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Conserved domains on  [gi|497583216|ref|WP_009897400|]
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FUSC family protein [Clostridioides difficile]

Protein Classification

FUSC family protein( domain architecture ID 11441727)

FUSC family protein containing a fusaric acid resistance protein (FUSC_2) domain; may be involved in membrane transport

Gene Ontology:  GO:0055085|GO:0022857|GO:0005886
TCDB:  2.A.85

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YccC COG1289
Uncharacterized membrane protein YccC [Function unknown];
348-508 7.42e-30

Uncharacterized membrane protein YccC [Function unknown];


:

Pssm-ID: 440900 [Multi-domain]  Cd Length: 280  Bit Score: 119.34  E-value: 7.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 348 IPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGA 427
Cdd:COG1289   26 LLRNLRRLKRLRANLSPDSPAFRHALRLALAALLALLIALLLGLPHPYWALLTVLIVLQPSYGATLSRALQRILGTLLGA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 428 VIFIVLFSIIKDSTLRSLIVLLAG---YINSYVVDYRKLMVCVTVSALGSAVVMgDPNVLTI--SRISYVALGAIIALIV 502
Cdd:COG1289  106 LAGLLLLALFPQPLLLLLALALVLglcFFALLTRSYAFALAGITAAVVLLFALL-GPGVFDValARVLDTLIGILIALLV 184

                 ....*.
gi 497583216 503 NKFILP 508
Cdd:COG1289  185 SYLLWP 190
 
Name Accession Description Interval E-value
YccC COG1289
Uncharacterized membrane protein YccC [Function unknown];
348-508 7.42e-30

Uncharacterized membrane protein YccC [Function unknown];


Pssm-ID: 440900 [Multi-domain]  Cd Length: 280  Bit Score: 119.34  E-value: 7.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 348 IPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGA 427
Cdd:COG1289   26 LLRNLRRLKRLRANLSPDSPAFRHALRLALAALLALLIALLLGLPHPYWALLTVLIVLQPSYGATLSRALQRILGTLLGA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 428 VIFIVLFSIIKDSTLRSLIVLLAG---YINSYVVDYRKLMVCVTVSALGSAVVMgDPNVLTI--SRISYVALGAIIALIV 502
Cdd:COG1289  106 LAGLLLLALFPQPLLLLLALALVLglcFFALLTRSYAFALAGITAAVVLLFALL-GPGVFDValARVLDTLIGILIALLV 184

                 ....*.
gi 497583216 503 NKFILP 508
Cdd:COG1289  185 SYLLWP 190
FUSC_2 pfam13515
Fusaric acid resistance protein-like;
381-502 3.17e-20

Fusaric acid resistance protein-like;


Pssm-ID: 433273 [Multi-domain]  Cd Length: 126  Bit Score: 86.91  E-value: 3.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216  381 VAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLAGYINSYVV-- 458
Cdd:pfam13515   1 LAALIAELLGLPRGYWAPIAAAIVLQPTLGATLRRAVQRILGTVLGVLLGLLLLALLPGPLQLILVVALLGFLAEYLIgr 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 497583216  459 DYRKLMVCVTVSAL--GSAVVMGDPNVLTISRISYVALGAIIALIV 502
Cdd:pfam13515  81 NYALAQVFVTPLALllASLAGGGGPPELALLRILDTLIGALIALLV 126
PRK10631 PRK10631
p-hydroxybenzoic acid efflux subunit AaeB; Provisional
362-499 1.02e-03

p-hydroxybenzoic acid efflux subunit AaeB; Provisional


Pssm-ID: 182600  Cd Length: 652  Bit Score: 42.36  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 362 FNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLT--------VFSL-TQPYAENCIQRSRKRIEGTFIGAVIFIV 432
Cdd:PRK10631   2 FSIANQRLRFAVKLAFAIVLALFVGFHFQLETPRWAVLTaaivaagpAFAAgGEPFSGAIRYRGMLRIIGTFIGCIAALV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 433 LfsIIkdSTLRSLIVLL------AGYI----------NSYV---VDYRKLMVCVTVSALGSAVvmgdPNvLTISRISYVA 493
Cdd:PRK10631  82 I--II--ATIRAPLLMIllcciwAGFCtwisslvrveNSYAwglAGYTALIIVITIQPEPLLT----PQ-FAVERCSEIV 152

                 ....*....
gi 497583216 494 LG---AIIA 499
Cdd:PRK10631 153 IGivcAILA 161
 
Name Accession Description Interval E-value
YccC COG1289
Uncharacterized membrane protein YccC [Function unknown];
348-508 7.42e-30

Uncharacterized membrane protein YccC [Function unknown];


Pssm-ID: 440900 [Multi-domain]  Cd Length: 280  Bit Score: 119.34  E-value: 7.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 348 IPHEFKRLSIYKKNFNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGA 427
Cdd:COG1289   26 LLRNLRRLKRLRANLSPDSPAFRHALRLALAALLALLIALLLGLPHPYWALLTVLIVLQPSYGATLSRALQRILGTLLGA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 428 VIFIVLFSIIKDSTLRSLIVLLAG---YINSYVVDYRKLMVCVTVSALGSAVVMgDPNVLTI--SRISYVALGAIIALIV 502
Cdd:COG1289  106 LAGLLLLALFPQPLLLLLALALVLglcFFALLTRSYAFALAGITAAVVLLFALL-GPGVFDValARVLDTLIGILIALLV 184

                 ....*.
gi 497583216 503 NKFILP 508
Cdd:COG1289  185 SYLLWP 190
FUSC_2 pfam13515
Fusaric acid resistance protein-like;
381-502 3.17e-20

Fusaric acid resistance protein-like;


Pssm-ID: 433273 [Multi-domain]  Cd Length: 126  Bit Score: 86.91  E-value: 3.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216  381 VAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKDSTLRSLIVLLAGYINSYVV-- 458
Cdd:pfam13515   1 LAALIAELLGLPRGYWAPIAAAIVLQPTLGATLRRAVQRILGTVLGVLLGLLLLALLPGPLQLILVVALLGFLAEYLIgr 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 497583216  459 DYRKLMVCVTVSAL--GSAVVMGDPNVLTISRISYVALGAIIALIV 502
Cdd:pfam13515  81 NYALAQVFVTPLALllASLAGGGGPPELALLRILDTLIGALIALLV 126
YgaE COG4129
Uncharacterized membrane protein YgaE, UPF0421/DUF939 family [Function unknown];
360-513 1.39e-11

Uncharacterized membrane protein YgaE, UPF0421/DUF939 family [Function unknown];


Pssm-ID: 443305 [Multi-domain]  Cd Length: 197  Bit Score: 63.85  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 360 KNFNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAVIFIVLFSIIKD 439
Cdd:COG4129    2 KRRRALRRIGLRTLKTALAAALAWLIAELLGLPYPFFAAIAAVLCLQPTVGRSLRRALERILGVLIGALVGVLFFLLLGY 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497583216 440 STLR-SLIVLLAGYInSYVVDYRKLMVCVTVSALGSAVVMGDPNVLT--ISRISYVALGAIIALIVNKFILPYDAKT 513
Cdd:COG4129   82 GPWQlGLAVLLAILL-AVLLKLGEGIVLAAVTALLVLLLGSPDDSLGyaLNRLLDTLIGVGVALLVNLLLLPPDPER 157
FUSC pfam04632
Fusaric acid resistance protein family; This family includes a conserved region found in two ...
371-508 7.81e-09

Fusaric acid resistance protein family; This family includes a conserved region found in two proteins associated with fusaric acid resistance, from Burkholderia cepacia and Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.


Pssm-ID: 428044 [Multi-domain]  Cd Length: 655  Bit Score: 58.83  E-value: 7.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216  371 YAVKIALATAVAGFIMDYFHLRDGRWIMLTVFSLTQPYAENCIQRSRKRIEGTFIGAV--IFIV--------LFSII--- 437
Cdd:pfam04632   3 FALKTFLAAMLALYIALRLELPQPYWAMTTVFIVSQPLSGAVLSKSFYRLLGTLVGAAaaVLLValfvqaplLFLLAlal 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216  438 ----------KDSTLRSLIVLLAGYinsyvvdyrklmvcvTVSALGSAVVMgDPN---VLTISRISYVALGAIIALIVNK 504
Cdd:pfam04632  83 wiglclalslLDRNFRSYAFVLAGY---------------TAAIIGLPAVA-DPEaifDIAVARVSEISLGILCAALVSA 146

                  ....
gi 497583216  505 FILP 508
Cdd:pfam04632 147 LVFP 150
PRK10631 PRK10631
p-hydroxybenzoic acid efflux subunit AaeB; Provisional
362-499 1.02e-03

p-hydroxybenzoic acid efflux subunit AaeB; Provisional


Pssm-ID: 182600  Cd Length: 652  Bit Score: 42.36  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 362 FNLNSIRFSYAVKIALATAVAGFIMDYFHLRDGRWIMLT--------VFSL-TQPYAENCIQRSRKRIEGTFIGAVIFIV 432
Cdd:PRK10631   2 FSIANQRLRFAVKLAFAIVLALFVGFHFQLETPRWAVLTaaivaagpAFAAgGEPFSGAIRYRGMLRIIGTFIGCIAALV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216 433 LfsIIkdSTLRSLIVLL------AGYI----------NSYV---VDYRKLMVCVTVSALGSAVvmgdPNvLTISRISYVA 493
Cdd:PRK10631  82 I--II--ATIRAPLLMIllcciwAGFCtwisslvrveNSYAwglAGYTALIIVITIQPEPLLT----PQ-FAVERCSEIV 152

                 ....*....
gi 497583216 494 LG---AIIA 499
Cdd:PRK10631 153 IGivcAILA 161
ALMT pfam11744
Aluminium activated malate transporter;
415-544 1.09e-03

Aluminium activated malate transporter;


Pssm-ID: 432042 [Multi-domain]  Cd Length: 408  Bit Score: 41.96  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583216  415 RSRKRIEGTFIGAVIFIVLFSIikdSTLRSLIVLLAGYinsyvvDYRKLMVCVTVS-ALGSAVVMGDPNVLTISRISYVA 493
Cdd:pfam11744  86 SSGKIGEPIVIGVSVFIIGFAA---TFSRFHPAIKARY------DYGFRVFLLTFClVTVSGYRTDEFIETAHQRFYTIA 156
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 497583216  494 LGAIIALIVNKFILPYDAKTgyqhviEMYKGIVKNiIDEVNKSIENVADVY 544
Cdd:pfam11744 157 IGAGICLIVSIFIFPIWAGE------DLHKLVAKN-FEKLANSLEGCVNEY 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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