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Conserved domains on  [gi|498360483|ref|WP_010674639|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Aeromonas]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-143 2.01e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 2.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483   1 MSKIIELLAHYPPYQLVHAAEMVRDTFEQFYQQrYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEK 80
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498360483  81 GILFTENSVQDKRISLVSFTPAGLTLFQQLKTEAGSWQHTLTDYLPAEARQSIRLHLQSVSDA 143
Cdd:COG1846   80 GLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-143 2.01e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 2.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483   1 MSKIIELLAHYPPYQLVHAAEMVRDTFEQFYQQrYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEK 80
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498360483  81 GILFTENSVQDKRISLVSFTPAGLTLFQQLKTEAGSWQHTLTDYLPAEARQSIRLHLQSVSDA 143
Cdd:COG1846   80 GLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
33-117 8.60e-13

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 60.69  E-value: 8.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483    33 QRYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQDKRISLVSFTPAGLTLFQQLKT 112
Cdd:smart00347   4 KPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83


                   ....*
gi 498360483   113 EAGSW 117
Cdd:smart00347  84 ARSET 88
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 35-94 3.96e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 55.29  E-value: 3.96e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483   35 YQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQDKRI 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
12-140 9.81e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 34.49  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483  12 PPYQLVHAAEMVRDTFEQFYQQRYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQD 91
Cdd:PRK11512  13 PLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPND 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 498360483  92 KRISLVSFTPAGLTLFQQLKTEAGSWQHT-LTDYLPAEARQSIRLHLQSV 140
Cdd:PRK11512  93 KRGVLVKLTTSGAAICEQCHQLVGQDLHQeLTKNLTADEVATLEHLLKKV 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-143 2.01e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 84.25  E-value: 2.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483   1 MSKIIELLAHYPPYQLVHAAEMVRDTFEQFYQQrYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEK 80
Cdd:COG1846    1 MSDEPDPAEERLGLLLRRLARALRRALDRALAE-LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498360483  81 GILFTENSVQDKRISLVSFTPAGLTLFQQLKTEAGSWQHTLTDYLPAEARQSIRLHLQSVSDA 143
Cdd:COG1846   80 GLVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
33-117 8.60e-13

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 60.69  E-value: 8.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483    33 QRYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQDKRISLVSFTPAGLTLFQQLKT 112
Cdd:smart00347   4 KPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83


                   ....*
gi 498360483   113 EAGSW 117
Cdd:smart00347  84 ARSET 88
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 35-94 3.96e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 55.29  E-value: 3.96e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483   35 YQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQDKRI 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 37-94 7.05e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.08  E-value: 7.05e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 498360483   37 LTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQDKRI 94
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
HTH_27 pfam13463
Winged helix DNA-binding domain;
37-103 3.58e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 36.88  E-value: 3.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498360483   37 LTVPQWRLMMVLG-PHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQDKRISLVSFTPAG 103
Cdd:pfam13463   1 LTRLEALILHNIGhRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 54-83 1.89e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 35.27  E-value: 1.89e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 498360483  54 ISQKELVEASGMDKVRISREIHRLVEKGIL 83
Cdd:COG2512   31 MTQSEIVKETGWSKSKVSRLLSRLEERGLI 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
12-140 9.81e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 34.49  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498360483  12 PPYQLVHAAEMVRDTFEQFYQQRYQLTVPQWRLMMVLGPHYPISQKELVEASGMDKVRISREIHRLVEKGILFTENSVQD 91
Cdd:PRK11512  13 PLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPND 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 498360483  92 KRISLVSFTPAGLTLFQQLKTEAGSWQHT-LTDYLPAEARQSIRLHLQSV 140
Cdd:PRK11512  93 KRGVLVKLTTSGAAICEQCHQLVGQDLHQeLTKNLTADEVATLEHLLKKV 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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