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Conserved domains on  [gi|498240560|ref|WP_010554716|]
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MULTISPECIES: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Pseudoalteromonas]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 6-271 7.46e-119

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 341.72  E-value: 7.46e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   6 SFSLIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFELTTDGGISVGGDTKDIPLN-DNLIYKAALLLQTHCKT 84
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDeDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  85 SLGVKINLIKRLPMgggvgggSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKLHQVK-L 163
Cdd:COG1947   81 PPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPpL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 164 EQKWYCVVHPNQHVSTAKIFTHPDLKRDTPKI-IGDWKH----------HTLTNDCEPLVKKLCPEVEKTLQWLLKYA-- 230
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPPPdIDALLAalaagdaalaALLRNDLEPVAFKLYPEIAEVLEALLEAGal 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 498240560 231 PSKMTGTGSCCFVEFASQVQAQDVLENLPHTWQGFVASSAN 271
Cdd:COG1947  241 AARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 6-271 7.46e-119

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 341.72  E-value: 7.46e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   6 SFSLIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFELTTDGGISVGGDTKDIPLN-DNLIYKAALLLQTHCKT 84
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDeDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  85 SLGVKINLIKRLPMgggvgggSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKLHQVK-L 163
Cdd:COG1947   81 PPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPpL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 164 EQKWYCVVHPNQHVSTAKIFTHPDLKRDTPKI-IGDWKH----------HTLTNDCEPLVKKLCPEVEKTLQWLLKYA-- 230
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPPPdIDALLAalaagdaalaALLRNDLEPVAFKLYPEIAEVLEALLEAGal 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 498240560 231 PSKMTGTGSCCFVEFASQVQAQDVLENLPHTWQGFVASSAN 271
Cdd:COG1947  241 AARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 11-276 1.64e-77

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 237.41  E-value: 1.64e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   11 APAKLNLFLHINARREDGYHELETLFTFLNFGDELHFELTTDGGISVGGDTKDIPLNDNLIYKAALLLQTHCKTSL---- 86
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANSKIksld 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   87 GVKINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKL-HQVKLEQ 165
Cdd:TIGR00154  87 GVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIItPFEDPPE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  166 KWYCVVHPNQHVSTAKIFTHPDLKRDTPKIIGDW----KHHTLT-------NDCEPLVKKLCPEVEKTLQWLLKY--APS 232
Cdd:TIGR00154 167 KWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWlkkiSLECLQlldsnglNDLEKVALKRHTEVAQALNWLLEYglAPE 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 498240560  233 KMTGTGSCCFVEFASQVQAQDVLENLPHTWQGFVASSANVSPAH 276
Cdd:TIGR00154 247 RMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIG 290
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-258 4.04e-56

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 182.36  E-value: 4.04e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   5 TSFSLIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFE------LTTDG----GISVGGDtkdiplndNLIYKA 74
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEpaealsLTVSGpfaaGLGDGDD--------NLVLRA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  75 ALLLQTHCKTSL-GVKINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHG 153
Cdd:PRK14608  77 ARALRARVGPGLpPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 154 IGEKLHQVK-LEQKWYCVVHPNQHVSTAKIF------THPDLKRDTP--KIIGDWKHH--TLTNDCEPLVKKLCPEVEKT 222
Cdd:PRK14608 157 IGEELTPLPgLPSLPAVLVNPGVPVATPDVFralglrDGPPLPGAPDplASADALLAAlaATRNDLEPPALALAPVIGEV 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 498240560 223 LQWLLKyAP----SKMTGTGSCCFVEFASQVQAQDVLENL 258
Cdd:PRK14608 237 LAALRA-QPgallARMSGSGATCFALFADEAAAEAAAAAI 275
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 212-262 2.60e-05

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 41.69  E-value: 2.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 498240560  212 VKKLCPEVEKTLQWLLKY-APSKMTGT--GSCCFVEFASQVQAQDVLENLPHTW 262
Cdd:pfam08544  30 VGILPPELDELLEALLELgLGAKLSGSggGPTVFALFKDEDDAEEVARALREAG 83
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 6-271 7.46e-119

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 341.72  E-value: 7.46e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   6 SFSLIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFELTTDGGISVGGDTKDIPLN-DNLIYKAALLLQTHCKT 84
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDeDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  85 SLGVKINLIKRLPMgggvgggSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKLHQVK-L 163
Cdd:COG1947   81 PPGVDIHLEKRIPVgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPpL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 164 EQKWYCVVHPNQHVSTAKIFTHPDLKRDTPKI-IGDWKH----------HTLTNDCEPLVKKLCPEVEKTLQWLLKYA-- 230
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPPPdIDALLAalaagdaalaALLRNDLEPVAFKLYPEIAEVLEALLEAGal 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 498240560 231 PSKMTGTGSCCFVEFASQVQAQDVLENLPHTWQGFVASSAN 271
Cdd:COG1947  241 AARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 11-276 1.64e-77

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 237.41  E-value: 1.64e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   11 APAKLNLFLHINARREDGYHELETLFTFLNFGDELHFELTTDGGISVGGDTKDIPLNDNLIYKAALLLQTHCKTSL---- 86
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANSKIksld 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   87 GVKINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKL-HQVKLEQ 165
Cdd:TIGR00154  87 GVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIItPFEDPPE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  166 KWYCVVHPNQHVSTAKIFTHPDLKRDTPKIIGDW----KHHTLT-------NDCEPLVKKLCPEVEKTLQWLLKY--APS 232
Cdd:TIGR00154 167 KWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWlkkiSLECLQlldsnglNDLEKVALKRHTEVAQALNWLLEYglAPE 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 498240560  233 KMTGTGSCCFVEFASQVQAQDVLENLPHTWQGFVASSANVSPAH 276
Cdd:TIGR00154 247 RMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIG 290
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-258 4.04e-56

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 182.36  E-value: 4.04e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   5 TSFSLIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFE------LTTDG----GISVGGDtkdiplndNLIYKA 74
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEpaealsLTVSGpfaaGLGDGDD--------NLVLRA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  75 ALLLQTHCKTSL-GVKINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHG 153
Cdd:PRK14608  77 ARALRARVGPGLpPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 154 IGEKLHQVK-LEQKWYCVVHPNQHVSTAKIF------THPDLKRDTP--KIIGDWKHH--TLTNDCEPLVKKLCPEVEKT 222
Cdd:PRK14608 157 IGEELTPLPgLPSLPAVLVNPGVPVATPDVFralglrDGPPLPGAPDplASADALLAAlaATRNDLEPPALALAPVIGEV 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 498240560 223 LQWLLKyAP----SKMTGTGSCCFVEFASQVQAQDVLENL 258
Cdd:PRK14608 237 LAALRA-QPgallARMSGSGATCFALFADEAAAEAAAAAI 275
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 11-224 2.21e-34

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 126.16  E-value: 2.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  11 APAKLNLFLHINARREDGYHELETLFTFLNFGDELhfELTTDGGISV---GGDTKDIPLN-DNLIYKAALLLQTHCKTSL 86
Cdd:PRK03188   5 APAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEV--TVTAADVLSVevsGEGADQVPTDeSNLAWRAAELLAEHVGRAP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  87 GVKINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKLHQVKLEQK 166
Cdd:PRK03188  83 DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLARGT 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498240560 167 WYCVVHP-NQHVSTAKIFTHPDLKRDTPKII--------------GDWKH--HTLTNDCEPLVKKLCPEVEKTLQ 224
Cdd:PRK03188 163 FHWVLAFaDGGLSTPAVFRELDRLREAGDPPrlgepdpllaalraGDPAQlaPLLGNDLQAAALSLRPSLRRTLR 237
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
9-243 1.14e-32

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 121.01  E-value: 1.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   9 LIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFELTTDggISVGGDTKDIPLNDNLIYKAALLLQTHCKTSLGV 88
Cdd:PRK14611   4 LLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHHT--LEVKTSSPQIKEEENIVYKALRLFERYTGIDINY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  89 KINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHGIGEKLHQV--KLEQK 166
Cdd:PRK14611  82 SIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLekPISRE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 167 WYcVVHPNQHVSTAKIFTHPDLKRDTPK--------IIGDWKHHTLTNDCE----PLVKKLCPEVEKTLQWL--LKYAPs 232
Cdd:PRK14611 162 IT-LVYPNIKSSTGRVYSKVTKQILTNKedlniiisLLREGEEKKIEEVIEntlgEIALELYPEIKEVYRFLeyLGYKP- 239

                        250
                 ....*....|.
gi 498240560 233 KMTGTGSCCFV 243
Cdd:PRK14611 240 FVSGSGSSVYV 250
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 13-215 4.11e-24

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 97.72  E-value: 4.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  13 AKLNLFLHINARReDGYHELETLFTFL-NFGDELHFELTTDGGISVGGDTkDIPLNDNLIYKAALLLQTH-CKTSL---- 86
Cdd:PRK04181   7 AKVNIFLKILGKR-GNYHELISRFVLVkDLFDEIEFVPKSAESFELIGNF-DCPLEENIIYKAYQELKNKgFSNELieff 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  87 -GVKINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLELNLEILAQLGLKLGADVPVFIQG-QSAIAHGIGEklhqvkle 164
Cdd:PRK04181  85 kKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGE-------- 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 498240560 165 qkwycVVHP-NQHVSTAKIFThPDLKRDTPKIIGDWKHHTLTNDCEPLVKKL 215
Cdd:PRK04181 157 -----IVEEfEEEILNLEIFT-PNIFCSTKAVYKAYREEFYDFISFNQAKEL 202
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
9-258 4.55e-23

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 95.74  E-value: 4.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560   9 LIAPAKLNLFLHINARREDGYHELETLFTFLNFGDELHFElTTDGGISVGGDTKDI---------------PLNDNLIYK 73
Cdd:PRK14613   1 MISPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIE-PAPNGVFELFSTNEIilekrklydqvsergDIKQNILYK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  74 AALLLQTHCKTSLGVKINLIKRLPMGGGVGGGSSDAASTLLALNKlWKLELNLEILAQLGLKLGADVPVFIQGQSAIAHG 153
Cdd:PRK14613  80 TFIKARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFS-WRNFFTSDEMQVFAKEIGSDVPFFLGEGHAFVTG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 154 IGEKLHQVKLEQKWYCVVHPNQHVSTAKIFTH--------------PDLKRDTPKII--GDWKH--HTLTNDCEPLVKKL 215
Cdd:PRK14613 159 KGEIMEEIEVHKGQGILALTPQVMNTGEMYALlkkplqesasqkngNTLSEDLISSLkvGDWVSlqGRLENDFEPVAFQL 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 498240560 216 CPEVEKTLQWLLKYAPS--KMTGTGSCCFVEFASQVQAQDVLENL 258
Cdd:PRK14613 239 HPELGVLKDKFLEFGSSycSLTGSGSSMYGLVQGLEIQEELLPRL 283
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
13-243 9.93e-12

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 63.71  E-value: 9.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  13 AKLNLFLHINARRED-GYHELETLFTFL-NFGDELHFEL--TTDGGISVGGDTKDIPLNDNLIYKAAL-LLQTHCKTSLG 87
Cdd:PRK05905   7 AKINLGLSIYKKCKKvTKHKLESIFILVeNVYDDIEIEKieKNIDDIHYFDETNEILVYSRLILVKTLeWLRDKYNIKNH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  88 VKINLIKRLPMGGGVGGGSSDAAStllalnkLWKLELNLEILAQLG-----LKLGADVPVFIQG-QSAIAHGIGEKLHQV 161
Cdd:PRK05905  87 FKIKIKKRIPIGSGLGSGSSNAAV-------LMKWILEFEGINEINykdvvNKLGSDIPFFLSGyKTAYISDYGSQVEDL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 162 KLEQKW-YCVVHPNQHVSTAKIFTHPD-----LKRDTPKIIGDWKHH---TLTNDCEPLVKKLCPEVEKTLQWLLKYAPS 232
Cdd:PRK05905 160 IGQFKLtYKVIFMNVNVSTKKVFEKFDdnqhvIKNNFKTIIKNLKENivvNIHNDLQEPCFELYPNLLYKYNELLNDGFY 239

                        250
                 ....*....|..
gi 498240560 233 K-MTGTGSCCFV 243
Cdd:PRK05905 240 TiLSGAGSSFIV 251
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 39-181 1.35e-11

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 63.58  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  39 LNFGDELHFELTTDGGISV---GGDTKDIPLN-DNLIYKAAL-LLQTHCKTSLGVKINLIKRLPMgggvgggS----SDA 109
Cdd:COG0083   25 LSLYDEVEVERSDEPGLEIeieGEGADELPTDeDNLVYQAALaLLEKLGKEPPGLRIEIEKGIPL-------GrglgSSA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 110 AST---LLALNKLWKLELNLEILAQLGLKL-G-AD--VP-VFiqGQSAIAHGIGEKLHQVKLE--QKWYCVV-HPNQHVS 178
Cdd:COG0083   98 AAIvagLVAANALLGLPLSKEELLELATEGeGhPDnvAPaLL--GGLVLSRSDGEPVRVVRLPvpPDLKAVVvIPDFELS 175


                 ...
gi 498240560 179 TAK 181
Cdd:COG0083  176 TKE 178
PRK01212 PRK01212
homoserine kinase; Provisional
 39-181 2.16e-07

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 51.30  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560  39 LNFGDELHFELTTDGG-----ISVGGDTKDIPLN--DNLIYKAALLLQTHCKTSLGVKINLIKRLPMgggvgggS----S 107
Cdd:PRK01212  26 LSLYDEVLVGDVVSVEaefsiEVIGEGADKLPLDpeKNLVYQAALKFLEKLGKPPGLRIELEKNIPL-------GrglgS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498240560 108 DAAS---TLLALNKLWKLELNLEILAQLGLKL-G-AD--VPVFIQGQSAIAHGIGEKLHQVKLEQKWYCVV-HPNQHVST 179
Cdd:PRK01212  99 SAASivaGLVAANELAGLPLSKEELLQLATEGeGhPDnvAPALLGGLVLALEENGVISVKIPVFDDLKWVVaIPNIELST 178


                 ..
gi 498240560 180 AK 181
Cdd:PRK01212 179 AE 180
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 212-262 2.60e-05

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 41.69  E-value: 2.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 498240560  212 VKKLCPEVEKTLQWLLKY-APSKMTGT--GSCCFVEFASQVQAQDVLENLPHTW 262
Cdd:pfam08544  30 VGILPPELDELLEALLELgLGAKLSGSggGPTVFALFKDEDDAEEVARALREAG 83
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 89-146 2.00e-04

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 38.68  E-value: 2.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498240560   89 KINLIKRLPMGGGVGGGSSDAASTLLALNKLWKLEL-----NLEILAQLGLKLGADVPVFIQG 146
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLaklalEAEELAGGGRGGGMDVAASLYG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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