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Conserved domains on  [gi|497589318|ref|WP_009903502|]
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ketose-bisphosphate aldolase [Clostridioides difficile]

Protein Classification

triose-phosphate isomerase; tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like( domain architecture ID 10793022)

triose-phosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate| tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (DUS1L) catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08185 PRK08185
hypothetical protein; Provisional
 5-287 0e+00

hypothetical protein; Provisional


:

Pssm-ID: 181275  Cd Length: 283  Bit Score: 541.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   5 MKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGEN 84
Cdd:PRK08185   1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLGDNFFAYVRERAKRSPVPFVIHLDHGAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  85 KEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKDFVEK 164
Cdd:PRK08185  81 IEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 165 TGVDTLAIAIGTAHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKCR 244
Cdd:PRK08185 161 TGVDTLAVAIGTAHGIYPKDKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 497589318 245 ELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKLKCF 287
Cdd:PRK08185 241 EILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKADLY 283
 
Name Accession Description Interval E-value
PRK08185 PRK08185
hypothetical protein; Provisional
 5-287 0e+00

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 541.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   5 MKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGEN 84
Cdd:PRK08185   1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLGDNFFAYVRERAKRSPVPFVIHLDHGAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  85 KEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKDFVEK 164
Cdd:PRK08185  81 IEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 165 TGVDTLAIAIGTAHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKCR 244
Cdd:PRK08185 161 TGVDTLAVAIGTAHGIYPKDKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 497589318 245 ELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKLKCF 287
Cdd:PRK08185 241 EILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKADLY 283
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-283 1.80e-138

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 391.76  E-value: 1.80e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEE-ANKSKVPMVIHL 79
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAaAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAK 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 160 DFVEKTGVDTLAIAIGTAHGIYPKgfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKG--EPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAF 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 497589318 240 YKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:COG0191  239 TAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGK 282
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-281 4.78e-128

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 365.31  E-value: 4.78e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   5 MKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSF-VASCIEEANKSKVPMVIHLDHGE 83
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELlVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  84 NKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYTDSKLAKDFVE 163
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIG--GEEDGVVGDEGLLTDPEEAEEFVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 164 KTGVDTLAIAIGTAHGIYPKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKC 243
Cdd:cd00947  159 ETGVDALAVAIGTSHGAYKGG-EPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAAL 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 497589318 244 RELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAI 281
Cdd:cd00947  238 REYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSA 275
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-283 6.58e-126

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 359.80  E-value: 6.58e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    3 INMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFL--GDSFVASCIEE-ANKSKVPMVIHL 79
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYagGAEALAALVRAaAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYTDSKLAK 159
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIG--GEEDGVVVDEKLYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  160 DFVEKTGVDTLAIAIGTAHGIYPkgFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYK--PGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAF 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 497589318  240 YKKCRElleqNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:pfam01116 237 TAAVRE----YPPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-283 7.06e-98

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 288.88  E-value: 7.06e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGD-----SFVASCIEEAnkSKVPMV 76
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGykmavAMVKTLIERM--SIVPVA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   77 IHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTgtssEGGTDE--IIYTD 154
Cdd:TIGR01859  79 LHLDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGI----EDGVDEkeAELAD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  155 SKLAKDFVEKTGVDTLAIAIGTAHGIYPKgfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSD 234
Cdd:TIGR01859 155 PDEAEQFVKETGVDYLAAAIGTSHGKYKG--EPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTD 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 497589318  235 VKSAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:TIGR01859 233 CRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGK 281
 
Name Accession Description Interval E-value
PRK08185 PRK08185
hypothetical protein; Provisional
 5-287 0e+00

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 541.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   5 MKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGEN 84
Cdd:PRK08185   1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLGDNFFAYVRERAKRSPVPFVIHLDHGAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  85 KEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKDFVEK 164
Cdd:PRK08185  81 IEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 165 TGVDTLAIAIGTAHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKCR 244
Cdd:PRK08185 161 TGVDTLAVAIGTAHGIYPKDKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 497589318 245 ELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKLKCF 287
Cdd:PRK08185 241 EILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKADLY 283
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-283 1.80e-138

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 391.76  E-value: 1.80e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEE-ANKSKVPMVIHL 79
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAaAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAK 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 160 DFVEKTGVDTLAIAIGTAHGIYPKgfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKG--EPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAF 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 497589318 240 YKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:COG0191  239 TAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGK 282
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-281 4.78e-128

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 365.31  E-value: 4.78e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   5 MKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSF-VASCIEEANKSKVPMVIHLDHGE 83
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELlVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  84 NKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYTDSKLAKDFVE 163
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIG--GEEDGVVGDEGLLTDPEEAEEFVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 164 KTGVDTLAIAIGTAHGIYPKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKC 243
Cdd:cd00947  159 ETGVDALAVAIGTSHGAYKGG-EPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAAL 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 497589318 244 RELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAI 281
Cdd:cd00947  238 REYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSA 275
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-283 6.58e-126

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 359.80  E-value: 6.58e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    3 INMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFL--GDSFVASCIEE-ANKSKVPMVIHL 79
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYagGAEALAALVRAaAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYTDSKLAK 159
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIG--GEEDGVVVDEKLYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  160 DFVEKTGVDTLAIAIGTAHGIYPkgFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYK--PGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAF 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 497589318  240 YKKCRElleqNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:pfam01116 237 TAAVRE----YPPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-278 4.21e-100

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 294.71  E-value: 4.21e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIE-EANKSKVPMVIHL 79
Cdd:PRK12857   2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRtAAEKASVPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDE--IIYTDSKL 157
Cdd:PRK12857  82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIG--GTEDDITVDEreAAMTDPEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 158 AKDFVEKTGVDTLAIAIGTAHGIYpKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKS 237
Cdd:PRK12857 160 ARRFVEETGVDALAIAIGTAHGPY-KG-EPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIRE 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 497589318 238 AYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLF 278
Cdd:PRK12857 238 AFVARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLF 278
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-283 7.06e-98

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 288.88  E-value: 7.06e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGD-----SFVASCIEEAnkSKVPMV 76
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGykmavAMVKTLIERM--SIVPVA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   77 IHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTgtssEGGTDE--IIYTD 154
Cdd:TIGR01859  79 LHLDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGI----EDGVDEkeAELAD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  155 SKLAKDFVEKTGVDTLAIAIGTAHGIYPKgfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSD 234
Cdd:TIGR01859 155 PDEAEQFVKETGVDYLAAAIGTSHGKYKG--EPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTD 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 497589318  235 VKSAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:TIGR01859 233 CRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGK 281
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-284 4.46e-97

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 287.29  E-value: 4.46e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG--DSFVASC--IEEANKSKVPMV 76
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAglGAISAMVkaMSEAYPYGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   77 IHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSK 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  157 LAKDFVEKTGVDTLAIAIGTAHGIYPKGFKpELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVK 236
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPK-GLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQ 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 497589318  237 SAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKL 284
Cdd:TIGR00167 241 IAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-275 4.62e-95

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 281.97  E-value: 4.62e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG-DSFVASCIEEANKSKVPMVIHL 79
Cdd:PRK12737   2 YIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGtDYIVAIAEVAARKYNIPLALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAK 159
Cdd:PRK12737  82 DHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKDAMYTNPDAAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 160 DFVEKTGVDTLAIAIGTAHGIYpKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:PRK12737 162 EFVERTGIDSLAVAIGTAHGLY-KG-EPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAF 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 497589318 240 YKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKM 275
Cdd:PRK12737 240 SDAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKI 275
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-276 2.28e-93

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 277.78  E-value: 2.28e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG-DSFVASCIEEANKSKVPMVIHL 79
Cdd:PRK09195   2 YLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGtEYLLAIVSAAAKQYHHPLALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAK 159
Cdd:PRK09195  82 DHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADALYTDPAQAR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 160 DFVEKTGVDTLAIAIGTAHGIYpKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:PRK09195 162 EFVEATGIDSLAVAIGTAHGMY-KG-EPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAF 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 497589318 240 YKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMN 276
Cdd:PRK09195 240 SQALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIA 276
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 2-277 1.48e-83

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 252.47  E-value: 1.48e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG-DSFVASCIEEANKSKVPMVIHLD 80
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGtEYIVALCSAASTTYNMPLALHLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   81 HGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKD 160
Cdd:TIGR01858  81 HHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDALYTDPQEAKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  161 FVEKTGVDTLAIAIGTAHGIYPKGfkPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYY 240
Cdd:TIGR01858 161 FVEATGVDSLAVAIGTAHGLYKKT--PKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVATELKIAFS 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 497589318  241 KKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNL 277
Cdd:TIGR01858 239 GAVKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINV 275
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
2-284 1.32e-76

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 235.03  E-value: 1.32e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG-DSFVASCIEEANKSKVPMVIHLD 80
Cdd:PRK06801   3 LISLANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISlESLVEAVKFEAARHDIPVVLNLD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  81 HGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTI-GTTGTSSEGGTDEIIYTDSKLAK 159
Cdd:PRK06801  83 HGLHFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVgGDEGGALYGEADSAKFTDPQLAR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 160 DFVEKTGVDTLAIAIGTAHGIYpKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAY 239
Cdd:PRK06801 163 DFVDRTGIDALAVAIGNAHGKY-KG-EPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 497589318 240 YKKCRELLEQNPSLYEPDTIYPPCIKAA-REVIEFKMNLFNAIDKL 284
Cdd:PRK06801 241 LAAVEQRMTHRHAIYDEFAELLLGIEEAiSDTVAQQMRIFGSAGQA 286
PRK06806 PRK06806
class II aldolase;
2-284 3.05e-76

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 233.88  E-value: 3.05e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHP-----NELSFLGDSFVAScieeANKSKVPMV 76
Cdd:PRK06806   3 LVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEvrlnhSPLHLIGPLMVAA----AKQAKVPVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  77 IHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttgtSSEGGT--DEIIYTD 154
Cdd:PRK06806  79 VHFDHGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVG----GSEDGSedIEMLLTS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 155 SKLAKDFVEKTGVDTLAIAIGTAHGIYPKgfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSD 234
Cdd:PRK06806 155 TTEAKRFAEETDVDALAVAIGNAHGMYNG--DPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATA 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 497589318 235 VKSAYYKKCRELLEQNPSlYEPDTIYPPCIKAAREVIEFKMNLFNAIDKL 284
Cdd:PRK06806 233 TFNSVITAVNNLVLNTPY-SDYFTYHQDVIKAAYENVKKHMQIFGSENKA 281
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
2-284 2.29e-75

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 231.85  E-value: 2.29e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG-DSFVASCIEEANKSKVPMVIHLD 80
Cdd:PRK12738   3 IISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIAlEEIYALCSAYSTTYNMPLALHLD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  81 HGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKD 160
Cdd:PRK12738  83 HHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 161 FVEKTGVDTLAIAIGTAHGIYPKgfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYY 240
Cdd:PRK12738 163 FVELTGVDSLAVAIGTAHGLYSK--TPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 497589318 241 KKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKL 284
Cdd:PRK12738 241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 2-285 2.52e-74

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 229.10  E-value: 2.52e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGD-----SFVASCIEEANKSkVPMV 76
Cdd:PRK08610   3 LVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSGfytvvKMVEGLMHDLNIT-IPVA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  77 IHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYTDSK 156
Cdd:PRK08610  82 IHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVG--GQEDDVVADGIIYADPK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 157 LAKDFVEKTGVDTLAIAIGTAHGIYpKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVK 236
Cdd:PRK08610 160 ECQELVEKTGIDALAPALGSVHGPY-KG-EPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQ 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 497589318 237 SAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKLK 285
Cdd:PRK08610 238 IASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK 286
gatY PRK07998
class II aldolase;
2-280 3.27e-71

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 221.17  E-value: 3.27e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEE-ANKSKVPMVIHLD 80
Cdd:PRK07998   3 LVNGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRhADKMDVPVSLHLD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  81 HGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIgtTGTSSEGGTDEIIYTDSKLAKD 160
Cdd:PRK07998  83 HGKTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAI--LGKEDDHVSEADCKTEPEKVKD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 161 FVEKTGVDTLAIAIGTAHGIypkGFKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYY 240
Cdd:PRK07998 161 FVERTGCDMLAVSIGNVHGL---EDIPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFI 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 497589318 241 KKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNA 280
Cdd:PRK07998 238 TTVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKMMNS 277
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 2-283 6.54e-71

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 220.70  E-value: 6.54e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGD-----SFVASCIEEANKSkVPMV 76
Cdd:PRK07709   3 LVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGfktvvAMVKALIEEMNIT-VPVA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  77 IHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYTDSK 156
Cdd:PRK07709  82 IHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVG--GQEDDVIAEGVIYADPA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 157 LAKDFVEKTGVDTLAIAIGTAHGIYpKGfKPELKLDLLKEIREVVDIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVK 236
Cdd:PRK07709 160 ECKHLVEATGIDCLAPALGSVHGPY-KG-EPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQ 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 497589318 237 SAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:PRK07709 238 IEFTKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGK 284
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
2-270 4.90e-68

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 215.20  E-value: 4.90e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKS--KVPMVIHL 79
Cdd:PRK09196   3 LISLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPFLRHLILAAVEEypHIPVVMHQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLP-------YEENVAISREIVEIAKGLNVSVEGELGTIGT---------TGTSS 143
Cdd:PRK09196  83 DHGNSPATCQRAIQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLGSletgmggeeDGHGA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 144 EGGTD-EIIYTDSKLAKDFVEKTGVDTLAIAIGTAHGIYPKGFKPE---LKLDLLKEI-REVVDIPLVLHGGSSNPD--- 215
Cdd:PRK09196 163 EGKLShDQLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKPTgdvLAIDRIKEIhARLPNTHLVMHGSSSVPQell 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497589318 216 ------------------EEIAQAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREV 270
Cdd:PRK09196 243 diineyggdmpetygvpvEEIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKI 315
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
2-292 4.20e-67

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 211.89  E-value: 4.20e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAI------HPNE--LSFLGDSFVASCIEEAnkSKV 73
Cdd:PRK07084   9 LVNTREMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVskgarkYANAtlLRYMAQGAVEYAKELG--CPI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  74 PMVIHLDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttGTSSEGGTDEIIYT 153
Cdd:PRK07084  87 PIVLHLDHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLA--GVEDEVSAEHHTYT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 154 DSKLAKDFVEKTGVDTLAIAIGTAHGIYPkgFKPE-----LKLDLLKEI-REVVDIPLVLHGGSSNPDEEIA-------- 219
Cdd:PRK07084 165 QPEEVEDFVKKTGVDSLAISIGTSHGAYK--FKPGqcpppLRFDILEEIeKRIPGFPIVLHGSSSVPQEYVKtineyggk 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 220 -------------QAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPcikaAReviefkmnlfnaiDKLKC 286
Cdd:PRK07084 243 lkdaigipeeqlrKAAKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGP----AR-------------DELKK 305


                 ....*.
gi 497589318 287 FYKNKN 292
Cdd:PRK07084 306 LYKHKI 311
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
2-279 9.04e-65

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 206.55  E-value: 9.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKS--KVPMVIHL 79
Cdd:PRK13399   3 LITLRQLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMypDIPICLHQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  80 DHGENKEQILRAIRCGFTSVMIDGSHLP-------YEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTD---- 148
Cdd:PRK13399  83 DHGNSPATCQSAIRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSLETGEAGEEDgvga 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 149 ------EIIYTDSKLAKDFVEKTGVDTLAIAIGTAHGIYPKGFKPE---LKLDLLKEI-REVVDIPLVLHGGSSNPDE-- 216
Cdd:PRK13399 163 egklshDQMLTDPDQAVDFVQRTGVDALAIAIGTSHGAYKFTRKPDgdiLAIDRIEEIhARLPNTHLVMHGSSSVPQElq 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 217 -------------------EIAQAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNL 277
Cdd:PRK13399 243 eiinayggkmketygvpveEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQRFEA 322


                 ..
gi 497589318 278 FN 279
Cdd:PRK13399 323 FG 324
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-284 1.44e-58

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 189.41  E-value: 1.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   1 MLINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKS--KVPMVIH 78
Cdd:PRK05835   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERypHIPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  79 LDHGENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIgtTGTSSEGGTDE--IIYTDSK 156
Cdd:PRK05835  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRL--MGIEDNISVDEkdAVLVNPK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 157 LAKDFVEKTGVDTLAIAIGTAHGIYPkgFKPELKLDL--LKEIREVVDIPLVLHGGSSNPD------------------- 215
Cdd:PRK05835 159 EAEQFVKESQVDYLAPAIGTSHGAFK--FKGEPKLDFerLQEVKRLTNIPLVLHGASAIPDdvrksyldaggdlkgskgv 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497589318 216 --EEIAQAVKLGVCKINISSDVKSAYYKKCRELLEQNPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDKL 284
Cdd:PRK05835 237 pfEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
PLN02858 PLN02858
fructose-bisphosphate aldolase
 6-278 4.81e-56

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 194.69  E-value: 4.81e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318    6 KEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVASCIEEANKSKVPMVIHLDHGENK 85
Cdd:PLN02858 1103 KELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVSCCIAAAEQASVPITVHFDHGTSK 1182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   86 EQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGTTGTSSEGGTDEIIYTDSKLAKDFVEKT 165
Cdd:PLN02858 1183 HELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYEAKLTDVDQAKEFIDET 1262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  166 GVDTLAIAIGTAHGIYPKGfKPELKLDLLKEIREVV---DIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYykk 242
Cdd:PLN02858 1263 GIDALAVCIGNVHGKYPAS-GPNLRLDLLKELRALSskkGVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAY--- 1338

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 497589318  243 crelLEQNPSLYEPDTIY--PPCIKAAREVIEFKMNLF 278
Cdd:PLN02858 1339 ----MEALSSPKKTDLIDvmSAAKEAMKAVVAEKLRLF 1372
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 6-282 2.26e-54

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 179.62  E-value: 2.26e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   6 KEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLGDSFVAS-----------------CIEEA 68
Cdd:cd00453    2 QKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSdvpqgaailgaisgahhVHQMA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  69 NKSKVPMVIHLDHGENK--EQILRAIRCG-----------FTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGT 135
Cdd:cd00453   82 EHYGVPVILHTDHCAKKllPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 136 IG--TTGTSSEGGTDEIIYTDSKLAKDFVEKTG----VDTLAIAIGTAHGIYPKGfKPELKLDLLKEIREVV-------- 201
Cdd:cd00453  162 TGgeEDGVDNSHMDASALYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKKG-NVVLTPTILRDSQEYVskkhnlph 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 202 -DIPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKCRELLEQNPS-----LYEPDTIYPPCIK---------- 265
Cdd:cd00453  241 nSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAylqgqLGNPKGEDQPNKKyydprvwlra 320

                        330       340
                 ....*....|....*....|
gi 497589318 266 ---AAREVIEFKMNLFNAID 282
Cdd:cd00453  321 gqtSMIARLEKAFQELNAID 340
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 2-283 5.19e-51

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 169.68  E-value: 5.19e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   2 LINMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIHPNELSFLG-----DSFVASCIEEANKSkVPMV 76
Cdd:PRK07315   3 IVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGgykvcKNLIENLVESMGIT-VPVA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  77 IHLDHGeNKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELGTIGttgtsseGGTDEIIYT--- 153
Cdd:PRK07315  82 IHLDHG-HYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIG-------GEEDGIIGKgel 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 154 -DSKLAKDFVEkTGVDTLAIAIGTAHGIYPKGFKpELKLDLLKEIREVV-DIPLVLHGGSSNPDEEIAQAVKLGVCKINI 231
Cdd:PRK07315 154 aPIEDAKAMVE-TGIDFLAAGIGNIHGPYPENWE-GLDLDHLEKLTEAVpGFPIVLHGGSGIPDDQIQEAIKLGVAKVNV 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497589318 232 SSDVKSAYYKKCRELLEQ---------NPSLYEPDTIYPPCIKAAREVIEFKMNLFNAIDK 283
Cdd:PRK07315 232 NTECQIAFANATRKFARDyeaneaeydKKKLFDPRKFLAPGVKAIQASVEERIDVFGSANK 292
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 7-242 2.10e-28

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 111.43  E-value: 2.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   7 EMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILaihpnELSFLGDSF--------------VASCI------- 65
Cdd:PRK09197  11 EMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVII-----QFSNGGAAFiagkgvkddgqgaaVLGAIagakhvh 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  66 EEANKSKVPMVIHLDH-------------GENKEQILRAIRCGFTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGE 132
Cdd:PRK09197  86 EVAEHYGVPVILHTDHcakkllpwidgllDAGEKHFAAGGKPLFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEIE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 133 LGTIG--TTGTSSEGGTDEIIYTDSKLAKDFVEKTGVD----TLAIAIGTAHGIYpkgfKP---ELKLDLLKEIREVVD- 202
Cdd:PRK09197 166 LGVTGgeEDGVDNSHEDNSKLYTQPEDVLYAYEALGKIsgrfTIAASFGNVHGVY----KPgnvKLRPEILKDSQEYVSk 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 497589318 203 --------IPLVLHGGSSNPDEEIAQAVKLGVCKINISSDVKSA-------YYKK 242
Cdd:PRK09197 242 kfglpakpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAfwrgvldYYFK 296
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 4-250 5.72e-26

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 104.76  E-value: 5.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318   4 NMKEMLKVAQENQFAVPAFNIGSGQILKAVVQSANEKNAPVILAIH------------PNE---LSFLGDSFVASCIEEA 68
Cdd:cd00946    3 DVLKLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSnggaafyagkglKNEkqkASIAGAIAAAHHVRSM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  69 NKSK-VPMVIHLDHGENK-----EQILRA-----IRCG---FTSVMIDGSHLPYEENVAISREIVEIAKGLNVSVEGELG 134
Cdd:cd00946   83 AEHYgVPVVLHTDHCAKKllpwfDGLLEAdeeyfKQHGeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 135 TIG--TTGTSSEGGTDEIIYTDS----KLAKDFVEKTGVDTLAIAIGTAHGIYPKG---FKPELKLDLLKEIREVV---- 201
Cdd:cd00946  163 ITGgeEDGVDNSGVDNAELYTQPedvwYVYEALSKISPNFSIAAAFGNVHGVYKPGnvkLQPEILGEHQDYVREKLglad 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497589318 202 DIPL--VLHGGSSNPDEEIAQAVKLGVCKINISSDVKSAYYKKCRELLEQN 250
Cdd:cd00946  243 DKPLyfVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKN 293
PEP_mutase pfam13714
Phosphoenolpyruvate phosphomutase; This domain includes the enzyme Phosphoenolpyruvate ...
 162-231 5.18e-04

Phosphoenolpyruvate phosphomutase; This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein Swiss:O86937 has been characterized as catalysing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr). This enzyme has a TIM barrel fold.


Pssm-ID: 433424  Cd Length: 241  Bit Score: 40.65  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  162 VEKTGVDTLAI---AIGTAHGiYPKG--FKPELKLDLLKEIREVVDIPLV--LHGGSSNPDEEIAQAVK----LGVCKIN 230
Cdd:pfam13714  25 VEAAGFPAIATssaGVAASLG-YPDGelLPRDELLAAARRIAAAVDLPVSadLETGYGDSPEEVAETVRrliaAGVVGVN 103


                  .
gi 497589318  231 I 231
Cdd:pfam13714 104 I 104
PRK12331 PRK12331
oxaloacetate decarboxylase subunit alpha;
141-208 9.24e-04

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 183446 [Multi-domain]  Cd Length: 448  Bit Score: 40.46  E-value: 9.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497589318 141 TSSEGGTDE--IIYTDS---------KLAKDFVEkTGVDTlaIAIGTAHGIypkgFKPELKLDLLKEIREVVDIPLVLH 208
Cdd:PRK12331 132 TKKAGGHAQvaISYTTSpvhtidyfvKLAKEMQE-MGADS--ICIKDMAGI----LTPYVAYELVKRIKEAVTVPLEVH 203
OYE_like_FMN_family cd02803
Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme ...
 90-227 3.66e-03

Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.


Pssm-ID: 239201 [Multi-domain]  Cd Length: 327  Bit Score: 38.32  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318  90 RAIRCGFTSVMIDGSH--L------PY------------EENVAISREIVEiakglnvSVEGELG---TIG-----TTGT 141
Cdd:cd02803  149 RAKEAGFDGVEIHGAHgyLlsqflsPYtnkrtdeyggslENRARFLLEIVA-------AVREAVGpdfPVGvrlsaDDFV 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 142 SSEGGTDEIIytdsKLAKDFvEKTGVDTLAIAIGT----AHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPdEE 217
Cdd:cd02803  222 PGGLTLEEAI----EIAKAL-EEAGVDALHVSGGSyespPPIIPPPYVPEGYFLELAEKIKKAVKIPVIAVGGIRDP-EV 295

                        170
                 ....*....|
gi 497589318 218 IAQAVKLGVC 227
Cdd:cd02803  296 AEEILAEGKA 305
FadH COG1902
2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family ...
 144-227 3.84e-03

2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family [Energy production and conversion];


Pssm-ID: 441506 [Multi-domain]  Cd Length: 365  Bit Score: 38.23  E-value: 3.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497589318 144 EGGT--DEIIYtdskLAKDFvEKTGVDTLAIAIGT--AHGIYPKGFKPELKLDLLKEIREVVDIPLVLHGGSSNPdEEIA 219
Cdd:COG1902  230 EGGLtlEESVE----LAKAL-EEAGVDYLHVSSGGyePDAMIPTIVPEGYQLPFAARIRKAVGIPVIAVGGITTP-EQAE 303


                 ....*...
gi 497589318 220 QAVKLGVC 227
Cdd:COG1902  304 AALASGDA 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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