NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|497642677|ref|WP_009956861|]
View 

MULTISPECIES: PadR family transcriptional regulator [Mycobacterium]

Protein Classification

PadR family transcriptional regulator( domain architecture ID 11447868)

PadR family transcriptional regulator similar to the phenolic acid decarboxylation repressor, which is a transcription factor that represses genes associated with the phenolic acid stress response in gram-positive bacteria

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  10908318|10679470|10473770|15808743|8831795

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
1-88 7.02e-23

DNA-binding transcriptional regulator, PadR family [Transcription];


:

Pssm-ID: 441301  Cd Length: 102  Bit Score: 87.68  E-value: 7.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497642677   1 MSLRDAVLAALLEGESSGYDLAKGFDASVANFWPATPQQLYRELDRLAEQGLIRARVVRQERRPNKRMFSLTEAGREAIR 80
Cdd:COG1695    8 GTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTEAGREELA 87


                 ....*...
gi 497642677  81 QFTAKAPK 88
Cdd:COG1695   88 EWLEEWEK 95
Vir_act_alpha_C pfam10400
Virulence activator alpha C-term; This structure is homo-dimeric, and the domain here is the ...
 92-180 3.89e-18

Virulence activator alpha C-term; This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.


:

Pssm-ID: 463075  Cd Length: 82  Bit Score: 74.93  E-value: 3.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497642677   92 IRDELLVKVQAADAGDMPAVRESILERMQWARAKLQRYERLRARMMDGrtekeylAHTDRVGPYLTLVRGISFEEENIRW 171
Cdd:pfam10400   1 IRDELLLKLFFADVLDPEALIELLERRRELHRAKLAEYRAIEERLFEP-------PDEDARGWYLTLRRGIRFEEAWIEW 73


                  ....*....
gi 497642677  172 AEQALAVIE 180
Cdd:pfam10400  74 CDEALELLE 82
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
1-88 7.02e-23

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 87.68  E-value: 7.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497642677   1 MSLRDAVLAALLEGESSGYDLAKGFDASVANFWPATPQQLYRELDRLAEQGLIRARVVRQERRPNKRMFSLTEAGREAIR 80
Cdd:COG1695    8 GTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTEAGREELA 87


                 ....*...
gi 497642677  81 QFTAKAPK 88
Cdd:COG1695   88 EWLEEWEK 95
Vir_act_alpha_C pfam10400
Virulence activator alpha C-term; This structure is homo-dimeric, and the domain here is the ...
 92-180 3.89e-18

Virulence activator alpha C-term; This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.


Pssm-ID: 463075  Cd Length: 82  Bit Score: 74.93  E-value: 3.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497642677   92 IRDELLVKVQAADAGDMPAVRESILERMQWARAKLQRYERLRARMMDGrtekeylAHTDRVGPYLTLVRGISFEEENIRW 171
Cdd:pfam10400   1 IRDELLLKLFFADVLDPEALIELLERRRELHRAKLAEYRAIEERLFEP-------PDEDARGWYLTLRRGIRFEEAWIEW 73


                  ....*....
gi 497642677  172 AEQALAVIE 180
Cdd:pfam10400  74 CDEALELLE 82
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 7-80 1.16e-12

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 60.34  E-value: 1.16e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497642677    7 VLAALLEGESSGYDLAKGFDASVANFWPATPQQLYRELDRLAEQGLIRARVVRQERRPNKRMFSLTEAGREAIR 80
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-85 9.75e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 34.11  E-value: 9.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 497642677    36 TPQQLYRELDRLAEQGLIRARVVRQERRpnKRMFSLTEAGREAIRQFTAK 85
Cdd:smart00347  37 SPSTVTRVLDRLEKKGLVRREPSPEDRR--SVLVSLTEEGRELIEQLLEA 84
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
1-88 7.02e-23

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 87.68  E-value: 7.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497642677   1 MSLRDAVLAALLEGESSGYDLAKGFDASVANFWPATPQQLYRELDRLAEQGLIRARVVRQERRPNKRMFSLTEAGREAIR 80
Cdd:COG1695    8 GTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTEAGREELA 87


                 ....*...
gi 497642677  81 QFTAKAPK 88
Cdd:COG1695   88 EWLEEWEK 95
Vir_act_alpha_C pfam10400
Virulence activator alpha C-term; This structure is homo-dimeric, and the domain here is the ...
 92-180 3.89e-18

Virulence activator alpha C-term; This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.


Pssm-ID: 463075  Cd Length: 82  Bit Score: 74.93  E-value: 3.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497642677   92 IRDELLVKVQAADAGDMPAVRESILERMQWARAKLQRYERLRARMMDGrtekeylAHTDRVGPYLTLVRGISFEEENIRW 171
Cdd:pfam10400   1 IRDELLLKLFFADVLDPEALIELLERRRELHRAKLAEYRAIEERLFEP-------PDEDARGWYLTLRRGIRFEEAWIEW 73


                  ....*....
gi 497642677  172 AEQALAVIE 180
Cdd:pfam10400  74 CDEALELLE 82
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 7-80 1.16e-12

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 60.34  E-value: 1.16e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497642677    7 VLAALLEGESSGYDLAKGFDASVANFWPATPQQLYRELDRLAEQGLIRARVVRQERRPNKRMFSLTEAGREAIR 80
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-85 9.75e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 34.11  E-value: 9.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 497642677    36 TPQQLYRELDRLAEQGLIRARVVRQERRpnKRMFSLTEAGREAIRQFTAK 85
Cdd:smart00347  37 SPSTVTRVLDRLEKKGLVRREPSPEDRR--SVLVSLTEEGRELIEQLLEA 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH