLQRMFAVMAERGVDTVVMEVSSHALALGRVDGCHFAVGGFTNLSQDHLDY--HRTMDEYFAA 244
Cdd:PRK14022 148 LDGETFFKSALTTPESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYH 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 245 KARLFEagsptraRQAAVCVDdvwGRRAADVAAQGAATPITVSTTGPADWSVVRTVRTDAGSQTVLIAGpdgaetEMTVP 324
Cdd:PRK14022 228 KRLLME-------NSKAVVVN---SDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAG------TYDIQ 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 325 LPGAYNVANALLAVAMTVAAGTDVDTAVAGLAHVAVPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTRGRLAVV 404
Cdd:PRK14022 292 LIGKFNQENAMAAGLACLRLGASLEDIQKGIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILL 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 405 LGAGGDRDTEKRPLMGAAAARGADL-VIVTDDNPRSEPPADIRAAVLAGARSvdaargEIREIGDRRDAIAAAVDWA-RP 482
Cdd:PRK14022 372 LGAAGNKGESRRPDFGRVANRHPYLqVILTADDPNNEDPKMITQEIASHITH------PVEIIDDRAEAIKHAMSITeGP 445
|
410 420
....*....|....*....|....
gi 497364317 483 GDVVLIAGKGHEKGQEIDGVKHPF 506
Cdd:PRK14022 446 GDAVIIAGKGADAYQIVPGHRDDY 469
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
134-339 |
2.71e-53 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 182.12 E-value: 2.71e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 134 ITGTSGKTTTAYLAEAALRAAGRVVGLVGTVeirvdgtVVPSSLTTPEAPDLQRMFAVMAERGVDTVVMEVSSHALALGR 213
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTY-------IGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 214 VDG-CHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEaGSPTRARqaAVC-VDDVWGRRAADVAAQGAATPITVSTTGP 291
Cdd:pfam08245 74 LSGlLKPDIAVFTNISPDHLDFHGTMENYAKAKAELFE-GLPEDGI--AVInADDPYGAFLIAKLKKAGVRVITYGIEGE 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 497364317 292 ADWsVVRTVRTDAGSQTVLIAGPDGAETEMTVPLPGAYNVANALLAVA 339
Cdd:pfam08245 151 ADL-RAANIELSSDGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIA 197
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
132-487 |
4.64e-38 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 147.15 E-value: 4.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 132 IGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVeirvdGTVVPSSLTTPEAPDLqrmfavmaergvdtVVMEVSSHALAL 211
Cdd:COG0771 108 IAITGTNGKTTTTTLIGHILKAAGLRVAVGGNI-----GTPLLDLLLEPEPPDV--------------YVLELSSFQLET 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 212 grVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAGSPTRArqAAVCVDDVWGRRAADVAAQGAAtPITVSTTGP 291
Cdd:COG0771 169 --TPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDY--AVLNADDPLTRALAEEAKARVV-PFSLKEPLE 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 292 ADWSVVRTVRTDAGSQTVLIAGPDgaetemtVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAH-VAVPGRLEKV-ER 369
Cdd:COG0771 244 GGAGLEDGKLVDRASGEELLPVDD-------LRLPGRHNLENALAALAAARALGVPPEAIREALRSfKGLPHRLEFVaEI 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 370 GQeflavVDY-----AHKPAAVEAVLATLGAQtrgrlaVVLGAGG-DRDTEKRPLMGAAAARGADLVIVTDDNPRseppa 443
Cdd:COG0771 317 NG-----VRFindskATNPDATLAALESFDGP------VVLIAGGlDKGADFSPLAPAVAERVKAVVLIGEDAEK----- 380
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 497364317 444 dIRAAvlagarsVDAARGEIREIGDRRDAIAAAVDWARPGDVVL 487
Cdd:COG0771 381 -IAAA-------LAGAGVPVVIVETMEEAVAAAAELARPGDVVL 416
|
|
| cya_phycin_syn |
TIGR02068 |
cyanophycin synthetase; Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and ... |
110-505 |
2.73e-28 |
|
cyanophycin synthetase; Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and energy, found in most Cyanobacteria. The polymer has a backbone of L-aspartic acid, with most Asp side chain carboxyl groups attached to L-arginine. The polymer is made by this enzyme, cyanophycin synthetase, and degraded by cyanophycinase. Heterologously expressed cyanophycin synthetase in E. coli produces a closely related, water-soluble polymer with some Arg replaced by Lys. It is unclear whether enzymes that produce soluble cyanophycin-like polymers in vivo in non-Cyanobacterial species should be designated as cyanophycin synthetase itself or as a related enzyme. This model makes the designation as cyanophycin synthetase. Cyanophycin synthesis is analogous to polyhydroxyalkanoic acid (PHA) biosynthesis, except that PHA polymers lack nitrogen and may be made under nitrogen-limiting conditions. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 273950 [Multi-domain] Cd Length: 864 Bit Score: 121.43 E-value: 2.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 110 PREVLGAVSARIY-GDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVVPSSLTTpeAPDLQRM 188
Cdd:TIGR02068 459 PRNVARAIVDMLFpAEDDGRIPIVSVTGTNGKTTTTRLVAHILKQTGKVVGMTTTDGVYIGKYLVEKGDNT--GPASARR 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 189 faVMAERGVDTVVMEVSS-----HALALGRVDgchfaVGGFTNLSQDHL--DYHRTMDEYFAAKARLFEAGSPTRArqAA 261
Cdd:TIGR02068 537 --ILMDPTVDAAVLETARggilrEGLAFDRCD-----VGVVTNIAGDHLgiGDINTIEDLADVKRVVVEVVLPDGY--AV 607
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 262 VCVDDvwgrRAADVAAQGAATPITVSTTGPADWSVVRTVRTDA--------------GSQTVLIAgpDGAETEMTVPLPG 327
Cdd:TIGR02068 608 LNADD----PMVAAMAEKCKGKIAYFSMDPNNPTVAAHIADGGravyyengyiviarGGDEVAIA--RIAAIPLTMGGRV 681
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 328 AYNVANALLAVAMTVAAGTDVDTAVAGLAHVAV-----PGRLEKVERGqEFLAVVDYAHKPAAVEAVLATLGAQTRGRLA 402
Cdd:TIGR02068 682 AFQIENALAAVAAAWALGVPIELIRAGIRTFDAdaaqaPGRFNLFNLG-GAHVLVDYGHNPAAIEAVGAAIRNWPARRRI 760
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 403 VVLGAGGDRDTEKRPLMGAAAARGADLVIV-TDDNPRSEPPADIRAAVLAGARSVDAARgEIREIGDRRDAIAAAVDWAR 481
Cdd:TIGR02068 761 GVIGGPGDRRDEDLVEQGELLGGAFDQIILkEDDDVRGRPRGEAAALLRQGLRQSARKA-AIEDILDETEAIAAALDDLR 839
|
410 420
....*....|....*....|....
gi 497364317 482 PGDVVLIAGKGHEKGQEIDGVKHP 505
Cdd:TIGR02068 840 AGDLVVIFPESVERAIKLILVRVW 863
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
123-490 |
4.59e-25 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 108.27 E-value: 4.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 123 GDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVG------LVGTVE-IRVDGTVVP-SSLTT------PEAPDLQR- 187
Cdd:COG0285 34 GNPQRKLPVIHVAGTNGKGSTAAMLESILRAAGYRVGlytsphLVRFNErIRINGEPISdEELVEaleevePAVEEVDAg 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 188 -----------MFAVMAERGVDTVVMEVsshalALG-RVDG---CHFAVGGFTNLSQDHLDY--HrTMDEYFAAKARLFE 250
Cdd:COG0285 114 pptffevttaaAFLYFAEAPVDVAVLEV-----GLGgRLDAtnvIDPLVSVITSIGLDHTDFlgD-TLEEIAREKAGIIK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 251 AGSPtrarqaAVC------VDDVWGRRaadvaAQGAATPITVSttGPaDWSVVRTvrtdaGSQTVLIAGPDGAETEMTVP 324
Cdd:COG0285 188 PGVP------VVTgdqqpeALEVIEER-----AAELGAPLYRA--GR-DFSVEER-----EGAVFSYQGPGGEYEDLPLP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 325 LPGAYNVANALLAVAM---TVAAGTDVDTAV--AGLAHVAVPGRLEKVERGQEFlaVVDYAHKPAAVEAVLATLGAQ-TR 398
Cdd:COG0285 249 LLGAHQAENAALALAAleaLRELGLPISEEAirEGLANARWPGRLEVLSRGPLV--ILDGAHNPAGARALAETLKELfPF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 399 GRLAVVLGAGGDRDTEKrplMGAAAARGADLVIVTD-DNPRSEPPADIRAAvlagARSVDAargEIREIGDRRDAIAAAV 477
Cdd:COG0285 327 RKLHLVFGMLADKDIEG---MLAALAPLADEVIVTTpPSPRALDAEELAEA----ARELGL---RVEVAPDVEEALEAAL 396
|
410
....*....|...
gi 497364317 478 DWARPGDVVLIAG 490
Cdd:COG0285 397 ELADPDDLILVTG 409
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
225-492 |
1.08e-23 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 104.76 E-value: 1.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 225 TNLSQDHLDYHRTMDEYFAAkarlFE--AGSPTRARQAAVCVDDVWGRRAADVAAQGAatpITVSTTGPADWSVVRtVRT 302
Cdd:COG0773 178 TNIEADHLDIYGDLEAIKEA----FHefARNVPFYGLLVLCADDPGLRELLPRCGRPV---ITYGFSEDADYRAEN-IRI 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 303 DAGSQTVLIAGPDGAETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAHVA-VPGRLEKVERGQEFLAVVDYAH 381
Cdd:COG0773 250 DGGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKgVKRRFELKGEVGGVTVIDDYAH 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 382 KPAAVEAVLATL-GAQTRGRLAVVL--------GAggdrdtekrpLMG--AAAARGADLVIVTDDNP-RSEPPADIRAAV 449
Cdd:COG0773 330 HPTEIAATLAAArEKYPDRRLVAVFqphrysrtRD----------FLDefAEALSLADEVILLDIYAaREKPIPGVSSED 399
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 497364317 450 LagARSVDAARGEIREIGDRRDAIAAAVDWARPGDVVLIAGKG 492
Cdd:COG0773 400 L--AEAIRKRGKDVVYVPDLDELVEALAEIARPGDVVLTMGAG 440
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
95-489 |
2.86e-23 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 103.19 E-value: 2.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 95 EDPEAADVTVL---VHARPREVLGAVSA--RIYGDPS-----SRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTV 164
Cdd:TIGR01087 58 EDLNNADLVVKspgIPPDHPLVQAAAKRgiPVVGDIElflrlVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNI 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 165 eirvdGTvvpsslttpeaPDLQrmfaVMAERGVDTVVMEVSSHALAlgRVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAA 244
Cdd:TIGR01087 138 -----GT-----------PALE----VLDQEGAELYVLELSSFQLE--TTESLRPEIALILNISEDHLDWHGSFEDYVAA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 245 KARLFeagspTRARQAAVCVDDVWGRRAADVAAQGAATPITVSTTGPAD-WSVVRTvrtdagSQTVLiagPDGAEtemTV 323
Cdd:TIGR01087 196 KLKIF-----ARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKDAErGLCIRD------GGLYL---KPNDL---EG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 324 PLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAH-VAVPGRLEKVERGQEFLAVVDY-AHKPAAVEAVLATLGAQtrgrl 401
Cdd:TIGR01087 259 SLLGLHNAENILAAIALAKSLGLNLEAILEALRSfKGLPHRLEYVGQKNGVHFYNDSkATNVHATLAALSAFDNP----- 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 402 aVVLGAGG-DRDTEKRPLMGAAAARGADLVIVTDDNPRSeppadiraavlagARSVDAARGEIREIGDRRDAIAAAVDWA 480
Cdd:TIGR01087 334 -VILIVGGdDKGADFSPLAPAAAGKVKAVLAIGEDAAKI-------------APLLKEAGLSVYLVESLEEAVQAAREVA 399
|
....*....
gi 497364317 481 RPGDVVLIA 489
Cdd:TIGR01087 400 SPGDVVLLS 408
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
360-446 |
2.34e-22 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 91.64 E-value: 2.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 360 VPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTRGRLAVVLGAGGDRDTEKRPLMGAAAARGADLVIVTDDNPRS 439
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADVVILTGDYPRA 80
|
....*..
gi 497364317 440 EPPADIR 446
Cdd:pfam02875 81 EDPGAII 87
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
24-492 |
5.11e-21 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 96.32 E-value: 5.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 24 LSALAAGFGLELHGD-DRDVSGATLRAQDAGAGYLFAALPGDRTHGANYAAQaraagaagVLTDPAGLALIrEDPEAADV 102
Cdd:COG0770 5 LAEIAEATGGRLIGDpDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQ--------ALAKGAAAALV-SRPLPADL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 103 TVLVHARPREVLGAVsARIYGDpSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGlvgTV-----EIrvdGtvVPssL 177
Cdd:COG0770 76 PLIVVDDTLKALQQL-AAAHRA-RFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLA---TPgnfnnEI---G--VP--L 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 178 TtpeapdLQRMfavmaERGVDTVVMEVS-SHAlalgrvdG-----CHFA---VGGFTNLSQDHLDYHRTMDEYFAAKARL 248
Cdd:COG0770 144 T------LLRL-----PEDHEFAVLEMGmNHP-------GeiaylARIArpdIAVITNIGPAHLEGFGSLEGIARAKGEI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 249 FEAGSPTRArqAAVCVDDvwgRRAADVAAQGAATPITVSTTGPADWSVvRTVRTDAGSQTVLIAGPDGaETEMTVPLPGA 328
Cdd:COG0770 206 FEGLPPGGV--AVLNADD---PLLAALAERAKARVLTFGLSEDADVRA-EDIELDEDGTRFTLHTPGG-ELEVTLPLPGR 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 329 YNVANALLAVAMTVAAGTDVDTAVAGLAHV-AVPGRLEKVERGQEFLaVVDYAHK--PAAVEAVLATLGAQ-TRGRLAVV 404
Cdd:COG0770 279 HNVSNALAAAAVALALGLDLEEIAAGLAAFqPVKGRLEVIEGAGGVT-LIDDSYNanPDSMKAALDVLAQLpGGGRRIAV 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 405 LGA----GGDRDTEKRPLMGAAAARGADLVIVTDDNprseppadirAAVLAGArsvdAARGEIREIGDRRDAIAAAVDWA 480
Cdd:COG0770 358 LGDmlelGEESEELHREVGELAAELGIDRLFTVGEL----------ARAIAEA----AGGERAEHFEDKEELLAALKALL 423
|
490
....*....|..
gi 497364317 481 RPGDVVLIagKG 492
Cdd:COG0770 424 RPGDVVLV--KG 433
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
104-488 |
7.39e-18 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 86.95 E-value: 7.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 104 VLVHARPREVLGAV--SARIygdpsSRLTLIGITGTSGKTTTAYLAEAALRAAGR---VVGLVGtveirvdgtvVPSSlt 178
Cdd:PRK14106 86 VQAHKKGIEVIGEVelAYRF-----SKAPIVAITGTNGKTTTTTLLGEIFKNAGRktlVAGNIG----------YPLI-- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 179 tpeapdlqrmFAVMAERGVDTVVMEVSSHALALgrVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAGSPTRAr 258
Cdd:PRK14106 149 ----------DAVEEYGEDDIIVAEVSSFQLET--IKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDY- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 259 qAAVCVDDvwgrraadvaaqgaatPITVSTTGPADWSVV---RTVRTDAG---SQTVLIAGPDGAETEM----TVPLPGA 328
Cdd:PRK14106 216 -TVLNYDD----------------PRTRSLAKKAKARVIffsRKSLLEEGvfvKNGKIVISLGGKEEEVididEIFIPGE 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 329 YNVANALLAVAMTVAAGTDVDTAVAGLahvavpGRLEKVERGQEFLAVVD--------YAHKPAAVEAVLATLGAqtrgr 400
Cdd:PRK14106 279 HNLENALAATAAAYLLGISPDVIANTL------KTFKGVEHRIEFVAEINgvkfindsKGTNPDAAIKALEAYET----- 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 401 lAVVLGAGG-DRDTEKRPLMGAAAARGADLVIVtddnprSEPPADIRAAVLagarsvDAARGEIREIGDRRDAIAAAVDW 479
Cdd:PRK14106 348 -PIVLIAGGyDKGSDFDEFAKAFKEKVKKLILL------GETAQEIAEAAR------KYGFDNILFAETLEEAVKKAYEI 414
|
....*....
gi 497364317 480 ARPGDVVLI 488
Cdd:PRK14106 415 AKPGDVVLL 423
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
112-492 |
1.78e-15 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 79.27 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 112 EVLGAVSARIYGdpssrltlIGITGTSGKTTTAYLAEAALRAAGrvvglvgtveirVDGTVVPSSLTtPEAPDLQRmfav 191
Cdd:TIGR01082 90 EMLAELMRFRHS--------IAVAGTHGKTTTTAMIAVILKEAG------------LDPTVVVGGLV-KEAGTNAR---- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 192 maERGVDTVVMEV---SSHALALGrvdgCHFAVggFTNLSQDHLD-YHRTMDEYFAAKARlFEAGSPTRARqAAVCVDDV 267
Cdd:TIGR01082 145 --LGSGEYLVAEAdesDASFLHLQ----PNVAI--VTNIEPDHLDtYGSSFERLKAAFEK-FIHNLPFYGL-AVICADDP 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 268 WGRRAADVAAQGAATPitvstTGPADWSVVRTVRTDA--GSQTVLIAGPDGAETEMTVPLPGAYNVANALLAVAMTVAAG 345
Cdd:TIGR01082 215 VLRELVPKATEQVITY-----GGSGEDADYRAENIQQsgAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELG 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 346 TDVDTAVAGLAHVAVPG-RLEKVERGQEFLAVVDYAHKPAAVEAVLATL-GAQTRGRLAVVLGAggDRDTEKRPLMG--A 421
Cdd:TIGR01082 290 IDFEAILRALANFQGVKrRFEILGEFGGVLLIDDYAHHPTEIKATLKAArQGYPDKRIVVVFQP--HRYSRTRDLFDdfA 367
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497364317 422 AAARGADLVIVTDDNPRSE-PPADIRAAVLAGARSVdaaRGEIREI--GDRRDAIAAAVDWARPGDVVLIAGKG 492
Cdd:TIGR01082 368 KVLSDADELILLDIYAAGEePINGIDGKSLARKITQ---LGKIEPYfvPDLAELVEFLAAVLQSGDLILTMGAG 438
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
50-490 |
4.83e-13 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 71.53 E-value: 4.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 50 QDAGAGYLFAALPGDRTHGANYAAQARAAGAAGVLTDPaglaliREDPEAADVTVLVHArPREVLGAVsARIYGDPSSrL 129
Cdd:TIGR01143 4 RAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDR------EVGPDNGLPQILVDD-TLEALQAL-ARAKRAKFS-G 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 130 TLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEirvdgtvvpSSLTTPeapdlqrMFAVMAERGVDTVVMEVS---- 205
Cdd:TIGR01143 75 KVIGITGSSGKTTTKEMLAAILSHKYKVFATPGNFN---------NEIGLP-------LTLLRAPGDHDYAVLEMGashp 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 206 ---SHALALGRVDgchfaVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAGSPTRArqAAVCVDDVWGrraADVAAQGAAT 282
Cdd:TIGR01143 139 geiAYLAEIAKPD-----IAVITNIGPAHLEGFGSLEGIAEAKGEILQGLKENGI--AVINADDPAF---ADLAKRLPNR 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 283 PITVSTTGPADWSVVRTVRTDAGSQTVLIAGPDGaETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAHVA-VP 361
Cdd:TIGR01143 209 NILSFGFEGGDFVAKDISYSALGSTSFTLVAPGG-EFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKlVK 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 362 GRLEKVERGQefLAVVD--YAHKPAAVEAVLATLGAQTRGRLAvVLGA----GGDRDTEKRPLMGAAAARGADLVIVTDD 435
Cdd:TIGR01143 288 GRFEVQTKNG--LTLIDdtYNANPDSMRAALDALARFPGKKIL-VLGDmaelGEYSEELHAEVGRYANSLGIDLVFLVGE 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 497364317 436 NprseppadirAAVLAGARSVdaargEIREIGDRRDAIAAAVDWARPGDVVLIAG 490
Cdd:TIGR01143 365 E----------AAVIYDSFGK-----QGKHFADKDELLAFLKTLVRKGDVVLVKG 404
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
21-364 |
1.38e-09 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 60.82 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 21 PVALSALAAGFGLELHGDDRDVSGATLRAQDAGAGYLFAALPGDRTHGANYAAQARAAGaagvltdpAGlALIREDPEAA 100
Cdd:PRK10773 3 SVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAG--------AG-ALLVSRPLDI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 101 DVTVLVHARPREVLGAVSARIYGDPSSRltLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDgtvVPSSL--T 178
Cdd:PRK10773 74 DLPQLVVKDTRLAFGQLAAWVRQQVPAR--VVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIG---VPLTLlrL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 179 TPEapdlqRMFAVMaERGVD-------TVVMEVSSHALAlgrvdgchfavggfTNLSQDHLDYHRTMDEYFAAKARLFeA 251
Cdd:PRK10773 149 TPE-----HDYAVI-ELGANhqgeiayTVSLTRPEAALV--------------NNLAAAHLEGFGSLAGVAKAKGEIF-S 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 252 GSPTRAR-------------QAAVCVDDVWgrraadvaaqgaatPITVSTTGPADWSVVRTVRTDAGSQTVLIAgPDGaE 318
Cdd:PRK10773 208 GLPENGIaimnadsndwlnwQSVIGSKTVW--------------RFSPNAANSVDFTATNIHVTSHGTEFTLHT-PTG-S 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 497364317 319 TEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAHV-AVPGRL 364
Cdd:PRK10773 272 VDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLkAVPGRL 318
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
109-255 |
4.92e-08 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 56.32 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 109 RPREVLGAVSARIYGD-PSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVVPSSLTTpeAPDLQR 187
Cdd:PRK14016 459 KPRNVGEAIVDMLFPEgDDGRIPIVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGVYIDGRLIDKGDCT--GPKSAR 536
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497364317 188 MfaVMAERGVDTVVMEVSSHAL---ALGrVDGCHfaVGGFTNLSQDHL--DYHRTMDEYFAAKARLFEAGSPT 255
Cdd:PRK14016 537 R--VLMNPDVEAAVLETARGGIlreGLA-YDRCD--VGVVTNIGEDHLglGGINTLEDLAKVKRVVVEAVKPD 604
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
129-490 |
1.48e-07 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 55.10 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 129 LTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVVPSSLTtpeAPDLQRMFAVMaERGVDTVvMEVSSHA 208
Cdd:PRK11929 603 LPVVAITGSNGKTTTKEMIAAILAAWQGEDRVLATEGNFNNEIGVPLTLL---RLRAQHRAAVF-ELGMNHP-GEIAYLA 677
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 209 lALGRVDgchfaVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAgsptrARQAAVCV---DDVW--------GRRAADVAA 277
Cdd:PRK11929 678 -AIAAPT-----VALVTNAQREHQEFMHSVEAVARAKGEIIAA-----LPEDGVAVvngDDPYtaiwaklaGARRVLRFG 746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 278 QGAATPITVSTTGPaDWSVVRtvRTDAGSQTVLIAGpdgaETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGL-A 356
Cdd:PRK11929 747 LQPGADVYAEKIAK-DISVGE--AGGTRCQVVTPAG----SAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLeR 819
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 357 HVAVPGRLEKVERGQEFLAVVD-YAHKPAAVEAVLATLGAQTRGRLAVVLG----AGGDRDTEKRPLMGAAAARGADLVI 431
Cdd:PRK11929 820 FQPVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGdmleLGDNGPAMHREVGKYARQLGIDALI 899
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 497364317 432 VTDDNPRseppaDIRAAVLAGARSVDAARGEIreigdrrdaIAAAVDWARPGDVVLIAG 490
Cdd:PRK11929 900 TLGEAAR-----DAAAAFGAGARGVCASVDEI---------IAALRGALPEGDSVLIKG 944
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
94-615 |
9.11e-07 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 52.57 E-value: 9.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 94 REDPEAAdvtVLVHARPREVLGAVSARIYGDPSSRLTLIGITGTSGKTTTAYLAEAALRAAGRVVGLVGTVEIRVDGTVV 173
Cdd:COG3321 870 REDAAAA---LLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALA 946
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 174 PSSLTTPEAPDLQRMFAVMAERGVDTVVMEVSSHALALGRVDGCHFAVGGFTNLSQDHLDYHRTMDEYFAAKARLFEAGS 253
Cdd:COG3321 947 AAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAA 1026
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 254 PTRARQAAVCVDDVWGRRAADVAAQGAATPITVSTTGPADWSVVRTVRTDAGSQTVLIAGPDGAETEMTVPLPGAYNVAN 333
Cdd:COG3321 1027 LLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAAL 1106
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 334 ALLAVAMTVAAGTDVDTAVAGLAHVAVPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTRGRLAVVLGAGGDRDT 413
Cdd:COG3321 1107 LLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAAALA 1186
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 414 ekRPLMGAAAARGADLVIVTDDNPRSEPPADIRAAVLAGARSVDAARGEIREIGDRRDAIAAAVDWARPGDVVLIAGKGH 493
Cdd:COG3321 1187 --AALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALAL 1264
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 494 EKGQEIDGVKHPFDDRQVLGELLSDRAAAPSTALRVLIADPAAGVDEARRAVRDLVALAADTGVGSAHRTGDAAHRTWVI 573
Cdd:COG3321 1265 LAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAALALA 1344
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 497364317 574 FGEFADVDGRDENARCIDHDGLGRQIVRLAVDKVIAVGDTVR 615
Cdd:COG3321 1345 AAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAAAVA 1386
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
77-588 |
2.76e-06 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 51.03 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 77 AAGAAGVLTDPAGLALIREDPEAADVTVLVHARPREVLGAVSARIYGDPSSRLTLIGI-TGTSGKTTTAYLAEAALRAAG 155
Cdd:COG3321 872 DAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALlALVALAAAAAALLALAAAAAA 951
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 156 RVVGLVGTVEIRVDGTVVPSSLTTPEAPDLQRMFAVMAERGVDTVVMEVSSHALALGRVDGCHFAVGGFTNLSQDHLDYH 235
Cdd:COG3321 952 AAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAALLAAA 1031
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 236 RTMDEYFAAKARLFEAGSPTRARQAAVCVDDVWGRRAADVAAQGAATPITVSTTGPADWSVVRTVRTDAGSQTVLIAGPD 315
Cdd:COG3321 1032 AAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAALLLLAL 1111
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 316 GAETEMTVPLPGAYNVANALLAVAMTVAAGTDVDTAVAGLAHVAVPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGA 395
Cdd:COG3321 1112 LAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAAALAAALAG 1191
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 396 QTRGRLAVVLGAGGDRDTEKRPLMGAAAARGADLVIVTDDNPRSEPPADIRAAVLAGARSVDAARGEIREIGDRRDAIAA 475
Cdd:COG3321 1192 LAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALALLAAAAGL 1271
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 476 AVDWARPGDVVLIAGkGHEKGQEIDGVKHPFDDRQVLGELLSDRAAAPSTALRVLIADPAAGVDEARRAVRDLVALAADT 555
Cdd:COG3321 1272 AALAAAAAAAAAALA-LAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAALALAAAAAAA 1350
|
490 500 510
....*....|....*....|....*....|...
gi 497364317 556 GVGSAHRTGDAAHRTWVIFGEFADVDGRDENAR 588
Cdd:COG3321 1351 AAAAAAAAAAAALAAAAGAAAAAAALALAALAA 1383
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
323-445 |
2.16e-04 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 44.42 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497364317 323 VPLPGAYNVANAllAVAMTVAA--GTDVDTAVAGLAHVA-VPGRLEKVERGQEFLAVVDYAHKPAAVEAVLATLGAQTrG 399
Cdd:PRK14573 265 LNLVGMHNVANA--AAAMGIALtlGIDEGAIRNALKGFSgVQRRLERKNSSETFLFLEDYAHHPSEISCTLRAVRDAV-G 341
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 497364317 400 RLAVVLGAGGDRDTEKRPLMGA--AAARGADLVIVTDDNPRSEPPADI 445
Cdd:PRK14573 342 LRRIIAICQPHRFSRLRECLDSfpSAFQDADEVILTDVYSAGEEPEDS 389
|
|
| |
