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Conserved domains on  [gi|498343437|ref|WP_010657593|]
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MULTISPECIES: succinate--CoA ligase subunit alpha [Brucella/Ochrobactrum group]

Protein Classification

succinate--CoA ligase subunit alpha( domain architecture ID 11481473)

ADP-forming/GDP-forming succinate--CoA ligase subunit alpha is the coenzyme A and phosphate binding subunit of the succinyl-CoA synthetase that couples the hydrolysis of succinyl-CoA to the synthesis of ATP/GTP, as part of the citric acid cycle (TCA)

CATH:  3.40.50.261
EC:  6.2.1.-
Gene Ontology:  GO:0000166|GO:0016874|GO:0003824
SCOP:  4000071

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-300 1.29e-177

succinyl-CoA synthetase subunit alpha; Validated


:

Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 491.61  E-value: 1.29e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   1 MSILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVP 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAY-GTNIVGGVTPGKGGTTVLG-----LPVFNTVAEAVEATGANASVIYVP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  81 PAGAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRS 160
Cdd:PRK05678  75 PPFAADAILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 161 GTLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAkrgrKKPM 240
Cdd:PRK05678 155 GTLTYEAVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANV----TKPV 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 241 VGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLKG 300
Cdd:PRK05678 231 VGYIAGVTAPPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKG 290
 
Name Accession Description Interval E-value
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-300 1.29e-177

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 491.61  E-value: 1.29e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   1 MSILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVP 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAY-GTNIVGGVTPGKGGTTVLG-----LPVFNTVAEAVEATGANASVIYVP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  81 PAGAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRS 160
Cdd:PRK05678  75 PPFAADAILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 161 GTLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAkrgrKKPM 240
Cdd:PRK05678 155 GTLTYEAVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANV----TKPV 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 241 VGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLKG 300
Cdd:PRK05678 231 VGYIAGVTAPPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKG 290
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-299 4.19e-168

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 467.61  E-value: 4.19e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   2 SILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPP 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAY-GTNVVAGVTPGKGGQTVLG-----VPVFDTVAEAVEETGADASVIFVPP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  82 AGAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRSG 161
Cdd:COG0074   75 PFAADAILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 162 TLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEakrgRKKPMV 241
Cdd:COG0074  155 TLTYEAVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN----MTKPVV 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498343437 242 GFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLK 299
Cdd:COG0074  231 AYIAGRTAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-298 1.14e-146

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 413.35  E-value: 1.14e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437    3 ILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPPA 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAY-GTNIVGGVTPGKGGTTVLG-----LPVFDSVKEAVEETGANASVIFVPAP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   83 GAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRSGT 162
Cdd:TIGR01019  75 FAADAIFEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  163 LTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAkrgrKKPMVG 242
Cdd:TIGR01019 155 LTYEAVHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNM----SKPVVG 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 498343437  243 FIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVL 298
Cdd:TIGR01019 231 FIAGATAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 157-281 1.23e-25

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 98.48  E-value: 1.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  157 VSRSGTLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIG-GSAEEDAAQFLKDEAK-R 234
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKAIKEaR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 498343437  235 GRKKPMVGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGI 281
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGA 127
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 4-106 6.65e-21

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 85.25  E-value: 6.65e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437     4 LVNKDTKVLVQGLTGKTGTFHTEQALAY--YGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPP 81
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMRNLleYGTKFVGGVYPGKVGPKVDG-----VPVYDSVAEAPEETGVDVAVIFVPA 75

                           90       100
                   ....*....|....*....|....*
gi 498343437    82 AGAADAIIEAIEAEIPFIVCITEGI 106
Cdd:smart00881  76 EAAPDAIDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-300 1.29e-177

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 491.61  E-value: 1.29e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   1 MSILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVP 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAY-GTNIVGGVTPGKGGTTVLG-----LPVFNTVAEAVEATGANASVIYVP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  81 PAGAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRS 160
Cdd:PRK05678  75 PPFAADAILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 161 GTLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAkrgrKKPM 240
Cdd:PRK05678 155 GTLTYEAVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANV----TKPV 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 241 VGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLKG 300
Cdd:PRK05678 231 VGYIAGVTAPPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKG 290
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-299 4.19e-168

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 467.61  E-value: 4.19e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   2 SILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPP 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAY-GTNVVAGVTPGKGGQTVLG-----VPVFDTVAEAVEETGADASVIFVPP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  82 AGAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRSG 161
Cdd:COG0074   75 PFAADAILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 162 TLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEakrgRKKPMV 241
Cdd:COG0074  155 TLTYEAVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN----MTKPVV 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498343437 242 GFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLK 299
Cdd:COG0074  231 AYIAGRTAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 3-299 4.36e-157

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 440.69  E-value: 4.36e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   3 ILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGQKgekLPIFATVAEAKERTGADASVIYVPPA 82
Cdd:PTZ00187  24 VWVNKNTKVICQGITGKQGTFHTEQAIEY-GTKMVGGVNPKKAGTTHLKHG---LPVFATVKEAKKATGADASVIYVPPP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  83 GAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERS-KSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRSG 161
Cdd:PTZ00187 100 HAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQnKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVSRSG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 162 TLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAKrgrKKPMV 241
Cdd:PTZ00187 180 TLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNNPI---KKPVV 256

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498343437 242 GFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLK 299
Cdd:PTZ00187 257 SFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMK 314
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-298 1.14e-146

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 413.35  E-value: 1.14e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437    3 ILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPPA 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAY-GTNIVGGVTPGKGGTTVLG-----LPVFDSVKEAVEETGANASVIFVPAP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   83 GAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRSGT 162
Cdd:TIGR01019  75 FAADAIFEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  163 LTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAkrgrKKPMVG 242
Cdd:TIGR01019 155 LTYEAVHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNM----SKPVVG 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 498343437  243 FIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVL 298
Cdd:TIGR01019 231 FIAGATAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 2-299 3.87e-134

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 382.01  E-value: 3.87e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437   2 SILVNKDTKVLVQGLTGKTGTFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPP 81
Cdd:PLN00125   6 AVFVDKNTRVICQGITGKNGTFHTEQAIEY-GTKMVGGVTPKKGGTEHLG-----LPVFNTVAEAKAETKANASVIYVPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  82 AGAADAIIEAIEAEIPFIVCITEGIPVMDMVRVKERLER-SKSRLLGPNCPGILTPEECKIGIMPGNIFKKGSVGVVSRS 160
Cdd:PLN00125  80 PFAAAAILEAMEAELDLVVCITEGIPQHDMVRVKAALNRqSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 161 GTLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKdeaKRGRKKPM 240
Cdd:PLN00125 160 GTLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIK---ESGTEKPV 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 498343437 241 VGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEVLK 299
Cdd:PLN00125 237 VAFIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFK 295
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 157-281 1.23e-25

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 98.48  E-value: 1.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  157 VSRSGTLTYEAVFQTSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIG-GSAEEDAAQFLKDEAK-R 234
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKAIKEaR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 498343437  235 GRKKPMVGFIAGRTAPAGRTMGHAGAVISGGKGGAEDKIAAMESAGI 281
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGA 127
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 4-106 6.65e-21

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 85.25  E-value: 6.65e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437     4 LVNKDTKVLVQGLTGKTGTFHTEQALAY--YGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPP 81
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMRNLleYGTKFVGGVYPGKVGPKVDG-----VPVYDSVAEAPEETGVDVAVIFVPA 75

                           90       100
                   ....*....|....*....|....*
gi 498343437    82 AGAADAIIEAIEAEIPFIVCITEGI 106
Cdd:smart00881  76 EAAPDAIDEAIEAGIKGIVVITEGI 100
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-105 1.73e-17

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 76.09  E-value: 1.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437    6 NKDTKVLVQGLTGKTG---TFHTEQALAYyGTQMVGGIHPKKGGETWEGqkgekLPIFATVAEAKERTGADASVIYVPPA 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLGIqglNYHFIQMLGY-GIKMVFGVNPGKGGTEILG-----IPVYNSVDELEEKTGVDVAVITVPAP 74

                          90       100
                  ....*....|....*....|...
gi 498343437   83 GAADAIIEAIEAEIPFIVCITEG 105
Cdd:pfam02629  75 FAQEAIDELVDAGIKGIVNITPG 97
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 99-297 9.64e-14

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 71.39  E-value: 9.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  99 IVCITEGIPVMDMVRVKERLERSKSRLLGPNCPGILTPEECKIG--------IMPGNIFKKGSVGVVSRSGTLTYEAVFQ 170
Cdd:PLN02522 107 VAIIAEGVPESDTKQLIAYARANNKVVIGPATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSNEMYNV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 171 TSNEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDETKSIVMIGEIGGSAEEDAAQFLKDEAKrgrKKPMVGFIAGRTA- 249
Cdd:PLN02522 187 IARVTDGIYEGIAIGGDVFPGSTLSDHVLRFNNIPQIKMIVVLGELGGRDEYSLVEALKQGKV---SKPVVAWVSGTCAr 263

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 498343437 250 --PAGRTMGHAGAVISGGKGGAEDKIAAMESAGIRVSPSPAQLGKTLVEV 297
Cdd:PLN02522 264 lfKSEVQFGHAGAKSGGDMESAQAKNKALKDAGAIVPTSFEALEAAIKET 313
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 151-290 2.15e-09

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 54.78  E-value: 2.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437  151 KGSVGVVSRSGTLTYEAVFQTSNEGLGQTTAVGIGG--DpvkgTEFIDVLEMFLADDETKSIVM-IGEIGgsaeeDAAQF 227
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLGNeaD----VDFADLLEYLADDPETRVILLyLEGIR-----DGRRF 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498343437  228 LkDEAKR-GRKKPMVGFIAGRTaPAGR--TMGHAGAVisggkgGAEDKI--AAMESAGIRVSPSPAQL 290
Cdd:pfam13607  72 L-RAARRaARRKPVVVLKAGRS-EAGAraAASHTGAL------AGSDAVydAAFRQAGVIRVDDLEEL 131
PRK06091 PRK06091
membrane protein FdrA; Validated
 106-213 1.28e-08

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 55.82  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498343437 106 IPVMDMVRVKERlERSKSRL-LGPNC-PGIltpeeckIGIMP---GNIFKKGSVGVVSRSGTLTYEAVFQTSNEGLGQTT 180
Cdd:PRK06091 151 VTLEDEIRLKTR-AREKGLLvMGPDCgTAM-------IAGTPlafANVMPEGNIGVIGASGTGIQELCSQIALAGEGITH 222

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 498343437 181 AVGIGG----DPVKGTEFIDVLEMFLADDETKSIVMI 213
Cdd:PRK06091 223 AIGLGGrdlsAEVGGISALTALEMLSADEKSEVIAFV 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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