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Conserved domains on  [gi|497577298|ref|WP_009891482|]
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EFR1 family ferrodoxin [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 2-247 1.32e-116

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


:

Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 333.36  E-value: 1.32e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298   2 ILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDelISAGKPFIFVCPTYAWRLPIVVTDFIKETKFLGDNRVYFV 81
Cdd:NF038196   1 IFYFSGTGNSLYVAKRIAEELGDELISISKAIKEGDFK--LKEDEPIGFVFPVYAWGLPRIVEDFIKKLKLKGNKYIFAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298  82 MTCGGDTAKSINYIQKLCKYKEWQLKGMAEIKMPENYIALFSTTDKETSKQMIKEADKQIYRIISDIRNENEFeTITPSG 161
Cdd:NF038196  79 ATCGGSIGNALAQLKKLLKKKGLKLSGGFSIKMPNNYIPLFDVPSKEKAKKILKKAEEKIKEIAEKIKNRKKG-PEKKKG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 162 LGGTIKSGIINTVFYKTIISAKGFHYTDKCIGCGKCVELCPLNNINLKNKKPVWKNSCTHCMACICGCPTEAIEYKNKTQ 241
Cdd:NF038196 158 FIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGKPVWGHNCTHCLACIHRCPKEAIEYGKKTK 237


                 ....*.
gi 497577298 242 NRERYY 247
Cdd:NF038196 238 KKGRYH 243
 
Name Accession Description Interval E-value
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 2-247 1.32e-116

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 333.36  E-value: 1.32e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298   2 ILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDelISAGKPFIFVCPTYAWRLPIVVTDFIKETKFLGDNRVYFV 81
Cdd:NF038196   1 IFYFSGTGNSLYVAKRIAEELGDELISISKAIKEGDFK--LKEDEPIGFVFPVYAWGLPRIVEDFIKKLKLKGNKYIFAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298  82 MTCGGDTAKSINYIQKLCKYKEWQLKGMAEIKMPENYIALFSTTDKETSKQMIKEADKQIYRIISDIRNENEFeTITPSG 161
Cdd:NF038196  79 ATCGGSIGNALAQLKKLLKKKGLKLSGGFSIKMPNNYIPLFDVPSKEKAKKILKKAEEKIKEIAEKIKNRKKG-PEKKKG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 162 LGGTIKSGIINTVFYKTIISAKGFHYTDKCIGCGKCVELCPLNNINLKNKKPVWKNSCTHCMACICGCPTEAIEYKNKTQ 241
Cdd:NF038196 158 FIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGKPVWGHNCTHCLACIHRCPKEAIEYGKKTK 237


                 ....*.
gi 497577298 242 NRERYY 247
Cdd:NF038196 238 KKGRYH 243
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 1-100 2.44e-15

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 70.32  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298   1 MILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDelISAGKPFIFVCPTYAWRLPIVVTDFIKETKFLGDNRVYF 80
Cdd:COG0716    2 LIVYGSTTGNTEKVAEAIAEALGAAGVDLFEIEDADLDD--LEDYDLLILGTPTWAGELPDDWEDFLEELKEDLSGKKVA 79

                         90       100
                 ....*....|....*....|..
gi 497577298  81 VMTCGG--DTAKSINYIQKLCK 100
Cdd:COG0716   80 LFGTGDssGYGDALGELKELLE 101
PRK13795 PRK13795
hypothetical protein; Provisional
 190-239 1.00e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 58.08  E-value: 1.00e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 190 KCIGCGKCVELCPLNNINLKNKKP---VWKNSCTHCMACICGCPteAIEYKNK 239
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRIEEGKRkisVDEEKCIHCGKCTEVCP--VVKYKDK 632
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 189-237 7.86e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 52.40  E-value: 7.86e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKP--VWKNSCTHCMACICGCPTEAIEYK 237
Cdd:cd10549   78 EKCIGCGLCVKVCPVDAITLEDELEivIDKEKCIGCGICAEVCPVNAIKLV 128
Fer4_9 pfam13187
4Fe-4S dicluster domain;
190-234 4.57e-08

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 48.32  E-value: 4.57e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 497577298  190 KCIGCGKCVELCPLNNINLKNKKPVWKN-----SCTHCMACICGCPTEAI 234
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTIRGdiaglACIGCGACVDACPRGAI 50
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 189-235 5.22e-08

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 50.95  E-value: 5.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497577298  189 DKCIGCGKCVELCPLNNINLKNKK--PVWKNSCTHCMACICGCPTEAIE 235
Cdd:TIGR01944 113 DNCIGCTKCIQACPVDAIVGAAKAmhTVIADECTGCDLCVEPCPTDCIE 161
 
Name Accession Description Interval E-value
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 2-247 1.32e-116

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 333.36  E-value: 1.32e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298   2 ILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDelISAGKPFIFVCPTYAWRLPIVVTDFIKETKFLGDNRVYFV 81
Cdd:NF038196   1 IFYFSGTGNSLYVAKRIAEELGDELISISKAIKEGDFK--LKEDEPIGFVFPVYAWGLPRIVEDFIKKLKLKGNKYIFAV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298  82 MTCGGDTAKSINYIQKLCKYKEWQLKGMAEIKMPENYIALFSTTDKETSKQMIKEADKQIYRIISDIRNENEFeTITPSG 161
Cdd:NF038196  79 ATCGGSIGNALAQLKKLLKKKGLKLSGGFSIKMPNNYIPLFDVPSKEKAKKILKKAEEKIKEIAEKIKNRKKG-PEKKKG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 162 LGGTIKSGIINTVFYKTIISAKGFHYTDKCIGCGKCVELCPLNNINLKNKKPVWKNSCTHCMACICGCPTEAIEYKNKTQ 241
Cdd:NF038196 158 FIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEMEDGKPVWGHNCTHCLACIHRCPKEAIEYGKKTK 237


                 ....*.
gi 497577298 242 NRERYY 247
Cdd:NF038196 238 KKGRYH 243
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 1-100 2.44e-15

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 70.32  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298   1 MILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDelISAGKPFIFVCPTYAWRLPIVVTDFIKETKFLGDNRVYF 80
Cdd:COG0716    2 LIVYGSTTGNTEKVAEAIAEALGAAGVDLFEIEDADLDD--LEDYDLLILGTPTWAGELPDDWEDFLEELKEDLSGKKVA 79

                         90       100
                 ....*....|....*....|..
gi 497577298  81 VMTCGG--DTAKSINYIQKLCK 100
Cdd:COG0716   80 LFGTGDssGYGDALGELKELLE 101
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 189-238 1.47e-13

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 63.92  E-value: 1.47e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPVWKNS-CTHCMACICGCPTEAIEYKN 238
Cdd:COG2221   15 EKCIGCGLCVAVCPTGAISLDDGKLVIDEEkCIGCGACIRVCPTGAIKGEK 65
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
188-243 2.38e-13

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 63.21  E-value: 2.38e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKNKKPV-WKNSCTHCMACICGCPTEAIEYKNKTQNR 243
Cdd:COG2768   10 EEKCIGCGACVKVCPVGAISIEDGKAViDPEKCIGCGACIEVCPVGAIKIEWEEDEE 66
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 188-240 3.97e-13

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 62.44  E-value: 3.97e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKNKKPVWKN--SCTHCMACICGCPTEAIEYKNKT 240
Cdd:COG1149   10 EEKCIGCGLCVEVCPEGAIKLDDGGAPVVDpdLCTGCGACVGVCPTGAITLEERE 64
NapF COG1145
Ferredoxin [Energy production and conversion];
188-239 7.19e-12

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 63.20  E-value: 7.19e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKNKKP---VWKNSCTHCMACICGCPTEAIEYKNK 239
Cdd:COG1145  181 AEKCIGCGLCVKVCPTGAIRLKDGKPqivVDPDKCIGCGACVKVCPVGAISLEPK 235
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 188-236 1.22e-10

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 55.87  E-value: 1.22e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKN--KKPVWKN--SCTHCMACICGCPTEAIEY 236
Cdd:COG1146    7 TDKCIGCGACVEVCPVDVLELDEegKKALVINpeECIGCGACELVCPVGAITV 59
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 188-237 1.29e-10

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 56.20  E-value: 1.29e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKNKKPVWK-NSCTHCMACICGCPTEAIEYK 237
Cdd:COG4231   21 EDKCTGCGACVKVCPADAIEEGDGKAVIDpDLCIGCGSCVQVCPVDAIKLE 71
PRK13795 PRK13795
hypothetical protein; Provisional
 190-239 1.00e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 58.08  E-value: 1.00e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 190 KCIGCGKCVELCPLNNINLKNKKP---VWKNSCTHCMACICGCPteAIEYKNK 239
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRIEEGKRkisVDEEKCIHCGKCTEVCP--VVKYKDK 632
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
189-238 2.91e-09

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 56.79  E-value: 2.91e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPVWKN--SCTHCMACICGCPTEAIEYKN 238
Cdd:COG1148  496 EKCTGCGRCVEVCPYGAISIDEKGVAEVNpaLCKGCGTCAAACPSGAISLKG 547
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 189-237 7.86e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 52.40  E-value: 7.86e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKP--VWKNSCTHCMACICGCPTEAIEYK 237
Cdd:cd10549   78 EKCIGCGLCVKVCPVDAITLEDELEivIDKEKCIGCGICAEVCPVNAIKLV 128
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 188-238 1.07e-08

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 50.51  E-value: 1.07e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKNKKPVWK-----NSCTHCMACICGCPTEAIEYKN 238
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDGEPGKVyvidpDKCIGCGLCVEVCPTGAISMTP 56
Fer4_9 pfam13187
4Fe-4S dicluster domain;
190-234 4.57e-08

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 48.32  E-value: 4.57e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 497577298  190 KCIGCGKCVELCPLNNINLKNKKPVWKN-----SCTHCMACICGCPTEAI 234
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTIRGdiaglACIGCGACVDACPRGAI 50
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 189-235 5.22e-08

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 50.95  E-value: 5.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497577298  189 DKCIGCGKCVELCPLNNINLKNKK--PVWKNSCTHCMACICGCPTEAIE 235
Cdd:TIGR01944 113 DNCIGCTKCIQACPVDAIVGAAKAmhTVIADECTGCDLCVEPCPTDCIE 161
Flavodoxin_5 pfam12724
Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins ...
 1-107 6.06e-08

Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.


Pssm-ID: 463681 [Multi-domain]  Cd Length: 144  Bit Score: 50.34  E-value: 6.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298    1 MILYFSGTGNSRYVARKIAQELNDELISLNqLIKEEKTDELiSAGKPFIFVCPTYAWRLPIVVTDFIKETK-FLGDNRVY 79
Cdd:pfam12724   1 LILYSSRDGQTKKIAERIAEELREEGELVD-VEDVEAGEDL-SSYDAVVIGASIYYGKHLPELRQFVTKHRdELSSKPVA 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 497577298   80 FVmTCGGDTAKS--INYIQK-LCKYKEWQLK 107
Cdd:pfam12724  79 FF-SVNLTARKPekNPYMRKfLLKSLLWQPK 108
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 189-237 9.74e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 49.50  E-value: 9.74e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 189 DKCIGCGKCVELCPLNNINL-KNKKPVWKnsCTHCM---ACICGCPTEAIEYK 237
Cdd:cd10550   80 DKCIGCGMCVEACPFGAIRVdPETGKAIK--CDLCGgdpACVKVCPTGALEFV 130
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 189-237 9.76e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 49.58  E-value: 9.76e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497577298 189 DKCIGCGKCVELCPLNNINLKN--KKPVwknSCTHCMACICGCPTEAIEYK 237
Cdd:cd16370   83 EKCIGCGNCVKACIVGAIFWDEetNKPI---ICIHCGYCARYCPHDVLAME 130
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 184-239 1.13e-07

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 50.85  E-value: 1.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497577298 184 GFHyTDKCIGCGKCVELCPLN--NINLKNKKpVWKnsCTHCM---------ACICGCPTEAIEYKNK 239
Cdd:cd10558   97 DFQ-SDKCIGCGYCIKGCPFDipRISKDDNK-MYK--CTLCSdrvsvglepACVKTCPTGALHFGTK 159
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
189-243 1.13e-07

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 51.22  E-value: 1.13e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497577298 189 DKCIGCGKCVELCPLNnINLKNKKpVWKNSCTHCMACICGCPTEAIEYKNKTQNR 243
Cdd:COG0348  210 GDCIDCGLCVKVCPMG-IDIRKGE-INQSECINCGRCIDACPKDAIRFSSRGEKT 262
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 189-236 1.26e-07

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 49.31  E-value: 1.26e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 497577298 189 DKCIGCGKCVELCPLNNINLkNKKPVWKNSCTHCM---------ACICGCPTEAIEY 236
Cdd:cd04410   80 DKCIGCGSCVEACPYGAIVF-DPEPGKAVKCDLCGdrldeglepACVKACPTGALTF 135
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
191-241 1.58e-07

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 51.09  E-value: 1.58e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497577298 191 CIGCGKCVELCPLNNINLKNKKPVW-KNSCTHCMACICGCPTEAIEYKNKTQ 241
Cdd:PRK07118 215 CIGCGKCVKACPAGAITMENNLAVIdQEKCTSCGKCVEKCPTKAIRILNKPP 266
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 189-235 2.21e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 48.55  E-value: 2.21e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPVWK------NSCTHCMACICGCPTEAIE 235
Cdd:cd10549    6 EKCIGCGICVKACPTDAIELGPNGAIARgpeideDKCVFCGACVEVCPTGAIE 58
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
171-242 2.84e-07

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 50.79  E-value: 2.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497577298 171 INTVFYKTIISAKGFHYTD--KCIGCGKCVELCPLNNINLKNKKPVWKNS-CTHCMACICGCPTEAIEYKNKTQN 242
Cdd:COG4624   71 IQVRGIIIIDKRGPSIIRDkeKCKNCYPCVRACPVKAIKVDDGKAEIDEEkCISCGQCVAVCPFGAITEKSDIEK 145
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 189-239 3.54e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 47.78  E-value: 3.54e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPVW----------KNSCTHCMACICGCPTEAIEYKNK 239
Cdd:cd10549   40 DKCVFCGACVEVCPTGAIELTPEGKEYvpkekeaeidEEKCIGCGLCVKVCPVDAITLEDE 100
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 165-234 4.31e-07

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 48.88  E-value: 4.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 165 TIKSGIInTVFY--KTIISAKGF-----HYTDKCIGCGKCVELCPLNNI----NLKNKKPVWKNSCTHCMacICG----- 228
Cdd:PRK12387   8 VIKTGTA-TSSYplEPIAVDKNFrgkpeYNPQQCIGCAACVNACPSNALtvetDLATGELAWEFNLGRCI--FCGrceev 84


                 ....*.
gi 497577298 229 CPTEAI 234
Cdd:PRK12387  85 CPTAAI 90
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 189-239 8.19e-07

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 48.54  E-value: 8.19e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497577298 189 DKCIGCGKCVELCPLNNI-NLKNKKPVWKNSCTHCMACICGCPTEAIEYKNK 239
Cdd:cd03110   64 EKCIRCGNCERVCKFGAIlEFFQKLIVDESLCEGCGACVIICPRGAIYLKDR 115
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 188-234 1.06e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 46.92  E-value: 1.06e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497577298 188 TDKCIGCGKCVELCPLNNINLknkkpVWKNSCTHCM-----ACICGCPTEAI 234
Cdd:cd16367   85 SDACCGCGNCASACPYGAIQM-----VRAVKCDLCAgyagpACVSACPTGAA 131
PRK08764 PRK08764
Rnf electron transport complex subunit RnfB;
191-235 1.36e-06

Rnf electron transport complex subunit RnfB;


Pssm-ID: 181550 [Multi-domain]  Cd Length: 135  Bit Score: 46.45  E-value: 1.36e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 497577298 191 CIGCGKCVELCPLNNI--NLKNKKPVWKNSCTHCMACICGCPTEAIE 235
Cdd:PRK08764  87 CIGCTKCIQACPVDAIvgGAKHMHTVIAPLCTGCELCVPACPVDCIE 133
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 189-236 1.73e-06

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 46.86  E-value: 1.73e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497577298 189 DKCIGCGKCVELCPLNNINL-KNKKPVWKnsCTHCM---------ACICGCPTEAIEY 236
Cdd:COG0437   90 DKCIGCRYCVAACPYGAPRFnPETGVVEK--CTFCAdrldegllpACVEACPTGALVF 145
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 185-236 2.17e-06

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 46.09  E-value: 2.17e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 497577298 185 FHYTDKCIGCGKCVELCPLNNI--NLKNKKpVWKnsCTHCM-----ACICGCPTEAIEY 236
Cdd:cd10563   84 IHDEEKCVGCWMCVMVCPYGAIrpDKERKV-ALK--CDLCPdretpACVEACPTGALVL 139
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 189-241 2.31e-06

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 46.14  E-value: 2.31e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497577298 189 DKCIGCGKCVELCPLN--NINLKNKKPvwkNSCTHCM---------ACICGCPTEAIEYKNKTQ 241
Cdd:cd10562  100 DKCIGCGYCVAACPFDvpRYDETTNKI---TKCTLCFdriengmqpACVKTCPTGALTFGDRDE 160
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 188-245 4.09e-06

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 46.23  E-value: 4.09e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497577298 188 TDKCIGCGKCVELCPLN--NINLKNKKpVWKnsCTHCM---------ACICGCPTEAIEYKNKTQNRER 245
Cdd:cd10560  107 PDICNGCGYCVAACPFGviDRNEETGR-AHK--CTLCYdrlkdglepACAKACPTGSIQFGPLEELRER 172
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 186-245 7.39e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 44.55  E-value: 7.39e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497577298 186 HYTDKCIGCGKCVELCPLNNINLKNKKPVWKNS-----------CTHCM-ACICGCPTEAIEYKNKTQNRER 245
Cdd:cd16373   11 EFLALCIRCGLCVEACPTGVIQPAGLEDGLEGGrtpyldpregpCDLCCdACVEVCPTGALRPLDLEEQKVK 82
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 189-235 7.96e-06

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 44.06  E-value: 7.96e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 497577298 189 DKCIGCGKCVELCPLNNINL---KNKKPVWKNSCTHCMACICGCPTEAIE 235
Cdd:PRK08348  42 DKCVGCRMCVTVCPAGVFVYlpeIRKVALWTGRCVFCGQCVDVCPTGALQ 91
PRK05113 PRK05113
electron transport complex protein RnfB; Provisional
 189-235 8.02e-06

electron transport complex protein RnfB; Provisional


Pssm-ID: 235347 [Multi-domain]  Cd Length: 191  Bit Score: 45.32  E-value: 8.02e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKK--PVWKNSCTHCMACICGCPTEAIE 235
Cdd:PRK05113 114 DNCIGCTKCIQACPVDAIVGATKAmhTVISDLCTGCDLCVAPCPTDCIE 162
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 185-235 8.39e-06

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 45.65  E-value: 8.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 185 FHYTDKCIGCGKCVELCPLNNINLKNKKPVWKN--SCTHCMACICGCPTEAIE 235
Cdd:PRK00783 165 IEVSEDCDECEKCVEACPRGVLELKEGKLVVTDllNCSLCKLCERACPGKAIR 217
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 189-235 8.45e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 43.12  E-value: 8.45e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPVWKNScTHCMAC-ICG--CPTEAIE 235
Cdd:COG1144   30 DKCIGCGLCWIVCPDGAIRVDDGKYYGIDY-DYCKGCgICAevCPVKAIE 78
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
188-236 8.90e-06

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 44.26  E-value: 8.90e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497577298 188 TDKCIGCGKCVELCPLNNINLKNKKPVWK-NSCTHC------MACICGCPTEAIEY 236
Cdd:COG1142   80 EEKCIGCGLCVLACPFGAITMVGEKSRAVaVKCDLCggreggPACVEACPTGALRL 135
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
191-241 9.09e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 45.69  E-value: 9.09e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497577298 191 CIGCGKCVELCPLNNINLKNKKP-VWKNSCTHCMACICGCPTEAIEYKNKTQ 241
Cdd:PRK07118 141 CLGLGSCVAACPFDAIHIENGLPvVDEDKCTGCGACVKACPRNVIELIPKSA 192
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 179-245 1.23e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 45.37  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 179 IISAKGFH--YTDKCIGCGKCVELCPLNNINLKNKKP-VWKNSC---------THCMACICG--CPTEAIEYKNKTQNRE 244
Cdd:COG2878  155 VGAAKGMHtvDEDKCTGCGLCVEACPVDCIEMVPVSPtVVVSSWdkgkavrkvVGCIGLCCKkcCPAAAITVNNLAAIID 234


                 .
gi 497577298 245 R 245
Cdd:COG2878  235 Y 235
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 189-235 1.64e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 43.09  E-value: 1.64e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPVwKNSCTHCMACICGCPTEAIE 235
Cdd:cd16372   77 KLCVGCLMCVGFCPEGAMFKHEDYPE-PFKCIACGICVKACPTGALE 122
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
188-238 1.72e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 44.92  E-value: 1.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 497577298 188 TDKCIGCGKCVELCPLNNINL-----------------KNKKPVWKNSCTHCMACICGCPTEAIEYKN 238
Cdd:PRK07118 167 EDKCTGCGACVKACPRNVIELipksarvfvacnskdkgKAVKKVCEVGCIGCGKCVKACPAGAITMEN 234
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 191-233 1.92e-05

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 40.97  E-value: 1.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 497577298  191 CIGCGKCVELCPLNNINL-----KNKKPVWK---NSCTHCMACICGCPTEA 233
Cdd:pfam12838   1 CIGCGACVAACPVGAITLdevgeKKGTKTVVidpERCVGCGACVAVCPTGA 51
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 189-236 2.19e-05

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 43.54  E-value: 2.19e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKP-VWKnsCTHCM---------ACICGCPTEAIEY 236
Cdd:cd16366  100 ETCIGCGYCVNACPFDIPRFDEETGrVAK--CTLCYdrisnglqpACVKTCPTGALTF 155
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 189-246 2.47e-05

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 42.79  E-value: 2.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497577298  189 DKCIGCGKCVELCPLNNINL---KNKKPVWK--------NSCTHCMACICGCPTEAI----EYKNKTQNRERY 246
Cdd:TIGR01971  43 EKCIGCTLCAAVCPADAIRVvpaEGEDGKRRlkfyeinfGRCIFCGLCEEACPTDAIvltpEFELATYTRSDL 115
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 188-240 4.29e-05

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 42.38  E-value: 4.29e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497577298 188 TDKCIGCGKCVELCPLNNIN----LKNKKPV----------WKNSCTHCM--ACICGCPTEAIeYKNKT 240
Cdd:cd04410    5 LDRCIGCGTCEVACKQEHGLrpgpDWSRIKVieggglerafLPVSCMHCEdpPCVKACPTGAI-YKDED 72
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 191-241 4.46e-05

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 43.44  E-value: 4.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 191 CIGCGKCVELCPLNNINLKNKK-P-VWKNSCTHCMACICGCPTEAIEYKNKTQ 241
Cdd:COG2878  139 CIGCGDCIKACPFDAIVGAAKGmHtVDEDKCTGCGLCVEACPVDCIEMVPVSP 191
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 189-230 4.68e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 40.31  E-value: 4.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 497577298  189 DKCIGCGKCVELCPLNNINLKNKKPVWKN--------SCTHCMACICGCP 230
Cdd:pfam13237   7 DKCIGCGRCTAACPAGLTRVGAIVERLEGeavrigvwKCIGCGACVEACP 56
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 186-234 5.74e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 41.85  E-value: 5.74e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 186 HYTDKCIGCGKCVELCPLNNI-NLKNKKPVW---KNSCTHCMACICGCPTEAI 234
Cdd:cd10564   10 LFLDLCTRCGDCVEACPEGIIvRGDGGFPELdfsRGECTFCGACAEACPEGAL 62
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 185-236 7.85e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 41.39  E-value: 7.85e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497577298 185 FHYTDKCIGCGKCVELCPLNNINL-KNKKPVWKnsCTHCM---------ACICGCPTEAIEY 236
Cdd:cd16371   80 VVDQDKCIGCGYCVWACPYGAPQYnPETGKMDK--CDMCVdrldegekpACVAACPTRALDF 139
PRK09898 PRK09898
ferredoxin-like protein;
188-240 1.71e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 41.36  E-value: 1.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497577298 188 TDKCIGCGKCVELCP--LNNINLKNKKpvwKNSCTHCMACICGCPTEA---IEYKNKT 240
Cdd:PRK09898 153 HKRCIGCSACTTACPwmMATVNTESKK---SSKCVLCGECANACPTGAlkiIEWKDIT 207
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 191-234 2.20e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 40.01  E-value: 2.20e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 497577298 191 CIGCGKCVELCPLNNINLKNKKPVW--KNSCTHCMACICGCPTEAI 234
Cdd:cd16372   49 CNQCGECIDVCPTGAITRDANGVVMinKKLCVGCLMCVGFCPEGAM 94
Flavodoxin_1 pfam00258
Flavodoxin;
2-55 2.29e-04

Flavodoxin;


Pssm-ID: 425562 [Multi-domain]  Cd Length: 142  Bit Score: 40.05  E-value: 2.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 497577298    2 ILYFSGTGNSRYVARKIAQELNDELIS--LNQLIKEEKTDELISAGKPFIFVCPTY 55
Cdd:pfam00258   1 IFYGSQTGNTEKLAEAIAEGLGEAGFEvdVVDLDDVDETLSEIEEEDLLLVVVSTW 56
HdrC COG1150
Heterodisulfide reductase, subunit C [Energy production and conversion];
190-230 3.37e-04

Heterodisulfide reductase, subunit C [Energy production and conversion];


Pssm-ID: 440764 [Multi-domain]  Cd Length: 79  Bit Score: 38.34  E-value: 3.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 497577298 190 KCIGCGKCVELCPLNN------------INLKNKKPVWKNS----CTHCMACICGCP 230
Cdd:COG1150    4 KCYQCGTCTASCPVARamdynprkiirlAQLGLKEEVLKSDsiwlCVSCYTCTERCP 60
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 146-241 4.73e-04

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 38.47  E-value: 4.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 146 SDI-RNENEF-ETITPSGLGGTIKSGIINTVFYKTIISAKgfHYTDKCIGCGKCVELCPLNNINLKNKK-PVWK-NSCTH 221
Cdd:PRK09624   8 ADIeRVQKEYsEKMTPGAIAYIPGSSVINKTGSWRVFMPE--FNRDKCVRCYLCYIYCPEPAIYLDEEGyPVFDyDYCKG 85

                         90       100
                 ....*....|....*....|
gi 497577298 222 CMACICGCPTEAIEYKNKTQ 241
Cdd:PRK09624  86 CGICANECPTKAIEMVRETK 105
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 189-236 5.37e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 39.18  E-value: 5.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 497577298 189 DKCIGCGKCVELCPLNNINL-KNKKPVWKnsCTHCM---------ACICGCPTEAIEY 236
Cdd:cd16374   73 DKCIGCGMCAMACPFGVPRFdPSLKVAVK--CDLCIdrrregklpACVEACPTGALKF 128
PRK13984 PRK13984
putative oxidoreductase; Provisional
 183-247 6.21e-04

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 40.52  E-value: 6.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 183 KGFHYTD--KCIGCGKCVELCPLNNINL------------KNKKPVWK-NSCTHCMACICGCPTEAI----EYKNKTQNR 243
Cdd:PRK13984  37 RGFHINDweKCIGCGTCSKICPTDAITMvevpdlpqeygkKPQRPVIDyGRCSFCALCVDICTTGSLkmtrEYIHISPDP 116


                 ....
gi 497577298 244 ERYY 247
Cdd:PRK13984 117 EDFI 120
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 189-232 1.03e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 36.49  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 497577298  189 DKCIGCGKCVELCPLNNINL-----KNKKPVWKNSCTHCMACICGCPTE 232
Cdd:pfam14697   6 DTCIGCGKCYIACPDTSHQAivgdgKRHHTVIEDECTGCNLCVSVCPVD 54
PRK06991 PRK06991
electron transport complex subunit RsxB;
191-235 1.32e-03

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 39.01  E-value: 1.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 497577298 191 CIGCGKCVELCPLNNINLKNKK--PVWKNSCTHCMACICGCPTEAIE 235
Cdd:PRK06991  87 CIGCTLCMQACPVDAIVGAPKQmhTVLADLCTGCDLCVPPCPVDCID 133
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 190-234 2.92e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 38.47  E-value: 2.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 497577298 190 KCIGCGKCVELCPLNNI----NLKNKKPVWKNSCTHCMACICGCPTEAI 234
Cdd:PRK12809  86 KCIGCKRCAIACPFGVVemvdTIAQKCDLCNQRSSGTQACIEVCPTQAL 134
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
189-214 4.46e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 37.61  E-value: 4.46e-03
                         10        20
                 ....*....|....*....|....*.
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKPV 214
Cdd:PRK07118 242 EKCTSCGKCVEKCPTKAIRILNKPPK 267
PRK09267 PRK09267
flavodoxin FldA; Validated
 2-55 4.49e-03

flavodoxin FldA; Validated


Pssm-ID: 236439 [Multi-domain]  Cd Length: 169  Bit Score: 36.73  E-value: 4.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 497577298   2 ILYFSGTGNSRYVARKIAQELNDELISLNQLIKEEKTDelISAGKPFIFVCPTY 55
Cdd:PRK09267   6 IFFGSDTGNTEDIAKMIQKKLGKDVADVVDIAKASKED--FEAYDLLILGIPTW 57
Flavodoxin_NdrI pfam07972
NrdI Flavodoxin like;
2-77 4.67e-03

NrdI Flavodoxin like;


Pssm-ID: 429763  Cd Length: 119  Bit Score: 35.95  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298    2 ILYFSGTGNSRYVARKIAQElndelislNQLIKEEKTDELISAGKPFIFVCPTYA-----WRLPIVVTDFIKEtkflGDN 76
Cdd:pfam07972   1 VYYSSISGNTRRFVEKLGLP--------AQRIPIEDIDPPLEVDEPYVLITPTYGgggndGAVPKQVIDFLNY----EDN 68


                  .
gi 497577298   77 R 77
Cdd:pfam07972  69 R 69
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 188-236 4.90e-03

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 36.57  E-value: 4.90e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497577298 188 TDKCIGCGKCVELCPLNninlknkKPVWKNS------CTHCM---------ACICGCPTEAIEY 236
Cdd:cd10553   88 QELCIGCKACIEACPWG-------IPQWNPAtgkvvkCDYCMdridqglkpACVTGCTTHALSF 144
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 189-234 5.05e-03

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 36.47  E-value: 5.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497577298 189 DKCIGCGKCVELCPLNNINL------------KNKKPVWKnsCTHCM------ACICGCPTEAI 234
Cdd:cd10554   85 ERCIGCKLCVLACPFGAIEMapttvpgvdwerGPRAVAVK--CDLCAgreggpACVEACPTKAL 146
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 191-234 5.17e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 36.07  E-value: 5.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 497577298 191 CIGCGKCVELCPLNNINLKNKKPV-WK----NSC-----THCMACICGCPTEAI 234
Cdd:cd10564   47 CTFCGACAEACPEGALDPAREAPWpLRaeigDSClalqgVECRSCQDACPTQAI 100
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 188-240 5.46e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 36.85  E-value: 5.46e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497577298 188 TDKCIGCGKCVELCplnniNLKNKKPVWKN----------------------SCTHCM--ACICGCPTEAIeYKNKT 240
Cdd:COG0437   12 LTKCIGCRACVVAC-----KEENNLPVGVTwrrvrryeegefpnvewlfvpvLCNHCDdpPCVKVCPTGAT-YKRED 82
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 188-206 5.64e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 33.38  E-value: 5.64e-03
                          10
                  ....*....|....*....
gi 497577298  188 TDKCIGCGKCVELCPLNNI 206
Cdd:pfam00037   5 EEKCIGCGACVEVCPVGAI 23
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
173-249 5.76e-03

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 36.40  E-value: 5.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 173 TVFY---KTIISAK--GFH----YTD---KCIGCGKCVELCPLNNINL-------KNKKPVWK----NSCTHCMACICGC 229
Cdd:PRK05888  30 TIQYpeeKLPLSPRfrGRHalrrDPNgeeRCIACKLCAAICPADAITIeaaeredGRRRTTRYdinfGRCIFCGFCEEAC 109

                         90       100
                 ....*....|....*....|....
gi 497577298 230 PTEAI----EYKNKTQNRERYYLE 249
Cdd:PRK05888 110 PTDAIvetpDFELATETREELIYD 133
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 189-235 5.77e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 37.80  E-value: 5.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNkKPVWKNS-------CTHCM------ACICGCPTEAIE 235
Cdd:PRK12769  85 QKCIGCKSCVVACPFGTMQIVL-TPVAAGKvkatahkCDLCAgrengpACVENCPADALQ 143
ndhI CHL00014
NADH dehydrogenase subunit I
 176-243 5.79e-03

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 36.66  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497577298 176 YKTIISAKGF----HYT-DKCIGCGKCVELCPLN--NINLKNKKPVWKNS----------CTHCMACICGCPTEAI---- 234
Cdd:CHL00014  41 YEKLITSERFrgriHFEfDKCIACEVCVRVCPIDlpVVDWKLETDIRKKRllnysidfgvCIFCGNCVEYCPTNCLsmte 120


                 ....*....
gi 497577298 235 EYKNKTQNR 243
Cdd:CHL00014 121 EYELSTYDR 129
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 189-234 6.81e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 36.36  E-value: 6.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497577298 189 DKCIGCGKCVELCP-----LNNINLKNKKPVWKNS------CTHCM---------ACICGCPTEAI 234
Cdd:cd10551   83 DKCIGCRYCMAACPygaryFNPEEPHEFGEVPVRPkgvvekCTFCYhrldegllpACVEACPTGAR 148
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 190-230 6.86e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 34.36  E-value: 6.86e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 497577298  190 KCIGCGKCVELCPLNNINLKNKKPV----------------WKNSCTHCMACICGCP 230
Cdd:pfam13534   1 RCIQCGCCVDECPRYLLNGDEPKKLmraaylgdleelqankVANLCSECGLCEYACP 57
NrdI COG1780
Flavodoxin NrdI, NrdF-interacting activator of class Ib ribonucleotide reductase [Nucleotide ...
 1-56 7.76e-03

Flavodoxin NrdI, NrdF-interacting activator of class Ib ribonucleotide reductase [Nucleotide transport and metabolism];


Pssm-ID: 441386  Cd Length: 135  Bit Score: 35.56  E-value: 7.76e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 497577298   1 MILYFSGTGNSRYVARKIAQElndelislNQLIKEEKTDELISAGKPFIFVCPTYA 56
Cdd:COG1780    3 LIYYSSLSGNTRRFVEKLGLP--------AQRIPIRESDPPLEVDEPFVLVTPTYG 50
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 187-239 7.86e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 35.39  E-value: 7.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497577298 187 YTDKCIGCGKCVELCP----------LNNINLKNKKPVWK-NSCTHCMACICGCPTEAIEYKNK 239
Cdd:cd16372    6 DPEKCIGCLQCEEACSktffkeedreKSCIRITETEGGYAiNVCNQCGECIDVCPTGAITRDAN 69
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
189-238 9.09e-03

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 35.40  E-value: 9.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497577298 189 DKCIGCGKCVELCPLNNINLKNKKP-----VWKN-------SCTHCMACIC--GCPTEAIEYKN 238
Cdd:COG1142   10 EKCIGCRTCEAACAVAHEGEEGEPFlprirVVRKagvsapvQCRHCEDAPCaeVCPVGAITRDD 73
RNAP_D cd07030
D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is ...
 185-235 9.82e-03

D subunit of Archaeal RNA polymerase; The D subunit of archaeal RNA polymerase (RNAP) is involved in the assembly of RNAP subunits. RNAP is a large multi-subunit complex responsible for the synthesis of RNA. It is the principal enzyme of the transcription process, and is a final target in many regulatory pathways that control gene expression in all living cells. A single distinct RNAP complex is found in archaea, which may be responsible for the synthesis of all RNAs. The archaeal RNAP harbors homologues of all eukaryotic RNAP II subunits with two exceptions (RPB8 and RPB9). The 12 archaeal subunits are designated by letters and can be divided into three functional groups that are engaged in: (I) catalysis (A'/A", B'/B" or B); (II) assembly (L, N, D and P); and (III) auxiliary functions (F, E, H and K). The D subunit is equivalent to the RPB3 subunit of eukaryotic RNAP II. It contains two subdomains: one subdomain is similar the eukaryotic Rpb11/AC19/archaeal L subunit which is involved in dimerization, and the other is an inserted beta sheet subdomain. The assembly of the two largest archaeal RNAP subunits that provide most of the enzyme's catalytic functions depends on the presence of the archaeal D/L heterodimer.


Pssm-ID: 132908 [Multi-domain]  Cd Length: 259  Bit Score: 36.48  E-value: 9.82e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 497577298 185 FHYTDKCIGCGKCVELCPLNNINLKNKKPVWKN--SCTHCMACICGCPTEAIE 235
Cdd:cd07030  165 IEIDEDCDGCGKCVEECPRGVLELEEGKVVVEDleDCSLCKLCERACDAGAIR 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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