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Conserved domains on  [gi|497582492|ref|WP_009896676|]
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MarR family winged helix-turn-helix transcriptional regulator [Clostridioides difficile]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
38-145 5.08e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 5.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492  38 LTSRQYMtILSILHLpEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTCSRTG 117
Cdd:COG1846   36 LTPAQFR-VLAALAE-AGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPAL 113

                         90       100
                 ....*....|....*....|....*...
gi 497582492 118 INFMADVFHEFTKDELETLWSLLKKMYR 145
Cdd:COG1846  114 EALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
38-145 5.08e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 5.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492  38 LTSRQYMtILSILHLpEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTCSRTG 117
Cdd:COG1846   36 LTPAQFR-VLAALAE-AGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPAL 113

                         90       100
                 ....*....|....*....|....*...
gi 497582492 118 INFMADVFHEFTKDELETLWSLLKKMYR 145
Cdd:COG1846  114 EALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
38-133 2.48e-15

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 68.00  E-value: 2.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492    38 LTSRQYMtILSILHlpeEETTLNN--IARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTCSR 115
Cdd:smart00347   8 LTPTQFL-VLRILY---EEGPLSVseLAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83

                           90
                   ....*....|....*...
gi 497582492   116 TGINFMADVFHEFTKDEL 133
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-97 7.98e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 57.60  E-value: 7.98e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492   38 LTSRQYMTILSILHlpEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRA 97
Cdd:pfam12802   3 LTPAQFRVLLALAR--NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
73-143 3.47e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.89  E-value: 3.47e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497582492  73 INRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTC-SRTGINFMADVFHEFTKDELETLWSLLKKM 143
Cdd:PRK11512  71 LTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQChQLVGQDLHQELTKNLTADEVATLEHLLKKV 142
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 40-106 7.34e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.79  E-value: 7.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497582492   40 SRQYMTILSILHlPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIpsphDKRAINVKVTDLG 106
Cdd:TIGR01884 142 SREELKILEVLK-ATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQK----GRKGKRYSLTKLG 203
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
38-145 5.08e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 5.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492  38 LTSRQYMtILSILHLpEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTCSRTG 117
Cdd:COG1846   36 LTPAQFR-VLAALAE-AGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEARPAL 113

                         90       100
                 ....*....|....*....|....*...
gi 497582492 118 INFMADVFHEFTKDELETLWSLLKKMYR 145
Cdd:COG1846  114 EALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
38-133 2.48e-15

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 68.00  E-value: 2.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492    38 LTSRQYMtILSILHlpeEETTLNN--IARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTCSR 115
Cdd:smart00347   8 LTPTQFL-VLRILY---EEGPLSVseLAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83

                           90
                   ....*....|....*...
gi 497582492   116 TGINFMADVFHEFTKDEL 133
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-97 7.98e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 57.60  E-value: 7.98e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 497582492   38 LTSRQYMTILSILHlpEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRA 97
Cdd:pfam12802   3 LTPAQFRVLLALAR--NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-98 4.32e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 45.23  E-value: 4.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497582492   38 LTSRQYMtILSILHlPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAI 98
Cdd:pfam01047   1 LTLTQFH-ILRILY-EHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
73-143 3.47e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.89  E-value: 3.47e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497582492  73 INRLVANLEKNGYVDVIPSPHDKRAINVKVTDLGKKVMVTC-SRTGINFMADVFHEFTKDELETLWSLLKKM 143
Cdd:PRK11512  71 LTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQChQLVGQDLHQELTKNLTADEVATLEHLLKKV 142
HTH_27 pfam13463
Winged helix DNA-binding domain;
38-106 9.93e-05

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 38.81  E-value: 9.93e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497582492   38 LTSRQYMtILSILHLPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHDKRAINVKVTDLG 106
Cdd:pfam13463   1 LTRLEAL-ILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 32-92 7.72e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 36.36  E-value: 7.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497582492   32 DKYFGILTSRQYMTILSILHlPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSP 92
Cdd:pfam12840   1 DDVAEALADPTRLRILRALV-GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
38-109 1.26e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.49  E-value: 1.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497582492  38 LTSRQYMTILSILHLPEE--ETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIPSPHdkrainVKVTDLGKKV 109
Cdd:COG1321    4 LSESEEDYLKAIYELSEEggPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG------ITLTEEGREL 71
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 40-106 7.34e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 35.79  E-value: 7.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497582492   40 SRQYMTILSILHlPEEETTLNNIARKMGTSKQNINRLVANLEKNGYVDVIpsphDKRAINVKVTDLG 106
Cdd:TIGR01884 142 SREELKILEVLK-ATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQK----GRKGKRYSLTKLG 203
COG1356 COG1356
Transcriptional regulator [Transcription];
32-82 8.44e-03

Transcriptional regulator [Transcription];


Pssm-ID: 440967 [Multi-domain]  Cd Length: 139  Bit Score: 35.21  E-value: 8.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497582492  32 DKYFGILTSRQYmtilSILHLPEEETTLNNIARKMGTSKQNI----NRLVANLEK 82
Cdd:COG1356    3 DAKYSLLTRRQA----EVLALRERGLTQQEIADILGTSRANVssieKSARENIEK 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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