|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
8-475 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 649.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQV 87
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKE-LGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DHLDLKVGESFTFHIIPgVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINL 167
Cdd:COG0469 81 GPVELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 168 PGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSDGVM 247
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 248 VARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFP 327
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 328 VRCVEMLHKIAERVEKTPGVGYVSDRIPSNKK----EEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPlIYA 403
Cdd:COG0469 320 VEAVETMARIAEEAEKSLDYRRILDRLRDEPErtitDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP-ILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498254234 404 FTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAGV-DRVETIQVREV 475
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVpGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
9-458 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 538.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQVD 88
Cdd:PRK05826 4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK-LGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 HLDLKVGESFTFHIIPGVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINLP 168
Cdd:PRK05826 83 KITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 169 GIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSA-IIAKIEDQEAVRNMVEIVEVSDGVM 247
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAkIIAKIERAEAVDNIDEIIEASDGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 248 VARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFP 327
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 328 VRCVEMLHKIAERVEKTPGVGYVSDRIP---SNKKEEMAKSAAMLSDSIKS-PAIIVITRRGTTALNVASFHPRQPlIYA 403
Cdd:PRK05826 323 VEAVEAMARICKGAEKEFSINLSKHRLDrqfDRIDEAIAMSAMYAANHLKGvKAIVALTESGRTARLISRFRPGAP-IFA 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 498254234 404 FTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILS 458
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTS 456
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
9-458 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 521.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKhPIAILLDTQGPEIRTGDLQVD 88
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGR-PVAILLDTKGPEIRTGEIKGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 HLDLKVGESFTFHIIPG-VESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINL 167
Cdd:TIGR01064 80 EVKLKKGDKVIITTDDIkGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 168 PGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEE-NNGHSAIIAKIEDQEAVRNMVEIVEVSDGV 246
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEkGAKDVKIIAKIENQEGVDNIDEIAEASDGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 247 MVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKF 326
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 327 PVRCVEMLHKIAERVEKTPGVGYV------SDRIPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPl 400
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNfndrknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP- 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 498254234 401 IYAFTNMTTVRRKLWLTRGVIPYRID-FSSDPEKTIKLAIETLKASGRIKDGDQVVILS 458
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDeEPSDTDARVNKALELLKEKGIVKKGDLVVVIQ 457
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
8-475 |
5.46e-164 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 471.80 E-value: 5.46e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQV 87
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEK-TGGPVAIALDTKGPEIRTGLFKG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DH-LDLKVGESFTFHIIPG-VESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQ-ETALKCKVVDGGKLGSRKH 164
Cdd:cd00288 80 GKdISLKAGDKFLVTTDPAaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 165 INLPGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSD 244
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 245 GVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAG 324
Cdd:cd00288 240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 325 KFPVRCVEMLHKIAERVEKTPG--VGYVSDR----IPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQ 398
Cdd:cd00288 320 KYPVEAVKAMARICLEAEKALShrVLFNEMRrltpRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 399 PLIYAFTNMTTVRRkLWLTRGVIPY-----RIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAGVDRVETIQVR 473
Cdd:cd00288 400 PIIAVTRNEQTARQ-LHLYRGVYPVlfeepKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478
|
..
gi 498254234 474 EV 475
Cdd:cd00288 479 TV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
8-344 |
4.64e-137 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 398.28 E-value: 4.64e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKdVLKHPIAILLDTQGPEIRTGDLQ- 86
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEE-KTGGTVAIALDTKGPEIRTGNTKd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 87 -VDHLDLKVGESFTFHIIPGV--ESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEI-QETALKCKVVDGGKLGSR 162
Cdd:pfam00224 80 gKKDIELKAGDEMIVSTDAKYkgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 163 KHINLPGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEV 242
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 243 SDGVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETA 322
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319
|
330 340
....*....|....*....|..
gi 498254234 323 AGKFPVRCVEMLHKIAERVEKT 344
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKA 341
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
8-475 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 649.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQV 87
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKE-LGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DHLDLKVGESFTFHIIPgVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINL 167
Cdd:COG0469 81 GPVELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 168 PGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSDGVM 247
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 248 VARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFP 327
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 328 VRCVEMLHKIAERVEKTPGVGYVSDRIPSNKK----EEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPlIYA 403
Cdd:COG0469 320 VEAVETMARIAEEAEKSLDYRRILDRLRDEPErtitDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP-ILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498254234 404 FTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAGV-DRVETIQVREV 475
Cdd:COG0469 399 LTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVpGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
9-458 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 538.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQVD 88
Cdd:PRK05826 4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK-LGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 HLDLKVGESFTFHIIPGVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINLP 168
Cdd:PRK05826 83 KITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 169 GIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSA-IIAKIEDQEAVRNMVEIVEVSDGVM 247
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAkIIAKIERAEAVDNIDEIIEASDGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 248 VARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFP 327
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 328 VRCVEMLHKIAERVEKTPGVGYVSDRIP---SNKKEEMAKSAAMLSDSIKS-PAIIVITRRGTTALNVASFHPRQPlIYA 403
Cdd:PRK05826 323 VEAVEAMARICKGAEKEFSINLSKHRLDrqfDRIDEAIAMSAMYAANHLKGvKAIVALTESGRTARLISRFRPGAP-IFA 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 498254234 404 FTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILS 458
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTS 456
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
9-458 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 521.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKhPIAILLDTQGPEIRTGDLQVD 88
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGR-PVAILLDTKGPEIRTGEIKGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 HLDLKVGESFTFHIIPG-VESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINL 167
Cdd:TIGR01064 80 EVKLKKGDKVIITTDDIkGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 168 PGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEE-NNGHSAIIAKIEDQEAVRNMVEIVEVSDGV 246
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEkGAKDVKIIAKIENQEGVDNIDEIAEASDGI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 247 MVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKF 326
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 327 PVRCVEMLHKIAERVEKTPGVGYV------SDRIPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPl 400
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLTNfndrknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP- 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 498254234 401 IYAFTNMTTVRRKLWLTRGVIPYRID-FSSDPEKTIKLAIETLKASGRIKDGDQVVILS 458
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDeEPSDTDARVNKALELLKEKGIVKKGDLVVVIQ 457
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
8-475 |
5.46e-164 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 471.80 E-value: 5.46e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQV 87
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEK-TGGPVAIALDTKGPEIRTGLFKG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DH-LDLKVGESFTFHIIPG-VESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQ-ETALKCKVVDGGKLGSRKH 164
Cdd:cd00288 80 GKdISLKAGDKFLVTTDPAaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDdDKTLVCEVLNGGVLGSRKG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 165 INLPGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSD 244
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 245 GVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAG 324
Cdd:cd00288 240 GIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 325 KFPVRCVEMLHKIAERVEKTPG--VGYVSDR----IPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQ 398
Cdd:cd00288 320 KYPVEAVKAMARICLEAEKALShrVLFNEMRrltpRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 399 PLIYAFTNMTTVRRkLWLTRGVIPY-----RIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAGVDRVETIQVR 473
Cdd:cd00288 400 PIIAVTRNEQTARQ-LHLYRGVYPVlfeepKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRIL 478
|
..
gi 498254234 474 EV 475
Cdd:cd00288 479 TV 480
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
9-476 |
3.38e-158 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 460.93 E-value: 3.38e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKHPIAILLDTQGPEIRTGDLQvD 88
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNVIAIMLDTKGPEVRSGDLP-Q 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 HLDLKVGESFTFHIIPGVeSEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINLP 168
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGV-STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 169 GIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSDGVMV 248
Cdd:PLN02623 268 GKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMV 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 249 ARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFPV 328
Cdd:PLN02623 348 ARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPL 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 329 RCVEMLHKIAERVEKTPGVGYVSDRIPSNKKEEMAK----SAAMLSDSIKSPaIIVITRRGTTALNVASFHPrQPLIYAF 404
Cdd:PLN02623 428 KAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEmfafHATMMANTLGTS-IIVFTRTGFMAILLSHYRP-SGTIFAF 505
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498254234 405 TNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAGVDRVET---IQVREVK 476
Cdd:PLN02623 506 TNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALVQSGRQPIWRSESthhIQVRKVQ 580
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
8-464 |
5.17e-158 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 460.55 E-value: 5.17e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvLKHPIAILLDTQGPEIRTGDLQV 87
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKK-LGKTVGILQDLQGPKIRLGRFED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DHLDLKVGESFTFHIIPGVESEEQSvFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETA--LKCKVVDGGKLGSRKHI 165
Cdd:PRK06354 86 GPIELKTGDEFILTSREVLGTQEKF-SVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVLSNKKGV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 166 NLPGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHS-AIIAKIEDQEAVRNMVEIVEVSD 244
Cdd:PRK06354 165 NFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHiPIIAKIEKQEAIDNIDAILELCD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 245 GVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAG 324
Cdd:PRK06354 245 GLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAG 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 325 KFPVRCVEMLHKIAERVEKTpgvgYVSDRIPSNKKEEM-----AKSAAM--LSDSIKSPAIIVITRRGTTALNVASFHPR 397
Cdd:PRK06354 325 DYPVEAVQTMATIAVRIEKD----LPYRDILSKRPEFTttitnAISQAVshIALQLDAAAIVTLTKSGATARNVSKYRPK 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498254234 398 QPlIYAFTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAGV 464
Cdd:PRK06354 401 TP-ILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGE 466
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
9-464 |
1.52e-151 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 440.13 E-value: 1.52e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLnKDVLKHPIAILLDTQGPEIRTGDLQVD 88
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREV-EDETGRPIGILADLQGPKLRLGRFADG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 HLDLKVGESFTFHIIPgVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINLP 168
Cdd:PRK06247 84 KVQLANGQTFRLDVDD-APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 169 GIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIeenNGHSAIIAKIEDQEAVRNMVEIVEVSDGVMV 248
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII---GGRVPVMAKIEKPQAIDRLEAIVEASDAIMV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 249 ARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFPV 328
Cdd:PRK06247 240 ARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 329 RCVEMLHKIAERVEKTP---GVGYVSDRIP-SNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPLIyAF 404
Cdd:PRK06247 320 EAVRTMARIIRQVERDPtypPLIHAQRPQPeATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPIL-AL 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 405 TNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVilsdIIAGV 464
Cdd:PRK06247 399 TPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVV----IVAGV 454
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
9-458 |
1.43e-144 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 422.16 E-value: 1.43e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKHpIAILLDTQGPEIRTGDLQV- 87
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKK-AAILLDTKGPEIRTMKLEGg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DHLDLKVGESFTFHIIPGVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINL 167
Cdd:PRK09206 81 NDVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 168 PGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNG-HSAIIAKIEDQEAVRNMVEIVEVSDGV 246
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGeNIQIISKIENQEGLNNFDEILEASDGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 247 MVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKF 326
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 327 PVRCVEMLHKIAERVEKTpGVGYVSDRIPSNKK---EEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPlIYA 403
Cdd:PRK09206 321 PLEAVSIMATICERTDRV-MNSRLESNNDNRKLritEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDAT-ILA 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 498254234 404 FTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILS 458
Cdd:PRK09206 399 LTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVS 453
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
8-344 |
4.64e-137 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 398.28 E-value: 4.64e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 8 FRKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKdVLKHPIAILLDTQGPEIRTGDLQ- 86
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEE-KTGGTVAIALDTKGPEIRTGNTKd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 87 -VDHLDLKVGESFTFHIIPGV--ESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEI-QETALKCKVVDGGKLGSR 162
Cdd:pfam00224 80 gKKDIELKAGDEMIVSTDAKYkgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKdDDKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 163 KHINLPGIRVNLPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEV 242
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 243 SDGVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETA 322
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319
|
330 340
....*....|....*....|..
gi 498254234 323 AGKFPVRCVEMLHKIAERVEKT 344
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKA 341
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
9-475 |
3.25e-129 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 384.10 E-value: 3.25e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNkDVLKHPIAILLDTQGPEIRTGDLQ-V 87
Cdd:PLN02762 25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLN-EEKGFAVAVMMDTEGSEIHMGDLGgA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 DHLDLKVGESFTFHIIPGVES-EEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHIN 166
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKFDGSrPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 167 L--PGIRVN-----LPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAI--IAKIEDQEAVRNMV 237
Cdd:PLN02762 184 FwrDGSLVRernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDSDIgvIAKIESLDSLKNLE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 238 EIVEVSDGVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIML 317
Cdd:PLN02762 264 EIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALML 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 318 SGETAAGKFPVRCVEMLHKIAERVEK------------TPGVG-YVSDRIpsnkKEEMAKSAAMLSDSIKSPAIIVITRR 384
Cdd:PLN02762 344 SGESAMGLYPEKALSVLRSVSLRMELwsreekrhealeLPQLSsSLSDRI----SEEICNSAAKMANNLGVDAIFVYTKH 419
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 385 GTTALNVASFHPRQPlIYAFTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILSDIIAgV 464
Cdd:PLN02762 420 GHMASLLSRNRPDCP-IFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAVSDLTP-S 497
|
490
....*....|.
gi 498254234 465 DRVETIQVREV 475
Cdd:PLN02762 498 SMLQSIQVRNV 508
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
10-476 |
3.97e-121 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 363.53 E-value: 3.97e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 10 KTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIK--SLNKDVLkhpIAILLDTQGPEIRTGDLQV 87
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRqaMANTGIL---CAVMLDTKGPEIRTGFLKD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 88 -DHLDLKVGESFTFHIIPGVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETA--LKCKVVDGGKLGSRKH 164
Cdd:PLN02461 99 gKPVQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAgtVRCRCENSAMLGERKN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 165 INLPGIRVNLPSITQKDQKDIL-FGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVS 243
Cdd:PLN02461 179 VNLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAES 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 244 DGVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAA 323
Cdd:PLN02461 259 DAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 324 GKFPVRCVEMLHKIAERVEKTPGVGYVSDRI------PSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPR 397
Cdd:PLN02461 339 GAYPELAVKTMARICREAEASLDYGALFKEImrsaplPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYRPA 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 398 QP-LIYAFTNMTT------------VRRKLwLTRGVIPY------RIDFSSDPEKTIKLAIETLKASGRIKDGDQVVILS 458
Cdd:PLN02461 419 VPiLSVVVPEITTdsfdwscsdeapARHSL-IYRGLIPVlaegsaKATDSESTEEILEAAIEHAKKKGLCKPGDSVVALH 497
|
490
....*....|....*...
gi 498254234 459 DIiaGVDRVetIQVREVK 476
Cdd:PLN02461 498 RI--GGASV--IKILTVK 511
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
9-457 |
8.33e-117 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 352.53 E-value: 8.33e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKHPIAILLDTQGPEIRTGDLQvD 88
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNANLGILLDTKGPEIRTGFLK-N 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 89 H--LDLKVGESFTFHIIPGVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHIN 166
Cdd:PTZ00066 117 HkpITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 167 LPGIRVNLPSITQKDQKDIL-FGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSDG 245
Cdd:PTZ00066 197 LPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDG 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 246 VMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGK 325
Cdd:PTZ00066 277 IMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGK 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 326 FPVRCVEMLHKI---AERVEKTP---GVGYVSDRIPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQP 399
Cdd:PTZ00066 357 FPVEAVNIMAKIcfeAETCIDYRvlyHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCT 436
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 498254234 400 lIYAFTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVIL 457
Cdd:PTZ00066 437 -ILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAV 493
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
14-342 |
6.36e-108 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 324.21 E-value: 6.36e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 14 ICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDvlkhpIAILLDTQGPEIRTGDLQVDHLDLK 93
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS-----IKILGDVQGPKIRLGEIKGEQITLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 94 VGESFTFHIIPgVESEEQSVFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVVDGGKLGSRKHINLPGIRVN 173
Cdd:PRK06739 81 AGDSFILHTQP-VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 174 LPSITQKDQKDILFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGHSA-IIAKIEDQEAVRNMVEIVEVSDGVMVARGD 252
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPnLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 253 LGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFPVRCVE 332
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330
....*....|
gi 498254234 333 MLHKIAERVE 342
Cdd:PRK06739 320 TLRLVSEFAE 329
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
35-457 |
1.36e-97 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 301.20 E-value: 1.36e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 35 MNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKHpIAILLDTQGPEIRTGDLQVDHLDLKVGESFTFHIIPGVESE--EQS 112
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN-IAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFADKgtKDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 113 VFVNYRDIVNDLKVGDRVTVDNGLINLVVEEIQ-ETALKCKVVDGGKLGSRKHINLPGIRVNLPSITQKDQKDILFGLEE 191
Cdd:PTZ00300 80 FYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEdEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 192 DVDFIALSFVRSKEDILQLRKIIEENNGHSAIIAKIEDQEAVRNMVEIVEVSDGVMVARGDLGVELPIEELPIIQRAIIR 271
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILIS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 272 ECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFPVRCVEMLHKIAerVEKTPGVG-YV 350
Cdd:PTZ00300 240 KCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARIC--LEAQSAVNeYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 351 S-------DRIPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPLIYAFTNMTTVrRKLWLTRGVIPY 423
Cdd:PTZ00300 318 FfnsikklQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTC-RQLNITQGVESV 396
|
410 420 430
....*....|....*....|....*....|....*....
gi 498254234 424 -----RIDFSSDPEKTIKLAIETLKASGRIKDGDQVVIL 457
Cdd:PTZ00300 397 ffdaeRLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVV 435
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
11-456 |
1.78e-80 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 259.22 E-value: 1.78e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 11 TKIICTIGPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVlKHPIAILLDTQGPEIRTGDLQVDHL 90
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNT-KKLCAVMLDTVGPELQVINKTEKPI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 91 DLKVGESFTfhIIPGVESEEQSVF--VNYRDIVNDLKVGDRVTVDNGL--------INLVVEEIQETALKCKVVDGGKL- 159
Cdd:PLN02765 109 SLKAGNTVT--LTPDQSKEASSEVlpINFPGLAKAVKPGDTIFVGQYLftgsettsVWLEVDEVKGDDVVCTVKNSATLa 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 160 GSRKHINLPGIRVNLPSITQKDQKDI-LFGLEEDVDFIALSFVRSKEDILQLRKIIEENNGH-SAIIAKIEDQEAVRNMV 237
Cdd:PLN02765 187 GSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSqTQIFAKIENVEGLTHFD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 238 EIVEVSDGVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVaTHLLESMINNPSPTRAEVTDVANAVYEESDAIML 317
Cdd:PLN02765 267 EILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 318 SGETAAGKFPVRCVEMLHKI---AERV-------EKTpgVGYVSDriPSNKKEEMAKSAAMLSDSIKSPAIIVITRRGTT 387
Cdd:PLN02765 346 GAETLRGLYPVETISTVGRIcaeAEKVfnqdlyfKKT--VKYVGE--PMSHLESIASSAVRAAIKVKASVIIVFTSSGRA 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 388 ALNVASFHPRQPLI-------------YAFTNMTTVRRKLwLTRGVIPYRID-------FSSDPEKTIKLAIETLKASGR 447
Cdd:PLN02765 422 ARLIAKYRPTMPVLsvviprlktnqlkWSFTGAFQARQCL-IVRGLFPMLADprhsaesTSATNESVLKVALDHGKAAGV 500
|
....*....
gi 498254234 448 IKDGDQVVI 456
Cdd:PLN02765 501 IKSHDRVVV 509
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
9-345 |
1.58e-47 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 170.97 E-value: 1.58e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTI-GPATADKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVlKHPIAILLDTQGPEIRTGDL-- 85
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERAT-GRRCKILMDLAGPKIRTGAVag 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 86 QVDHLDLKVGESFTFHIIPGVESEEQSVF---VNYRDIVNDLKVGDRVTVDNGLINLVVEEIQETALKCKVV----DGGK 158
Cdd:PRK08187 212 PLGKTRLYTGDRLALVAQGPPRRIDEEHFqvtCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTharpKGLK 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 159 LGSRKHINLPGIRVNLPSITQKDQKDILFGLEEdVDFIALSFVRSKEDILQLRKIIEENNGHS----AIIAKIEDQEAVR 234
Cdd:PRK08187 292 LKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALAARRPDDwrklGLVLKIETPRAVA 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 235 NMVE-IVEVSD----GVMVARGDLGVELPIEELPIIQRAIIRECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAvy 309
Cdd:PRK08187 371 NLPElIVQAAGrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA-- 448
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 498254234 310 EESDAIMLSgetaAGKFPVRCVEMLHKIAERVE-----KTP 345
Cdd:PRK08187 449 ARAECVMLN----KGPYLVEAVTFLDDLLARMDghqhkKTP 485
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
9-342 |
1.65e-38 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 147.79 E-value: 1.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 9 RKTKIICTIgPATA--DKKMILALAEAGMNVARLNMSHGNHEFHRSIIKIIKSLNKDVLKhPIAILLDTQGPEIRTGDL- 85
Cdd:PRK14725 139 RPTRIMVTL-PTEAadDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGR-RCRIAMDLAGPKLRTGPIa 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 86 ---QVDHL-------------------------------------------------------------DLKVGE----- 96
Cdd:PRK14725 217 pgpRVIKLrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrKLTVTEvddeg 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 97 -----------------------SFTFHIIPGVEseeQSVFVN-------YRD----------------------IVNDL 124
Cdd:PRK14725 297 vlaegsqtaylangtllrlgrhdSTRVGGLPPVE---QKLRLKvgdrlvlTRDdapgdpaqgdapparisctlpeAFRAA 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 125 KVGDRVTVDNGLINLVVEEIQETALKCKVVD----GGKLGSRKHINLPGIRVNLPSITQKDQKDILFgLEEDVDFIALSF 200
Cdd:PRK14725 374 RVGERVWFDDGKIGAVVVKVEADEVELRITHarpgGSKLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSF 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 201 VRSKEDILQLRKIIEENNG-HSAIIAKIEDQEAVRNMVEIV-----EVSDGVMVARGDLGVELPIEELPIIQRAIIRECA 274
Cdd:PRK14725 453 VRSPEDVRLLLDALEKLGAdDLGVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCE 532
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498254234 275 VRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEEsdAIMLSgetaAGKFPVRCVEMLHKIAERVE 342
Cdd:PRK14725 533 AAHVPVIWATQVLESLAKKGLPSRAEITDAAMALRAE--CVMLN----KGPHIVEAVRVLDDILRRME 594
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
272-464 |
9.07e-28 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 112.69 E-value: 9.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 272 ECAVRGKRVIVATHLLESMINNPSPTRAEVTDVANAVYEESDAIMLSGETAAGKFPVRCVEMLHKIAERVEKTpgvgYVS 351
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEED----LEY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 352 DRIPSNKKEEMAKSAAmlsDSI-----------KSPAIIVITRRGTTALNVASFHPRQPLIyAFTNMTTVRRKLWLTRGV 420
Cdd:COG3848 77 REQRVPRAKESSTTIT---DAIshavattaadlGAAAIITATESGATARMVSKYRPKAPII-AVTPSERVARQLSLVWGV 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 498254234 421 IPYRIDFSSDPEKTIKLAIETLKASGRIKDGDQVVilsdIIAGV 464
Cdd:COG3848 153 YPLLVEESASTDEMFAVAVALALEAGLVKDGDLVV----ITAGV 192
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
360-464 |
3.25e-20 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 85.61 E-value: 3.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498254234 360 EEMAKSAAMLSDSIKSPAIIVITRRGTTALNVASFHPRQPlIYAFTNMTTVRRKLWLTRGVIPYRIDFSSDPEKTIKLAI 439
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVP-IIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAV 79
|
90 100
....*....|....*....|....*
gi 498254234 440 ETLKASGRIKDGDQVVILSDIIAGV 464
Cdd:pfam02887 80 KVAKEAGLVKKGDLVVITAGVPFGV 104
|
|
| HpcH |
COG3836 |
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism]; |
214-280 |
7.01e-03 |
|
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
Pssm-ID: 443047 [Multi-domain] Cd Length: 237 Bit Score: 38.17 E-value: 7.01e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498254234 214 IEENNGHSAIIAKIEDQEAVRNMVEIVEVS--DGVMVARGDLGVELPIE---ELPIIQRAI---IRECAVRGKRV 280
Cdd:COG3836 135 LARANDETLVIVQIETAEAVENLDEIAAVPgvDGVFIGPADLSASLGHPgqpDHPEVQAAIervIAAARAAGKPA 209
|
|
| |
