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Conserved domains on  [gi|498359275|ref|WP_010673431|]
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MULTISPECIES: monovalent cation:proton antiporter family protein [Aeromonas]

Protein Classification

monovalent cation:proton antiporter family protein( domain architecture ID 13438007)

monovalent cation:proton antiporter family protein such as Na/H antiporters which are key transporters in maintaining the pH of actively metabolising cells, and glutathione-regulated potassium-efflux system proteins that confer protection against electrophiles and catalyzes K+/H+ antiport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 3-559 1.35e-119

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 367.38  E-value: 1.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   3 ADVLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLV 82
Cdd:COG4651    8 TTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAVRKIA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  83 LGVGSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMI 162
Cdd:COG4651   88 LPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLMLVLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 163 PILAQPevqGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMALG 242
Cdd:COG4651  168 PALAGG---GGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALFGLSFALG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 243 AFLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRD 322
Cdd:COG4651  245 AFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIAFLIVLALGYPLRT 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 323 AMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWLVLRALGLAHSLTDSALLSRAEVAQSGLSK- 401
Cdd:COG4651  325 ALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARLERDRPEESd 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 402 -HQHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRV 480
Cdd:COG4651  405 lVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAIPAAAAA 484

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498359275 481 DAMLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGALMLVSHLLLNCDIPIGRVIRRMEHERSSQYRFLH 559
Cdd:COG4651  485 LLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVEEEEEAAEAALLLLLLLLLLRALAERAILRAARRRLRAER 563
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 583-646 5.08e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


:

Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 47.22  E-value: 5.08e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498359275  583 VLLHDQAWAVGHRVRDLALGE---VRIKAIHRGERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRL 646
Cdd:pfam02080   4 VTVPENSPLVGKTLKELNLPErfgVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 3-559 1.35e-119

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 367.38  E-value: 1.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   3 ADVLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLV 82
Cdd:COG4651    8 TTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAVRKIA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  83 LGVGSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMI 162
Cdd:COG4651   88 LPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLMLVLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 163 PILAQPevqGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMALG 242
Cdd:COG4651  168 PALAGG---GGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALFGLSFALG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 243 AFLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRD 322
Cdd:COG4651  245 AFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIAFLIVLALGYPLRT 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 323 AMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWLVLRALGLAHSLTDSALLSRAEVAQSGLSK- 401
Cdd:COG4651  325 ALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARLERDRPEESd 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 402 -HQHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRV 480
Cdd:COG4651  405 lVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAIPAAAAA 484

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498359275 481 DAMLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGALMLVSHLLLNCDIPIGRVIRRMEHERSSQYRFLH 559
Cdd:COG4651  485 LLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVEEEEEAAEAALLLLLLLLLLRALAERAILRAARRRLRAER 563
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 6-533 9.90e-94

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 301.91  E-value: 9.90e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   6 LILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVLGV 85
Cdd:PRK03562  11 LIYLGAAVLIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRLWKLRRSIFGG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  86 GSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMIPIL 165
Cdd:PRK03562  91 GALQMVACGGLLGLFCMLLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAIPLVAMIPLL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 166 AQpeVQGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMALGAFL 245
Cdd:PRK03562 171 AA--SGASTTLGAFALSALKVAGALALVVLGGRYVTRPALRFVARSGLREVFTAVALFLVFGFGLLMEEVGLSMALGAFL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 246 AGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRDAMA 325
Cdd:PRK03562 249 AGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSIDFGTLLENPLRILILLLGFLAIKIAMLWLLARPLGVPRKQRRW 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 326 AGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWLVLralglahsLTDSALLSRAEVAQSG--LSKHQ 403
Cdd:PRK03562 329 FAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMAATPLLLV--------LLDRLEQSRTEEAREAdeIDEQQ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 404 H-VIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRVDA 482
Cdd:PRK03562 401 PrVIIAGFGRFGQIVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTSLQ 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 498359275 483 MLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGALMLVSHLL 533
Cdd:PRK03562 481 LVELVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKSGRLVL 531
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 9-283 7.10e-56

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 190.94  E-value: 7.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275    9 LIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVLGVGSL 88
Cdd:TIGR00932   1 LLAAVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   89 QV-----LLTSLLFFGLGWWWGLSLAQALvvsgTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMIP 163
Cdd:TIGR00932  81 QVlvpgvLLGLLLGHLLGLALGAAVVIGI----ILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  164 ILAqpevqGSALLAEVAWASLKGLFALSVLLAV--GKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMAL 241
Cdd:TIGR00932 157 LLA-----TSASTEHVALALLLLKVFLAFLLLVllGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFADLLGLSMAL 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 498359275  242 GAFLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMD 283
Cdd:TIGR00932 232 GAFLAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMSVD 273
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 5-366 1.00e-45

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 166.66  E-value: 1.00e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275    5 VLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMM-QTIGELGIVFLMFSLGLEFSLPRLLAMRKLVL 83
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDEDlEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   84 GVGSLQVLLTSLL--FFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVM 161
Cdd:pfam00999  81 LLALLGVLIPFVLigLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVVLLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  162 IPILAQPEVQGSALLAevAWASLKGLFALSVLLAVGKWLLPMLFFEVARaRSDELFVLSALLVALLAASLTQWMGLSMAL 241
Cdd:pfam00999 161 LLALAQGVGGGSDLGW--LLLIFLVVAVGGLLLGLLIGWLLRLITRFTD-DDRELEVLLVLLLALLAALLAEALGVSGIL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  242 GAFLAGMMLGESHYRHQLEVDIKPFRDVLM-GLFFITIGMTMD-WALVADAWWQVLACVTGLILCKSLLILLAGRLMGER 319
Cdd:pfam00999 238 GAFLAGLVLSEYPFANKLSEKLEPFGYGLFnPLFFVLVGLSLDlSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLS 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 498359275  320 KRDAMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISI 366
Cdd:pfam00999 318 LREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTV 364
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 583-646 5.08e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 47.22  E-value: 5.08e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498359275  583 VLLHDQAWAVGHRVRDLALGE---VRIKAIHRGERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRL 646
Cdd:pfam02080   4 VTVPENSPLVGKTLKELNLPErfgVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 571-646 4.69e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 46.45  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 571 LETDQQLERLHPVLLHDQAWAVGHRVRDLALGE---VRIKAIHR-GERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRL 646
Cdd:COG0490   61 LIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQrtgVTVVAIRRgGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
PRK05326 PRK05326
potassium/proton antiporter;
589-650 3.88e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 43.65  E-value: 3.88e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498359275 589 AWAVGHRVRDLALGE-VRIKAIHRGERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRLLEGR 650
Cdd:PRK05326 425 SWLVGKALRDLRLPRgALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLFSQSP 487
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 3-559 1.35e-119

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 367.38  E-value: 1.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   3 ADVLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLV 82
Cdd:COG4651    8 TTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAVRKIA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  83 LGVGSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMI 162
Cdd:COG4651   88 LPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLMLVLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 163 PILAQPevqGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMALG 242
Cdd:COG4651  168 PALAGG---GGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALFGLSFALG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 243 AFLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRD 322
Cdd:COG4651  245 AFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIAFLIVLALGYPLRT 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 323 AMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWLVLRALGLAHSLTDSALLSRAEVAQSGLSK- 401
Cdd:COG4651  325 ALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARLERDRPEESd 404

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 402 -HQHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRV 480
Cdd:COG4651  405 lVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAIPAAAAA 484

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498359275 481 DAMLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGALMLVSHLLLNCDIPIGRVIRRMEHERSSQYRFLH 559
Cdd:COG4651  485 LLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVEEEEEAAEAALLLLLLLLLLRALAERAILRAARRRLRAER 563
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 1-380 1.75e-98

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 306.69  E-value: 1.75e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   1 MYADVLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRK 80
Cdd:COG0475    5 LLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKMGR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  81 LVLGVGSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLV 160
Cdd:COG0475   85 RALGIGLLQVLLPFLLGFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAAILLLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 161 MIPILAQpevqGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMA 240
Cdd:COG0475  165 LVPALAG----GGSVAGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLLAAALAELLGLSAA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 241 LGAFLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERK 320
Cdd:COG0475  241 LGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSALLSNPLLALLLVLAAIVGKLLGAYLAARLFGLSR 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 321 RDAMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWLVLRALGLA 380
Cdd:COG0475  321 REALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRLA 380
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 6-533 9.90e-94

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 301.91  E-value: 9.90e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   6 LILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVLGV 85
Cdd:PRK03562  11 LIYLGAAVLIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRLWKLRRSIFGG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  86 GSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMIPIL 165
Cdd:PRK03562  91 GALQMVACGGLLGLFCMLLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAIPLVAMIPLL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 166 AQpeVQGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMALGAFL 245
Cdd:PRK03562 171 AA--SGASTTLGAFALSALKVAGALALVVLGGRYVTRPALRFVARSGLREVFTAVALFLVFGFGLLMEEVGLSMALGAFL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 246 AGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRDAMA 325
Cdd:PRK03562 249 AGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSIDFGTLLENPLRILILLLGFLAIKIAMLWLLARPLGVPRKQRRW 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 326 AGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWLVLralglahsLTDSALLSRAEVAQSG--LSKHQ 403
Cdd:PRK03562 329 FAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMAATPLLLV--------LLDRLEQSRTEEAREAdeIDEQQ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 404 H-VIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRVDA 482
Cdd:PRK03562 401 PrVIIAGFGRFGQIVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTSLQ 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 498359275 483 MLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGALMLVSHLL 533
Cdd:PRK03562 481 LVELVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKSGRLVL 531
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 5-528 1.19e-89

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 290.78  E-value: 1.19e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   5 VLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVLG 84
Cdd:PRK03659  10 GVLFLFAAVVAVPLAQRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKLWQLRRSIFG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  85 VGSLQVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMIPI 164
Cdd:PRK03659  90 VGAAQVLLSAAVLAGLLMLTDFSWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALVPL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 165 LAQpEVQGSALLAEVAWAslkgLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMALGAF 244
Cdd:PRK03659 170 LAG-SADEHFDWMKIGMK----VLAFAGMLIGGRYLLRPLFRFIAASGVREVFTAAALLLVLGSALFMDALGLSMALGTF 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 245 LAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRDAM 324
Cdd:PRK03659 245 IAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLGVLYTHLLWVLISVVVLVAVKGLVLYLLARLYGLRSSERM 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 325 AAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPwLVLRALG--LAHSLTDSallSRAEVAQSGLSKH 402
Cdd:PRK03659 325 QFAGVLSQGGEFAFVLFSAASSQRLLQGDQMALLLVVVTLSMMTTP-LLMKLIDkwLARRLNGP---EEEDEKPWVEDDK 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 403 QHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRVDA 482
Cdd:PRK03659 401 PQVIIVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATQLELLRAAGAEKAEAIVITCNEPEDTMK 480

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 498359275 483 MLTLIRELAGEIKVLVRTRddSFLEHYK--QAGAFEVIPESQEGALML 528
Cdd:PRK03659 481 IVELCQQHFPHLHILARAR--GRVEAHEllQAGVTQFSRETFSSALEL 526
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 9-283 7.10e-56

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 190.94  E-value: 7.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275    9 LIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVLGVGSL 88
Cdd:TIGR00932   1 LLAAVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   89 QV-----LLTSLLFFGLGWWWGLSLAQALvvsgTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMIP 163
Cdd:TIGR00932  81 QVlvpgvLLGLLLGHLLGLALGAAVVIGI----ILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  164 ILAqpevqGSALLAEVAWASLKGLFALSVLLAV--GKWLLPMLFFEVARARSDELFVLSALLVALLAASLTQWMGLSMAL 241
Cdd:TIGR00932 157 LLA-----TSASTEHVALALLLLKVFLAFLLLVllGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFADLLGLSMAL 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 498359275  242 GAFLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMD 283
Cdd:TIGR00932 232 GAFLAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMSVD 273
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 9-525 2.08e-51

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 186.84  E-value: 2.08e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   9 LIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVLGVGSL 88
Cdd:PRK10669  15 LVLAFILGMLANRLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKDLMAVKSIAIPGAIA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  89 QVLLTSLLFFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVMIP----I 164
Cdd:PRK10669  95 QIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDLVMVLTLVLLPavagM 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 165 LAQPEVQGSALLAEVAWASLKGLFALSVLLAVGKWLLPMLFFEVARARSDELFVLSALLVAL-LAASLTQWMGLSMALGA 243
Cdd:PRK10669 175 MEQGDVGFATLAVDLGITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALgIAFGAVELFDVSFALGA 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 244 FLAGMMLGESHYRHQLEVDIKPFRDVLMGLFFITIGMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRDA 323
Cdd:PRK10669 255 FFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPMILIQQPLAVLATLAIIVFGKSLAAFFLVRLFGHSRRTA 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 324 MAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWL--VLRALGLAHSLTDSALLSRA--EVAQSGL 399
Cdd:PRK10669 335 LTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNPVLftLLERYLAKTETLEEQTLEEAieEEKQIPV 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 400 SKHQHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKR 479
Cdd:PRK10669 415 DICNHALLVGYGRVGSLLGEKLLAAGIPLVVIETSRTRVDELRERGIRAVLGNAANEEIMQLAHLDCARWLLLTIPNGYE 494

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 498359275 480 VDAMLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGA 525
Cdd:PRK10669 495 AGEIVASAREKRPDIEIIARAHYDDEVAYITERGANQVVMGEREIA 540
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
279-556 5.38e-49

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 172.61  E-value: 5.38e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 279 GMTMDWALVADAWWQVLACVTGLILCKSLLILLAGRLMGERKRDAMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLL 358
Cdd:COG1226    1 LGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAALALAALLLLLLLAGGGGFFLLLLLAAAALLLLLLLAAALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 359 IGIGVISIALTPWLVLRALGLAHSLTDSALLSRAEVAQSGLSKHQHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERV 438
Cdd:COG1226   81 LLLVLLLLLLLLLLLLLLALLLLLLALAAREEEAEAAEDAIDLEGHVIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 439 SEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDQKRVDAMLTLIRELAGEIKVLVRTRDDSFLEHYKQAGAFEVI 518
Cdd:COG1226  161 EELRRFGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRIVELARELNPDLKIIARARDREHAEELRQAGADEVV 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 498359275 519 PESQEGALMLVSHLLLNCDIPIGRVIRRMEHERSSQYR 556
Cdd:COG1226  241 RETFESALQLARHALEALGVPEEEAARAIQEFRRRDYE 278
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 5-366 1.00e-45

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 166.66  E-value: 1.00e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275    5 VLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMM-QTIGELGIVFLMFSLGLEFSLPRLLAMRKLVL 83
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDEDlEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   84 GVGSLQVLLTSLL--FFGLGWWWGLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQLGVSVLLFQDLAVVPLLVM 161
Cdd:pfam00999  81 LLALLGVLIPFVLigLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVVLLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  162 IPILAQPEVQGSALLAevAWASLKGLFALSVLLAVGKWLLPMLFFEVARaRSDELFVLSALLVALLAASLTQWMGLSMAL 241
Cdd:pfam00999 161 LLALAQGVGGGSDLGW--LLLIFLVVAVGGLLLGLLIGWLLRLITRFTD-DDRELEVLLVLLLALLAALLAEALGVSGIL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  242 GAFLAGMMLGESHYRHQLEVDIKPFRDVLM-GLFFITIGMTMD-WALVADAWWQVLACVTGLILCKSLLILLAGRLMGER 319
Cdd:pfam00999 238 GAFLAGLVLSEYPFANKLSEKLEPFGYGLFnPLFFVLVGLSLDlSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLS 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 498359275  320 KRDAMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISI 366
Cdd:pfam00999 318 LREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTV 364
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 323-631 1.25e-27

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 113.24  E-value: 1.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 323 AMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIALTPWL--VLRALGLAHSLTDSALLSRAEVAQSGLS 400
Cdd:COG0569   14 MGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGytLITFGDAVLFGGLLEALRRRRMERGIKK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 401 KHQHVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDqkrv 480
Cdd:COG0569   94 LKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGD---- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 481 DA---MLTLI-RELaGEIKVLVRTRDDSFLEHYKQAGAFEVIPESQEGALMLVSHLLLncdipiGRVIRRMEherssqyr 556
Cdd:COG0569  170 DEaniLACLLaKEL-GVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLR------PGVLDVLE-------- 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498359275 557 FLHGFYwggksagnletdqqleRLHPVLLHDQAWAVGHRVRDLALGE---VRIKAIHRGERSLDPRRELVLAAGDTLV 631
Cdd:COG0569  235 LADGDA----------------EIVEVTVPEGSPLVGKTLKELDLRErygVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 405-518 4.95e-22

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 91.43  E-value: 4.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  405 VIIAGFGRTGQTCARFLKlEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARLVIITFDDqKRVDAML 484
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGD-DEANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 498359275  485 TLI-RELAGEIKVLVRTRDDSFLEHYKQAGAFEVI 518
Cdd:pfam02254  79 VLLaRELNPDKKIIARANDPEHAELLRRLGADHVI 113
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
5-507 2.38e-13

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 72.69  E-value: 2.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   5 VLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPH-GVAIVTGQAMMQTIGELGIVFLMFSLGLEFSLPRLLAMRKLVL 83
Cdd:COG0025    7 ILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGPGlGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPIL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  84 GVGSLQVLLTSLLFFGLGWWW-GLSLAQALVVSGTLALSSTAVVIKQLGELKQLHTRRAQL-GVSvlLFQD-LAVVPLLV 160
Cdd:COG0025   87 RLAVVGVLLTTLAVALAAHWLlGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTILeGES--LLNDaTALVLFVL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 161 MIPILAQPEVQGSALLAEVAWASLKGLfALSVLLAvgkWLLPMLFFevaRARSDELFVLSALLVALLAASLTQWMGLSMA 240
Cdd:COG0025  165 ALAAALGGGFSLGEALLDFLLAILGGI-LVGLLLG---WLLGRLLR---RLPDPLLEILLTLALPFLAYLLAEALHGSGV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 241 LGAFLAGMMLGESHYRHQLEVDIKPFRD-------VLMGLFFITIGMTMDWALVADAWWQVLACVT-GLILCKSLLILLA 312
Cdd:COG0025  238 LAVVVAGLVLGNAGRRSLSPETRLQLLEfwetlefLLNSLLFVLLGAQLPLILLGALGLGGILLVLlALLVVRPLWVFLS 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 313 GRLMGERKRdaMAAGIMLSQVGEFGFVLLALAS---HHGLLDHQLVSLLIGIGVISIALTpwLVLralglaHSLTDSALL 389
Cdd:COG0025  318 LALRGSRLS--WRERLFLSWGGPRGIVSLALALslpLHGGAGFPGRDLILALAFGVILLT--LVL------QGLTLPPLA 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 390 SRAEVAQSGLSKHQHVIIAGfgrtgqtcARFLKLEEIPFLALDLDPERVSEAKLAGEQVAFGDASRRDILLAAGLLRARL 469
Cdd:COG0025  388 RRLGLREDEPEGEELEAALA--------RAALLELLAAELLADDEEVVLRAARRARRRREAAELLSEEAEEELDEDLLRL 459

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 498359275 470 VIITFDDQKRVDAMLTLIRELAGEIKVLVRTRDDSFLE 507
Cdd:COG0025  460 LLALLRLRLLNALAAARLERLLLRRRVEELLRLLERLL 497
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 583-646 5.08e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 47.22  E-value: 5.08e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498359275  583 VLLHDQAWAVGHRVRDLALGE---VRIKAIHRGERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRL 646
Cdd:pfam02080   4 VTVPENSPLVGKTLKELNLPErfgVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
trkA PRK09496
Trk system potassium transporter TrkA;
404-646 1.37e-06

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 51.28  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 404 HVIIAGFGRTGQTCARFLKLEEIPFLALDLDPERVSEAKLAGE-QVAFGDASRRDILLAAGLLRARLVI-ITFDDQkrVD 481
Cdd:PRK09496   2 KIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDvRTVVGNGSSPDVLREAGAEDADLLIaVTDSDE--TN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 482 AMLTLI-RELAGEIKVLVRTRDDSFLEHykqagafevipesqegalmlvSHLLLNCDIPIGRVI-----------RRMEH 549
Cdd:PRK09496  80 MVACQIaKSLFGAPTTIARVRNPEYAEY---------------------DKLFSKEALGIDLLIspellvareiaRLIEY 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 550 ERSSQYRFLHGfywggksaGNLetdqqleRLHPVLLHDQAWAVGHRVRDLAL----GEVRIKAIHRGERSLDPRRELVLA 625
Cdd:PRK09496 139 PGALDVEEFAD--------GRV-------QLVEVKVYEGSPLVGKPLSDLREhfpdIDVRVVAIFRGGRLIIPRGDTVIE 203

                        250       260
                 ....*....|....*....|.
gi 498359275 626 AGDTLVLFGTAVAMEQAEQRL 646
Cdd:PRK09496 204 AGDEVYFIGAREHIRAVMSEF 224
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 571-646 4.69e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 46.45  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 571 LETDQQLERLHPVLLHDQAWAVGHRVRDLALGE---VRIKAIHR-GERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRL 646
Cdd:COG0490   61 LIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQrtgVTVVAIRRgGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
578-646 1.75e-05

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 47.36  E-value: 1.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498359275 578 ERLHPVLLHDQAWAVGHRVRDLALGE---VRIKAIHRGERS-LDPRRELVLAAGDTLVLFGTAVAMEQAEQRL 646
Cdd:COG3273  313 ERIVRVTVPPGSPLVGKTLGELKLETetgVRVIAIRRGGGWiYDPDGDTRLRAGDVLIVKGTREGLERLEELA 385
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 7-117 4.27e-05

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 46.64  E-value: 4.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   7 ILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIV----TGQAmmQTIGELGIVFLMFSLGLEFSLPRLLAMRKLV 82
Cdd:COG3263   13 LLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIqfddAELA--QLIGSLALAVILFDGGLRTRWSSFRPVLAPA 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 498359275  83 LGVGSLQVLLTSLLFFGLGWWW-GLSLAQAL----VVSGT 117
Cdd:COG3263   91 LSLATLGVLLTAGLTGVFAHWLlGLSWLEGLllgaIVSST 130
PRK05326 PRK05326
potassium/proton antiporter;
589-650 3.88e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 43.65  E-value: 3.88e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498359275 589 AWAVGHRVRDLALGE-VRIKAIHRGERSLDPRRELVLAAGDTLVLFGTAVAMEQAEQRLLEGR 650
Cdd:PRK05326 425 SWLVGKALRDLRLPRgALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLFSQSP 487
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 5-370 1.04e-03

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 42.18  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   5 VLILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGVAIVTGQAMM----------QTIGELGIVFLMFSLGLEFSLP- 73
Cdd:PLN03159  48 LTLVVVTTRLLVFILKPFRQPRVISEILGGVILGPSVLGQSEVFANTifplrsvmvlETMANLGLLYFLFLVGVEMDISv 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275  74 -RLLAMRKLVLGVGSLqvlltsLLFFGLGWWWGLSLAQ--------ALVVSGTLALSSTA--VVIKQLGELKQLHTRRAQ 142
Cdd:PLN03159 128 iRRTGKKALAIAIAGM------ALPFCIGLAFSFIFHQvsrnvhqgTFILFLGVALSVTAfpVLARILAEIKLINTELGR 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 143 LGVSVLLFQDLAVVPLLVMIPILAqpEVQGSALLAevAWASLKGLFALSVLLAVGKwllPMLFFEVARARSDELFVLSAL 222
Cdd:PLN03159 202 IAMSAALVNDMCAWILLALAIALA--ENDSTSLAS--LWVLLSSVAFVLFCFYVVR---PGIWWIIRRTPEGETFSEFYI 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 223 LVALLAASL----TQWMGLSMALGAFLAGMMLGESHYRHQLEVDIKPF-RDVLMGLFFITIGMTMDWALVADAwwqvlac 297
Cdd:PLN03159 275 CLILTGVMIsgfiTDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFvSGLLLPLFFAISGLKTNVTKIQGP------- 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275 298 VTGLILCKSLLILLAGRLMGE---------RKRDAMAAGIMLSQVGEFGFVLLALASHHGLLDHQLVSLLIGIGVISIAL 368
Cdd:PLN03159 348 ATWGLLVLVIIMASAGKIMGTiiiaffytmPFREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAMTAL 427


                 ...
gi 498359275 369 -TP 370
Cdd:PLN03159 428 iTP 430
PRK05326 PRK05326
potassium/proton antiporter;
7-117 4.06e-03

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 40.18  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498359275   7 ILLIFAVVLVAIFRRLGQPVILAYLFAGMLLGPHGV-AIVTGQA-MMQTIGELGIVFLMFSLGLE--FSLPRLLAMRKLV 82
Cdd:PRK05326  13 LLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLgGIQFDNYpLAYLVGNLALAVILFDGGLRtrWSSFRPALGPALS 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 498359275  83 LgvGSLQVLLTSLLfFGLG--WWWGLSLAQAL----VVSGT 117
Cdd:PRK05326  93 L--ATLGVLITAGL-TGLFahWLLGLDWLEGLllgaIVGST 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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