NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|498430776|ref|WP_010736547|]
View 

TIR domain-containing protein [Enterococcus mundtii]

Protein Classification

TIR domain-containing protein( domain architecture ID 581104)

TIR (Toll/interleukin-1 receptor) domain-containing protein

CATH:  3.40.50.10140
PubMed:  32002590|29395922|34868065

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SEFIR super family cl23749
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 2-113 2.97e-13

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


The actual alignment was detected with superfamily member pfam08937:

Pssm-ID: 474043  Cd Length: 127  Bit Score: 63.96  E-value: 2.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498430776    2 HKTFISYHHANEQELKDEIIKLG--SGDNFVDKSVSDGDIDTDLPE---------ETIMRKIRDDfLGESTVVIVLIGEE 70
Cdd:pfam08937   1 RKVFISFHHEDDVWRYDKLRNLFanSNDIIGDPNINWGFPDGNDHEpikrrnddsEYIKRWIRDQ-LNGSSVTIVLVGPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 498430776   71 TSDRPFINSEIQAAmWAKSTGLVGVVKDDL--YDRLYTSTTCRDN 113
Cdd:pfam08937  80 TWSRRWVDWEIAIS-LKKGKGLLGVRIPGLkrSDLPRGPSALGAN 123
 
Name Accession Description Interval E-value
DUF1863 pfam08937
MTH538 TIR-like domain (DUF1863); This domain adopts the flavodoxin fold, that is, five ...
 2-113 2.97e-13

MTH538 TIR-like domain (DUF1863); This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.


Pssm-ID: 430330  Cd Length: 127  Bit Score: 63.96  E-value: 2.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498430776    2 HKTFISYHHANEQELKDEIIKLG--SGDNFVDKSVSDGDIDTDLPE---------ETIMRKIRDDfLGESTVVIVLIGEE 70
Cdd:pfam08937   1 RKVFISFHHEDDVWRYDKLRNLFanSNDIIGDPNINWGFPDGNDHEpikrrnddsEYIKRWIRDQ-LNGSSVTIVLVGPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 498430776   71 TSDRPFINSEIQAAmWAKSTGLVGVVKDDL--YDRLYTSTTCRDN 113
Cdd:pfam08937  80 TWSRRWVDWEIAIS-LKKGKGLLGVRIPGLkrSDLPRGPSALGAN 123
 
Name Accession Description Interval E-value
DUF1863 pfam08937
MTH538 TIR-like domain (DUF1863); This domain adopts the flavodoxin fold, that is, five ...
 2-113 2.97e-13

MTH538 TIR-like domain (DUF1863); This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.


Pssm-ID: 430330  Cd Length: 127  Bit Score: 63.96  E-value: 2.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498430776    2 HKTFISYHHANEQELKDEIIKLG--SGDNFVDKSVSDGDIDTDLPE---------ETIMRKIRDDfLGESTVVIVLIGEE 70
Cdd:pfam08937   1 RKVFISFHHEDDVWRYDKLRNLFanSNDIIGDPNINWGFPDGNDHEpikrrnddsEYIKRWIRDQ-LNGSSVTIVLVGPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 498430776   71 TSDRPFINSEIQAAmWAKSTGLVGVVKDDL--YDRLYTSTTCRDN 113
Cdd:pfam08937  80 TWSRRWVDWEIAIS-LKKGKGLLGVRIPGLkrSDLPRGPSALGAN 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH