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Conserved domains on  [gi|497583953|ref|WP_009898137|]
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PTS sugar transporter subunit IIA [Clostridioides difficile]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10006772)

PTS mannose/fructose/sorbose family sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

CATH:  3.40.50.510
Gene Ontology:  GO:0009401|GO:0016310|GO:0016301|GO:0008643|GO:1902495
PubMed:  11532441|10393270
SCOP:  4000512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-125 6.94e-35

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 117.16  E-value: 6.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   4 IILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANND 83
Cdd:COG2893    1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGDDPEDLREKLEEAIAELDSGDGVLILTDLFGGTPSNVAARLLAKH 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 497583953  84 SRIKIISGLNLGMVIESAF----LDTKELAAKLEKIGKDNISMVEQ 125
Cdd:COG2893   81 ENVEVIAGVNLPMLLEALTyredLSLDELVEKALEAGREGIKSLSE 126
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-125 6.94e-35

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 117.16  E-value: 6.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   4 IILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANND 83
Cdd:COG2893    1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGDDPEDLREKLEEAIAELDSGDGVLILTDLFGGTPSNVAARLLAKH 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 497583953  84 SRIKIISGLNLGMVIESAF----LDTKELAAKLEKIGKDNISMVEQ 125
Cdd:COG2893   81 ENVEVIAGVNLPMLLEALTyredLSLDELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 3-118 1.14e-25

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 93.44  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   3 SIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANN 82
Cdd:cd00006    2 GIIIATHGGFASGLLNSAEMILGEQENVEAIDFPPGESPDDLLEKIKAALAELDSGEGVLILTDLFGGSPNNAAARLSME 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 497583953  83 DSRIKIISGLNLGMVIESAF-----LDTKELAAKLEKIGKD 118
Cdd:cd00006   82 HPPVEVIAGVNLPMLLEAARarelgLSLDELVENALEAGRE 122
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-112 2.02e-18

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 74.81  E-value: 2.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953    1 MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVA 80
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGEQNNVGAVPFVPGENAETLQEKYNAALADLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 497583953   81 NNDSRIKIISGLNLGMVIESAF----LDTKELAAKL 112
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMarddLSFDDLVALL 116
EIIA-man pfam03610
PTS system fructose IIA component;
3-111 6.67e-18

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 73.44  E-value: 6.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953    3 SIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANN 82
Cdd:pfam03610   1 GIVIVSHGELAEGLLELAEMMAGEQENVIAVGGTPGESIGTSFEKIVEAIENLDSGDGVLVLVDLGGATPNNEAALELLE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 497583953   83 DSRIKIISGLNLGMVIES----AFLDTKELAAK 111
Cdd:pfam03610  81 KERMEVITGVNLPMVEGAyaarVSASLGELVEA 113
AgaF NF040761
PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;
1-102 1.85e-13

PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;


Pssm-ID: 468721  Cd Length: 144  Bit Score: 62.88  E-value: 1.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   1 MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVA 80
Cdd:NF040761   1 MIGIILTGHGGFASGLESAVEQIIGEQPQFIAIDFPESMSTAQLEAQLEQALAELDSGEGVVFLTDLLGGSPFRVASTLA 80

                         90       100
                 ....*....|....*....|..
gi 497583953  81 NNDSRIKIISGLNLGMVIESAF 102
Cdd:NF040761  81 LQRPNIEVITGTNLQMLLEMLL 102
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 4-99 2.05e-12

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 62.32  E-value: 2.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   4 IILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANND 83
Cdd:PRK15088   5 IIIGTHGWAAEQLLKTAEMLLGEQENVAWIDFVPGENAETLIEKYNAQLAKLDTSKGVLFLVDTWGGSPFNAASRIVVDK 84

                         90
                 ....*....|....*.
gi 497583953  84 SRIKIISGLNLGMVIE 99
Cdd:PRK15088  85 ENYEVITGVNIPMLVE 100
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-125 6.94e-35

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 117.16  E-value: 6.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   4 IILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANND 83
Cdd:COG2893    1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGDDPEDLREKLEEAIAELDSGDGVLILTDLFGGTPSNVAARLLAKH 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 497583953  84 SRIKIISGLNLGMVIESAF----LDTKELAAKLEKIGKDNISMVEQ 125
Cdd:COG2893   81 ENVEVIAGVNLPMLLEALTyredLSLDELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 3-118 1.14e-25

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 93.44  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   3 SIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANN 82
Cdd:cd00006    2 GIIIATHGGFASGLLNSAEMILGEQENVEAIDFPPGESPDDLLEKIKAALAELDSGEGVLILTDLFGGSPNNAAARLSME 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 497583953  83 DSRIKIISGLNLGMVIESAF-----LDTKELAAKLEKIGKD 118
Cdd:cd00006   82 HPPVEVIAGVNLPMLLEAARarelgLSLDELVENALEAGRE 122
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-112 2.02e-18

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 74.81  E-value: 2.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953    1 MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVA 80
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGEQNNVGAVPFVPGENAETLQEKYNAALADLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 497583953   81 NNDSRIKIISGLNLGMVIESAF----LDTKELAAKL 112
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMarddLSFDDLVALL 116
EIIA-man pfam03610
PTS system fructose IIA component;
3-111 6.67e-18

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 73.44  E-value: 6.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953    3 SIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANN 82
Cdd:pfam03610   1 GIVIVSHGELAEGLLELAEMMAGEQENVIAVGGTPGESIGTSFEKIVEAIENLDSGDGVLVLVDLGGATPNNEAALELLE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 497583953   83 DSRIKIISGLNLGMVIES----AFLDTKELAAK 111
Cdd:pfam03610  81 KERMEVITGVNLPMVEGAyaarVSASLGELVEA 113
AgaF NF040761
PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;
1-102 1.85e-13

PTS galactosamine/N-acetylgalactosamine transporter subunit IIA;


Pssm-ID: 468721  Cd Length: 144  Bit Score: 62.88  E-value: 1.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   1 MNSIILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVA 80
Cdd:NF040761   1 MIGIILTGHGGFASGLESAVEQIIGEQPQFIAIDFPESMSTAQLEAQLEQALAELDSGEGVVFLTDLLGGSPFRVASTLA 80

                         90       100
                 ....*....|....*....|..
gi 497583953  81 NNDSRIKIISGLNLGMVIESAF 102
Cdd:NF040761  81 LQRPNIEVITGTNLQMLLEMLL 102
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 4-99 2.05e-12

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 62.32  E-value: 2.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497583953   4 IILMSHGNMAEEVLNSAKMIIGDSIDYPTVNMKQDDGIEGTIEKLKKALEVYKESSEIIIMADLLGGTPCNAALLVANND 83
Cdd:PRK15088   5 IIIGTHGWAAEQLLKTAEMLLGEQENVAWIDFVPGENAETLIEKYNAQLAKLDTSKGVLFLVDTWGGSPFNAASRIVVDK 84

                         90
                 ....*....|....*.
gi 497583953  84 SRIKIISGLNLGMVIE 99
Cdd:PRK15088  85 ENYEVITGVNIPMLVE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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