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Conserved domains on  [gi|498359081|ref|WP_010673237|]
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MULTISPECIES: cAMP-activated global transcriptional regulator CRP [Aeromonas]

Protein Classification

Crp/Fnr family transcriptional regulator( domain architecture ID 11485491)

Crp/Fnr family transcriptional regulator such as Escherichia coli cAMP-activated global transcriptional regulator CRP, which complexes with cyclic AMP (cAMP) to allosterically activate DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') and to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome

Gene Ontology:  GO:0003677|GO:0006355
PubMed:  29146813|24914983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
1-212 8.55e-165

cAMP-activated global transcriptional regulator CRP;


:

Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 452.13  E-value: 8.55e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   1 MIIGKPQSDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEEN 80
Cdd:PRK11753   2 MVLGKPQTDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  81 enPERSAWVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAM 160
Cdd:PRK11753  82 --QERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMALSAQMARRLQNTSRKVGDLAFLDVTGRIAQTLLDLAKQPDAM 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 498359081 161 THPDGMQIKITRQEIGQIVGCSRETVGRILKMLEEQELISAHGKTIVVFGTR 212
Cdd:PRK11753 160 THPDGMQIKITRQEIGRIVGCSREMVGRVLKMLEDQGLISAHGKTIVVYGTR 211
 
Name Accession Description Interval E-value
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
1-212 8.55e-165

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 452.13  E-value: 8.55e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   1 MIIGKPQSDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEEN 80
Cdd:PRK11753   2 MVLGKPQTDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  81 enPERSAWVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAM 160
Cdd:PRK11753  82 --QERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMALSAQMARRLQNTSRKVGDLAFLDVTGRIAQTLLDLAKQPDAM 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 498359081 161 THPDGMQIKITRQEIGQIVGCSRETVGRILKMLEEQELISAHGKTIVVFGTR 212
Cdd:PRK11753 160 THPDGMQIKITRQEIGRIVGCSREMVGRVLKMLEDQGLISAHGKTIVVYGTR 211
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 8-208 5.07e-54

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 171.71  E-value: 5.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   8 SDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFeenENPERSA 87
Cdd:COG0664    5 SDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQILGFLGPGDFFGELSLL---GGEPSPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  88 WVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAmthpdGMQ 167
Cdd:COG0664   82 TAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADRLDG-----RID 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 498359081 168 IKITRQEIGQIVGCSRETVGRILKMLEEQELISAHGKTIVV 208
Cdd:COG0664  157 LPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGRITI 197
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 8-119 2.18e-33

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 115.89  E-value: 2.18e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   8 SDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFeenENPERSA 87
Cdd:cd00038    6 DDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREQIVGFLGPGDLFGELALL---GNGPRSA 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 498359081  88 WVRAKGACEVAEISYKKFRQLIQVNPDILMRL 119
Cdd:cd00038   83 TVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 8-123 1.93e-24

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 92.85  E-value: 1.93e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081     8 SDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEENENPeRSA 87
Cdd:smart00100   6 DAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGEEQIVGTLGPGDFFGELALLTNSRRA-ASA 84

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 498359081    88 WVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQM 123
Cdd:smart00100  85 AAVALELATLLRIDFRDFLQLLPELPQLLLELLLEL 120
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 21-112 5.79e-24

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 90.75  E-value: 5.79e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   21 IHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEENenpERSAWVRAKGACEVAEI 100
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGREQILAVLGPGDFFGELALLGGE---PRSATVVALTDSELLVI 77

                          90
                  ....*....|..
gi 498359081  101 SYKKFRQLIQVN 112
Cdd:pfam00027  78 PREDFLELLERD 89
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 9-132 2.17e-06

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 47.20  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081    9 DPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSyLNQGDFLGEMGMFeeNENPERSAW 88
Cdd:TIGR03896 151 ESDVAWMMASGTPQKLPAGTILIHEGGTVDALYILLYGEASLSISPDGPGREVGS-SRRGEILGETPFL--NGSLPGTAT 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 498359081   89 VRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQ 132
Cdd:TIGR03896 228 VKAIENSVLLAIDKQQLAAKLQQDVGFASRFYRVIASLLSQRSR 271
 
Name Accession Description Interval E-value
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
1-212 8.55e-165

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 452.13  E-value: 8.55e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   1 MIIGKPQSDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEEN 80
Cdd:PRK11753   2 MVLGKPQTDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  81 enPERSAWVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAM 160
Cdd:PRK11753  82 --QERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMALSAQMARRLQNTSRKVGDLAFLDVTGRIAQTLLDLAKQPDAM 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 498359081 161 THPDGMQIKITRQEIGQIVGCSRETVGRILKMLEEQELISAHGKTIVVFGTR 212
Cdd:PRK11753 160 THPDGMQIKITRQEIGRIVGCSREMVGRVLKMLEDQGLISAHGKTIVVYGTR 211
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 8-208 5.07e-54

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 171.71  E-value: 5.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   8 SDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFeenENPERSA 87
Cdd:COG0664    5 SDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEDGREQILGFLGPGDFFGELSLL---GGEPSPA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  88 WVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAmthpdGMQ 167
Cdd:COG0664   82 TAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFLSAEERLARFLLELADRLDG-----RID 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 498359081 168 IKITRQEIGQIVGCSRETVGRILKMLEEQELISAHGKTIVV 208
Cdd:COG0664  157 LPLTQEEIASYLGLTRETVSRILKKLEKEGLIELERGRITI 197
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 8-119 2.18e-33

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 115.89  E-value: 2.18e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   8 SDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFeenENPERSA 87
Cdd:cd00038    6 DDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEDGREQIVGFLGPGDLFGELALL---GNGPRSA 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 498359081  88 WVRAKGACEVAEISYKKFRQLIQVNPDILMRL 119
Cdd:cd00038   83 TVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 8-123 1.93e-24

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 92.85  E-value: 1.93e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081     8 SDPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEENENPeRSA 87
Cdd:smart00100   6 DAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKVLEDGEEQIVGTLGPGDFFGELALLTNSRRA-ASA 84

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 498359081    88 WVRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQM 123
Cdd:smart00100  85 AAVALELATLLRIDFRDFLQLLPELPQLLLELLLEL 120
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 21-112 5.79e-24

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 90.75  E-value: 5.79e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   21 IHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEENenpERSAWVRAKGACEVAEI 100
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRTLEDGREQILAVLGPGDFFGELALLGGE---PRSATVVALTDSELLVI 77

                          90
                  ....*....|..
gi 498359081  101 SYKKFRQLIQVN 112
Cdd:pfam00027  78 PREDFLELLERD 89
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 142-208 1.03e-14

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 66.15  E-value: 1.03e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498359081 142 VTGRIAQTLLNLAKQPDAmthPDGMQIKITRQEIGQIVGCSRETVGRILKMLEEQELISAHG-KTIVV 208
Cdd:cd00092    1 AKERLASFLLNLSLRYGA---GDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLISRRGrGKYRV 65
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
162-208 3.75e-14

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 64.00  E-value: 3.75e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 498359081   162 HPDGMQIKITRQEIGQIVGCSRETVGRILKMLEEQELISAHGKTIVV 208
Cdd:smart00419   1 EGIRVRLPLTRQEIAELLGLTRETVSRTLKRLEKEGLISREGGRIVI 47
PRK13918 PRK13918
CRP/FNR family transcriptional regulator; Provisional
 24-204 5.07e-12

CRP/FNR family transcriptional regulator; Provisional


Pssm-ID: 237557 [Multi-domain]  Cd Length: 202  Bit Score: 62.14  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  24 YPAKSTLIHAGE--KAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFeeneNPERSAWVRAKGACEVAEIS 101
Cdd:PRK13918  11 YRPGAVILYPGVpgPSDMLYRVRSGLVRLHTVDDEGNALTLRYVRPGEYFGEEALA----GAERAYFAEAVTDSRIDVLN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081 102 YKkfrqliQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDG-MQIKITRQEIGQIVG 180
Cdd:PRK13918  87 PA------LMSAEDNLVLTQHLVRTLARAYESIYRLVGQRLKNRIAAALLELSDTPLATQEDSGeTMIYATHDELAAAVG 160

                        170       180
                 ....*....|....*....|....*
gi 498359081 181 CSRETVGRILKMLEEQELISA-HGK 204
Cdd:PRK13918 161 SVRETVTKVIGELSREGYIRSgYGK 185
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 144-200 6.73e-10

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 53.23  E-value: 6.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 498359081  144 GRIAQTLLNLAKQPDAMThpdgMQIKITRQEIGQIVGCSRETVGRILKMLEEQELIS 200
Cdd:pfam13545   1 QRLARFLLELAARDGGGR----IDLPLTQEDLADLLGTTRETVSRVLSELRREGLIE 53
PRK11161 PRK11161
fumarate/nitrate reduction transcriptional regulator Fnr;
29-208 2.44e-07

fumarate/nitrate reduction transcriptional regulator Fnr;


Pssm-ID: 183004 [Multi-domain]  Cd Length: 235  Bit Score: 49.71  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  29 TLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGemgmFEENENPERSAWVRAKGACEVAEISYkkfrql 108
Cdd:PRK11161  47 TLFKAGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVG----FDAIGSGQHPSFAQALETSMVCEIPF------ 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081 109 iqvnpDILMRLSGQMAKRLQHTSQKVGN-----------LAFLDVTGRIAQTLLNLAKQPDAMT-HPDGMQIKITRQEIG 176
Cdd:PRK11161 117 -----ETLDDLSGKMPKLRQQIMRLMSGeikgdqemillLSKKNAEERLAAFIYNLSRRFAQRGfSPREFRLTMTRGDIG 191

                        170       180       190
                 ....*....|....*....|....*....|..
gi 498359081 177 QIVGCSRETVGRILKMLEEQELISAHGKTIVV 208
Cdd:PRK11161 192 NYLGLTVETISRLLGRFQKSGMLAVKGKYITI 223
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 9-132 2.17e-06

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 47.20  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081    9 DPTLEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSyLNQGDFLGEMGMFeeNENPERSAW 88
Cdd:TIGR03896 151 ESDVAWMMASGTPQKLPAGTILIHEGGTVDALYILLYGEASLSISPDGPGREVGS-SRRGEILGETPFL--NGSLPGTAT 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 498359081   89 VRAKGACEVAEISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQ 132
Cdd:TIGR03896 228 VKAIENSVLLAIDKQQLAAKLQQDVGFASRFYRVIASLLSQRSR 271
Crp pfam00325
Bacterial regulatory proteins, crp family;
168-199 6.89e-06

Bacterial regulatory proteins, crp family;


Pssm-ID: 425608  Cd Length: 32  Bit Score: 41.51  E-value: 6.89e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 498359081  168 IKITRQEIGQIVGCSRETVGRILKMLEEQELI 199
Cdd:pfam00325   1 LRMSRQDIANYLGLTRETVSRVLGKLQEKGLI 32
fixK PRK09391
transcriptional regulator FixK; Provisional
 23-207 7.48e-06

transcriptional regulator FixK; Provisional


Pssm-ID: 236494 [Multi-domain]  Cd Length: 230  Bit Score: 45.03  E-value: 7.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  23 KYPAKSTLIHAGEKAETLYYIVKGTVAV--LIKDdeGKEMILSYLNQGDFLG-EMGmfeenenPERSAWVRAKGACEVAE 99
Cdd:PRK09391  42 SYKKGEEIYGEGEPADYVYQVESGAVRTyrLLSD--GRRQIGAFHLPGDVFGlESG-------STHRFTAEAIVDTTVRL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081 100 ISYKKFRQLIQVNPDILMRLSGQMAKRLQHTSQKVGNLAFLDVTGRIAQTLLNLAKQpdaMTHPDGMQIKITRQEIGQIV 179
Cdd:PRK09391 113 IKRRSLEQAAATDVDVARALLSLTAGGLRHAQDHMLLLGRKTAMERVAAFLLEMDER---LGGAGMMALPMSRRDIADYL 189

                        170       180
                 ....*....|....*....|....*....
gi 498359081 180 GCSRETVGRILKMLEEQELISAHG-KTIV 207
Cdd:PRK09391 190 GLTIETVSRALSQLQDRGLIGLSGaRQIE 218
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 12-206 2.98e-04

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 40.65  E-value: 2.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   12 LEWFLSHCHIHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMI----LSYLNQGDFLGEMGMFEEN------E 81
Cdd:TIGR03896   1 IDWMVAIGHQREIAAGTTLIEEGKAADFLFILLDGTFTVTTPQPEDNPLTrafeLARLSRGEIVGEMSLLETRppvatiK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081   82 NPERSAWVR-------AKGACEV--AEISYKKF---------RQLIQVNpdilmRLSGQMAKRLQHTSQKVGNLAFLDV- 142
Cdd:TIGR03896  81 AVPKSRVMSipvgelaAKLQSDVgfAAHFYRAIaiklalqiqNQNHQLH-----RRNGADSEPLRKVLFIFGELHESDVa 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  143 ----TGRIAQTLLN--LAKQPDAMthpDG--------MQIKITRQEIGQIVGCSR--ETVGRiLKMLEEQELISAHGKTI 206
Cdd:TIGR03896 156 wmmaSGTPQKLPAGtiLIHEGGTV---DAlyillygeASLSISPDGPGREVGSSRrgEILGE-TPFLNGSLPGTATVKAI 231
PRK10402 PRK10402
DNA-binding transcriptional activator YeiL; Provisional
 21-139 3.10e-03

DNA-binding transcriptional activator YeiL; Provisional


Pssm-ID: 236682 [Multi-domain]  Cd Length: 226  Bit Score: 37.40  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359081  21 IHKYPAKSTLIHAGEKAETLYYIVKGTVAVLIKDDEGKEMILSYLNQGDFLGEMGMFEENENPeRSawVRAKGACEVAEI 100
Cdd:PRK10402  33 LFHFLAREYIVQEGQQPSYLFYLTRGRAKLYATLANGKVSLIDFFAAPCFIGEIELIDKDHET-KA--VQAIEECWCLAL 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 498359081 101 SYKKFRQLIQVNPDILMRL----SGQMAKRLQHTSQkvgNLAF 139
Cdd:PRK10402 110 PMKDCRPLLLNDALFLRKLckflSHKNYRNIVSLTQ---NQSF 149
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
171-205 3.83e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 37.18  E-value: 3.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 498359081 171 TRQEIGQIVGCSRETVGRILKMLEEQELISAHGKT 205
Cdd:COG4742   31 TRSELAESLDVSRSTILRQLKELEERGLIERDDGE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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