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Conserved domains on  [gi|497574156|ref|WP_009888340|]
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BlaI/MecI/CopY family transcriptional regulator [Clostridioides difficile]

Protein Classification

BlaI/MecI/CopY family transcriptional regulator( domain architecture ID 10007832)

BlaI/MecI/CopY family transcriptional regulator similar to Mycobacterium tuberculosis transcriptional regulator BlaI and Staphylococcus aureus repressor and methicillin resistance regulatory protein MecI

CATH:  1.10.10.10
Gene Ontology:  GO:0045892|GO:0003677
PubMed:  8226686
SCOP:  4000185

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-119 7.62e-37

Transcriptional regulator, CopY/TcrY family [Transcription];


:

Pssm-ID: 442898  Cd Length: 125  Bit Score: 121.43  E-value: 7.62e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497574156   4 KLFDSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYTVIKKLVSKGAIERIEPN--FVCKALISKEEVQKQETETL 81
Cdd:COG3682    4 KLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGraYVYRPLVSREEYQAQELRDL 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 497574156  82 INKMFGGSSEKFLSAFINKENLSSDEITKLKQIVEKLK 119
Cdd:COG3682   84 LDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKK 121
 
Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-119 7.62e-37

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 121.43  E-value: 7.62e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497574156   4 KLFDSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYTVIKKLVSKGAIERIEPN--FVCKALISKEEVQKQETETL 81
Cdd:COG3682    4 KLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGraYVYRPLVSREEYQAQELRDL 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 497574156  82 INKMFGGSSEKFLSAFINKENLSSDEITKLKQIVEKLK 119
Cdd:COG3682   84 LDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKK 121
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 7-117 6.20e-28

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 98.44  E-value: 6.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497574156    7 DSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYTVIKKLVSKGAIERIE--PNFVCKALISKEEVQKQETETLINK 84
Cdd:pfam03965   3 EAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKdgRAFIYSPLVSREEYKAGQVKQLLDR 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 497574156   85 MFGGSSEKFLSAFINKENLSSDEITKLKQIVEK 117
Cdd:pfam03965  83 FFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
 
Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-119 7.62e-37

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 121.43  E-value: 7.62e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497574156   4 KLFDSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYTVIKKLVSKGAIERIEPN--FVCKALISKEEVQKQETETL 81
Cdd:COG3682    4 KLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGraYVYRPLVSREEYQAQELRDL 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 497574156  82 INKMFGGSSEKFLSAFINKENLSSDEITKLKQIVEKLK 119
Cdd:COG3682   84 LDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKK 121
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 7-117 6.20e-28

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 98.44  E-value: 6.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497574156    7 DSELKVMEVLWERGESKAGELVKILKEETGWNRNTTYTVIKKLVSKGAIERIE--PNFVCKALISKEEVQKQETETLINK 84
Cdd:pfam03965   3 EAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKdgRAFIYSPLVSREEYKAGQVKQLLDR 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 497574156   85 MFGGSSEKFLSAFINKENLSSDEITKLKQIVEK 117
Cdd:pfam03965  83 FFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 7-59 5.27e-04

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 35.96  E-value: 5.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 497574156    7 DSELKVMEVLWERGESKAGELVKILKEEtgwnRNTTYTVIKKLVSKGAIERIE 59
Cdd:pfam01978   8 EYEAKVYLALLKLGPATADEIAEESGVP----RSKVYEVLRSLEDKGLVEREK 56
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 5-59 1.62e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 34.89  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497574156   5 LFDSELKVMEVLWER-GESKAGELVKilkeETGWNRNTTYTVIKKLVSKGAIERIE 59
Cdd:COG2512   13 LLEDERRVLELLRENgGRMTQSEIVK----ETGWSKSKVSRLLSRLEERGLIEKER 64
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-57 4.29e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.56  E-value: 4.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 497574156   8 SELKVMEVLWERGESKAGELVkilkEETGWNRNTTYTVIKKLVSKGAIER 57
Cdd:COG1846   39 AQFRVLAALAEAGGLTQSELA----ERLGLTKSTVSRLLDRLEEKGLVER 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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