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Conserved domains on  [gi|498399969|ref|WP_010713166|]
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MULTISPECIES: diacylglycerol kinase family protein [Enterococcus]

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the phospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-297 1.46e-99

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 294.07  E-value: 1.46e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:COG1597    2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  81 ayRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGKLA 160
Cdd:COG1597   82 --GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 161 YFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDLLK 240
Cdd:COG1597  160 YVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498399969 241 GVDQSTDNLVYLTFKEgtISLENQEELTTNVDGDE-GAALPITLEILPKHLTVYCGEE 297
Cdd:COG1597  240 GRHLRHPGVRYFRARE--VEIESDRPLPVQLDGEPlGLATPLEFEVLPGALRVLVPAD 295
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-297 1.46e-99

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 294.07  E-value: 1.46e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:COG1597    2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  81 ayRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGKLA 160
Cdd:COG1597   82 --GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 161 YFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDLLK 240
Cdd:COG1597  160 YVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498399969 241 GVDQSTDNLVYLTFKEgtISLENQEELTTNVDGDE-GAALPITLEILPKHLTVYCGEE 297
Cdd:COG1597  240 GRHLRHPGVRYFRARE--VEIESDRPLPVQLDGEPlGLATPLEFEVLPGALRVLVPAD 295
PRK13337 PRK13337
putative lipid kinase; Reviewed
 1-298 6.16e-69

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 216.45  E-value: 6.16e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEfeTLAE--EKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLA 78
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKK--NLPDvlQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  79 EQAYRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGK 158
Cdd:PRK13337  79 EKENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 159 LAYFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDL 238
Cdd:PRK13337 159 LAYYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLA 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 239 LKGVDQSTDNLVYLtfKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTVYCGEEQ 298
Cdd:PRK13337 239 LRGEHIKHPKVIYT--KANRIKVSSFDKMQLNLDGEYGGKLPAEFENLYRHIEVFVPKDQ 296
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 1-292 2.14e-63

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 201.96  E-value: 2.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969    1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   81 AYRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDY-FMNVVAIGTIPESINDVDVEQKTKLGKL 159
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  160 AYFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDLL 239
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 498399969  240 KGVDQSTDNLVYltFKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTV 292
Cdd:TIGR00147 241 EGKHTDNPNIIY--GKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 3-127 8.17e-48

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 156.21  E-value: 8.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969    3 KAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQAY 82
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 498399969   83 RPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKI 127
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 5-108 2.85e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 65.40  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969     5 VLIVNPSSGGEKAKEFEtlaeEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAE---QA 81
Cdd:smart00046   1 LVFVNPKSGGGKGEKLL----RKFRLLLNPRQVFDLTKKGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKrelPL 76

                           90       100
                   ....*....|....*....|....*..
gi 498399969    82 YRPKFGFFPLGTVNDLARALNLPMDPE 108
Cdd:smart00046  77 PEPPVAVLPLGTGNDLARSLGWGGGYD 103
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-297 1.46e-99

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 294.07  E-value: 1.46e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:COG1597    2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  81 ayRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGKLA 160
Cdd:COG1597   82 --GPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 161 YFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDLLK 240
Cdd:COG1597  160 YVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 498399969 241 GVDQSTDNLVYLTFKEgtISLENQEELTTNVDGDE-GAALPITLEILPKHLTVYCGEE 297
Cdd:COG1597  240 GRHLRHPGVRYFRARE--VEIESDRPLPVQLDGEPlGLATPLEFEVLPGALRVLVPAD 295
PRK13337 PRK13337
putative lipid kinase; Reviewed
 1-298 6.16e-69

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 216.45  E-value: 6.16e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEfeTLAE--EKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLA 78
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKK--NLPDvlQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  79 EQAYRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGK 158
Cdd:PRK13337  79 EKENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 159 LAYFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDL 238
Cdd:PRK13337 159 LAYYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLA 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 239 LKGVDQSTDNLVYLtfKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTVYCGEEQ 298
Cdd:PRK13337 239 LRGEHIKHPKVIYT--KANRIKVSSFDKMQLNLDGEYGGKLPAEFENLYRHIEVFVPKDQ 296
PRK13055 PRK13055
putative lipid kinase; Reviewed
 1-297 8.88e-68

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 214.47  E-value: 8.88e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQF-AREAAESHFDSVFVMGGDGTVNEGISGLAE 79
Cdd:PRK13055   2 QKRARLIYNPTSGQEIMKKNVADILDILEQAGYETSAFQTTPEPNSAKNeAKRAAEAGFDLIIAAGGDGTINEVVNGIAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  80 QAYRPKFGFFPLGTVNDLARALNLPM-DPEEAIQQLDLEKTSALDVGKINDD-YFMNVVAIGTIPESINDVDVEQKTKLG 157
Cdd:PRK13055  82 LEKRPKMAIIPAGTTNDYARALKIPRdNPVEAAKVILKNQTIKMDIGRANEDkYFINIAAGGSLTELTYSVPSQLKSMFG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 158 KLAYFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPD 237
Cdd:PRK13055 162 YLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLFELLHLMAL 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498399969 238 LLKGVDQSTD-NLVYLTFKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTVYCGEE 297
Cdd:PRK13055 242 ILNGGKHIDDpRVIYIKTSKLTIEPLGDDRLMVNLDGEYGGDAPMTFENLKQHIEFFANTD 302
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 1-292 2.14e-63

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 201.96  E-value: 2.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969    1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   81 AYRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDY-FMNVVAIGTIPESINDVDVEQKTKLGKL 159
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  160 AYFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDLL 239
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 498399969  240 KGVDQSTDNLVYltFKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTV 292
Cdd:TIGR00147 241 EGKHTDNPNIIY--GKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 3-127 8.17e-48

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 156.21  E-value: 8.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969    3 KAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQAY 82
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 498399969   83 RPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKI 127
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
PRK13057 PRK13057
lipid kinase;
6-293 1.42e-38

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 137.36  E-value: 1.42e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   6 LIVNPSSggEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAEShFDSVFVMGGDGTVNEGISGLAEQayRPK 85
Cdd:PRK13057   2 LLVNRHA--RSGRAALAAARAALEAAGLELVEPPAEDPDDLSEVIEAYADG-VDLVIVGGGDGTLNAAAPALVET--GLP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  86 FGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGKLAYFISG 165
Cdd:PRK13057  77 LGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHYFFNVASLGLSAELARRLTKELKRRWGTLGYAIAA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 166 AKHLANAQtyPFHLSLDQKEQTIESSTVLVGLTNS--IGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPDLLKGVD 243
Cdd:PRK13057 157 LRVLRRSR--PFTAEIEHDGRTERVKTLQVAVGNGryYGGGMTVAHDATIDDGRLDLYSLEVAHWWRLLALLPALRRGRH 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 498399969 244 QSTDNLvyLTFKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTVY 293
Cdd:PRK13057 235 GEWPDV--RAFRTTELELRTRKPRPINTDGELTTYTPAHFRVLPKALRVL 282
PRK13059 PRK13059
putative lipid kinase; Reviewed
 1-292 3.80e-38

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 136.32  E-value: 3.80e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEK-AKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFarEAAESHFDSVFVMGGDGTVNEGISGLAE 79
Cdd:PRK13059   1 MKKVKFIYNPYSGENAiISELDKVIRIHQEKGYLVVPYRISLEYDLKNAF--KDIDESYKYILIAGGDGTVDNVVNAMKK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  80 QAYRPKFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGKL 159
Cdd:PRK13059  79 LNIDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDKYFINVASTGLFTDVSQKTDVNLKNTIGKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 160 AYFISGAKHLANAQtyPFHLSLDQKEQTIESSTVLVGLTN--SIGGFEtLLPEAQVDDGKLHLVYLKDQSLWDAVKAVPD 237
Cdd:PRK13059 159 AYYLKGLEELPNFR--KLKVKVTSEEVNFDGDMYLMLVFNgqTAGNFN-LAYKAEVDDGLLDVIIIKACPIIDLIPLFIK 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 498399969 238 LLKGVDQSTDNLVyLTFKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTV 292
Cdd:PRK13059 236 VLKGEHLEDVNGL-IYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKV 289
PRK13054 PRK13054
lipid kinase; Reviewed
 1-290 2.38e-34

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 126.53  E-value: 2.38e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVN-PSSGGEKAKEfetlAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLA- 78
Cdd:PRK13054   3 FPKSLLILNgKSAGNEELRE----AVGLLREEGHTLHVRVTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAq 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  79 -EQAYRPKFGFFPLGTVNDLARALNLPMDPEEAIqQLDLE-KTSALDVGKINDD-YFMNVVAIGTIPESINDVDVEQKTK 155
Cdd:PRK13054  79 lEGDARPALGILPLGTANDFATAAGIPLEPDKAL-KLAIEgRAQPIDLARVNDRtYFINMATGGFGTRVTTETPEKLKAA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 156 LGKLAYFISGAKHLANAQTYP-------FHLSLDqkeqtiessTVLVGLTNS--IGGFETLLPEAQVDDGKLHLVYLKdq 226
Cdd:PRK13054 158 LGGVAYLIHGLMRMDTLKPDRceirgpdFHWQGD---------ALVIGIGNGrqAGGGQQLCPEALINDGLLDLRILP-- 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498399969 227 SLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLENqeELTTNVDGDEGAALPITLEILPKHL 290
Cdd:PRK13054 227 APQELLPTLLSTLTGGSEDNPNIIRARLPWLEIQAPH--ELTFNLDGEPLSGRHFRIEVLPAAL 288
PRK12361 PRK12361
hypothetical protein; Provisional
 2-300 1.38e-33

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 128.58  E-value: 1.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   2 KKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDeVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQa 81
Cdd:PRK12361 243 KRAWLIANPVSGGGKWQEYGEQIQRELKAYFD-LTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELVNT- 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  82 yRPKFGFFPLGTVNDLARAL----NLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLG 157
Cdd:PRK12361 321 -DITLGIIPLGTANALSHALfglgSKLIPVEQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRERKNALG 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 158 KLAYfISGA-KHLANAQTYPFHLSLDQKE-QTIESSTVLVGltnSIGGFETLLP----EAQVDDGKLHLVYL-KDQSLWD 230
Cdd:PRK12361 400 QLAY-LDGLwRAVNENETLTLTVTLDDAEpQTISTHSLVVA---NAAPFTSLLAqgggEPNMTDGLLDITWLdSGGEPGE 475

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498399969 231 AVKAVPDL-LKGV-DQSTDNLVYLTfKEGTISLENQEELTTNVDGDEGAALPITLEILPKHLTVYCGEEQTK 300
Cdd:PRK12361 476 QLLSLAELaLSGLgKEPEANKVHHA-HAKKVTISSQKPIKYVIDGELFEDEDLTIEVQPASLKVFVPYQEIN 546
PRK00861 PRK00861
putative lipid kinase; Reviewed
 1-293 6.22e-32

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 120.11  E-value: 6.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGdAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAE- 79
Cdd:PRK00861   2 TRSACLIFNPVAGQGNPEVDLALIRAILEPEMDLDIYLTTPEIG-ADQLAQEAIERGAELIIASGGDGTLSAVAGALIGt 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  80 QAYrpkFGFFPLGTVNDLARALNLPMDPEEAIQQLDLEKTSALDVGKINDDYFMNVVAIGTIPESINDVDVEQKTKLGKL 159
Cdd:PRK00861  81 DIP---LGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCNGQPMILLAGIGFEAETVEEADREAKNRFGIL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 160 AYFISGAKHLANAQtyPFHLSLDQKEQTIESSTVLVGLTN-----SI--GGFETLLPeaqvDDGKLHLVYLKDQSLWDAV 232
Cdd:PRK00861 158 AYILSGLQQLRELE--SFEVEIETEDQIITTNAVAVTVANaapptSVlaQGPGAVIP----DDGLLDVTIVAPKNLAEAV 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498399969 233 KAVPDLLKGVDQST----DNLVYLTFKEGTISLENQEELTtnVDGDEGAALPITLEILPKHLTVY 293
Cdd:PRK00861 232 AASYHLLQTALQGNpaerDDIGYLRAKQVKITTDPPQKVV--IDGEVVGTTPIEIECLPRSLKVF 294
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 1-292 1.19e-21

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 92.54  E-value: 1.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSGGEKAKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:PRK11914   8 IGKVTVLTNPLSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVISNALQVLAGT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  81 AYrpKFGFFPLGTVNDLARALNLPM-DPEEAIQQLDLEKTSALDVGKINDD-----YFMNVVAIGtIPESINDVDVEQKT 154
Cdd:PRK11914  88 DI--PLGIIPAGTGNDHAREFGIPTgDPEAAADVIVDGWTETVDLGRIQDDdgivkWFGTVAATG-FDSLVTDRANRMRW 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969 155 KLGKLAYFISGAKHLANAQTYPFHLSLDQKEQ-TIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVK 233
Cdd:PRK11914 165 PHGRMRYNLAMLAELSKLRPLPFRLVLDGTEEiVTDLTLAAFGNTRSYGGGMLICPNADHTDGLLDITMVQSASRTRLLR 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 498399969 234 AVPDLLKGVDQSTDNLVylTFKEGTISLENqEELTTNVDGDEGAALPITLEILPKHLTV 292
Cdd:PRK11914 245 LFPTVFKGTHVELDEVS--TARAKTVHVEC-PGINAYADGDFACPLPAEISAVPGALQI 300
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 5-108 2.85e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 65.40  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969     5 VLIVNPSSGGEKAKEFEtlaeEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAE---QA 81
Cdd:smart00046   1 LVFVNPKSGGGKGEKLL----RKFRLLLNPRQVFDLTKKGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKrelPL 76

                           90       100
                   ....*....|....*....|....*..
gi 498399969    82 YRPKFGFFPLGTVNDLARALNLPMDPE 108
Cdd:smart00046  77 PEPPVAVLPLGTGNDLARSLGWGGGYD 103
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 156-294 9.40e-08

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 50.66  E-value: 9.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  156 LGKLAYFISGAKHLANAQTYPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLLPEAQVDDGKLHLVYLKDQSLWDAVKAV 235
Cdd:pfam19279  22 PGALSYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARVDDGLLDVVVIEAASRRTLLRLL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 498399969  236 PDLLKGVDQSTDNLVYLTFKEgtISLENQEELTTNVDGDEGAALPITLEILPKHLTVYC 294
Cdd:pfam19279 102 PKVYDGRHVRLPQVEVLRGRE--VRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 2-151 9.97e-04

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 40.61  E-value: 9.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   2 KKAVLIVNPSSGGEKA-KEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFDSVFVMGGDGTVNEGISGLAEQ 80
Cdd:PLN02958 112 KRLLVFVNPFGGKKSAsKIFFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNGLLER 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969  81 -----AYRPKFGFFPLGTVNDLARAL----NLPMDPEEAIQQLDLEKTSALDVGKI--NDDYFMNVV--AIGTIPesinD 147
Cdd:PLN02958 192 edwktAIKLPIGMVPAGTGNGMAKSLldsvGEPCSATNAVLAIIRGHKCSLDVATIlqGETKFFSVLmlAWGLVA----D 267


                 ....
gi 498399969 148 VDVE 151
Cdd:PLN02958 268 IDIE 271
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
1-70 4.06e-03

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 38.19  E-value: 4.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498399969   1 MKKAVLIVNPSSggEKAKEFETLAEEKLKQLFDEVVVkqtEKGGDAEQFAREAAESHFDSVFVMGGDGTV 70
Cdd:COG0061    1 MKRIAIVAKPGK--PEALEAAEELAELLEERGIEVVL---DEDTAVPGVPLEELGEEADLVIVLGGDGTL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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