|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
6-395 |
1.74e-102 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 309.16 E-value: 1.74e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 6 KAMRILLAGFCINLCLGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGL 85
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 86 GMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHaSKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTS 165
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 166 FLVLGVGILAIAVPLAATINNPPADYTPAEPKVkegQAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNI 245
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDP---LANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 246 TTIAS--VQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATF-KTEFTLIIGTAIAAVG 322
Cdd:cd17353 237 KPIGQefAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIgSVAVLFVLGVALIGFC 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497389965 323 YGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGdGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17353 317 YGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG-GYNAAFIIAAALSLVALALALL 388
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-405 |
7.79e-69 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 222.83 E-value: 7.79e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 6 KAMRIL-LAGFCINLCLGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTG 84
Cdd:COG2223 2 GRWRVLlLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 85 LGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQT 164
Cdd:COG2223 82 IGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 165 SFLVLGVGILAIAVPLAATINNPPADYTPAEpkvkegqapkvvkKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGN 244
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAA-------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 245 ITTIASVQANLP--NAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTL-IIGTAIAAV 321
Cdd:COG2223 228 LPPYLVDQFGLSaaTAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 322 GYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFITKPLTE 401
Cdd:COG2223 308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
....
gi 497389965 402 AKVA 405
Cdd:COG2223 388 RAAA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-396 |
3.85e-39 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 144.34 E-value: 3.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 9 RILLAGFCINLCL--GILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLG 86
Cdd:cd17355 2 WVVLAVTFLILILswGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 87 MIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSF 166
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 167 LVLGVGILAIAVPLAATINNPPADYTPAEPKVKEGQAPkvvkksdDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNIT 246
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASP-------GSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 247 TIASVQANLP-NAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIA-AVGYG 324
Cdd:cd17355 235 PYLADRGISPaAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497389965 325 TLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFIT 396
Cdd:cd17355 315 ATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-401 |
2.65e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 116.89 E-value: 2.65e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINLCLGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIA 89
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 90 SGFVNSPLMLNITFgVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVL 169
Cdd:COG2271 92 FGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 170 GVGILAIAVplaatinnppadytpaepkvkegqapkvvkksddltwkamlktPQFYSLWIMYAFAASVGLMIIGNITTIA 249
Cdd:COG2271 171 GLPGLLLAL-------------------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 250 SVQANLP--NAVYLASILAVFNSGGRVAAGMLADKIG--GVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGT 325
Cdd:COG2271 208 VEVRGLSlaQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497389965 326 LLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGdGYGLAYTISAVMMAVCIVLAFITKPLTE 401
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-393 |
6.25e-29 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 116.36 E-value: 6.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 19 LCLGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLM 98
Cdd:cd17314 14 MSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 99 LNITFGVITGAGIGFGYACLSPSAMKWFhASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAV 178
Cdd:cd17314 94 LSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 179 PLAATINNPPADytpaepkvkeGQAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNA 258
Cdd:cd17314 173 VVSLLGFKEPPD----------NQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 259 VY--LASILAVFNSGGRVAAGMLADKIGG---VRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTL 333
Cdd:cd17314 243 FVtkLMSIYGLFNAFGRLLWGIVADFFGGrlsTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPAT 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 334 TAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLA 393
Cdd:cd17314 323 VSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAIL 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
10-395 |
3.16e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 108.81 E-value: 3.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINLCLGI-LYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMI 88
Cdd:COG2807 19 LLLAIVLVALNLRPaITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 89 ASGFVNSPLMLNITFGVItGAGIGFGYACLSPSAMKWFhASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLV 168
Cdd:COG2807 99 LRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 169 LGVGILAIAVPLAATINNPPADYTPAEPKVkegqapkvvkksddlTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTI 248
Cdd:COG2807 177 WALLALLALLLWLPLLRRRPAAAAAAPAAA---------------SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 249 AsVQANLP--NAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTL 326
Cdd:COG2807 242 L-RDAGLSaaTAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 327 LAVFPTLTAE-FYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:COG2807 321 FPLALTLIGLrARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-360 |
4.04e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 4.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 1 MSKIDKAMRILLAGFCINLCLGIL--YAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILIL 78
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLgiGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 79 GTVLTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALID 158
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 159 SMGIQTSFLVLGVGILAIAVPLAATINNPPADYTPAEPKvkegqapkvvkksddlTWKAMLKTPQFYSLWIMYAFAASVG 238
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG----------------SLRELLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 239 LMIIGNITTIASVQANLPNAVY--LASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGT 316
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAglLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 497389965 317 AIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAI 360
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
10-395 |
1.72e-22 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 97.62 E-value: 1.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINLC-LGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMI 88
Cdd:cd17352 4 VVFASFLVNFFtDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 89 ASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFhASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLV 168
Cdd:cd17352 84 LSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 169 LGvGILAIAVPLAATInnppadytpaepkvkegqapkvvkksddltwkAMLKTPqFYSLWIMYAFAASVGLMI--IGNIT 246
Cdd:cd17352 163 LG-GLCLNLCVCGLLL--------------------------------RLLKDP-TFVLLALGVSFAMLGFFVpfVYLPS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 247 TIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKiGGVRTLLLAFVLQGIN--MVLFATFKTEFTLIIGTAIA-AVGY 323
Cdd:cd17352 209 YAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-PRIGRLYLYIFTLLILglSLLAFPLATTYVGLIVFSVLfGFCS 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497389965 324 GTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17352 288 GSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-362 |
1.29e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 1.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINLCLGILyaWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIA 89
Cdd:pfam07690 1 LFLAAFLAALGRSLL--GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 90 SGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVL 169
Cdd:pfam07690 79 LLFASSLWLL-LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 170 GVGILAIAVPLAATINNPPADYTPAEPKvkegqapkvVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIA 249
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEE---------ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 250 SVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQ---GINMVLFATFKTEFTLIIGTAIAAVGYGTL 326
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilaALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
330 340 350
....*....|....*....|....*....|....*.
gi 497389965 327 LAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGA 362
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-397 |
1.31e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 95.34 E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINLCLGILYawSVFNKaLVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIA 89
Cdd:cd17325 1 LSLALFLDMLGYGIII--PILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 90 SGFVNSPLMLnitfgVITGAGIGFGYACLSPSAMKW----FHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTS 165
Cdd:cd17325 78 FAFATSYWQL-----LLARFLQGLASAAVWPAAMALiadiAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 166 FLVLGVGILAIAVPLAATInnppadytpaEPKVKEGQAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNI 245
Cdd:cd17325 153 FLVCAALALLALVLALLLL----------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 246 TTIASVQANLPNAV--YLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGY 323
Cdd:cd17325 223 PLYAAELGGLSPAQigLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497389965 324 GTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGdGYGLAYTISAVMMAVCIVLAFITK 397
Cdd:cd17325 303 GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
11-395 |
2.10e-17 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 83.07 E-value: 2.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 11 LLAGFCINLCLGILYAWSVFNKALVTESGWSAAEaSAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLG-MIA 89
Cdd:cd17354 6 FVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQ-NNLLSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGyGVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 90 SGFVNSPL------MLNITFGVITGAGIGFGYACLSpSAMKWFHASKkGMVNGIIAAGFGLAAIYLAPVTSALI--DSMG 161
Cdd:cd17354 85 WLVVTGLIsdlsfwLMCLCFFLIGNSTSSLYTAALV-TCAKNFPESR-GLAIGIPKGCYGLSGAIGSQLYKALFfhDSAR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 162 IqtsFLVLGVGILAIAVPLAATInnppadytpaepkvkegqapKVVKKSDDLtwkaMLKTPQFYSLWIMYAFAASVGLMI 241
Cdd:cd17354 163 V---FLFLAVLPAVVGLLAWFSV--------------------RIVSIEEGE----FLKDIDFWLLFISLFLGVGPGEMF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 242 IGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTL--LLAFVLQGINMVL-FATFKTEF---TLIIG 315
Cdd:cd17354 216 INNLGQIGQSLTGPSNTSTLVSLFSIFSFLGRLLSGLLSDLFVRKFRLprPSRMVLLLLILSLgHLLQAFGLpsgALYVA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 316 TAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17354 296 SALIGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYDNGGEGAGSDDLSCIGPHCFSLTFL 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-394 |
2.34e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.08 E-value: 2.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 23 ILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnIT 102
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLL-LL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 103 FGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSmgIQTSFLVLGVGILAIAVPLAA 182
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS--LGFGWRAVFLIAAALALLAAI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 183 TINNPPADYTPAEPKVKEGQAPKVVKKSddltWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAV--Y 260
Cdd:cd06174 168 LLLLVVPDPPESARAKNEEASSKSVLKL----LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVagL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 261 LASILAVFNSGGRVAAGMLADKIGGVRTLLLA-FVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYG 339
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 497389965 340 LKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAF 394
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
62-335 |
2.13e-14 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 74.39 E-value: 2.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 62 VAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGyacLSPSAM---KWFHaSKKGMVNGII 138
Cdd:TIGR00892 73 ISSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFN---FQPSLTmlgKYFY-RRRPLANGLA 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 139 AAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGvGILAIAVPLAATINNPPADYTPAEPKVKEG--QAPKVVKKSDDLTWK 216
Cdd:TIGR00892 149 MAGSPVFLSTLAPLNQYLFESFGWRGSFLILG-GLLLHCCVCGALMRPVGPSQRVSKSKSKEGlpPDGSTKKLSKKSTAE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 217 AMLKTPQF-------YSLWIMYAFAASVGL----MIIGNITTIASVQANlpNAVYLASILAVFNSGGRVAAGMLADKiGG 285
Cdd:TIGR00892 228 KINRFLDFslfthrgFLVYLSGNVIMFLGFfapiIFLVPYAKDKGVDEY--EAAFLLSIIGFVDIFARPSCGLIAGL-KW 304
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 497389965 286 VRTLL-----LAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAV-FPTLTA 335
Cdd:TIGR00892 305 IRPHVqylfsFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALlFEVLMD 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
11-394 |
7.86e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 72.28 E-value: 7.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 11 LLAGFCINLCLGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIAS 90
Cdd:cd17341 2 HLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 91 GFVNSPLMLNITFGVITGAGiGFGYACLSPSAMKWFHASKKGMVNGIIA----AGFGLAAIYLAPVTSALI---DSMGIQ 163
Cdd:cd17341 82 ALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVfdgGFVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 164 TSFLVLGVGILAIAVPLAATINNPPADytpaepkvkegqapkvvKKSDDLTWKAMLKTPQFYSLWIM-----YAFAASVG 238
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTG-----------------KASALEFLKVQLAVLKNYRTWILsllygVTFGSFVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 239 LMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAI 318
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 319 AA---------VGYGTLLAVFPtltaeFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVC 389
Cdd:cd17341 304 ALfvalglgagAGNGSVFRMVP-----FIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVAC 378
|
....*
gi 497389965 390 IVLAF 394
Cdd:cd17341 379 TLLVW 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-403 |
2.85e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.65 E-value: 2.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 6 KAMRILLAGFCINLCLGILYA-WSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTG 84
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATAlWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 85 LGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNgIIAAGFGLAAIYLAPVTSALID---SMG 161
Cdd:COG0738 85 LGLLLFALAPSYPLL-LLALFLLGLGLGLLDVAANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILlglSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 162 IQTSFLVLGVGILAIAVPLAATinnppadytpaepKVKEGQAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMI 241
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRS-------------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 242 IGNITTIASVQANLP--NAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIA 319
Cdd:COG0738 230 GDWLPLYLKDVLGLSeaTAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 320 AVGYGTLLAVFPTLTAEFYGlKNYGTNYGVLYTAWGIGGAIGAAVVGFsMTNGDGYGLAYTISAVMMAVCIVLAFITKPL 399
Cdd:COG0738 310 GLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGF-LADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
....
gi 497389965 400 TEAK 403
Cdd:COG0738 388 RRKK 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
39-392 |
5.05e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.93 E-value: 5.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 39 GWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACL 118
Cdd:cd17489 27 GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL-LVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 119 SPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVlGVGILAIAVPLAATINNPPadytpaePKV 198
Cdd:cd17489 106 ATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-AAVLALLALLLVFLVKDPP-------PVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 199 KEGQAPKVVKKSDDLTWKAMLKTpqfyslwiMYAFAASVGLMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGM 278
Cdd:cd17489 178 AEEAEAGTRAFRRLVEKKVLPPA--------LILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 279 LADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGtllAVFPTLTAEFYGL---KNYGTNYGVLYTAWG 355
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFG---LLFPALQALAVDLvppHRRGAANGTFFIFFD 326
|
330 340 350
....*....|....*....|....*....|....*..
gi 497389965 356 IGGAIGAAVVGFSMTNGdGYGLAYTISAVMMAVCIVL 392
Cdd:cd17489 327 LGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVL 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-395 |
3.63e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.23 E-value: 3.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 33 ALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNItFGVITGAGIG 112
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 113 FGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAATINnppadyt 192
Cdd:cd17365 103 AAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTLL------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 193 paepkvkegqapkvvkksddltwkamlktpqfysLWIMYaFAASVGLMIIGNITTIASVQANLPnAVYLASILAVFNSG- 271
Cdd:cd17365 176 ----------------------------------LWVTF-FMGLLLVYLLNSWLPKLMVEAGYS-LSQALTITLLLNIGg 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 272 --GRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLiIGTAIAAVGYGTL--LAVFPTLTAEFYGLKNYGTNY 347
Cdd:cd17365 220 viGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVL-LYVLVFLAGACVNgaQVGLYALAARFYPTEVRATGV 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 497389965 348 GVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17365 299 GWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
26-395 |
5.90e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 66.44 E-value: 5.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 26 AWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGV 105
Cdd:cd17319 21 NISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL-YVLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 106 ITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVgilaIAVPLAatin 185
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGL----LGLLLA---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 186 nppadytpaepkvkegqapkvvkksddLTWKAMLktPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAV--YLAS 263
Cdd:cd17319 172 ---------------------------VLWWFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQvgLLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 264 ILAVFNSGGRVAAGMLADKIGGVRTLLLAFV---LQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGL 340
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLLRGARRLVIIIgllLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 497389965 341 KNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17319 303 EAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
58-395 |
6.62e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 6.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 58 ICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnitfgVITGAGIGFGYACLSPSAM----KWFHASKKGM 133
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-----LASRALLGIGVAGIMTLATaligDYFEGEERAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 134 VNGIIAAGFGLAAIyLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAatinnppadYTPAEPKVKEGQAPKVVKKSDDL 213
Cdd:cd17473 125 MLGLQSAAMSLGGV-VFLLLGGALAEIGWRAPFLVYLLALPVLILVLL---------FLPEPARKSKSAASPGAATAAAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 214 TWKAMLktpqfysLWIMYAFAASVGLMIIgnITTIASV--QANLPNAVYLASILAVFNSGGRVAA---GMLADKIGGVRT 288
Cdd:cd17473 195 PWKRVL-------PIYFLAFLAMLLFYVI--PIQLPFLlqERGGGSAALIGLALAIASLAGAIGAllfGRLKRRLGKRRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 289 LLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFS 368
Cdd:cd17473 266 LAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
|
330 340
....*....|....*....|....*..
gi 497389965 369 MTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17473 346 VNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
20-360 |
3.89e-11 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 64.28 E-value: 3.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 20 CLGILYAWSVFNK--------ALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASG 91
Cdd:cd17343 7 SMFVGYTLYYFNRksfsfvlpSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 92 FVNSPLMLNItFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAiYLAP-VTSALIDSMGIQTSFLVLG 170
Cdd:cd17343 87 GSSSVWVFSI-LWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAG-SLGPiLATLLALSYGWRSTLSISG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 171 VGILAIAVPLAATINNPPADYTPAEPKVKEGQAPKVVKKSDDLTWKAMLKTPQFY--SLWIMYAFAASVGLMIIGNITTI 248
Cdd:cd17343 165 TVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWllSLGYLVVFGVKTAVTDWGQLFLI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 249 ASVQANLPNAVYLASILAVFNSGGRVAAGMLADKI---------GGVR-TLLLAFVL-QGINMVLFATFKTE-----FTL 312
Cdd:cd17343 245 QDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhgsssrGNPRmPLALVFMAgLTVSLHLFRVHITSdsselFIL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 497389965 313 IIGTAIAAVGYGTlLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAI 360
Cdd:cd17343 325 LLGFLIGFSLYGP-IAIFGVIANESAPSHLCGTSHAIVALAANVGGVL 371
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
10-367 |
2.23e-10 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 61.64 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCIN-LCLGILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMI 88
Cdd:cd17423 4 VVLAAFLQNaLVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 89 ASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFhASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLV 168
Cdd:cd17423 84 LASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYF-SRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 169 LGvGILAIAVPLAATINNPPADYTPAEPKVKegqapkvvkksddltwkamLKTPQFYSL---WIMYAFAASVGLMIIGNI 245
Cdd:cd17423 163 LS-ALSLHLVPCGALLRPLALPGDPPAPPRS-------------------LSAAFGLSLlthRAFLRYALATTLINTGYF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 246 TTIASVQANLPN-------AVYLASILAVFNSGGRVAAGMLADkIGGVRTLLLAFV---LQGINMVLFATFKTEFTLIig 315
Cdd:cd17423 223 IPYVHLVAHARAlglgeyqAAFVVSVAAVADAVGRLFSGWLAD-LGPLRLLHLLVLwtaLTGLSLLLLPLAKVYGSLL-- 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 497389965 316 taIAAVGY----GTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGF 367
Cdd:cd17423 300 --ALAVAYgfcaGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGW 353
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-394 |
2.65e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.42 E-value: 2.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 34 LVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnitfgVITGAGIGF 113
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL-----LLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 114 GYACLSPSAMKWFHA---SKKGMVNGIIAAGfGLAAIYLAPV-TSALIDSMGIQTSFLVLGVGILAIAVPLAATINNPPA 189
Cdd:cd17478 97 GSAAFHPEGARLASQaagGRRGLAMSIFSVG-GNLGFALGPLiAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 190 DYTPAEPKVKEGQAPKVVKKS-DDLTWKAMLKTpqfyslWIMYAFAASVGLMIIGNITTIASVQanlpnavYLASILAVF 268
Cdd:cd17478 176 EAKKAAAKSSARSTLKGVWRAlLLLLIIVFLRS------WVLSSLTTFLPFYLVQRGYSLVFAG-------LLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 269 NSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFAtfkteFTLIIGTAIAAVGYGTLLAVFPTLT---AEFYGLKNYGT 345
Cdd:cd17478 243 GAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL-----LTPGIWSYILLVLAGFLLFASFPVTvvlAQELLPGNVGL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 497389965 346 NYGVLYT-AWGIGGaIGAAVVGFSMTNGdGYGLAYTISAVMMAVCIVLAF 394
Cdd:cd17478 318 ASGLMMGlSFGLGG-IGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-394 |
3.93e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.03 E-value: 3.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 53 TITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKG 132
Cdd:cd17324 44 ALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAHGGFWAIAAAYAADLVPPEKRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 133 MVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAATINNPPadytpaepkvkegqAPKVVKKSDD 212
Cdd:cd17324 123 RAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP--------------PKKPGSLGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 213 LTWKAMLKTPQfysLWIMYAFAASVGLMIIGNITTIASVQANLPNAVYLASILAVFNSG-----GRVAAGMLADKIGGVR 287
Cdd:cd17324 189 SSLLLLLRNPR---LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGvagvvGSPLAGRLADRGGRRA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 288 TLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEfYGLKNYGTNYGVLYTAWGIGGAIGAAVVGF 367
Cdd:cd17324 266 LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALGGL 344
|
330 340
....*....|....*....|....*..
gi 497389965 368 SMTNGDGYGLAYtISAVMMAVCIVLAF 394
Cdd:cd17324 345 VLDHGGWAGVGW-VGAALLLLALLLAL 370
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
22-392 |
6.24e-10 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 60.15 E-value: 6.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 22 GILYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNI 101
Cdd:cd17422 17 GVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 102 TFGVITGAGIGFGYACLSPSAMKWFhASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPla 181
Cdd:cd17422 97 TIGIISGLGYCFTFLPTVTILSQYF-KKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVC-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 182 atinnppadytpaepkvkeGQAPKVVKKSDDLtwkamlktpqFYSLWIMYA----FAASVGLMIIGNittiaSVQANLPN 257
Cdd:cd17422 174 -------------------GALLRVLKEPGFI----------CYALFGLFAtlgfFAPQLYIIPLSL-----SLGIDQDW 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 258 AVYLASILAVFNSGGRVAAGMLADK--IGGVRTLLLAFVLQGINMVLFaTFKTEF-TLIIGTAIAAVGYGTLLAVFPTLT 334
Cdd:cd17422 220 AAYMLSAMAIAELFGRISAGWVLNKcpIRKIYIELICVILLCVVLLLF-PFAYGFwSLLVCSIFYGFMFGTVAGTHIPLL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497389965 335 AE--FYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMM---AVCIVL 392
Cdd:cd17422 299 AEddVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMalgAVFLAL 361
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
34-367 |
8.01e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 60.08 E-value: 8.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 34 LVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSpLMLNITFGVITGAGIGF 113
Cdd:TIGR00881 21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS-LWVMAALWALNGIFQGM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 114 GYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMG------IQTSFLVLGVGILAIAV--PLAATIN 185
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYswhwvfIVPGIIAIIVSLICFLLlrDSPQSCG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 186 NPPAD-YTPAEPKVKEGQAPKVVKKSDDLTWKaMLKTPQFYSLWIMYAFAASVGLMII--GNI--TTIASVQANLPNAVY 260
Cdd:TIGR00881 180 LPPAEeMPNEEPDGDAEKKEEELTKKQIFLQY-VLLNKVLWYISLGYVFVYVVRTGILdwSPLylTQEKGFSKEKASWAF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 261 LASILAVFNsgGRVAAGMLADKI-GGVRTLLLAFVLQGINMVLFATFKTEFT-----LIIGTAIAAVGYGTLLaVFPTLT 334
Cdd:TIGR00881 259 TLYELGGLV--GTLLAGWLSDKLfNGRRGPLAVFFMALIIVSLLVYWLNPAAnplmdLICLFALGFLVYGPQM-LIGVIA 335
|
330 340 350
....*....|....*....|....*....|...
gi 497389965 335 AEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGF 367
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGY 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-395 |
1.54e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.16 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 9 RILLAGFCINLCLGILyaWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMI 88
Cdd:cd17329 3 VLLIGSFLNRLGFFMV--WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 89 ASGFVNSPLMLNITFgVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIyLAPVTSALIDSMGIQTSFLV 168
Cdd:cd17329 81 LLGFAHSPWLFAIAL-VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVA-IGPLLGGLLLLYSFRLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 169 LGVGILAIAVPLAATINNPPAdYTPAEPKVKEGQAPKVVKKsDDLTWKAMLktpqFYSLWIMYAFAASVGLMIIGNITTI 248
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETRP-KRRAAEKTEILRGYKIVLR-DRAFLLFLL----ASFLISLIYFQLESTLPVYVVEILG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 249 ASVQAnlpnAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLA 328
Cdd:cd17329 233 LGESL----LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFP 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497389965 329 VFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17329 309 AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-367 |
1.61e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.29 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 8 MRILLAGFCINLCLGI-LYAWSVFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLG 86
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYdLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 87 MIASGFVNSPLMLNItFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSF 166
Cdd:TIGR00895 96 TLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 167 LVLGVGILAIAVPLAATINNPpADYT--------------PAEPKVKEGQAPKVVKKSDDLTWKA---MLKTPQF----Y 225
Cdd:TIGR00895 175 YVGGIAPLLLLLLLMRFLPES-IDFLvskrpetvrrivnaIAPQMQAEAQSALPEQKSTQGTKRSvfkALFQGKTaritV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 226 SLWIMYaFAASVGLMIIGNITTIASVQANLpNAVYLASILAVFNSG---GRVAAGMLADKIGgVRTLLLAFVLQGINMVL 302
Cdd:TIGR00895 254 LLWLLY-FMLLVGVYFLTNWLPKLMVELGF-SLSLAATGGALFNFGgviGSIIFGWLADRLG-PRVTALLLLLGAVFAVL 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497389965 303 FATFKTEFTLIIgTAIAAVG--YGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGF 367
Cdd:TIGR00895 331 VGSTLFSPTLLL-LLGAIAGffVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGY 396
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
62-170 |
3.10e-09 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 58.29 E-value: 3.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 62 VAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHaSKKGMVNGIIAAG 141
Cdd:cd17427 57 ISSILVNKYGSRPVVIAGGLLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFY-KKRPIANGLAMAG 135
|
90 100
....*....|....*....|....*....
gi 497389965 142 FGLAAIYLAPVTSALIDSMGIQTSFLVLG 170
Cdd:cd17427 136 SPVFLSTLAPLNQFLFNQFGWRGSFLILG 164
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
41-394 |
5.42e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 5.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 41 SAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSP 120
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL-LVLRFLQGIGIGGEYPGAST 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 121 SAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTS----FLVLGVGILAIAvplaatinnppadytpaep 196
Cdd:cd17316 113 YVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwrilFLIGALPALLAL------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 197 kvkegqapkvvkksddLTWKAMLKtpqfysLWIMYAFAASVGLMIIGNITTIASVQANLPN--AVYLASILAVFNSGGRV 274
Cdd:cd17316 174 ----------------LLRRRTLL------LILLWFFISFGYYGLTTFLPTYLQTVLGLSPatSSLYLLLISLGALVGAL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 275 AAGMLADKIGGVRTLLLAFVLQGINMVLFATF--KTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYT 352
Cdd:cd17316 232 IAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYN 311
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 497389965 353 AWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAF 394
Cdd:cd17316 312 LGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
276-394 |
5.78e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.17 E-value: 5.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 276 AGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWG 355
Cdd:cd17370 254 AGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVG 333
|
90 100 110
....*....|....*....|....*....|....*....
gi 497389965 356 IGGAIGAAVVGFsMTNGDGYGLAYTISAVMMAVCIVLAF 394
Cdd:cd17370 334 IGWLLASLIAGY-LWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
58-397 |
1.77e-08 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 55.97 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 58 ICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHaSKKGMVNGI 137
Cdd:cd17424 53 LCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFH-KRKALAYGI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 138 IAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAATinnppadytpaepkvkegqapkvvkksddltwkA 217
Cdd:cd17424 132 AMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALM---------------------------------R 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 218 MLKTPQFYSLWIMYAFAAS-VGLMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKiggvRTL------- 289
Cdd:cd17424 179 FLLMPDFLVLAVSVLFLAYgCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDR----RCLkkyryfc 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 290 -LLAFVLQGInMVLFATFKTEFTLIIGTAIaAVGY--GTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVG 366
Cdd:cd17424 255 yLFAVGMDGL-CCLFLPILKTFPLLVPFSF-TFGYfdGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAG 332
|
330 340 350
....*....|....*....|....*....|.
gi 497389965 367 FSMTNGDGYGLAYTISAVMMAVCIVLAFITK 397
Cdd:cd17424 333 WLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
53-397 |
1.87e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.64 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 53 TITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnitfgVITGAGIGFGYACLSPSAM----KWFHA 128
Cdd:cd17321 41 LLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-----IAARALQGIGAAAIMPASLaliaATFPG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 129 SKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLgVGILAIAVPLAATInnppadytpaepkvkegqapkvvk 208
Cdd:cd17321 116 ERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN-VPIGLVALLLARTF------------------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 209 ksddltwkamlktpqFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVYLASI-LAVFNSGGRVAAGMLADKIGGVR 287
Cdd:cd17321 171 ---------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLpLALAMLVAAPLAGRLADRFGPRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 288 TLLLAFVLQGINMVLFATFKTEFT---LIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAV 364
Cdd:cd17321 236 VLVAGLLLTAVGLLLLALLGADSSvwlLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVAL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 497389965 365 VGFSMTNG----------------------DGYGLAYTISAVMMAVCIVLAFITK 397
Cdd:cd17321 316 LGALLTAGlsanlgdsgvaallsaaaaafaAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-408 |
4.64e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 4.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 12 LAGFCINLCLGILYAWsvFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRL-----ILILGTVLTGLG 86
Cdd:COG2211 17 LGDLGLNLAFGLLSAY--LLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 87 MIASGFV-NSPLMLNITFGVITGAGIGFGYACLSPSAMKWF-----HASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSM 160
Cdd:COG2211 95 FVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGaeltpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 161 GIQTS---FLVLGVGILAIAVPLAATINNPPADYTPAEPKVKEGQApkvvkksddltWKAMLKTPQFYSLWIMYAFAASV 237
Cdd:COG2211 175 GGDAAlgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES-----------LKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 238 GLMIIGNITTIASVQANLPNAVY--LASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTE--FTLI 313
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVglLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 314 IGTAIAAVGYGTLLAVFPTLTAE-------FYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNG-------------D 373
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqspsalT 403
|
410 420 430
....*....|....*....|....*....|....*
gi 497389965 374 GYGLAYTISAVMMAVCIVLAFITKPLTEAKVAQLK 408
Cdd:COG2211 404 GIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIR 438
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
62-170 |
6.79e-08 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 54.11 E-value: 6.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 62 VAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHaSKKGMVNGIIAAG 141
Cdd:cd17426 57 ISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFY-KKRPLANGLAMAG 135
|
90 100
....*....|....*....|....*....
gi 497389965 142 FGLAAIYLAPVTSALIDSMGIQTSFLVLG 170
Cdd:cd17426 136 SPVFLSTLAPLNQWFFDIFGWRGSFLILG 164
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
58-201 |
7.03e-08 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 54.07 E-value: 7.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 58 ICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYaclSPSAMKWFHASKK--GMVN 135
Cdd:cd17420 58 FCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAY---QPSLVILGHYFKRrlGLVN 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497389965 136 GIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGvgiLAIAVPLAATINNPPADYTPAEPKVKEG 201
Cdd:cd17420 135 GFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLS---LFMFVLILCSFTYRPLHPSPEDPKSKPG 197
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
60-189 |
7.17e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.17 E-value: 7.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 60 LLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNS-PLMLNITFGVitgagiGFGYACLSPSA----MKWFHASKKGMV 134
Cdd:cd17475 48 MLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSyPVLLVLLFLV------GAGYGSVQPGGgraiMRWFPPRERGLA 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 497389965 135 NGI----IAAGFGLAAIYLAPVTSAlidsMGIQTSFLVLGVGILAIAVPLAATINNPPA 189
Cdd:cd17475 122 MGIrqtgVPLGGALAAALLPPLALH----YGWRAAFVVAGLVSILAAVLFWLFYREPPA 176
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
65-170 |
9.02e-08 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 53.62 E-value: 9.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 65 ILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYAClSPSAMKWFHASKKGMVNGIIAAGFGL 144
Cdd:cd17425 60 ILVERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQS-SVTVLGFYFVRRRALANALASTGTSI 138
|
90 100
....*....|....*....|....*.
gi 497389965 145 AAIYLAPVTSALIDSMGIQTSFLVLG 170
Cdd:cd17425 139 GLTLWPLLSQYLLEEMGWRGSFLVFG 164
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
56-395 |
1.65e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.71 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 56 FSICLLVAGILQDRMGPRLILILGTVLTGLGmIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFhASKKGMVN 135
Cdd:cd17333 44 YLIGSLLAGFLMKRLGRRRTLILGLLLISLA-LALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 136 GIIAAGFGLAAIYLAPVTSALIDSmGIQTSFLVLGVGILAIAVPLAATINNPPADYTPAEPKVKEGQAPKVVKKSDDLTW 215
Cdd:cd17333 122 NVLHGFFGLGALIGPLIATSLLTS-ELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 216 KAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVYLASILavfnsgGRVAAGMLADKIGGVRTLLLAFVL 295
Cdd:cd17333 201 IILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITI------GRLLGGPISRRIKPHTLLVLSGSG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 296 QGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNyGTNYGVLYTAWGIGGAIGAAVVGFSMtNGDGY 375
Cdd:cd17333 275 ALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIA-EAVGI 352
|
330 340
....*....|....*....|
gi 497389965 376 GLAYTISAVMMAVCIVLAFI 395
Cdd:cd17333 353 QTAMLLITILYAIIFVLALL 372
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
15-305 |
2.22e-07 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 52.30 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 15 FCINLCLGILYAWSVFNKALVTES-GWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFV 93
Cdd:TIGR00886 8 FGFFLSFLVWFAFSPLAVFLIKDDlGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 94 NSPLMLNITFGVITGAGiGFGYACLSPSAMKWFHASKKGMVNGIIA----AGFGLAAIYLAPVTSALIDSMGIQT----- 164
Cdd:TIGR00886 88 VQSYSVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGQPAhlawg 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 165 --SFLVLGVGILAIAVPLAAT-INNPPADYTPAEPKVKEgqAPKVVKKSDdlTWkamlktpqFYSLWIMYAFAASVGLMI 241
Cdd:TIGR00886 167 waFVIVPAGILLLPALLIFFVgADTPPGKPATGKLSFKE--ALKVFGNRH--TW--------ILALLYSVTFGSFLGVSS 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497389965 242 IGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVL--QGINMVLFAT 305
Cdd:TIGR00886 235 IFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGvaMGAFLVVLGL 300
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
59-384 |
3.86e-07 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 51.72 E-value: 3.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 59 CLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYaclSPSAMKWFHASKK--GMVNG 136
Cdd:cd17464 59 CSPIVSVFTDLFGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAY---QPSLVILGHYFKKrlGLVNG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 137 IIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLgvGILAIAVPLAATInnppadYTPAEPKVKEGQAPKVVKKSDDLTWK 216
Cdd:cd17464 136 IVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVL--CIFMFVLFLAGFT------YKPLVPMKKDKEGKKRKFKCPPLKKI 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 217 AMLKTPQF--YSLWIMYAFAASVGLMI--IGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLL- 291
Cdd:cd17464 208 FNFNIWKStgYRIWAFGIPAALFGYFVpyVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKVYLq 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 292 --AFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSM 369
Cdd:cd17464 288 vsSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLR 367
|
330
....*....|....*
gi 497389965 370 TNGDGYGLAYTISAV 384
Cdd:cd17464 368 DRLGSYDVAFYLAGV 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
33-395 |
4.81e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.53 E-value: 4.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 33 ALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNItFGVITGAGIG 112
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI-LRALAGLGFG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 113 FGYACLSPSAMKWFHASKKGMVNGII----AAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVplaatinnpp 188
Cdd:cd17371 103 GEWAAGAALMAEYVPARHRGKALGYVqsgwAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLF---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 189 adytpAEPKVKEG----QAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLP---NAVYL 261
Cdd:cd17371 173 -----IRRFVKEPpqwqAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGErglSFEGS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 262 ASILAVFNSG---GRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLI-IGTAIAAVGYGTLLAVFPTLTAEF 337
Cdd:cd17371 248 AGYLVVTILGgflGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLIlILGFPLGFFASGPFSGMGAYLTEL 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 497389965 338 YGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17371 328 FPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
10-170 |
6.78e-07 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 50.88 E-value: 6.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINlclGILYAW----SVFNKALVTESGWSAAEasapyaTATITfSICLL-------VAGILQDRMGPRLILIL 78
Cdd:cd17430 4 VLFGCFVIT---GFSYAFpkavSVFFKELMREFGVGYSD------TAWIS-SILLAmlygtgpLCSILVNRFGCRPVMLV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 79 GTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYaclSPS--AMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSAL 156
Cdd:cd17430 74 GGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNF---QPSliMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQIL 150
|
170
....*....|....
gi 497389965 157 IDSMGIQTSFLVLG 170
Cdd:cd17430 151 LEEYGWRGGFLILG 164
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-394 |
6.84e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.06 E-value: 6.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 64 GILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGVITGAG--IGFGYACLSPSAMKWFHASKKGMVNGIIAAG 141
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL-ILGRALQGSGaiSSVVMALLADLTREENRTKAMALIGASIGIA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 142 FGLAAIyLAPVTSALIdsmGIQTSFLVLGV-GILAIAVPLAatinnppadYTPAEPKVKEGQAPKVVKKsddltwKAMLK 220
Cdd:cd17472 132 FAISMV-LGPLLAAHL---GVSGLFLITAIlSLVSLLILLF---------FVPDPPKIVQISEKEKKKL------KKLLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 221 TPQFYSLWIMyAFAASVGLMIIGNITTIASVQANLPNA----VYLASILAVFNSGgrVAAGMLADKIGGVR-TLLLAFVL 295
Cdd:cd17472 193 NKRLLRLDFS-IFILHFVLMAFFYILPLLLTQLGGGKGqlwkVYLPAILIGFILM--VPFVIYAEKKGKMKqVFVSSILL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 296 QGIN-MVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDG 374
Cdd:cd17472 270 IAVGfLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGY 349
|
330 340
....*....|....*....|
gi 497389965 375 YGLAYTISAVMMAVCIVLAF 394
Cdd:cd17472 350 SSVFLTILILALLWLLVSFL 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-395 |
1.25e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 53 TITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSplmlnITFGVITGAGIGFGYACLSPSAM----KWFHA 128
Cdd:cd17474 44 TLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS-----FALLLAGRALQGIGAAGLGPLALtligDLFEG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 129 SKKGMVNGIIAAGFGLAaIYLAPVTSALIDSMGIQTSFLVLGVGILaIAVPLAATINNPPadytpaEPKVKEGQAPKVVK 208
Cdd:cd17474 119 GERAKAMGLYEAALGLG-IAVGPLLGGLLAAISWRYPFFLLAALIP-VAFLAILFLLPEP------KEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 209 KSDDLTWKAMLKtpqFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRT 288
Cdd:cd17474 191 LKKALRGRGLLT---FLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 289 LLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFS 368
Cdd:cd17474 268 LVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLL 347
|
330 340
....*....|....*....|....*..
gi 497389965 369 MTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17474 348 LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
224-406 |
1.53e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 224 FYSLWIMYAFAASVGLMIIGNITTIA-SVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVL 302
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAaDLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 303 FATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFsMTNGDGYGLAYTIS 382
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLFGWRWVFLVN 170
|
170 180
....*....|....*....|....
gi 497389965 383 AVMMAVCIVLAFITKPLTEAKVAQ 406
Cdd:COG2814 171 AVLALLALLLLLRLLPESRPAARA 194
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-403 |
1.80e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 227 LWIMYAFAASVGLMIIGNITTIASVQANLPNAVY--LASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFA 304
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIglLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 305 TFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGdGYGLAYTISAV 384
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLILAI 159
|
170
....*....|....*....
gi 497389965 385 MMAVCIVLAFITKPLTEAK 403
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESK 178
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
50-280 |
2.46e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 2.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 50 ATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHAS 129
Cdd:COG0477 56 SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELL-IAARALQGIGAGGLMPGALALIAELFPAR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 130 KKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLV---LGVGILAIAVPLAATINNPPADYTPAEPKVKEGQAPKV 206
Cdd:COG0477 135 ERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLInapLGLLALVLRLRLPESRGLLLALLALALAALLLAALALA 214
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497389965 207 VKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLA 280
Cdd:COG0477 215 LLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-180 |
4.39e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 35 VTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITF---GVITGAGI 111
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFilwGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497389965 112 GFGYACLSPSAmkwfHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVlGVGILAIAVPL 180
Cdd:cd17370 306 SIERAAVADLV----PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF-SAVLALIALLL 369
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-395 |
7.24e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.57 E-value: 7.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 42 AAEASAPYATATITFSICL-------LVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNItFGVITGAGIGFG 114
Cdd:cd17320 26 ARDLGASASAVQLTLSAYLlgfalgqLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI-ARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 115 YACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIyLAPVT-SALIDSMGIQTSFLVLGVGILAIAVPLAAtinnppadytp 193
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPA-LAPLLgGLLLLFFGWRAIFVFLALLGLLLLLLVLL----------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 194 AEPKVKEGQAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVY--LASILAVFNSG 271
Cdd:cd17320 173 FLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFglLFALNAIALIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 272 GRVAAGMLADKIGGVRTLLLAFVLQGINMVL-----FATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGlKNYGTN 346
Cdd:cd17320 253 GSLLNGRLVRRFGPRRLLRLGLLLLLAAALVlllaaLLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 497389965 347 YGVLYTAWGIGGAIGAAVVGFSMtngDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17320 332 SALLGFLQFLIGALAGALVGLLP---NGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-181 |
1.24e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.80 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 8 MRILLAGFCINLCLGILyaWSVFNKALVTESGWSAAEASAPYATATITFSIC-LLVAGILQDRMGPRLILILGTVLTGLG 86
Cdd:cd17330 177 RRLLLVYFLIALAFAGL--ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 87 MIASGFVNSPLMLNItFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSF 166
Cdd:cd17330 255 LLLLPFASSVPLLVL-AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
170
....*....|....*
gi 497389965 167 LvLGVGILAIAVPLA 181
Cdd:cd17330 334 L-LAAGLLLIALFLL 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-184 |
1.69e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.41 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCINLCLGILYAW--SVFNKAL---VTESGWSAAeasAPYATATITfsicLLVAGILQDRMGP---RLILILGTV 81
Cdd:cd17319 184 LALGYFGINYALYGLLTWlpTYLKQARgfsLKQVGLLAA---IPFLAGAIG----MILGGRLSDRLLRgarRLVIIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 82 LTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMG 161
Cdd:cd17319 257 LAAVGLLLAYLTTSPVVA-VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335
|
170 180
....*....|....*....|...
gi 497389965 162 IQTSFLVLGVGILAIAVPLAATI 184
Cdd:cd17319 336 SYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-395 |
2.41e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 34 LVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGF 113
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 114 GYACLSPSAMKWF----HASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAAtinnppa 189
Cdd:cd06173 105 ASAFFGPARQALLpelvPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLF------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 190 dyTPAEPKVKEGQAPKVVKKSDDLTWKAMLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVY--LASILAV 267
Cdd:cd06173 178 --IRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYglLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 268 FNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNY 347
Cdd:cd06173 256 GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVF 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 497389965 348 GVLYTAWGIGGAIGAAVVGFsMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd06173 336 SVYNALNSGAMPLGALLAGL-LADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
36-392 |
2.84e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 2.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 36 TESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASgfvnsPLMLNITFGVITGAGIGFGY 115
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLL-----ALTDSPWVWFLLRFVMGIGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 116 ACLSPSAMKWFHA----SKKGMVNGIIAAGFGLAAIyLAPVTSALIDSMGiQTSFLVLGVGILAIAVPLAATINNPPADY 191
Cdd:cd17477 99 AGLFVVSESWLNAlatnENRGRVLGLYSTVLGLGFA-LGPLLLALVGTAG-ALPFLIAAVLLLLALVPLLLTRRAAPEIE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 192 TPAEPKVkegqapkvvkksddltWKAMLKTPqfysLWIMYAFAASVGLMIIGNITTIASVQANLPNAVyLASILAVFNSG 271
Cdd:cd17477 177 EAESISL----------------RRLLRIAP----LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQ-AALLLAAFVLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 272 GRVA---AGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIgtAIAAVGYGTLLAVFP---TLTAEFYGLKNYGT 345
Cdd:cd17477 236 GLLLqwpLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL--VLLFLWGGAAGPLYTlalALAGDRLPGDELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 497389965 346 NYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVMMAVCIVL 392
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
258-406 |
4.12e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 4.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 258 AVYLASILAvfnsggRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEF 337
Cdd:cd17489 39 LFTLAALLA------RPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497389965 338 YGLKNYGTNYGVLYTAWGIGGAIGAAvVGFSMTNGDGYGLAYTISAVMMAVCIVLAFITKPLTEAKVAQ 406
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPA-LGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEE 180
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
54-188 |
5.10e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.96 E-value: 5.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 54 ITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSpLMLNITFGVITGAGIGFGYACLSPSAMKWFHASKKGM 133
Cdd:cd17312 49 IAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTS-LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGT 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 497389965 134 VNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAATINNPP 188
Cdd:cd17312 128 VYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
61-394 |
5.79e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.99 E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 61 LVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLnITFGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAA 140
Cdd:cd06180 52 LLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAAL-LALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 141 GFGLA-AIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAATINNPPADYTPAEPKVKEGQAPKVVkksddltwkaml 219
Cdd:cd06180 131 GVGLGiALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPL------------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 220 ktpqfySLWIMYAFAASVGLMIIGN-ITTIASVQAN---LPNAVYLASILAVFNSGgrVAAGMLADKIGGVRTLLLAFVL 295
Cdd:cd06180 199 ------WRLALAYGLFGFGYIITATfLPLIARETGAgslLAGLLWSLFGLAAVPSC--FLWGALSDRWGTRRALAANLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 296 QGINMVLFATFKTEFTLIIGtaiaAVGYGTLLAVFPTLT---AEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNG 372
Cdd:cd06180 271 QAVGVLLPLLSPGPAGLVLS----AVLFGGTFMAITALVmalARELAPPAAPRALALMTASFGVGQILGPLLAGWLADAT 346
|
330 340
....*....|....*....|..
gi 497389965 373 DGYGLAYTISAVMMAVCIVLAF 394
Cdd:cd06180 347 GGFAPALILAAAALVVAALLAL 368
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
59-171 |
1.56e-04 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 43.63 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 59 CLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYaclSPSAMKWFHASKK--GMVNG 136
Cdd:cd17465 59 CSPVVSIFTDRFGCRKTAMGGAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAF---QPSLVILGHYFRRrlGLANG 135
|
90 100 110
....*....|....*....|....*....|....*
gi 497389965 137 IIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGV 171
Cdd:cd17465 136 VVTAGSSLFSMLLPFLLKMVGDAIGLAHTFQVLSL 170
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
218-397 |
1.72e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.30 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 218 MLKTPQFYSLWIMYAFAASVGLMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVA----AGMLADKIGGVRTLLLAF 293
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLaslpAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 294 VLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGlKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGD 373
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGL 159
|
170 180
....*....|....*....|....*.
gi 497389965 374 GYG--LAYTISAVMMAVCIVLAFITK 397
Cdd:COG0738 160 SLSwhLPYLILAVLLLLLALLFLRSK 185
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
72-393 |
2.24e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 72 PRLILILGTVLTGLGMIASGFVNSPLMLNITFGVItgagigFGYACLSPS--------AMKWFHASKKGMVNGIIAAGFG 143
Cdd:cd17485 65 RRSWLLPTQLGLALLLLALAFLPPTTNLLAFLGLL------FLLNLFSATqdiatdglAVELLTPEERGLGNAAQVVGYK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 144 LAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAATINNPPADYTPAEPKVKEGQApkvvkksddlTWKAMLKTPQ 223
Cdd:cd17485 139 LGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKA----------SLRAFLRRPG 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 224 FYSlWIMYAFAASVGLMIIGNITTIASVQA--NLPNAVYLASIL-AVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINM 300
Cdd:cd17485 209 TRW-LLLFLLLYKLGEQGALAMLPPFLVDRgfSLSQIGLLSGVGgSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 301 VLFATFKTEFTLIIGTAIAA-------VGYGTLLAVFpTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFsMTNGD 373
Cdd:cd17485 288 GLYTLLALGGSGLNWVLLLAslallhlVGGMITTALF-TLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGF-LADHL 365
|
330 340
....*....|....*....|
gi 497389965 374 GYGLAYTISAVMMAVCIVLA 393
Cdd:cd17485 366 GYAAAFLLFAILSALSVLLL 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
248-398 |
3.17e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 248 IASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLL 327
Cdd:cd06174 23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497389965 328 AVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGF-SMTNGDGYGLAYTISAVMMAVCIVLAFITKP 398
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIlASSLGFGWRAVFLIAAALALLAAILLLLVVP 174
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-182 |
3.79e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 3.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 8 MRILLAGFCINLCLGILYAWsvFNKALVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGM 87
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTF--LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 88 IASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAM-KWFHASKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSF 166
Cdd:cd17316 258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLaELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVP 337
|
170
....*....|....*.
gi 497389965 167 LVLGVGILAIAVPLAA 182
Cdd:cd17316 338 ALILALLAIVALIVAL 353
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
62-396 |
5.11e-04 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 41.72 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 62 VAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHaSKKGMVNGIIAAG 141
Cdd:cd17428 57 VCSACVSSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFD-KRRGLALGLISTG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 142 FGLAAIYLAPVTSALIDSMGIQTSFLVLG---VGILAIAVPLAATINnppadytpaepkvkegqapkvvkKSDDLTWKAM 218
Cdd:cd17428 136 SSVGLFIYAALQRELIELYGLDGCLLIVGalaLNLLACGSLMRLFKN-----------------------RVFSALFIAI 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 219 LktpqfysLWIMYAFAASVGLMIIGNITTIASVQANLPnavyLASILAVFNSGGRVAAGMLADK--IGGVRTLLLAFVLQ 296
Cdd:cd17428 193 L-------LFDIGAFPPSLLMEDVARSENIIEEIALIP----LVSIIGITTAIGKLILGVLADFkwVNSLYLYVLTLIGM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 297 GINMVLFATFKTEFTLIIGTAIAAVGYGTLlAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYG 376
Cdd:cd17428 262 GAALLAIPFAKSYLTLAVLSAILGFLSGNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYD 340
|
330 340
....*....|....*....|
gi 497389965 377 LAYTISAVMMAVCIVLAFIT 396
Cdd:cd17428 341 IAFYFSGFCVLLGGFLLLLA 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
10-170 |
5.34e-04 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 41.73 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 10 ILLAGFCIN-LCLGILYAWSVFNKALVTESGWSAAEASApyaTATITFSICLL---VAGILQDRMGPRLILILGTVLTGL 85
Cdd:cd17421 4 IVLHFFLVNvLVMGTLKTFGIFFVAFQEEFGGSSEQISW---IGSIMSSLRLSagpLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 86 GMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHaSKKGMVNGIIAAGFGLaAIYLAPVTSALIDSMGIQTS 165
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFK-KRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGA 158
|
....*
gi 497389965 166 FLVLG 170
Cdd:cd17421 159 LLIFG 163
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-146 |
8.53e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 8.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 11 LLAGFCINLCLGILYAWSVFNKALVteSGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIAS 90
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGV--LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL 251
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 497389965 91 GFVNSPLMLNITFG--VITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFGLAA 146
Cdd:cd17321 252 ALLGADSSVWLLLPglVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
55-178 |
9.66e-04 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 41.15 E-value: 9.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 55 TFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPL-MLNITFGVITGAGIGFGYACLSPSAM----KWFHAS 129
Cdd:cd17342 75 SYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLhFYNKYLYCILWVLNGLLQSTGWPCVVaimgNWFGKS 154
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 497389965 130 KKGMVNGIIAAGFGLAAIYLAPVTSALIDsMGIQTSFLVLGVGILAIAV 178
Cdd:cd17342 155 SRGFVLGLWSACASVGNIIGALLASSVLD-YGYEYAFLVTSSLLFAGAI 202
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
272-396 |
1.37e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.65 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 272 GRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLY 351
Cdd:cd17365 50 GALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMF 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 497389965 352 TAWGIGGAIGaAVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFIT 396
Cdd:cd17365 130 CGYPLGAALG-GFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT 173
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
230-398 |
1.47e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.73 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 230 MYAFAASVGLMIIGNITTIASVQANLPNA--------VYLASILAVFNSGGrvaagmLADKIGGVRTLLLAFVLQGInMV 301
Cdd:TIGR01299 174 LALMADGVEVFVVGFVLPSAEKDLCIPDSgkgmlgliVYLGMMVGAFFWGG------LADKLGRKQCLLICLSVNGF-FA 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 302 LFATFKTEF-TLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGAAVV-------GFSMTNGD 373
Cdd:TIGR01299 247 FFSSFVQGYgFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAwaiiphyGWSFQMGS 326
|
170 180
....*....|....*....|....*....
gi 497389965 374 GYGL----AYTISAVMMAVCIVLAFITKP 398
Cdd:TIGR01299 327 AYQFhswrVFVIVCAFPCVFAIGALTFMP 355
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
52-395 |
2.45e-03 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 39.81 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 52 ATITFSICLLV---AGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFGVITGAGIGFGYACLSPSAMKWFHa 128
Cdd:cd17429 44 SSLSMGITLIVgpfIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQ- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 129 SKKGMVNGIIAAGFGLAAIYLAPVTSALIDSMGIQTSFLVLGVGILAIAVPLAatinnppadytpaepkvkegqapkvvk 208
Cdd:cd17429 123 KRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGA--------------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 209 ksddLTWKAMLKTPQFYSLWIMYAFAASVGLMI----IGNITTIASVQANLPnavyLASILAVFNSGGRVAAGMLADK-- 282
Cdd:cd17429 176 ----LMRLFTNKVFVAFIFWALFAYCSFVIPFIhlpeIVKLYGLSEQNDKFP----LTSIIAIVHIFGKVILGIICDLpc 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 283 IGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGtLLAVFPTLTAEFYGLKNYGTNYGVLYTAWGIGGAIGA 362
Cdd:cd17429 248 ISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSG-YFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGP 326
|
330 340 350
....*....|....*....|....*....|...
gi 497389965 363 AVVGFSMTNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17429 327 PFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
64-392 |
3.23e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 39.53 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 64 GILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITfGVITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIAAGFG 143
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLS-RFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 144 LAAIYLAPVTSALIDSMGIQTSFLvlgVGILAIAVPLAATINNPPADYTPAEPKVKEGQAPKVVKKSDDLTWKAMLKTPQ 223
Cdd:PRK12307 153 IGNIIAAYFMPSFAEAYGWRAAFF---VGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQ 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 224 FYSLWIMYAFAASV---GLMIIGNITT-IASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGIN 299
Cdd:PRK12307 230 FPLTLCVFIVLFSIfgaNWPIFGLLPTyLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLF 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 300 MV-LFATFKTEFTLI----IGTAIAAVGYGTLLavfPTLTAEFYGLKNYGTNYGVLYTAWGIGGaIGAAVVGFSMTNGDG 374
Cdd:PRK12307 310 IFpLFRIPQDNYLLLgaclFGLMATNVGVGGLV---PKFLYDYFPLEVRGLGTGLIYNLAATSG-TFNSMAATWLGITMG 385
|
330
....*....|....*...
gi 497389965 375 YGLAYTISAVMMAVCIVL 392
Cdd:PRK12307 386 LGAALTFIVAFWTATILL 403
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
276-395 |
5.54e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 276 AGMLADKIGGVRTLLLAFVLQGINMVLFATFKTE-FTLIIGTAIAAVGYGTLLAVFPTLTAEFYGLKNYGTNYGVLYTAW 354
Cdd:cd17504 237 AGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLR 316
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 497389965 355 GIGGAIGAAVVGFSMTNGDGYGL--------AYTISAVMMAVCIVLAFI 395
Cdd:cd17504 317 TIGSAIGPAIAGAILTTYTVSITsggvptegAYVLAFLIGAALALAALL 365
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
261-395 |
5.61e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.79 E-value: 5.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 261 LASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGL 340
Cdd:cd17312 43 IGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSK 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 497389965 341 KNYGTNYGVLYTAWGIGGAIGAAVVGFSMtNGDGYGLAYTISAVMMAVCIVLAFI 395
Cdd:cd17312 123 KERGTVYGIWSTSHNFGGILAPILAASLA-SYYGWRAAFLVPGIVGLVVAIILFF 176
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
261-394 |
6.05e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 6.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 261 LASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFATFKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGL 340
Cdd:COG0477 54 IVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPA 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 497389965 341 KNYGTNYGVLYTAWGIGGAIGAAVVGFsMTNGDGYGLAYTISAVMMAVCIVLAF 394
Cdd:COG0477 134 RERGRALGLWGAAIGLGLALGPLLGGL-LVAALGWRWIFLINAPLGLLALVLRL 186
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
61-171 |
6.90e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 61 LVAGILQDRMGPRLILILGTVLTGLGMIASGFVNSPLMLNITFG-VITGAGIGFGYACLSPSAMKWFHASKKGMVNGIIA 139
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSrILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
90 100 110
....*....|....*....|....*....|..
gi 497389965 140 AGFGLAAIYLAPVTSALIDSMGIQTSFLVLGV 171
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
227-397 |
7.60e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.07 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 227 LWIMY-AFAASVGLMIIGNITTIASVQANLPNAVYLASILAVFNSGGRVAAGMLADKIGGVRTLLLAFVLQGINMVLFAT 305
Cdd:cd17333 1 LYISFfSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 306 FKTEFTLIIGTAIAAVGYGTLLAVFPTLTAEFYGlKNYGTNYGVLYTAWGIGGAIGAAVVGFSMTNGDGYGLAYTISAVM 385
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLI 159
|
170
....*....|..
gi 497389965 386 MAVCIVLAFITK 397
Cdd:cd17333 160 YLLLAILILLTL 171
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
12-178 |
7.88e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.01 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 12 LAGFCINLCLGILYAWSVFNkaLVTESGWSAAEASAPYATATITFSICLLVAGILQDRMGPRLILILGTVLTGLGMIASG 91
Cdd:cd17393 206 LLALAAALAEGAAADWSALY--LRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497389965 92 FVNSPLMLNITFGVitgagIGFGYACLSPSAMKwfHASKKGMVNGIIA----AGFGLAAIYLAPVT-SALIDSMGIQTSF 166
Cdd:cd17393 284 LAPSVWVALAGFAL-----MGLGLSVVVPLAFS--AAGALPGLAAGIAvarvATLGYLGFLVGPPLiGFLADATGLRTAF 356
|
170
....*....|..
gi 497389965 167 LVLGVGILAIAV 178
Cdd:cd17393 357 LVVALLALLVAL 368
|
|
| |
