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Conserved domains on  [gi|498035181|ref|WP_010349337|]
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Xaa-Pro peptidase family protein [Paenibacillus peoriae]

Protein Classification

M24 family metallopeptidase( domain architecture ID 11414248)

M24 family metallopeptidase cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.90.230.10
EC:  3.4.-.-
Gene Ontology:  GO:0008233|GO:0016787|GO:0004177|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24|M24B
PubMed:  7674922|16229471|30536999
SCOP:  3000126

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
7-358 6.44e-119

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


:

Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 346.04  E-value: 6.44e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181   7 RLYDELKSQVWDGLLVTDPKHIYYLTGFaSEPHERFLGLVLLRDQEPELIVPaldaeaaqaassvtristhtdtdnpydl 86
Cdd:COG0006    2 RLRALMAEAGLDALLLTDPSNFAYLTGF-RGSPERLAALLVTADGEPVLFVD---------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  87 lrqrtgsgvkafALEKEHvsvlryeqlhtaigaaQYVDLGPVLQEMRVRKTPEEVERLKHAARLVEDALRHGLTHVREGV 166
Cdd:COG0006   53 ------------ELEAER----------------ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGV 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 167 TEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELE 246
Cdd:COG0006  105 TEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQR 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 247 TIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGMSVHEYPSVHGGNNDLLHEGFVFTIEPG 326
Cdd:COG0006  185 EIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVHEGPQISPGNDRPLEPGMVFTIEPG 264

                        330       340       350
                 ....*....|....*....|....*....|..
gi 498035181 327 IYVPGLGGVRIEDDVLVTSDGVEVLTSFPKEL 358
Cdd:COG0006  265 IYIPGIGGVRIEDTVLVTEDGAEVLTRLPREL 296
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
7-358 6.44e-119

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 346.04  E-value: 6.44e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181   7 RLYDELKSQVWDGLLVTDPKHIYYLTGFaSEPHERFLGLVLLRDQEPELIVPaldaeaaqaassvtristhtdtdnpydl 86
Cdd:COG0006    2 RLRALMAEAGLDALLLTDPSNFAYLTGF-RGSPERLAALLVTADGEPVLFVD---------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  87 lrqrtgsgvkafALEKEHvsvlryeqlhtaigaaQYVDLGPVLQEMRVRKTPEEVERLKHAARLVEDALRHGLTHVREGV 166
Cdd:COG0006   53 ------------ELEAER----------------ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGV 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 167 TEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELE 246
Cdd:COG0006  105 TEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQR 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 247 TIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGMSVHEYPSVHGGNNDLLHEGFVFTIEPG 326
Cdd:COG0006  185 EIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVHEGPQISPGNDRPLEPGMVFTIEPG 264

                        330       340       350
                 ....*....|....*....|....*....|..
gi 498035181 327 IYVPGLGGVRIEDDVLVTSDGVEVLTSFPKEL 358
Cdd:COG0006  265 IYIPGIGGVRIEDTVLVTEDGAEVLTRLPREL 296
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 141-347 2.93e-108

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 315.22  E-value: 2.93e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 141 VERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFD 220
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 221 MGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGMS 300
Cdd:cd01092   81 FGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRTGHGVGLE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 498035181 301 VHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDG 347
Cdd:cd01092  161 VHEAPYISPGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLVTEDG 207
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 142-344 2.76e-84

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 254.47  E-value: 2.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  142 ERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEY-QMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFD 220
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAaRLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  221 MGV-YSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGM 299
Cdd:pfam00557  81 VGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 498035181  300 SVHEYPSVHGGNND-LLHEGFVFTIEPGIY-VPGLGGVRIEDDVLVT 344
Cdd:pfam00557 161 EVHEGPYISRGGDDrVLEPGMVFTIEPGIYfIPGWGGVRIEDTVLVT 207
PRK09795 PRK09795
aminopeptidase; Provisional
 132-362 1.06e-70

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 224.82  E-value: 1.06e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 132 MRVRKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKL 211
Cdd:PRK09795 124 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIV 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 212 EYGDLLMFDMGVYSNGYASDITRTFAFG-----KLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYG 286
Cdd:PRK09795 204 AAGEFVTLDFGALYQGYCSDMTRTLLVNgegvsAESHPLFNVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYG 283

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498035181 287 PAFNHRVGHGLGMSVHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDGVEVLTSFPKELTMLG 362
Cdd:PRK09795 284 DYFGHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTG 359
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 138-286 1.36e-03

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 40.26  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  138 PEEVERLKHAARLVEDALRHGLTHVREGVTEVELV--------AEIE--YQMKKIGADGPSFDTTV----LSGHKTALPH 203
Cdd:TIGR00495  17 PEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICekgdafimEETAkiFKKEKEMEKGIAFPTCIsvnnCVGHFSPLKS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  204 GipGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELET--IYNTVLRSNEAGIAA---IRPGVSCASVDQAARA 278
Cdd:TIGR00495  97 D--QDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTgrKADVIAAAHLAAEAAlrlVKPGNTNTQVTEAINK 174


                  ....*...
gi 498035181  279 VveAAGYG 286
Cdd:TIGR00495 175 V--AHSYG 180
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
7-358 6.44e-119

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 346.04  E-value: 6.44e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181   7 RLYDELKSQVWDGLLVTDPKHIYYLTGFaSEPHERFLGLVLLRDQEPELIVPaldaeaaqaassvtristhtdtdnpydl 86
Cdd:COG0006    2 RLRALMAEAGLDALLLTDPSNFAYLTGF-RGSPERLAALLVTADGEPVLFVD---------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  87 lrqrtgsgvkafALEKEHvsvlryeqlhtaigaaQYVDLGPVLQEMRVRKTPEEVERLKHAARLVEDALRHGLTHVREGV 166
Cdd:COG0006   53 ------------ELEAER----------------ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGV 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 167 TEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELE 246
Cdd:COG0006  105 TEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQR 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 247 TIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGMSVHEYPSVHGGNNDLLHEGFVFTIEPG 326
Cdd:COG0006  185 EIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVHEGPQISPGNDRPLEPGMVFTIEPG 264

                        330       340       350
                 ....*....|....*....|....*....|..
gi 498035181 327 IYVPGLGGVRIEDDVLVTSDGVEVLTSFPKEL 358
Cdd:COG0006  265 IYIPGIGGVRIEDTVLVTEDGAEVLTRLPREL 296
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 141-347 2.93e-108

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 315.22  E-value: 2.93e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 141 VERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFD 220
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 221 MGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGMS 300
Cdd:cd01092   81 FGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRTGHGVGLE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 498035181 301 VHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDG 347
Cdd:cd01092  161 VHEAPYISPGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLVTEDG 207
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 142-344 2.76e-84

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 254.47  E-value: 2.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  142 ERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEY-QMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFD 220
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAaRLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  221 MGV-YSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGM 299
Cdd:pfam00557  81 VGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 498035181  300 SVHEYPSVHGGNND-LLHEGFVFTIEPGIY-VPGLGGVRIEDDVLVT 344
Cdd:pfam00557 161 EVHEGPYISRGGDDrVLEPGMVFTIEPGIYfIPGWGGVRIEDTVLVT 207
PRK09795 PRK09795
aminopeptidase; Provisional
 132-362 1.06e-70

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 224.82  E-value: 1.06e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 132 MRVRKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTALPHGIPGTRKL 211
Cdd:PRK09795 124 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIV 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 212 EYGDLLMFDMGVYSNGYASDITRTFAFG-----KLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYG 286
Cdd:PRK09795 204 AAGEFVTLDFGALYQGYCSDMTRTLLVNgegvsAESHPLFNVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYG 283

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498035181 287 PAFNHRVGHGLGMSVHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDGVEVLTSFPKELTMLG 362
Cdd:PRK09795 284 DYFGHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLLTG 359
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 141-347 7.33e-69

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 215.01  E-value: 7.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 141 VERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGAdGPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFD 220
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 221 MGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLGMS 300
Cdd:cd01066   80 LGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGHRTGHGIGLE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 498035181 301 VHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDG 347
Cdd:cd01066  160 IHEPPVLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTEDG 206
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 141-353 1.09e-53

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 176.99  E-value: 1.09e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 141 VERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADgPSFDTTVLSGHKTALPHGIPGTRKLEYGDLLMFD 220
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 221 MGVYSNGYASDITRTFAF-GKLSDELETIYNTVLRSNEAGIAAIRPGVSCASV-DQAAR-----------------AVVE 281
Cdd:cd01087   80 AGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhLLAHRvlaeglkelgilkgdvdEIVE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 282 AAGYGPAFNHRVGHGLGMSVHEYPSVHGGN--NDLLHEGFVFTIEPGIYVP----------GLGGVRIEDDVLVTSDGVE 349
Cdd:cd01087  160 SGAYAKFFPHGLGHYLGLDVHDVGGYLRYLrrARPLEPGMVITIEPGIYFIpdlldvpeyfRGGGIRIEDDVLVTEDGPE 239


                 ....
gi 498035181 350 VLTS 353
Cdd:cd01087  240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 120-353 7.95e-38

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 140.63  E-value: 7.95e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 120 AQYVDLGPVLQEMRVRKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPSFDTTVLSGHKT 199
Cdd:PRK10879 158 ATLTDWRPWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSYNTIVGSGENG 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 200 ALPHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAF-GKLSDELETIYNTVLRSNEAGIAAIRPGVSCASV-DQAAR 277
Cdd:PRK10879 238 CILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVtGEVVR 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 278 AVV-----------------EAAGYGPAFNHRVGHGLGMSVHEYpSVHGGNND-LLHEGFVFTIEPGIY------VP--- 330
Cdd:PRK10879 318 IMVsglvklgilkgdvdqliAENAHRPFFMHGLSHWLGLDVHDV-GVYGQDRSrILEPGMVLTVEPGLYiapdadVPeqy 396

                        250       260
                 ....*....|....*....|....
gi 498035181 331 -GLgGVRIEDDVLVTSDGVEVLTS 353
Cdd:PRK10879 397 rGI-GIRIEDDIVITETGNENLTA 419
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
136-357 4.89e-37

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 133.98  E-value: 4.89e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 136 KTPEEVERLKHAARLVEDALRHGLTHVREGVT--EVELVAEiEYqMKKIGADgPSF---------------DTTVlsghk 198
Cdd:COG0024    4 KTPEEIEKMREAGRIVAEVLDELAEAVKPGVTtlELDRIAE-EF-IRDHGAI-PAFlgyygfpksictsvnEVVV----- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 199 talpHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARA 278
Cdd:COG0024   76 ----HGIPSDRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 279 VVEAAGYGP--AFnhrVGHGLGMSVHEYPSV----HGGNNDLLHEGFVFTIEPGIyVPGLGGVRIEDD------------ 340
Cdd:COG0024  152 YAESNGYSVvrEF---VGHGIGREMHEEPQVpnygRPGRGPRLKPGMVLAIEPMI-NAGTPEVKVLDDgwtvvtkdgsls 227

                        250       260
                 ....*....|....*....|...
gi 498035181 341 ------VLVTSDGVEVLTSFPKE 357
Cdd:COG0024  228 aqfehtVAVTEDGPEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 136-357 5.58e-34

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 126.02  E-value: 5.58e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 136 KTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADgPSFdttvLSGH---KTA-------LPHGI 205
Cdd:PRK05716   6 KTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAI-PAP----LGYHgfpKSIctsvnevVCHGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 206 PGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGY 285
Cdd:PRK05716  81 PSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 286 GPAFNHrVGHGLGMSVHEYPSV-HGGNND---LLHEGFVFTIEPGIYVpGLGGVRIEDD------------------VLV 343
Cdd:PRK05716 161 SVVREY-CGHGIGRKFHEEPQIpHYGAPGdgpVLKEGMVFTIEPMINA-GKREVKTLKDgwtvvtkdgslsaqyehtVAV 238

                        250
                 ....*....|....
gi 498035181 344 TSDGVEVLTSFPKE 357
Cdd:PRK05716 239 TEDGPEILTLRPEE 252
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 141-353 9.18e-32

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 119.52  E-value: 9.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 141 VERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGAdGPSF-------DTTVLSGHKTALpHGIPGTRKLEY 213
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGA-YPAPlgyygfpKSICTSVNEVVC-HGIPDDRVLKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 214 GDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHrV 293
Cdd:cd01086   79 GDIVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREF-G 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 294 GHGLGMSVHEYPSV-HGGNND---LLHEGFVFTIEPGIYVpGLGGVRIEDD------------------VLVTSDGVEVL 351
Cdd:cd01086  158 GHGIGRKFHEEPQIpNYGRPGtgpKLKPGMVFTIEPMINL-GTYEVVTLPDgwtvvtkdgslsaqfehtVLITEDGPEIL 236


                 ..
gi 498035181 352 TS 353
Cdd:cd01086  237 TL 238
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 130-352 2.24e-31

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 119.17  E-value: 2.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 130 QEMRVrKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADgPSFD-------TTVLS-GHKTAl 201
Cdd:PRK12896   6 RGMEI-KSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAI-PSPEgyygfpgSTCISvNEEVA- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 202 pHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVE 281
Cdd:PRK12896  83 -HGIPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 282 AAGYGPAFNHrVGHGLGMSVHEYPSV-----HGGNNDLLHEGFVFTIEPGIyvpGLGG--VRIEDD-------------- 340
Cdd:PRK12896 162 KNGYSVVRDL-TGHGVGRSLHEEPSViltytDPLPNRLLRPGMTLAVEPFL---NLGAkdAETLDDgwtvvtpdkslsaq 237

                        250
                 ....*....|....*.
gi 498035181 341 ----VLVTSDGVEVLT 352
Cdd:PRK12896 238 fehtVVVTRDGPEILT 253
PRK15173 PRK15173
peptidase; Provisional
 122-358 1.60e-29

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 115.97  E-value: 1.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 122 YVDLGPVLQEMRVRKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEieYQMKKIGADGPSFDT-TVLSGHKTA 200
Cdd:PRK15173  82 FVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAA--YKAAVMSKSETHFSRfHLISVGADF 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 201 LPHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVV 280
Cdd:PRK15173 160 SPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVI 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 281 EAAGYgPAFNH-RVGHGLG--MSVHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDGVEVLTSFPKE 357
Cdd:PRK15173 240 KKSGL-PNYNRgHLGHGNGvfLGLEESPFVSTHATESFTSGMVLSLETPYYGYNLGSIMIEDMILINKEGIEFLSKLPRD 318


                 .
gi 498035181 358 L 358
Cdd:PRK15173 319 L 319
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 161-357 5.85e-29

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 111.88  E-value: 5.85e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 161 HVREGVTEVELVAEIEYQMKKI-GADGPSFDTTVLSGHKTALPHGIP---GTRKLEYGDLLMFDMGV-YSNGyASDITRT 235
Cdd:cd01085   25 PKGETITELSAADKLEEFRRQQkGYVGLSFDTISGFGPNGAIVHYSPteeSNRKISPDGLYLIDSGGqYLDG-TTDITRT 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 236 FAFGKLSDELETIYNTVLRSNEAGIAAIRP-GVSCASVDQAARAVVEAAGYGpaFNHRVGHGLGM--SVHEYP-SVHG-G 310
Cdd:cd01085  104 VHLGEPTAEQKRDYTLVLKGHIALARAKFPkGTTGSQLDALARQPLWKAGLD--YGHGTGHGVGSflNVHEGPqSISPaP 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 498035181 311 NNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVtsdgVEVLTSFPKE 357
Cdd:cd01085  182 NNVPLKAGMILSNEPGYYKEGKYGIRIENLVLV----VEAETTEFGG 224
PRK14575 PRK14575
putative peptidase; Provisional
 122-358 1.07e-28

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 115.19  E-value: 1.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 122 YVDLGPVLQEMRVRKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEieYQMKKIGADGPSFDT-TVLSGHKTA 200
Cdd:PRK14575 165 FVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAA--YKAAVMSKSETHFSRfHLISVGADF 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 201 LPHGIPGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVV 280
Cdd:PRK14575 243 SPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVI 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 281 EAAGYgPAFNH-RVGHGLG--MSVHEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDGVEVLTSFPKE 357
Cdd:PRK14575 323 KKSGL-PNYNRgHLGHGNGvfLGLEESPFVSTHATESFTSGMVLSLETPYYGYNLGSIMIEDMILINKEGIEFLSKLPRD 401


                 .
gi 498035181 358 L 358
Cdd:PRK14575 402 L 402
PRK14576 PRK14576
putative endopeptidase; Provisional
 18-358 1.10e-25

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 106.64  E-value: 1.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  18 DGLLVTDPKHIYYLTGFASE-----PHERFLGLVLLRDQE-PELIV----PALDAEAAQAASSVTRISTHTDTDNPYDLL 87
Cdd:PRK14576  26 DALVVTVCDNFYYLTGFASFfmytfRHTGAAVAIMFRDANiPSQIImnefEAASTHFDMPNSVLKTFPVWVDVDDPRNPH 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  88 R------------------------QRTGSGVKAFALEKEHVSVLRYEQLHTAIGAAQYVDLGPVLQEMRVRKTPEEVER 143
Cdd:PRK14576 106 HhykkrdrpigppveavfslvknalEDAGVLDKTIAIELQAMSNGGKGVLDKVAPGLKLVDSTALFNEIRMIKSPWEIEH 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 144 LKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPSFDTTVLSGHKTAlPHGIPGTRKLEYGDLLMFDMGV 223
Cdd:PRK14576 186 LRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLISVGDNFS-PKIIADTTPAKVGDLIKFDCGI 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 224 YSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRVGHGLG--MSV 301
Cdd:PRK14576 265 DVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGLPHYNRGHLGHGDGvfLGL 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 498035181 302 HEYPSVHGGNNDLLHEGFVFTIEPGIYVPGLGGVRIEDDVLVTSDGVEVLTSFPKEL 358
Cdd:PRK14576 345 EEVPFVSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILITDSGFEFLSKLDRDL 401
PRK12318 PRK12318
methionyl aminopeptidase;
136-356 6.54e-22

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 94.12  E-value: 6.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 136 KTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGA-------DGPSFDTTVLSGHKTALPHGIPGT 208
Cdd:PRK12318  44 KTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAipaplnyGSPPFPKTICTSLNEVICHGIPND 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 209 RKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVveAAGYG-P 287
Cdd:PRK12318 124 IPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENC--ADKYGfS 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 288 AFNHRVGHGLGMSVHEYPSV-HGGNND--LLHEGFVFTIEPGIYVPGLGGV------------------RIEDDVLVTSD 346
Cdd:PRK12318 202 VVDQFVGHGVGIKFHENPYVpHHRNSSkiPLAPGMIFTIEPMINVGKKEGVidpinhweartcdnqpsaQWEHTILITET 281

                        250
                 ....*....|
gi 498035181 347 GVEVLTSFPK 356
Cdd:PRK12318 282 GYEILTLLDK 291
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 136-353 6.83e-20

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 89.90  E-value: 6.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 136 KTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMkkIGADG-PS------FDTTVLSGHKTALPHGIPGT 208
Cdd:PLN03158 138 KTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEAT--IAAGGyPSplnyhfFPKSCCTSVNEVICHGIPDA 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 209 RKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPA 288
Cdd:PLN03158 216 RKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVV 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 289 FNHrVGHGLGMSVHEYPSV-HGGNND---LLHEGFVFTIEPGI-----------------YVPGLGGVRIEDDVLVTSDG 347
Cdd:PLN03158 296 KSY-CGHGIGELFHCAPNIpHYARNKavgVMKAGQVFTIEPMInagvwrdrmwpdgwtavTADGKRSAQFEHTLLVTETG 374


                 ....*.
gi 498035181 348 VEVLTS 353
Cdd:PLN03158 375 VEVLTA 380
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 142-325 4.50e-17

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 80.37  E-value: 4.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 142 ERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGAdGPSFDTTVLSGHKTAlpHGIPG---TRKLEYGDLLM 218
Cdd:cd01088    2 EKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-GPAFPVNLSINECAA--HYTPNagdDTVLKEGDVVK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 219 FDMGVYSNGYASDITRTFAFGKLSDELetiYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYGPAFNHRvGHGL- 297
Cdd:cd01088   79 LDFGAHVDGYIADSAFTVDFDPKYDDL---LEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT-GHSIe 154

                        170       180       190
                 ....*....|....*....|....*....|....
gi 498035181 298 ------GMSVheyPSVHGGNNDLLHEGFVFTIEP 325
Cdd:cd01088  155 ryrlhaGKSI---PNVKGGEGTRLEEGDVYAIEP 185
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 5-134 1.16e-16

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 75.42  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181    5 ITRLYDELKSQVWDGLLVTDPKHIYYLTGFasePHERFLGLVLLRDqEPELIVPALDAEAAQAASSV-TRISTHTDTDNP 83
Cdd:pfam01321   2 LEKLRKLMEEKGLDAALVTSPENLRYLTGF---TGSRGLLLLVTAD-GALLLVDALEYERAAAESAPdFDVVPYRDYEAL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 498035181   84 YDLLRQrTGSGVKAFALEKEHVSVLRYEQLHTAIGAAQYVDLGPVLQEMRV 134
Cdd:pfam01321  78 ADLLKE-LGAGGKRVGFEADALTVAFYEALKEALPGAELVDVSGLIERLRM 127
PRK12897 PRK12897
type I methionyl aminopeptidase;
132-329 4.47e-15

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 73.91  E-value: 4.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 132 MRVRKTPEEVERLKHAARLVEDALRHGLTHVREGVTEVELVAEIEYQMKKIGADGPS-----FDTTVLSGHKTALPHGIP 206
Cdd:PRK12897   1 MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQkgyngYPYAICASVNDEMCHAFP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 207 GTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVEAAGYG 286
Cdd:PRK12897  81 ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 498035181 287 PAFNHrVGHGLGMSVHEYPSV----HGGNNDLLHEGFVFTIEPGIYV 329
Cdd:PRK12897 161 VARDF-TGHGIGKEIHEEPAIfhfgKQGQGPELQEGMVITIEPIVNV 206
PRK13607 PRK13607
proline dipeptidase; Provisional
 133-352 1.59e-14

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 74.16  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 133 RVRKTPEEVERLKHAARL-------VEDALRHGLThvregvtevelvaEIEYQMKKIGADGPSfDTTVLSG--------- 196
Cdd:PRK13607 159 RAYKTDYELACMREAQKIavaghraAKEAFRAGMS-------------EFDINLAYLTATGQR-DNDVPYGnivalneha 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 197 ---HKTALPHGIPGTRKLeygdlLMFDMGVYSNGYASDITRTFAFGKLSDELETIyNTVLRSNEAGIAAIRPGVS----- 268
Cdd:PRK13607 225 avlHYTKLDHQAPAEMRS-----FLIDAGAEYNGYAADITRTYAAKEDNDFAALI-KDVNKEQLALIATMKPGVSyvdlh 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 269 ----------------CASVDqaARAVVEAAGYGPAFNHRVGHGLGMSVH------------------EYPSVHggNNDL 314
Cdd:PRK13607 299 iqmhqriakllrkfqiVTGLS--EEAMVEQGITSPFFPHGLGHPLGLQVHdvagfmqddrgthlaapeKHPYLR--CTRV 374

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498035181 315 LHEGFVFTIEPGIY-VPGL------------------------GGVRIEDDVLVTSDGVEVLT 352
Cdd:PRK13607 375 LEPGMVLTIEPGLYfIDSLlaplregpfskhfnwqkidalkpfGGIRIEDNVVVHENGVENMT 437
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 144-352 1.61e-10

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 60.24  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 144 LKHAARLVEDALRHGLTHVREGVTEVEL-VAEIEYQMKKIGADGPS---FDTTVL--SGHKTALPHGIPGTRKLEYGDLL 217
Cdd:cd01090    4 IRHGARIADIGGAAVVEAIREGVPEYEVaLAGTQAMVREIAKTFPEvelMDTWTWfqSGINTDGAHNPVTNRKVQRGDIL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 218 MFDMGVYSNGYASDITRTFAFGKLSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVE--------AAGYGPAF 289
Cdd:cd01090   84 SLNCFPMIAGYYTALERTLFLDEVSDAHLKIWEANVAVHERGLELIKPGARCKDIAAELNEMYRehdllryrTFGYGHSF 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 290 ---NHRVGHGLGMSVHEypsvhgGNNDLLHEGFVFTIEPGIYV----PGLGGVRIEDDVLVTSDGVEVLT 352
Cdd:cd01090  164 gvlSHYYGREAGLELRE------DIDTVLEPGMVVSMEPMIMLpegqPGAGGYREHDILVINENGAENIT 227
CDC68-like cd01091
Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in ...
 221-353 2.13e-07

Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.


Pssm-ID: 238524 [Multi-domain]  Cd Length: 243  Bit Score: 51.19  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 221 MGVYSNGYASDITRTFAFGKlSDELETIYNTVLRSNEAGIAAIRPGVSCASVDQAARAVVE--AAGYGPAFNHRVGHGLG 298
Cdd:cd01091   98 LGARYKSYCSNIARTFLIDP-TSEQQKNYNFLLALQEEILKELKPGAKLSDVYQKTLDYIKkkKPELEPNFTKNLGFGIG 176

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498035181 299 MSVHEYPSVHGGNND-LLHEGFVFTIEPGIY-VPGLGGVR---------IEDDVLVTSDG-VEVLTS 353
Cdd:cd01091  177 LEFRESSLIINAKNDrKLKKGMVFNLSIGFSnLQNPEPKDkesktyallLSDTILVTEDEpAIVLTN 243
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 141-282 9.09e-06

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 46.17  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 141 VERLKHAARLVEDALRHGLTHVREGVTEVEL--------VAEIE--YQMKKIGADGPSFDTTV----LSGHKTALPHGIP 206
Cdd:cd01089    1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLcekgdkliLEELGkvYKKEKKLEKGIAFPTCIsvnnCVCHFSPLKSDAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181 207 GTrkLEYGDLLMFDMGVYSNGYASDITRTFAF---------GKLSDELETIYNtvlrSNEAGIAAIRPGVSCASVDQAAR 277
Cdd:cd01089   81 YT--LKDGDVVKIDLGCHIDGYIAVVAHTIVVgaeaetpvtGKKADVIAAAHY----ALEAALRLLRPGNQNSDITEAIQ 154


                 ....*
gi 498035181 278 AVVEA 282
Cdd:cd01089  155 KVIVD 159
COG5406 COG5406
Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and ...
 175-356 6.67e-05

Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics];


Pssm-ID: 227693 [Multi-domain]  Cd Length: 1001  Bit Score: 45.00  E-value: 6.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  175 IEYQMKKIGADGPSFDTTvlsghktalPHGIPGTRKLeYGDLLMFDMGVYSNGYASDITRTFAFGKlSDELETIYNTVLR 254
Cdd:COG5406   241 LEWCYTPIIQSGGSIDLT---------PSAFSFPMEL-TGDVVLLSIGIRYNGYCSNMSRTILTDP-DSEQQKNYEFLYM 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  255 SNEAGIAAIRPGVSCASVDQAARAVVEAAG--YGPAFNHRVGHGLGMSVHEYPSVHGGNND-LLHEGFVFTIEPGI---- 327
Cdd:COG5406   310 LQKYILGLVRPGTDSGIIYSEAEKYISSNGpeLGPNFIYNVGLMIGIEFRSSQKPFNVKNGrVLQAGCIFNISLGFgnli 389

                         170       180       190
                  ....*....|....*....|....*....|.
gi 498035181  328 --YVPGLGGVRIEDDVLVTSDGVEVLTSFPK 356
Cdd:COG5406   390 npHPKNNYALLLIDTEQISLSNPIVFTDSPK 420
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 138-286 1.36e-03

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 40.26  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  138 PEEVERLKHAARLVEDALRHGLTHVREGVTEVELV--------AEIE--YQMKKIGADGPSFDTTV----LSGHKTALPH 203
Cdd:TIGR00495  17 PEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICekgdafimEETAkiFKKEKEMEKGIAFPTCIsvnnCVGHFSPLKS 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498035181  204 GipGTRKLEYGDLLMFDMGVYSNGYASDITRTFAFGKLSDELET--IYNTVLRSNEAGIAA---IRPGVSCASVDQAARA 278
Cdd:TIGR00495  97 D--QDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTgrKADVIAAAHLAAEAAlrlVKPGNTNTQVTEAINK 174


                  ....*...
gi 498035181  279 VveAAGYG 286
Cdd:TIGR00495 175 V--AHSYG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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