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Conserved domains on  [gi|498239900|ref|WP_010554056|]
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MULTISPECIES: universal stress protein UspE [Pseudoalteromonas]

Protein Classification

universal stress protein UspE( domain architecture ID 11485249)

universal stress protein UspE is a tandem-type universal stress protein (USP) that consists of two Usp domains and is required for resistance to DNA-damaging agents; enhances the rate of cell survival during prolonged exposure to stress agents

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 5-303 0e+00

universal stress protein UspE; Provisional


:

Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 529.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   5 KRIIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRQLWLNDLVSPYKD--I 82
Cdd:PRK11175   4 QNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYLDagI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900  83 NIETQVVWHNRPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVKEMAWPANGNILAAVNAVS 162
Cdd:PRK11175  84 PIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVNVAS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 163 ENEEHVALNKRVIKDAQYLCE-LANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALAAEFNLSPEQCF 241
Cdd:PRK11175 164 EEPYHDALNEKLVEEAIDLAEqLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEEQTH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498239900 242 IEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKPDGYVS 303
Cdd:PRK11175 244 VEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 5-303 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 529.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   5 KRIIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRQLWLNDLVSPYKD--I 82
Cdd:PRK11175   4 QNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYLDagI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900  83 NIETQVVWHNRPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVKEMAWPANGNILAAVNAVS 162
Cdd:PRK11175  84 PIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVNVAS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 163 ENEEHVALNKRVIKDAQYLCE-LANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALAAEFNLSPEQCF 241
Cdd:PRK11175 164 EEPYHDALNEKLVEEAIDLAEqLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEEQTH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498239900 242 IEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKPDGYVS 303
Cdd:PRK11175 244 VEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 151-298 2.85e-58

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 184.01  E-value: 2.85e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 151 NGNILAAVNAVSENEEHVALNKRVIKDAQYLCELANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALA 230
Cdd:cd23660    1 GGRILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKALR 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498239900 231 AEFNLSPEQCFIEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKP 298
Cdd:cd23660   81 QKFGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-143 4.81e-21

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 86.90  E-value: 4.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   3 TIKRIIAVIDPTKDDQHGLARSIDLAKKSGASITAFmTVYDFSYEMttmlsGDEREAMRDAVLKDRQLWLNDLVSPYK-- 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLL-HVVDPPPSA-----AAGPEELEEELREEAEEALEEAAERLEea 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498239900  81 DINIETQVVwHNRPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFV 143
Cdd:COG0589   75 GVEVETVVR-EGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-144 1.74e-17

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 77.45  E-value: 1.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900    7 IIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRQLWLNDLVSPYKDINIET 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 498239900   87 QVVWHNrPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVK 144
Cdd:pfam00582  81 VVVVGD-PAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 5-303 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 529.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   5 KRIIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRQLWLNDLVSPYKD--I 82
Cdd:PRK11175   4 QNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYLDagI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900  83 NIETQVVWHNRPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVKEMAWPANGNILAAVNAVS 162
Cdd:PRK11175  84 PIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVNVAS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 163 ENEEHVALNKRVIKDAQYLCE-LANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALAAEFNLSPEQCF 241
Cdd:PRK11175 164 EEPYHDALNEKLVEEAIDLAEqLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEEQTH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498239900 242 IEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKPDGYVS 303
Cdd:PRK11175 244 VEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 151-298 2.85e-58

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 184.01  E-value: 2.85e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 151 NGNILAAVNAVSENEEHVALNKRVIKDAQYLCELANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALA 230
Cdd:cd23660    1 GGRILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKALR 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498239900 231 AEFNLSPEQCFIEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKP 298
Cdd:cd23660   81 QKFGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 5-144 7.15e-57

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 180.06  E-value: 7.15e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   5 KRIIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRQLWLNDLVSPYKD--I 82
Cdd:cd23943    2 QNMLVVIDPNQDDQPALRRAVYLVQRIGGKIKAFLPIYDLSYEMTTLLSPDERTAMRQGVISQRTAWIREQAKYYLEagI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498239900  83 NIETQVVWHNRPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVK 144
Cdd:cd23943   82 PIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-143 4.81e-21

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 86.90  E-value: 4.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   3 TIKRIIAVIDPTKDDQHGLARSIDLAKKSGASITAFmTVYDFSYEMttmlsGDEREAMRDAVLKDRQLWLNDLVSPYK-- 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLL-HVVDPPPSA-----AAGPEELEEELREEAEEALEEAAERLEea 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498239900  81 DINIETQVVwHNRPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFV 143
Cdd:COG0589   75 GVEVETVVR-EGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-144 1.74e-17

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 77.45  E-value: 1.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900    7 IIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRQLWLNDLVSPYKDINIET 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 498239900   87 QVVWHNrPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVK 144
Cdd:pfam00582  81 VVVVGD-PAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 6-143 6.12e-17

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 75.85  E-value: 6.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   6 RIIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRD---AVLKDRQLWLNDlvspyKDI 82
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEeaeELLEEAKKLAEE-----AGV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498239900  83 NIETQVVWHNrPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFV 143
Cdd:cd00293   76 EVETIVVEGD-PAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
153-294 2.19e-16

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 74.19  E-value: 2.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 153 NILAAVNAvSENeehvalNKRVIKDAQYLCELANAKLNLVNAFPATPIniaieiPEFNPGLYNESVKKHHHESTNALAAE 232
Cdd:COG0589    4 RILVPTDG-SEE------AERALEYAAELAKALGAELHLLHVVDPPPS------AAAGPEELEEELREEAEEALEEAAER 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498239900 233 FNLS--PEQCFIEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVL 294
Cdd:COG0589   71 LEEAgvEVETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVL 134
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 153-294 3.40e-12

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 62.75  E-value: 3.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 153 NILAAVNAvSENeehvalNKRVIKDAQYLCELANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALAAE 232
Cdd:cd00293    1 KILVAVDG-SEE------SERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEEAEELLEEAKKLAEEA 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498239900 233 fnLSPEQCFIEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVL 294
Cdd:cd00293   74 --GVEVETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVL 133
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 172-297 4.77e-12

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 62.43  E-value: 4.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900  172 KRVIKDAQYLCELANAKLNLVNAFPATPINIAIEIPEFNPGLYNESVKKHHHESTNALAAEFNLSPEQCFIEEGLPEDVI 251
Cdd:pfam00582  12 KRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEVVVVVGDPAEEI 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 498239900  252 PDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALK 297
Cdd:pfam00582  92 LEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 153-298 4.06e-09

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 54.24  E-value: 4.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900 153 NILAAVnAVSENeehvalNKRVIKDAQYLCELANAKLNLvnafpatpINIAIEIPEFNPGLYNESVK-------KHHHES 225
Cdd:cd23657    3 HILVAV-DLSPE------SQSLVDKAVEIARENDAKLSL--------IHVDEDISEYYTGLIDVDIAalqdlesTMLEEA 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498239900 226 TNALAAEFNLSPEQCFIEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSaaLVGNTAEHVIDSLDCDVLALKP 298
Cdd:cd23657   68 LKNLSELAGYPVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVPL 138
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 6-144 1.58e-04

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 41.07  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   6 RIIAV-IDPTKDDQHGLARSIDLAKKSGASITAFMTV--YDFSYEMTTMLSGDEREAMRDAVLKDRQLW--LNDLVSPYK 80
Cdd:cd23659    1 RKVLIaVDGSEESEYALEWALENLHRPGDEVVLLHVIepPSLPAASLGSGSEEWEALEEEAREKAEKLLekYEKKLKEEK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498239900  81 DINIETQVVWHNrPYEAIINTVIEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVK 144
Cdd:cd23659   81 GIKVKVEVVAGD-PGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 242-294 4.03e-04

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 39.91  E-value: 4.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 498239900 242 IEEGLPEDVIPDIAKRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVL 294
Cdd:cd23659   88 VVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVL 140
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 7-144 3.96e-03

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 36.72  E-value: 3.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498239900   7 IIAVIDPTKDDQHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSGDEREAMRDAVLKDRqlwLNDLVSPYKDINIeT 86
Cdd:cd23661    2 VVVGVDGSPASELATEIAFDEASRRGVDLVALHAWSDMGPGGFLGIDWRESEQDQERMLAER---LAGWQERYPDVHV-H 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498239900  87 QVVWHNRPYEAIINTviEQKYDLVIKSTHQHGALKSVIFTPTDWHLVRKCPAPVLFVK 144
Cdd:cd23661   78 KVVVRDRPARVLLEA--SERAQLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIVVR 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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