|
Name |
Accession |
Description |
Interval |
E-value |
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
1-720 |
0e+00 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 1562.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 1 MDVSELLDGLNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGT 80
Cdd:PRK11773 1 MDVSYLLDSLNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLLGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 81 SQGGMWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIKSMNLDDKQWPARQGMWYINGKKDEGLRPKHIE 160
Cdd:PRK11773 81 SQGGMWVGTFHGLAHRLLRAHWQDANLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAQWYINGQKDEGLRPQHIQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 161 SYGNPIEQTWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDS 240
Cdd:PRK11773 161 SYGDPVEQTWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTNAIQYAWIRLLAGDT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 241 GRVIIVGDDDQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNYRSTNNILKAANALIANNNGRLGKELWTEGSDGEPISI 320
Cdd:PRK11773 241 GKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNGRLGKELWTDGGDGEPISL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 321 YCAFNELDEARFVVNRIKVWMENGGALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMAN 400
Cdd:PRK11773 321 YCAFNELDEARFVVERIKTWQDNGGALSDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDALAYLRLIAN 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 401 RNDDAAFERVVNTPTRGVGDRTLDVVRQTARERQMTLWQATRELLQSRALAGRAASALQRFCELVDSLATETAELPLHVQ 480
Cdd:PRK11773 401 RNDDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQACRALLQEKVLAGRAASALQRFIELIDALAQETADMPLHEQ 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 481 TDRVIKDSGLWLMYEQEKGEKGQARIENLEELVTATRQFSYQDEDEDLMPLQAFLSHAALEAGEGQADKWQDAVQLMTLH 560
Cdd:PRK11773 481 TDRVIKDSGLRAMYEQEKGEKGQARIENLEELVTATRQFSYPDEDEDLTPLQAFLSHAALEAGEGQADAHEDAVQLMTLH 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 561 SAKGLEFSQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHRPSRFIGELPEAC 640
Cdd:PRK11773 561 SAKGLEFPLVFIVGMEEGLFPSQMSLEEGGRLEEERRLAYVGITRAMQKLTLTYAESRRLYGKEVYHRPSRFIREIPEEC 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 641 IEEVRLRASVSRPVNHQRMGAPVTKN-DSGFALGQRVHHAKFGEGTIINLEGSGEHSRLQVAFQGQGIKWLVAAYAKLET 719
Cdd:PRK11773 641 VEEVRLRATVSRPVSHQRMGTPAVEAnDSGFKLGQRVRHPKFGEGTIVNFEGSGAHARVQVAFQGQGIKWLVAAYAKLEA 720
|
.
gi 497943157 720 L 720
Cdd:PRK11773 721 V 721
|
|
| uvrD |
TIGR01075 |
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, ... |
6-718 |
0e+00 |
|
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130147 [Multi-domain] Cd Length: 715 Bit Score: 1349.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 6 LLDGLNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGTSQGGM 85
Cdd:TIGR01075 1 LLDGLNDKQREAVAAPPGNLLVLAGAGSGKTRVLTHRIAWLLSVENASPHSIMAVTFTNKAAAEMRHRIGALLGTSARGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 86 WIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIKSMNLDDKQWPARQGMWYINGKKDEGLRPKHIESYGNP 165
Cdd:TIGR01075 81 WIGTFHGLAHRLLRAHHLDAGLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAMWYINNQKDEGLRPSHIQAFDNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 166 IEQTWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVII 245
Cdd:TIGR01075 161 VERTWIKIYQAYQEACDRAGLVDFAELLLRAHELLRNKPHILQHYQERFTHILVDEFQDTNKIQYAWIRLLAGNTGNVMI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 246 VGDDDQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNYRSTNNILKAANALIANNNGRLGKELWTEGSDGEPISIYCAFN 325
Cdd:TIGR01075 241 VGDDDQSIYGWRGAQVENIQKFLKDFPGAETIRLEQNYRSTANILAAANALIANNDERLGKNLWTDGEVGEPISLYSAFN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 326 ELDEARFVVNRIKVWMENGGALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRNDDA 405
Cdd:TIGR01075 321 ELDEARFVVSRIKTWQRNGGALDECAVLYRSNAQSRVLEEALLQASIPYRIYGGMRFFERQEIKDALAYLRLIANRNDDA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 406 AFERVVNTPTRGVGDRTLDVVRQTARERQMTLWQATRELLQSRALAGRAASALQRFCELVDSLATETAELPLHVQTDRVI 485
Cdd:TIGR01075 401 AFERVINTPTRGIGDRTLDVVRQAARDRGLTLWQAARELTQEKVLAGRAASALQRFVELIEALANETADMPLHVQTDHVI 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 486 KDSGLWLMYEQEKGEKGQARIENLEELVTATRQFSYQDEDEDLMPLQAFLSHAALEAGEGQADKWQDAVQLMTLHSAKGL 565
Cdd:TIGR01075 481 KDSGLREMYQQEKGEKGQARIENLEELVTATRQFSLPENDEDMTPLTAFLSHAALEAGEGQADAGQDAVQLMTLHSAKGL 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 566 EFSQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHRPSRFIGELPEACIEEVR 645
Cdd:TIGR01075 561 EFPLVFLVGMEEGMFPSQMSLDEGGRLEEERRLAYVGITRAMQKLTITYAETRRLYGKEVYHIPSRFIRELPEECLHEVR 640
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497943157 646 LRASVSRPVNHQRMGAPVTK--NDSGFALGQRVHHAKFGEGTIINLEGSGEHSRLQVAFQGQGIKWLVAAYAKLE 718
Cdd:TIGR01075 641 LRAQVSRPTNLGRVGTPSVDeiNDAGFKLGQRVRHPKFGEGTIINAEGSGEHSRLQIAFQGQGIKWLVAAYAKLE 715
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
4-720 |
0e+00 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 927.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 4 SELLDGLNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGTSQG 83
Cdd:COG0210 1 SDLLAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALLGRLAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 84 GMWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIKSMNLDDKQWPARQGMWYINGKKDEGLRPKHIESY- 162
Cdd:COG0210 81 GLWVGTFHSLALRILRRHAELLGLPPNFTILDGDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEELAELl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 163 -GNPIEQTWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSG 241
Cdd:COG0210 161 aADPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLLAGDGR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 242 RVIIVGDDDQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNYRSTNNILKAANALIANNNGRLGKELWTEGSDGEPISIY 321
Cdd:COG0210 241 NLCVVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWTDNGEGEKVRLY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 322 CAFNELDEARFVVNRIKVWMENGGALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANR 401
Cdd:COG0210 321 VAPDEEEEARFVADEIRELHEEGVPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLANP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 402 NDDAAFERVVNTPTRGVGDRTLDVVRQTARERQMTLWQATRELLQSRALAGRAASALQRFCELVDSLATETAELPLHVQT 481
Cdd:COG0210 401 DDDVALLRILNVPRRGIGAATLERLREAAREEGISLLEALRDLGELAGLSGRAAKALRRFAELLEALRAAAERLPLEELL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 482 DRVIKDSGLWLMYEQEKGEKGQARIENLEELVTATRQFsyqDEDEDLMPLQAFLSHAALEAGEGQADKWQDAVQLMTLHS 561
Cdd:COG0210 481 EALLDESGYEEELREEAGEEAERRLENLEELVDAAARF---EERNPGASLEAFLEELALLSDLDAADEDEDAVTLMTLHA 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 562 AKGLEFSQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHRPSRFIGELPEACI 641
Cdd:COG0210 558 AKGLEFPVVFLVGLEEGLFPHQRSLDDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQDNEPSRFLDELPEELL 637
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497943157 642 EEVRLRASVSRPVNHQRMGAPVTKNDSGFALGQRVHHAKFGEGTIINLEGSGEHSRLQVAFQGQGIKWLVAAYAKLETL 720
Cdd:COG0210 638 EWVRPKAEAAAAAASAAAALPASGAGAAALAAGAAAAAAAAGGGAAVAGAGLGRAAAAGGADGGAAGAGGGLAAVALTV 716
|
|
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
6-718 |
0e+00 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 748.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 6 LLDGLNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGTSQGGM 85
Cdd:TIGR01073 1 LLAHLNPEQREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLIAEKNVAPWNILAITFTNKAAREMKERVEKLLGPVAEDI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 86 WIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIKSMNLDDKQWPARQGMWYINGKKDEGLRP-KHIESYGN 164
Cdd:TIGR01073 81 WISTFHSMCVRILRRDIDRIGINRNFSIIDPTDQLSLMKTILKDKNLDPKKFEPRSILGTISNAKNELLPPeDFAKEATN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 165 PIEQTWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVI 244
Cdd:TIGR01073 161 YFEKVVAEVYQEYQKRLLRNNALDFDDLIMTTINLFQRVPDVLEYYQRKFQYIHVDEYQDTNRAQYTLVRLLASRFRNLC 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 245 IVGDDDQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNYRSTNNILKAANALIANNNGRLGKELWTEGSDGEPISIYCAF 324
Cdd:TIGR01073 241 VVGDADQSIYGWRGADIQNILSFEKDYPNATTILLEQNYRSTKNILQAANEVIEHNSNRKPKNLWTENSSGDKITYYEAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 325 NELDEARFVVNRIKVWMENG-GALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRND 403
Cdd:TIGR01073 321 TERDEAQFVAGEIDKLVKNGeRKYGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILAYLRVIANPDD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 404 DAAFERVVNTPTRGVGDRTLDVVRQTARERQMTLWQATRELLQSRALAGRAASALQRFCELVDSLATETAELPLHVQTDR 483
Cdd:TIGR01073 401 DLSLLRIINVPKRGIGASSLEKIVNYALELNISLFEAIGEIDEIGGLAAKSANALLAFATMIENLRQQQEYLSPTELVEE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 484 VIKDSGLWLMYEQEKGEKGQARIENLEELVTATRQFsyQDEDEDlMPLQAFLSHAALEAGEGQADKWQ--DAVQLMTLHS 561
Cdd:TIGR01073 481 VLDKSGYREMLKAEKTEEAQSRLENLDEFLSVTKEF--EDESED-KSLIDFLTDLALVSDLDELEETEegGAVTLMTLHA 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 562 AKGLEFSQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHRPSRFIGELPEACI 641
Cdd:TIGR01073 558 AKGLEFPVVFLIGMEEGVFPHSRSLMDEKELEEERRLAYVGITRAEEELYLTHATMRTLFGRIQMNPPSRFLNEIPAELL 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 642 EEVR---------------LRASVSRPVNHQrmgaPVTKNDSG-FALGQRVHHAKFGEGTIINLEGSGEHSRLQVAFQGQ 705
Cdd:TIGR01073 638 ETAStgrrtgatdpkgpsiRQAGASRPTTSQ----PTAGGDTLsWAVGDRVNHKKWGIGTVVSVKGGGDDQELDIAFPSI 713
|
730
....*....|...
gi 497943157 706 GIKWLVAAYAKLE 718
Cdd:TIGR01073 714 GVKRLLAAFAPIE 726
|
|
| rep |
TIGR01074 |
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. ... |
9-638 |
0e+00 |
|
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130146 [Multi-domain] Cd Length: 664 Bit Score: 552.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 9 GLNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLmsVENC--SPYSIMAVTFTNKAAAEMRHRIEHLIGTSQG-GM 85
Cdd:TIGR01074 1 KLNPQQQEAVEYVTGPCLVLAGAGSGKTRVITNKIAYL--IQNCgyKARNIAAVTFTNKAAREMKERVAKTLGKGEArGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 86 WIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIKSMNLDDKQWpARQGMWYINGKKDEGLRPKHI-ESYGN 164
Cdd:TIGR01074 79 TISTFHTLGLDIIKREYNALGYKSNFSLFDETDQLALLKELTEGLIKDDKDL-LDKLISTISNWKNDLLTPEQAlASARG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 165 PIEQTWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVI 244
Cdd:TIGR01074 158 EREQTFAHCYALYQAHLRAYNALDFDDLILLPTLLLQQNEEVRNRWQNKIRYLLVDEYQDTNTSQYELVKLLVGDRARFT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 245 IVGDDDQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNYRSTNNILKAANALIANNNGRLGKELWTEGSDGEPISIYCAF 324
Cdd:TIGR01074 238 VVGDDDQSIYSWRGARPENLVLLKEDFPQLKVIKLEQNYRSTGRILKAANILIANNPHVFEKKLFSELGYGEKIKVIECN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 325 NELDEARFVVNRI-KVWMENGGALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRND 403
Cdd:TIGR01074 318 NEEHEAERIAGEIiAHKLVNKTQYKDYAILYRGNHQSRLLEKALMQNRIPYKLSGGTSFFSRPEIKDLLSYLRLLVNPDD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 404 DAAFERVVNTPTRGVGDRTLDVVRQTARERQMTLWQATRELLQSRALAGRAASALQRFCELVDSLATETAELPLHVQTDR 483
Cdd:TIGR01074 398 DAAFLRIVNTPKREIGPATLEKLGELAMERNKSLFTASFDMGLLQTLSGRGYESLQRFTDWLVEIRRLAERSEPIEAVRS 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 484 VIKDSGL--WLmYEQEKGEKG-QARIENLEELVTATRQFSYQDEDEDLMPLQAFLSHAAL----EAGEGQADKwqDAVQL 556
Cdd:TIGR01074 478 LIEDIDYenWL-YETSPSPKAaEMRMKNVNTLFSWFKEMLEGDEEDEPMTLTQVVTRLTLrdmlERGEDEEEL--DQVQL 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 557 MTLHSAKGLEFSQVFIVGMEEGMFPSQMSLDEgGRLEEERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHRPSRFIGEL 636
Cdd:TIGR01074 555 MTLHASKGLEFPYVFIVGMEEGILPHQSSIEE-DNVEEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLDEL 633
|
..
gi 497943157 637 PE 638
Cdd:TIGR01074 634 PQ 635
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
10-638 |
9.17e-146 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 441.20 E-value: 9.17e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 10 LNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGTSQG-GMWIG 88
Cdd:PRK10919 3 LNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVAQTLGRKEArGLMIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 89 TFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIKSMNLDDKQWPARQGMWYINGKKDEGLRPKHIESYGNPIEQ 168
Cdd:PRK10919 83 TFHTLGLDIIKREYAALGMKSNFSLFDDTDQLALLKELTEGLIEDDKVLLQQLISTISNWKNDLKTPAQAAAGAKGERDR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 169 TWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVIIVGD 248
Cdd:PRK10919 163 IFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTVVGD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 249 DDQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNYRSTNNILKAANALIANNNGRLGKELWTEGSDGEPISIYCAFNELD 328
Cdd:PRK10919 243 DDQSIYSWRGARPQNLVLLSQDFPALQVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGDELKVLSANNEEH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 329 EARFVVNR-IKVWMENGGALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRNDDAAF 407
Cdd:PRK10919 323 EAERVTGElIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDDSAF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 408 ERVVNTPTRGVGDRTLDVVRQTARERQMTLWQATRELLQSRALAGRAASALQRFCELVDSLATETAELPLHVQTDRVIK- 486
Cdd:PRK10919 403 LRIVNTPKREIGPATLQKLGEWAMTRNKSLFTASFDMGLSQTLSGRGYESLTRFTHWLAEIQRLAEREPVAAVRDLIHGi 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 487 DSGLWLmYEQEKGEK-GQARIENLEELVTATRQFSYQDEDEDLMPLQAFLSHAALE--AGEGQADKWQDAVQLMTLHSAK 563
Cdd:PRK10919 483 DYESWL-YETSPSPKaAEMRMKNVNQLFSWMTEMLEGSELDEPMTLTQVVTRFTLRdmMERGESEEELDQVQLMTLHASK 561
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497943157 564 GLEFSQVFIVGMEEGMFPSQMSLDEGGrLEEERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHRPSRFIGELPE 638
Cdd:PRK10919 562 GLEFPYVYLVGMEEGLLPHQSSIDEDN-IDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLLELPQ 635
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
10-272 |
1.17e-117 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 353.86 E-value: 1.17e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 10 LNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGTSQ-GGMWIG 88
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERILKLLGKAElSELNIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 89 TFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLKRLIK--SMNLDDKQWPARQGMWYINGKKDEGLRPKHIESY-GNP 165
Cdd:pfam00580 81 TFHSFCLRILRKYANRIGLLPNFSILDELDQLALLKELLEkdRLNLDPKLLRKLELKELISKAKNRLLSPEELQQGaADP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 166 IEQTWLRIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVII 245
Cdd:pfam00580 161 RDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHENLFL 240
|
250 260
....*....|....*....|....*..
gi 497943157 246 VGDDDQSIYGWRGAQVENIQRFLQDFP 272
Cdd:pfam00580 241 VGDPDQSIYGFRGADIENILKFEKDFP 267
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
10-619 |
8.85e-93 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 307.66 E-value: 8.85e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 10 LNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIG---------- 79
Cdd:COG1074 6 WTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRERLAeaadledpdl 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 80 --------------TSQGGMWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQL------------------------- 120
Cdd:COG1074 86 eelararrrlaralENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAEALlleeavddllreayapldalalarl 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 121 ------------RLLKRLIKSMNLDDKQWPARQGMWYINGKKDEGLRPK--------HIESYGNPIEQTWLR----IYQA 176
Cdd:COG1074 166 ldafgrdddsleELLLALYKLRSRPDWLEELAELDEALEALREALLKAKealaalreALAAAAAPLLAALLRllaaVLAR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 177 YQEACDRAGLVDFAELLLRAHELwLNKPH---ILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDS----GRVIIVGDD 249
Cdd:COG1074 246 YERRKRERGLLDFDDLLHRALRL-LRDEDapwVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEAladgRTLFLVGDP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 250 DQSIYGWRGAQVENIQRFLQDFPG---AETIRLEQNYRSTNNILK--------------AANALIANNNGRLGK----EL 308
Cdd:COG1074 325 KQSIYRFRGADPELFLEARRALEGrvdGERLTLTTNFRSTPEVVDavnalfaqlmgagfGEIPYEPVEALRPGAypavEL 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 309 WTEGSDGEPISIYcafnELDEARFVVNRIKVWMENGGALN---------DCAILYRSNAQSRVLEEALLQSSMPYRIYGG 379
Cdd:COG1074 405 WPLEPDDVSEEDA----REREARAVAARIRRLLAEGTTVEgggrpvrpgDIAVLVRTRSEAAAIARALKAAGIPVAASDR 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 380 MRFFERQEIKDALSYLRLMANRNDDAAFERVVNTPTRGVGDRTLDVVRQTARERqmTLWQATRellqsralagrAASALQ 459
Cdd:COG1074 481 LSLFESPEVRDLLALLRALLNPEDDLALAAVLRSPLFGLSDEDLAALAADRKGE--SLWEALR-----------AYERLA 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 460 RFCELVDSLATETAELPLHVQTDRVIKDSGLWLMY-EQEKGEKGQARIENLEELVTATRQFSyQDEDEDLMPLQAFLSHA 538
Cdd:COG1074 548 RALERLRALRELARRLGLAELLERLLEETGLLERLlALPGGERRLANLLHLDELLQLALEYE-QTGGPGLAGFLRWLERL 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 539 ALEAGEGQA---DKWQDAVQLMTLHSAKGLEFSQVFIVGMEEgmfpsqMSLDEggRLEEERRLAYVGVTRAMLKLTLTYA 615
Cdd:COG1074 627 IEDGGDEEKrrlESDADAVRIMTIHKSKGLEFPVVFLPALRE------RARAE--ELAEELRLLYVALTRARDRLVLSGA 698
|
....
gi 497943157 616 ETRR 619
Cdd:COG1074 699 VKKK 702
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
11-283 |
1.76e-88 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 275.16 E-value: 1.76e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 11 NDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIG-TSQGGMWIGT 89
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLLGeQLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 90 FHGLAHRLLRAHHldaglpqdfqildsedqlrllkrliksmnlddkqwparqgmwyingkkdeglrpkhiesygnpieqt 169
Cdd:cd17932 81 FHSFALRILRRYG------------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 170 wlriyqayqeacdraglvDFAELLLRAHELWLNKPHILNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVIIVGDD 249
Cdd:cd17932 94 ------------------DFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLFVVGDD 155
|
250 260 270
....*....|....*....|....*....|....
gi 497943157 250 DQSIYGWRGAQVENIQRFLQDFPGAETIRLEQNY 283
Cdd:cd17932 156 DQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
277-617 |
5.34e-85 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 273.13 E-value: 5.34e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 277 IRLEQNYRSTNNILKAANALIANNNGR----LGKELWTEGSDGEPISIYCAFNELDEARFVVNRIKVWMENGGALNDCAI 352
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRatiyPKKILAETVEDGEKIKIIEAETEEEEAEWIALEIKKLVARDEKYNDIAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 353 LYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRNDDAAFERVVNTPTRGVGDRTLDVVRQtARE 432
Cdd:pfam13361 81 LTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNGPKRGIGNATLERIRE-YKK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 433 RQMTLWQATRELLQ------SRALAGR----------------------AASALQRFCELVDSLATetaelplHVQTDRV 484
Cdd:pfam13361 160 RGLRLSDFINPDTLtygdpfVIALEQDnivvfdvettgldttedeiiqiAAIKLNKKGVVIESFER-------FLRLKKP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 485 IKDS----GLWLMYEQEKGEKGQA-------RIENLEELVTATRQFSYQDEDEDLM-PLQAFLSHAALEAGEGQADKWQD 552
Cdd:pfam13361 233 VGDSlqvhGFSDEFLQENGETPAEalrdfleKLENLRELYSILREYDDIEETPEPEdALRNFLEIATLSNSELEGSDIKE 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497943157 553 AVQLMTLHSAKGLEFSQVFIVGMEEGMFPSQMSLDEGGRLEEERRLAYVGVTRAMLKLTLTYAET 617
Cdd:pfam13361 313 RIPIMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIKDEGNLEEERRLFYVAITRAKKRLYISYSKS 377
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
24-283 |
1.34e-28 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 110.65 E-value: 1.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 24 NLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRhriehligtsqggmwigtfhglahrllrahhl 103
Cdd:cd17914 1 LSLIQGPPGTGKTRVLVKIVAALMQNKNGEPGRILLVTPTNKAAAQLD-------------------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 104 daglpqdfqildsedqlrllkrliksmnlddkqwparqgmwyingkkdeglrpkhiesygnpieqtwlriyqayqeacdr 183
Cdd:cd17914 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 184 aglvdfaelllrahelwlnkphilnhyrerftNVLVDEFQDTNNIQYAWIRMLAGDSGRVIIVGDDDQSIYGWRGAQVEN 263
Cdd:cd17914 49 --------------------------------NILVDEAAQILEPETSRLIDLALDQGRVILVGDHDQLGPVWRGAVLAK 96
|
250 260
....*....|....*....|....*
gi 497943157 264 -----IQRFLQDFPGAETIRLEQNY 283
Cdd:cd17914 97 icneqSLFTRLVRLGVSLIRLQVQY 121
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
12-612 |
2.31e-28 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 122.12 E-value: 2.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 12 DNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIawLMSVENCSPYS-IMAVTFTNKAAAEMRHRIE--------------H 76
Cdd:TIGR02785 4 DEQWQAIYTRGQDILVSASAGSGKTAVLVERI--IRKITRGVDVDrLLVVTFTNAAAREMKERIAealekelvqepnskH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 77 L------IGTSQggmwIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLK-------------------------- 124
Cdd:TIGR02785 82 LrrqlalLNTAN----ISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKevlddvfeeeyykedkeaffelvdnf 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 125 ----------RLIKSM---------------NL------------DDKQW------------------------------ 137
Cdd:TIGR02785 158 sgdrsddglrDLILQLydfsrstpnpekwlnNLaeayevkekftiESLKLqqqikellkneleglqeklqralelfmaed 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 138 ---PARQGMWY--------INGKKD----------------EGLRPKHIESYGNPI------------------------ 166
Cdd:TIGR02785 238 glaPRLENFQLdlqnidelIQESLAqadwnelrkavaafkfKNLKAAKGDEEDADLleeadklreeakkqleklktdyft 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 167 --EQTWLRIYQ------------------AYQEACDRAGLVDFAELLLRAHELWLNKPH----ILNHYRERFTNVLVDEF 222
Cdd:TIGR02785 318 rsEEDHLRIMQemkpvvktlvqlvkdfieRFGAEKREKNILDFSDLEHYALQILTNENEspseAAEFYREKFHEVLVDEY 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 223 QDTNNIQYAWIRMLAGDS---GRVIIVGDDDQSIYGWRGAQ----VENIQRFLQDFPGA-ETIRLEQNYRSTNNILKAAN 294
Cdd:TIGR02785 398 QDTNLVQESILQLVKRGPeeeGNLFMVGDVKQSIYRFRQADpllfLEKYHRFAQEGEEHgKRIDLAENFRSRAEVLDTTN 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 295 ALIANNNG--------------RLGKELWTEGSDG---------------EPISIYCAFNELD----EARFVVNRIK--- 338
Cdd:TIGR02785 478 FLFKQLMDeevgeidydeeaqlKFGAAKYPENPDNkteellyekllieeaEEEEIDEEAEILDkaqqEATMVAERIKali 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 339 -----VW-MENGG----ALNDCAILYRSNAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRNDDAAFE 408
Cdd:TIGR02785 558 kegfkVYdKKTGTyrpvTYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPLV 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 409 RVVNTPTRGVGDRTLDVVRqtARERQMTLWQATRELLQSRALAGRAASALQRFcelVDSLatetAELPLHVQTDRVikDS 488
Cdd:TIGR02785 638 AVLRSPIVGFDENELALIR--LENKDSSYYEAVKDYVKAGLIEDELYEKLNTF---LDSL----QKWREFARTHSV--SE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 489 GLWLMYEQEK----------GEKGQArieNLEELVTATRQFS----------------YQDEDEDLmplqaflshaALEA 542
Cdd:TIGR02785 707 LIWKIYNDTGyydyvgglpgGKQRQA---NLYALYERARQYEstsfkglfqfirfierMQERQKDL----------ASAV 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 543 GEGQADkwqDAVQLMTLHSAKGLEFSQVFIVGM-----------------------------EEGMFPS----------Q 583
Cdd:TIGR02785 774 AVGEAE---NAVRLMTIHKSKGLEFPVVFVLGMgkqfnkqdlnssylldrqlglgikyidpqERLSYPSlpkvaikqkmK 850
|
890 900
....*....|....*....|....*....
gi 497943157 584 MSLdeggrLEEERRLAYVGVTRAMLKLTL 612
Cdd:TIGR02785 851 REL-----LSEEMRVLYVALTRAKEKLIL 874
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
546-614 |
2.87e-26 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 105.01 E-value: 2.87e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 497943157 546 QADKWQDA--VQLMTLHSAKGLEFSQVFIVGMEEGMFPSQMS----LDEGGRLEEERRLAYVGVTRAMLKLTLTY 614
Cdd:cd18807 76 QARVIEEAlrVTLMTIHASKGLEFPVVFIVGLGEGFIPSDASyhaaKEDEERLEEERRLLYVALTRAKKELYLVG 150
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
26-638 |
3.69e-24 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 108.68 E-value: 3.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 26 LVLAGAGSGKTRVLVHRIAwlmsvENCSPYSIMAVTFTNKAAAEMRHRIehLIGTSQGGMW---IGTFHGLAHRLLRAHH 102
Cdd:COG3857 2 FILGRAGSGKTTYLLEEIK-----EELKEGKPIILLVPEQMTFQAERAL--LKRLGLGGSIraqVLSFSRLAWRVLQETG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 103 LDAGLPQD--------FQILDS-EDQLRLLKRLIKSMNLDDKQWPARQGMwyingkKDEGLRPKHIESYGNPIEQ--TWL 171
Cdd:COG3857 75 GATRPLLSdagkrmllRKILEEhKDELKVFARAADKPGFIEQLAELITEL------KRYGITPEDLEEAAELLKEklRDL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 172 -RIYQAYQEACdRAGLVDFAELLLRAHElWLNKPHILNHyrerfTNVLVDEFQDTNNIQYAWIRMLAGDSGRVIIVGDDD 250
Cdd:COG3857 149 aLIYEAYEEKL-AGRYIDSEDLLRLLAE-KLEKSEFLEG-----AEIYIDGFTDFTPQELELLEALLKKAKEVTITLTLD 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 251 QSIYGWRGAQVENIQRFLQDfpgAETIRLEQNYRSTNNILkaanaliannngRLGKEL--WTEGSDGEPISIYCAFNELD 328
Cdd:COG3857 222 PDELDLFSATGETYERLLEL---AKENGVEVEFKKSPELA------------HLERNLfaYPPEEEPEGIEIIEAANRRA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 329 EARFVVNRIKVWMENGG-ALNDCAILYRS-NAQSRVLEEALLQSSMPYRIYGGMRFFERQEIKDALSYLRLMANRNDDAA 406
Cdd:COG3857 287 EVEAVAREIRRLVREEGyRYRDIAVVVRDlEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVRSNFRYED 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 407 FERVVNTP-TRGVGDRTLDVVRQTARER--------QMTLWQA-------TRELLQSRALAGRAASALQRFCELVDSLAT 470
Cdd:COG3857 367 VFRLLKTGlLRPLSREEIDRLENYVLAYgirgrrwlERYLEEEeeltdeeEEDLERLNELRDRLLEPLLPLRERLKKAKT 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 471 ------------ETAELPLHVQTDRVIKDSGLWLMYEqekgEKGQAR---IENLEELVTAtrqfsyqdEDEDLMPLQAF- 534
Cdd:COG3857 447 vrewaealyeflEELGVPEKLEEWREAEEAGDLEEAR----EHEQAWnalIELLDELVEV--------LGDEKLSLEEFl 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 535 --LSHAALEAGEGQADKWQDAVQLMTLHSAKGLEFSQVFIVGMEEGMFPSQMS------------LDEGG---------R 591
Cdd:COG3857 515 riLESGLEELTFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPRedgllsdeererLNELGlelpptsreR 594
|
650 660 670 680
....*....|....*....|....*....|....*....|....*..
gi 497943157 592 LEEERRLAYVGVTRAMLKLTLTYAETRRLyGKEVyhRPSRFIGELPE 638
Cdd:COG3857 595 LLEERFLFYRALTRASERLYLSYPLADEE-GKAL--LPSPLIDRLRE 638
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
12-628 |
6.85e-22 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 101.30 E-value: 6.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 12 DNQRAAvAAPRSNLLVLAGAGSGKTRVLVHRIAWLMsVENCSPYSIMAVTFTNKAAAEM-------------------RH 72
Cdd:TIGR02784 1 ARQAQA-ADPAASAWVSANAGSGKTHVLTQRVIRLL-LAGTEPSKILCLTYTKAAAAEMqnrvfkrlgewavlddadlRA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 73 RIEHLIGT-------------------SQGGMWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLK--------- 124
Cdd:TIGR02784 79 RLEALEGKrpdaaklaearrlfaraleTPGGLKIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLEearrallag 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 125 ----------------------------------------------------RLIKSMNLD---------DKQWP----- 138
Cdd:TIGR02784 159 paapddaladalatvleaagetgleallaeivarrdalmafldeaggegaeaRLRRALGLApgdtaedllEAVWPlpglp 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 139 -----------------------------------------------------ARQGMWYINGKKD-------------- 151
Cdd:TIGR02784 239 rlalaliaallksgggskdaaaalsqlreaaaepdpvarldlllgafltskgePKSASFVIKKAIQkslpdlaealedaa 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 152 ---EGLRPKHIESYGNPIEQTWLRIYQAYQEACDR----AGLVDFAELLLRAHELwLNKPHILN--HYR-ERFTN-VLVD 220
Cdd:TIGR02784 319 srvEALRERLRALRMAQRTLAALRLAARLLQRYARlkkaRGLLDFNDLIERTVAL-LARPGAGAwvHYKlDRGIDhILVD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 221 EFQDTNNIQYAWIRMLA-----GDSGR------VIIVGDDDQSIYGWRGAQVENIQR----FLQDFPGAET----IRLEQ 281
Cdd:TIGR02784 398 EAQDTSPEQWDIIQALAeeffsGEGARsgvertIFAVGDEKQSIYSFQGADPERFAEerreFSRKVRAVGRkfedLSLNY 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 282 NYRSTNNILKAANALIANNNGRLGK--------------------ELW--TEGSDGEPISIYCA-FNELDE-------AR 331
Cdd:TIGR02784 478 SFRSTPDVLAAVDLVFADPENARGLsadsdapvheafrddlpgrvDLWdlISKEEGEEPEDWTDpVDELGErapevrlAE 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 332 FVVNRIKVWMENGGAL---------NDCAILYRS-----NAQSRvleeALLQSSMPyrIYGGMRFFERQEI--KDALSYL 395
Cdd:TIGR02784 558 RIAAEIRAWLDRGTPIpgrgravrpGDILVLVRKrdaffSALIR----ALKRRGIP--VAGADRLKLTSHIavKDLMALG 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 396 RLMANRNDDAAFERVVNTPTRGVGDRtlDVVRQTARERQMTLWQATRellqsralagRAASALQRFCELVDSLATETAEL 475
Cdd:TIGR02784 632 RFVLQPEDDLSLAALLKSPLFGLDED--DLFRLAAGRSGGSLWAALR----------RREAEFAATLAVLRDWLSLADFL 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 476 PLHVQTDRVIkdsglwlmyeqeKGEKGQARI-----ENLEELVTATRQFSYQDEDEDLMPLQAFLShaALEAGE----GQ 546
Cdd:TIGR02784 700 TPFEFYARLL------------GRDGGRRKLlarlgAEAEDILDEFLSQALAYERTGLPGLQAFLS--WLEADDpeikRE 765
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 547 ADKWQDAVQLMTLHSAKGLEFSQVFIVGMEEGMFPSQMSLD---EGGR-----------------------------LEE 594
Cdd:TIGR02784 766 MDQARDEVRVMTVHGAKGLEAPVVFLVDTGSKPFASQRAPLllaTGGSggkaplwrpasafdpslsaaarerlkeraEDE 845
|
890 900 910
....*....|....*....|....*....|....
gi 497943157 595 ERRLAYVGVTRAMLKLTLTYAETRRLYGKEVYHR 628
Cdd:TIGR02784 846 YRRLLYVAMTRAEDRLIVCGYRGKRESPKDSWHA 879
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
26-617 |
1.03e-21 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 100.97 E-value: 1.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 26 LVLAGAGSGKT--------RVLVHriAWLMSVENcspysIMAVTFTNKAAAEMRHRIEHLIG----------TSQGG--- 84
Cdd:TIGR00609 13 LIEASAGTGKTftiaqlylRLLLE--GGPLTVEE-----ILVVTFTNAATEELKTRIRGRIHqalralkaalTSQELpep 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 85 --------------------------MWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQL------------------ 120
Cdd:TIGR00609 86 lkeaiqdekvkqaitrlrnalatmdeAAIYTIHGFCQRMLEQHAFESDEIFDVELIEDESLLlaeitkdfwrrnfynlpf 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 121 --------------RLLKRL-----------IKSMNLDDKQWPARQGMWY--INGKKDEGLRP-----KHIE---SYGNP 165
Cdd:TIGR00609 166 diaqivlktkkspqAVLTQIladlllqsylaFPSPPLDLEQLIKWHEQIYkdLDKLDHAVFEEidklnAERNnlfCLKDR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 166 IEQTWLR-IYQAYQEACDRAGLVDFAELLLRAHELwLNKPH---ILNHYRERFTNVLVDEFQDTNNIQYAWIRML--AGD 239
Cdd:TIGR00609 246 VFLTLLKeVQEELKKEKKRRREIGFDDLLSRLETA-LKSAEgekLAQAIREQYPIALIDEFQDTDPQQYRIFSKLfiAQK 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 240 SGRVIIVGDDDQSIYGWRGAqveNIQRFLQdfpGAETIR----LEQNYRST-------NNILKAANALIANNNGRL---- 304
Cdd:TIGR00609 325 ETSLFLIGDPKQAIYSFRGA---DIFTYLQ---AKSKADarytLGTNWRSTpalvgslNKLFSLISNPFLEKPIFIpvla 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 305 -GKE----LWTEGSDGEPISiycaFNELDEARFVVNRIKVWM------------------------ENGG---ALNDCAI 352
Cdd:TIGR00609 399 hQKNskgsFVINGQEQPPIH----FFTTEVESEGVDDYRQTIaqkcareialwlasaalglanfiaTFGGrplRAGDIAV 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 353 LYRSNAQSRVLEEALLQSSMPyRIYGGMR--FFERQEIKDALSYLR-LMANRNDD----AAFERVVNTPTRGV-----GD 420
Cdd:TIGR00609 475 LVRGRKEANQIRKALKKAQIP-SVYLSDKssVFATEEAQELLALLEaLLEPENEGtlraALASSIFGLSALELetlnqDE 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 421 RTLDVVRQTARE--------------RQMTLWQATRELLQSRALAGRAASALQRFCELVDSLAT-ETAELPLHVqtdrvi 485
Cdd:TIGR00609 554 ITWERVVEKFREyhdiwrkigvlamfQRLMLEKGIGERLLSQPGGERILTNLLHLAELLQEAAHqERNKLSLLR------ 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 486 kdsglWLmyeqekgEKGQARIENLEElvtatrQFSYQDEDEDLmplqaflshaaleagegqadkwqdaVQLMTLHSAKGL 565
Cdd:TIGR00609 628 -----WL-------EDQISNEEEEEE------EIIRLESDAEL-------------------------VKIVTIHKSKGL 664
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 497943157 566 EFSQVFIVGMEEGMFPSQMSLD----------------------EGGRLEEERRLAYVGVTRAMLKLTLTYAET 617
Cdd:TIGR00609 665 EYPIVFLPFITDAKKSNFASLHdqhsheyqlydfnqseenqklaRVERLAEDLRLLYVALTRAKKQLFIGIAPL 738
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
29-291 |
6.23e-19 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 91.57 E-value: 6.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 29 AGAGSGKTRVLVHR-IAWLMSVENcsPYSIMAVTFTNKAAAEMRHRI---------------------------EHLIGT 80
Cdd:PRK13909 5 ASAGSGKTFALSVRfLALLFKGAN--PSEILALTFTKKAANEMKERIidtllnlekekeeselneleeklglskEELLNK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 81 SQGGMW--------IGTFHGLAHRLLRAHHLDAGLPQDFQI---------------LDSEDQLRLLKRLIKSMNLDDKQW 137
Cdd:PRK13909 83 RDKVYQeflnselkISTIDAFFQKILRKFCLNLGLSPDFSIkedtkeelnekflsaLSKEELLELLAFIKQCESKKNNSF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 138 PARQGMWYingKKDEGLrpKHIESYGNPIEQTWLRI----------YQAYQEACDRAG-LVDF--AELLLRAHELWLNK- 203
Cdd:PRK13909 163 FELLEKLY---EKNNEL--KLFEKAKNPIEFDEEKFleelrslkqqIQSIETASKNAKkAFKKedFEELLNSSKTWLEKe 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 204 ----------------------------------------PHILNHYRE------------------------------- 212
Cdd:PRK13909 238 seyryfkklyneeldaefeelknalkryydakenyklsklFKLLQLYKEaknelnkkknaldfddiskkvyellgeeeid 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 213 ----------RFTNVLVDEFQDTNNIQYAWIRML-----AGDS----GRVIIVGDDDQSIYGWRGAQVENIQRFLQDFpG 273
Cdd:PRK13909 318 kdflyfrldsKISHILIDEFQDTSVLQYKILLPLideikSGEGqkkfRSFFYVGDVKQSIYRFRGGKKELFDKVSKDF-K 396
|
410
....*....|....*...
gi 497943157 274 AETIRLEQNYRSTNNILK 291
Cdd:PRK13909 397 QKVDNLDTNYRSAPLIVD 414
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
10-289 |
6.44e-19 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 91.16 E-value: 6.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 10 LNDNQRAAVAAPRSNLLVLAGAGSGKTRVLVHRIAWLMSVENCSPYSIMAVTFTNKAAAEMRHRIEHLIGTSqgGMWIGT 89
Cdd:PRK11054 197 LNPSQARAVVNGEDSLLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEEMDERIRERLGTE--DITART 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 90 FHGLAHRLLRahhldAGLPQDFQI--LDSEDQLR---LLKRLIK--SMNLDD----KQWPARqgmwYINGKKDEG---LR 155
Cdd:PRK11054 275 FHALALHIIQ-----QGSKKVPVIskLENDSKARhalLIAEWRKqcSEKKAQakgwRQWLTE----ELQWDVPEGnfwDD 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 156 PKHIESYGNPIEQtWL---------------------------RI------YQAYQEACDRAGLVDFAELLLRAHELwLN 202
Cdd:PRK11054 346 EKLQRRLASRLER-WVslmrmhggsqaemiaqapeevrdlfqkRLklmaplLKAWKKALKAENAVDFSGLIHQAVNY-LE 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 203 KphilNHYRERFTNVLVDEFQDTNNIQYAWIRMLAGDSGRVII--VGDDDQSIYGWRGAQVENIQRFLQDFPGAETIRLE 280
Cdd:PRK11054 424 K----GRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLfaVGDDWQAIYRFSGADLSLTTAFHERFGEGDRCHLD 499
|
....*....
gi 497943157 281 QNYRSTNNI 289
Cdd:PRK11054 500 TTYRFNSRI 508
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
14-138 |
7.57e-18 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 80.34 E-value: 7.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 14 QRAAV--AAPRSNLLVLAGAGSGKTRVLVHRIAWLmSVENCSPYSIMAVTFTNKAAAEMRHRIehligtsqgGMWIGTFh 91
Cdd:pfam13245 1 QREAVrtALPSKVVLLTGGPGTGKTTTIRHIVALL-VALGGVSFPILLAAPTGRAAKRLSERT---------GLPASTI- 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497943157 92 glaHRLLRAHHLDAG---------LPQD------FQILDSEDQLRLLKRLIKSMNL----DDKQWP 138
Cdd:pfam13245 70 ---HRLLGFDDLEAGgflrdeeepLDGDllivdeFSMVDLPLAYRLLKALPDGAQLllvgDPDQLP 132
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
24-94 |
1.76e-11 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 60.61 E-value: 1.76e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 497943157 24 NLLVLAGAGSGKTRVLVHRIAWLMSvencSPYSIMAVTFTNKAAAEMRHRIE--HLIGTSQGGMWIGTFHGLA 94
Cdd:cd17912 1 NILHLGPTGSGKTLVAIQKIASAMS----SGKSVLVVTPTKLLAHEILIVIDeiQ*ILDPAAGWAWATRALLG 69
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
14-367 |
1.85e-08 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 57.53 E-value: 1.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 14 QRAAVAAPRSNLLVLAGAGSGKTRVLVHRiAWLMSVENcsPYSIMAVTFTNKA-AAEMRHRIEH-LIGTSQGGMW----I 87
Cdd:COG3972 165 ERIARSIPDGPQRIRGVAGSGKTVLLAAK-AAYLALKH--PGWRILVTCFNRSlADHLRDLIPRfLRRFSNGEPEdnvkL 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 88 GTFHGLAHRLLRAHHLDaglpqdfqildsedqlrllkrliksmnlddkqwparqgmwyingkKDEGLRPKhiesygnpie 167
Cdd:COG3972 242 IVFHAWGGKLLKQYGIP---------------------------------------------PLTFSQPN---------- 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 168 qtwlriyQAYQEACDRaglvdfaelLLRAhelwLNKPHIlnhyRERFTNVLVDEFQDTNNIqyaWIR----MLAGDSGRV 243
Cdd:COG3972 267 -------EAFDEACKA---------LLEA----IQGEII----PPIYDAILIDEAQDFEPE---FLRllyqLLKPPKKRL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 244 IIVGDDDQSIYG---WRGAQVENIQRflqdfpgaETIRLEQNYRSTNNIL---------------------KAANALIAN 299
Cdd:COG3972 320 IWAYDEAQNIYGrkiPSAGGIPAGIG--------RDTILKKNYRNTRPILtfahafgmgllrppgllqgdaEDYEVERPG 391
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497943157 300 NNGRLGKELWTEGSDGEPISIYCAFNELDEARFVVNRIKVWMENGG-ALNDCAILYRSNAQSRVLEEAL 367
Cdd:COG3972 392 DKVTLIRPPEPAGRKGPLPEFKKYDDRAEELEAIAEEIKKNLRDEGlRPSDIAVIYLGNNEAKELGDRL 460
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
543-613 |
3.13e-08 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 51.67 E-value: 3.13e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 497943157 543 GEGQADKWQDAVQLMTLHSAKGLEFSQVFIVGMEEGMfpsqmsldeggrleEERRLAYVGVTRAMLKLTLT 613
Cdd:cd18786 32 GLSLDEFDLQLVGAITIDSSQGLTFDVVTLYLPTANS--------------LTPRRLYVALTRARKRLVIY 88
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
548-636 |
5.57e-07 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 53.03 E-value: 5.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 548 DKWQD-----AVQLMTLHSAKGLEFSQVFIVGMEEG--MFPS--QMSLDEGGRLE--------EERRLAYVGVTRAMLKL 610
Cdd:PRK11054 578 DKAATrwpklQIDFMTIHASKGQQADYVIILGLQEGqdGFPApaRESIMEEALLPppedfpdaEERRLLYVALTRAKHRV 657
|
90 100
....*....|....*....|....*.
gi 497943157 611 TLTYAETrrlygkevyhRPSRFIGEL 636
Cdd:PRK11054 658 WLLFNKG----------NPSPFVEEL 673
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
557-613 |
8.41e-07 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 46.41 E-value: 8.41e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 497943157 557 MTLHSAKGLEFSQVFIVgmeegmfpsQMSLDEGGRLEEERRLAYVGVTRAMLKLTLT 613
Cdd:pfam13538 5 LTVHKAQGSEFPAVFLV---------DPDLTAHYHSMLRRRLLYTAVTRARKKLVLV 52
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
65-289 |
1.05e-06 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 52.17 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 65 KAAAEMRHRIEHLIGTSQGGMWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSEDQLRLLkrliksmnLDDKQWPARqgmw 144
Cdd:COG3973 354 RLRERLLDALKDQLAAELGKLWDEERDELRRELRRSKPVRAALNRLWPFLDPAELYRDL--------FSDPELLAR---- 421
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 145 yINGKKDEGLRPKHIESYGNPIEQTWlriyqayqEACDRAGLVDFAELLLRAHELWlnkphilnhyreRFTNVLVDEFQD 224
Cdd:COG3973 422 -AAGWLSPEERALLLRPTRELKKGRW--------TVADVALLDELAELLGGPDRTW------------TYGHVVVDEAQD 480
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 497943157 225 TNNIQYAWIRMLaGDSGRVIIVGDDDQSIYGWRGAqvENIQRFLQDFPG--AETIRLEQNYRSTNNI 289
Cdd:COG3973 481 LSPMQWRVLKRR-FPSASFTIVGDLAQAIHPYRGA--ESWEEVLEPLGGdrARLVELTKSYRSTAEI 544
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
537-617 |
2.16e-05 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 47.94 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 537 HAALEAGEG------QADKWQDAVQLMTLHSAKGLEFSQVFIVgmeegmFPSQMSLDEggrlEEERRLAYVGVTRAMLKL 610
Cdd:COG3973 616 YAALKAGLPvtliddESEELEAGVVVLPAYLAKGLEFDAVVVV------DPDEIVYES----PRGRRLLYVALTRATHRL 685
|
....*..
gi 497943157 611 TLTYAET 617
Cdd:COG3973 686 TVLHTGE 692
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
211-286 |
8.98e-05 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 46.12 E-value: 8.98e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 497943157 211 RERFTNVLVDEFQDTNNIQYAWIRMLAG---DSGRVIIvGDDDQSIYGWRGAQVENIQRFLQDFPGAETirLEQNYRST 286
Cdd:PRK10876 375 RTRYPVAMIDEFQDTDPQQYRIFRRIYRhqpETALLLI-GDPKQAIYAFRGADIFTYMKARSEVSAHYT--LDTNWRSA 450
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
10-103 |
3.00e-04 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 43.81 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497943157 10 LNDNQRAAV--AAPRSNLLVLAG-AGSGKTRvLVHRIAWLMSVENcspYSIMAVTFTNKAAAEMR----------HRieh 76
Cdd:COG0507 125 LSDEQREAValALTTRRVSVLTGgAGTGKTT-TLRALLAALEALG---LRVALAAPTGKAAKRLSestgieartiHR--- 197
|
90 100
....*....|....*....|....*..
gi 497943157 77 LIGTSQGGmwiGTFHGLAHRLLRAHHL 103
Cdd:COG0507 198 LLGLRPDS---GRFRHNRDNPLTPADL 221
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
216-249 |
9.10e-04 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 38.65 E-value: 9.10e-04
10 20 30
....*....|....*....|....*....|....*...
gi 497943157 216 NVLVDEFQDTNNIQYAW----IRMLAGDSGRVIIVGDD 249
Cdd:cd17912 44 LIVIDEIQ*ILDPAAGWawatRALLGLKAEKVIGVGAT 81
|
|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
544-606 |
1.56e-03 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 37.93 E-value: 1.56e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497943157 544 EGQADKWQDAVQL--MTLHSAKGLEFSQVFIV-GMEEGMFpsqmsldeggrleeERRLAYVGVTRA 606
Cdd:cd18809 21 KGGVDALNERLQAyaMTIHKSQGSEFDRVIVVlPTSHPML--------------SRGLLYTALTRA 72
|
|
| |
