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Conserved domains on  [gi|498314451|ref|WP_010628607|]
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MULTISPECIES: nucleotide sugar dehydrogenase [Halomonadaceae]

Protein Classification

UDP-glucose dehydrogenase family protein( domain architecture ID 1903913)

UDP-glucose dehydrogenase family protein similar to UDP-glucose dehydrogenase which catalyzes the conversion of UDP-glucose into UDP-glucuronate, one of the precursors of teichuronic acid.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ugd super family cl43304
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
76-427 3.36e-111

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG1004:

Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 333.91  E-value: 3.36e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  76 EAI---DILWLALSPEQRE--EAD----ELVAEVAGRQ-QGALILVNNSTFPVGETERLEARLGGNGRRAVALVDMI--- 142
Cdd:COG1004   72 EAVaeaDVVFIAVGTPSDEdgSADlsyvLAAARSIGEAlKGYKVVVTKSTVPVGTADRVRAIIAEELRGAGVDFDVVsnp 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 143 E---EGRSWASFTRPGRWLLGCDDEHAEAQVRELLRAFNRRRDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADS 219
Cdd:COG1004  152 EflrEGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEK 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 220 LGVDVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRD---LMRLAdvQEAsGRQSALLEQVLDINEQKKETLFRKLWTHF 296
Cdd:COG1004  232 VGADVEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDvraLIATA--REL-GYDLRLLEAVEEVNERQKRRLVEKIREHL 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 297 HGQLEGRTVAIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVPALRAEVGDHplLSLFDgDPYAACENADAL 376
Cdd:COG1004  309 GGDLKGKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPVAMENARRLLPDD--ITYAD-DAYEALEGADAL 385
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 498314451 377 MLVTEWKHYWNPDWSRLAKLLHEKLLLDGRNIYDPTHVASWGLAYRGIGRR 427
Cdd:COG1004  386 VILTEWPEFRALDFARLKALMKGPVIFDGRNLLDPEELRAAGFTYYGIGRP 436
 
Name Accession Description Interval E-value
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
76-427 3.36e-111

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 333.91  E-value: 3.36e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  76 EAI---DILWLALSPEQRE--EAD----ELVAEVAGRQ-QGALILVNNSTFPVGETERLEARLGGNGRRAVALVDMI--- 142
Cdd:COG1004   72 EAVaeaDVVFIAVGTPSDEdgSADlsyvLAAARSIGEAlKGYKVVVTKSTVPVGTADRVRAIIAEELRGAGVDFDVVsnp 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 143 E---EGRSWASFTRPGRWLLGCDDEHAEAQVRELLRAFNRRRDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADS 219
Cdd:COG1004  152 EflrEGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEK 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 220 LGVDVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRD---LMRLAdvQEAsGRQSALLEQVLDINEQKKETLFRKLWTHF 296
Cdd:COG1004  232 VGADVEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDvraLIATA--REL-GYDLRLLEAVEEVNERQKRRLVEKIREHL 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 297 HGQLEGRTVAIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVPALRAEVGDHplLSLFDgDPYAACENADAL 376
Cdd:COG1004  309 GGDLKGKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPVAMENARRLLPDD--ITYAD-DAYEALEGADAL 385
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 498314451 377 MLVTEWKHYWNPDWSRLAKLLHEKLLLDGRNIYDPTHVASWGLAYRGIGRR 427
Cdd:COG1004  386 VILTEWPEFRALDFARLKALMKGPVIFDGRNLLDPEELRAAGFTYYGIGRP 436
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
91-407 2.90e-58

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 196.29  E-value: 2.90e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451   91 EEADELVAEVAgrQQGALIlVNNSTFPVGETERLEAR-LGGNGRRAVALVDM------IEEGRSWASFTRPGRWLLGcDD 163
Cdd:TIGR03026 100 ESAAETIAKHL--RKGATV-VLESTVPPGTTEEVVKPiLERSGLKLGEDFYLaynpefLREGNAVHDLLHPDRIVGG-ET 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  164 EHAEAQVRELLRAFNRrrDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADSLGVDVEYVRQGMGADSRIGYEYLY 243
Cdd:TIGR03026 176 EEAGEAVAELYSPIID--GPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVYEVIEAAGTDPRIGFNFLN 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  244 PGCGFGGPHFSRDLMRLADVQEASGRQSALLEQVLDINEQKKETLFRKLWTHFhGQLEGRTVAIWGAAFKPGSARIDHAP 323
Cdd:TIGR03026 254 PGPGVGGHCIPKDPLALIAKAKELGYNPELIEAAREINDSQPDYVVEKIKDLL-GPLKGKTVLILGLAFKPNTDDVRESP 332
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  324 VLTLLRALWAQGVRVQLHDPAAVPALRAEVGDHPllslfdgDPYAACENADALMLVTEWKHYWNPDWSRLAKLLHEKLLL 403
Cdd:TIGR03026 333 ALDIIELLKEKGAKVKAYDPLVPEEEVKGLPSID-------DLEEALKGADALVILTDHSEFKDLDLEKIKDLMKGKVVV 405

                  ....
gi 498314451  404 DGRN 407
Cdd:TIGR03026 406 DTRN 409
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
71-430 1.33e-35

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 137.11  E-value: 1.33e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  71 GAASGEAIDI-LWlalspeqrEEADELVAEVAgrqQGALILVNNSTFPVGETERLEARLGGNGR----RAVALVDMIEEG 145
Cdd:PLN02353  94 GLGAGKAADLtYW--------ESAARMIADVS---KSDKIVVEKSTVPVKTAEAIEKILTHNSKginfQILSNPEFLAEG 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 146 RSWASFTRPGRWLLGC-DDEHAEAQVRELLRAFNR--RRDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADSLGV 222
Cdd:PLN02353 163 TAIEDLFKPDRVLIGGrETPEGQKAVQALKDVYAHwvPEERIITTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGA 242
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 223 DVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRDLMRLADVQEASGrqsaLLE------QVLDINEQKKETLFRKLWTHF 296
Cdd:PLN02353 243 DVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNG----LPEvaeywkQVIKMNDYQKSRFVNRVVSSM 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 297 HGQLEGRTVAIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVP-------ALRAEVGDHP--LLSLFDG--- 364
Cdd:PLN02353 319 FNTVSGKKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEeqiqrdlSMNKFDWDHPrhLQPMSPTavk 398
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498314451 365 ------DPYAACENADALMLVTEWKHYWNPDWSRLAKLLHE-KLLLDGRNIYDPTHVASWGLAYRGIGRRAEP 430
Cdd:PLN02353 399 qvsvvwDAYEATKGAHGICILTEWDEFKTLDYQKIYDNMQKpAFVFDGRNVLDHEKLREIGFIVYSIGKPLDP 471
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
191-282 5.45e-33

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 119.41  E-value: 5.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  191 AAELTKLATIGMLATRISYMNEIAGLADSLGVDVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRDLMRLADVQEASGRQ 270
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDPRIGPKFLYPGPGVGGSCLPKDPRALIYLARELGVP 80
                          90
                  ....*....|..
gi 498314451  271 SALLEQVLDINE 282
Cdd:pfam00984  81 ARLLEAAREVNE 92
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
306-410 2.04e-29

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 110.29  E-value: 2.04e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451   306 AIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVPALRaevgdHPLLSLFDgDPYAACENADALMLVTEWKHY 385
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPYAMEEAR-----EYGLTYVS-DLEEALKGADAVVIATEHDEF 74
                           90       100
                   ....*....|....*....|....*
gi 498314451   386 WNPDWSRLAKLLHEKLLLDGRNIYD 410
Cdd:smart00984  75 RSLDPEELKDLMKKPVVVDGRNILD 99
 
Name Accession Description Interval E-value
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
76-427 3.36e-111

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 333.91  E-value: 3.36e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  76 EAI---DILWLALSPEQRE--EAD----ELVAEVAGRQ-QGALILVNNSTFPVGETERLEARLGGNGRRAVALVDMI--- 142
Cdd:COG1004   72 EAVaeaDVVFIAVGTPSDEdgSADlsyvLAAARSIGEAlKGYKVVVTKSTVPVGTADRVRAIIAEELRGAGVDFDVVsnp 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 143 E---EGRSWASFTRPGRWLLGCDDEHAEAQVRELLRAFNRRRDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADS 219
Cdd:COG1004  152 EflrEGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEK 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 220 LGVDVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRD---LMRLAdvQEAsGRQSALLEQVLDINEQKKETLFRKLWTHF 296
Cdd:COG1004  232 VGADVEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDvraLIATA--REL-GYDLRLLEAVEEVNERQKRRLVEKIREHL 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 297 HGQLEGRTVAIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVPALRAEVGDHplLSLFDgDPYAACENADAL 376
Cdd:COG1004  309 GGDLKGKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPVAMENARRLLPDD--ITYAD-DAYEALEGADAL 385
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 498314451 377 MLVTEWKHYWNPDWSRLAKLLHEKLLLDGRNIYDPTHVASWGLAYRGIGRR 427
Cdd:COG1004  386 VILTEWPEFRALDFARLKALMKGPVIFDGRNLLDPEELRAAGFTYYGIGRP 436
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
91-407 2.90e-58

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 196.29  E-value: 2.90e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451   91 EEADELVAEVAgrQQGALIlVNNSTFPVGETERLEAR-LGGNGRRAVALVDM------IEEGRSWASFTRPGRWLLGcDD 163
Cdd:TIGR03026 100 ESAAETIAKHL--RKGATV-VLESTVPPGTTEEVVKPiLERSGLKLGEDFYLaynpefLREGNAVHDLLHPDRIVGG-ET 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  164 EHAEAQVRELLRAFNRrrDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADSLGVDVEYVRQGMGADSRIGYEYLY 243
Cdd:TIGR03026 176 EEAGEAVAELYSPIID--GPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVYEVIEAAGTDPRIGFNFLN 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  244 PGCGFGGPHFSRDLMRLADVQEASGRQSALLEQVLDINEQKKETLFRKLWTHFhGQLEGRTVAIWGAAFKPGSARIDHAP 323
Cdd:TIGR03026 254 PGPGVGGHCIPKDPLALIAKAKELGYNPELIEAAREINDSQPDYVVEKIKDLL-GPLKGKTVLILGLAFKPNTDDVRESP 332
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  324 VLTLLRALWAQGVRVQLHDPAAVPALRAEVGDHPllslfdgDPYAACENADALMLVTEWKHYWNPDWSRLAKLLHEKLLL 403
Cdd:TIGR03026 333 ALDIIELLKEKGAKVKAYDPLVPEEEVKGLPSID-------DLEEALKGADALVILTDHSEFKDLDLEKIKDLMKGKVVV 405

                  ....
gi 498314451  404 DGRN 407
Cdd:TIGR03026 406 DTRN 409
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
71-430 1.33e-35

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 137.11  E-value: 1.33e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  71 GAASGEAIDI-LWlalspeqrEEADELVAEVAgrqQGALILVNNSTFPVGETERLEARLGGNGR----RAVALVDMIEEG 145
Cdd:PLN02353  94 GLGAGKAADLtYW--------ESAARMIADVS---KSDKIVVEKSTVPVKTAEAIEKILTHNSKginfQILSNPEFLAEG 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 146 RSWASFTRPGRWLLGC-DDEHAEAQVRELLRAFNR--RRDVMQLMPRRAAELTKLATIGMLATRISYMNEIAGLADSLGV 222
Cdd:PLN02353 163 TAIEDLFKPDRVLIGGrETPEGQKAVQALKDVYAHwvPEERIITTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGA 242
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 223 DVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRDLMRLADVQEASGrqsaLLE------QVLDINEQKKETLFRKLWTHF 296
Cdd:PLN02353 243 DVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKDILNLVYICECNG----LPEvaeywkQVIKMNDYQKSRFVNRVVSSM 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 297 HGQLEGRTVAIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVP-------ALRAEVGDHP--LLSLFDG--- 364
Cdd:PLN02353 319 FNTVSGKKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEeqiqrdlSMNKFDWDHPrhLQPMSPTavk 398
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498314451 365 ------DPYAACENADALMLVTEWKHYWNPDWSRLAKLLHE-KLLLDGRNIYDPTHVASWGLAYRGIGRRAEP 430
Cdd:PLN02353 399 qvsvvwDAYEATKGAHGICILTEWDEFKTLDYQKIYDNMQKpAFVFDGRNVLDHEKLREIGFIVYSIGKPLDP 471
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
191-282 5.45e-33

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 119.41  E-value: 5.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  191 AAELTKLATIGMLATRISYMNEIAGLADSLGVDVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRDLMRLADVQEASGRQ 270
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDPRIGPKFLYPGPGVGGSCLPKDPRALIYLARELGVP 80
                          90
                  ....*....|..
gi 498314451  271 SALLEQVLDINE 282
Cdd:pfam00984  81 ARLLEAAREVNE 92
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
306-410 2.04e-29

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 110.29  E-value: 2.04e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451   306 AIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVPALRaevgdHPLLSLFDgDPYAACENADALMLVTEWKHY 385
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPYAMEEAR-----EYGLTYVS-DLEEALKGADAVVIATEHDEF 74
                           90       100
                   ....*....|....*....|....*
gi 498314451   386 WNPDWSRLAKLLHEKLLLDGRNIYD 410
Cdd:smart00984  75 RSLDPEELKDLMKKPVVVDGRNILD 99
UDPG_MGDP_dh_C pfam03720
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose ...
306-411 4.67e-28

UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 427462 [Multi-domain]  Cd Length: 103  Bit Score: 106.51  E-value: 4.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451  306 AIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPAAVPALRAEVGDHPLLSlfdGDPYAACENADALMLVTEWKHY 385
Cdd:pfam03720   1 AVLGLAFKPNTDDLRESPALDIIELLLEEGAEVKVYDPYVPEEAIEALGDGVTLV---DDLEEALKGADAIVILTDHDEF 77
                          90       100
                  ....*....|....*....|....*.
gi 498314451  386 WNPDWSRLAKLLHEKLLLDGRNIYDP 411
Cdd:pfam03720  78 KSLDWEKLKKLMKPPVVFDGRNVLDP 103
WecC COG0677
UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];
160-410 9.22e-23

UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440441 [Multi-domain]  Cd Length: 413  Bit Score: 99.37  E-value: 9.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 160 GCDDEHAEAQVRELLRAFNRRRDVmqLMPR-RAAELTKLATigmlAT-R---ISYMNEIAGLADSLGVDVEYVRQGmgAD 234
Cdd:COG0677  170 GGITPESAERAAALYGSVVTAGVV--PVSSiKVAEAAKLIE----NTyRdvnIALANELALICDRLGIDVWEVIEA--AN 241
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 235 SRIGYEYLYPGCGFGG------PHFsrdlmrLADVQEASGRQSALLEQVLDINEQKKE---TLFRKLWTHFHGQLEGRTV 305
Cdd:COG0677  242 TKPGFLIFYPGPGVGGhcipvdPYY------LTWKARELGYHPRLILAAREINDSMPEyvvERVVKALNEAGKSLKGARV 315
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 306 AIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDPaAVPALRAEVGDHPLLSLFDgdpyaACENADALMLVTEWKHY 385
Cdd:COG0677  316 LVLGLAYKENVDDLRESPALDIIEELREYGAEVDVHDP-YVDEEEVEGEYGELVDLEE-----ALEGADAVVLAVDHDEF 389
                        250       260
                 ....*....|....*....|....*
gi 498314451 386 WNPDWSRLaKLLHEKLLLDGRNIYD 410
Cdd:COG0677  390 DELDPEEL-RLKGAKVVVDTRGVLD 413
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
109-343 2.41e-15

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 77.37  E-value: 2.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 109 ILVNNSTFPVGETERLEARLggNGRRAVALVDMIEEGRSWASFTRPGRWLLGCDDEHAEaQVRELLRAFNRRRDVMQLMP 188
Cdd:PRK15057 112 VMVIKSTVPVGFTAAMHKKY--RTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAE-RFAALLQEGAIKQNIPTLFT 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498314451 189 RRA-AELTKLATIGMLATRISYMNEIAGLADSLGVDVEYVRQGMGADSRIGYEYLYPGCGFGGPHFSRDLMR-LADVQEA 266
Cdd:PRK15057 189 DSTeAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQlLANYQSV 268
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498314451 267 SGRqsaLLEQVLDINEQKKETLFRKLWTHfhgqlEGRTVAIWGAAFKPGSARIDHAPVLTLLRALWAQGVRVQLHDP 343
Cdd:PRK15057 269 PNN---LISAIVDANRTRKDFIADAILSR-----KPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEP 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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