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Conserved domains on  [gi|498431920|ref|WP_010737668|]
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MULTISPECIES: enhanced intracellular survival protein Eis [Enterococcus]

Protein Classification

enhanced intracellular survival protein Eis( domain architecture ID 11468262)

enhanced intracellular survival protein Eis, similar to Mycobacterium tuberculosis Eis, a secretory protein that is released into the host cell to modulate inflammatory responses; it is an acetyltransferase of the GCN5-related family of N-acetyltransferases that initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

EC:  2.3.1.-
Gene Symbol:  eis
PubMed:  10940244|9175471|10629183|24106131

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Eis COG4552
Predicted acetyltransferase [General function prediction only];
10-406 1.82e-142

Predicted acetyltransferase [General function prediction only];


:

Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 411.21  E-value: 1.82e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  10 LELKPVTEKDVDQFNELLSYVFqvteadieesGFESKGAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNIHGKPY 89
Cdd:COG4552    1 MEIRPLTEDDLDAFARLLAYAF----------GPEPDDEELEAYRPLLEPGRVLGVFDDGELVGTLALYPFTLNVGGARV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  90 KMGGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEIMSDKLTFKIRDTQLPKNVPVDGMV 169
Cdd:COG4552   71 PMAGITGVAVAPEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRYTIPPESLPLRPDAPGRV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 170 ERL-PVDHPDVYRVYQKFAAQNHGALFRSQFHWEEYWRFENKEERTAAIYYTKEHEPIGVLFYWVAEE----IFHVKEMF 244
Cdd:COG4552  151 RRVdPDDAELLAALYERFARRRPGALDRDEAWWERVLRDLGGEPLRAAVHYDEDGEPDGYVLYRVKDGgdggTLEVRELV 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 245 YLNQEARNGLWNFISAHFSMVYWVHGDIYKNEPLAFLIEDS-QIKEQIEPYYMARIVDVKEFLKQFPFVSTAKPFHFIVE 323
Cdd:COG4552  231 ALTPEARRALWRFLASHDSQVDRVRWRLPVDDPLPLLLPDPrAAKTTIRPGLMLRIVDVPAALEARGYPAGDGDLVLEVT 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 324 DPIASWNNGVFGLVWnEDGQLDVVDEPVGQSVQLSIQTLSCLMMNYRRPSYLARIERIK-TDDETLKTLELILPNMEAYF 402
Cdd:COG4552  311 DPLLPWNAGRFRLEV-DDGRATVERTDAEADLTLDIRALSALYLGGVSPAALARAGRLTeGDPEALAALDALFPGRAPYL 389


                 ....
gi 498431920 403 SDYF 406
Cdd:COG4552  390 SDYF 393
 
Name Accession Description Interval E-value
Eis COG4552
Predicted acetyltransferase [General function prediction only];
10-406 1.82e-142

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 411.21  E-value: 1.82e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  10 LELKPVTEKDVDQFNELLSYVFqvteadieesGFESKGAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNIHGKPY 89
Cdd:COG4552    1 MEIRPLTEDDLDAFARLLAYAF----------GPEPDDEELEAYRPLLEPGRVLGVFDDGELVGTLALYPFTLNVGGARV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  90 KMGGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEIMSDKLTFKIRDTQLPKNVPVDGMV 169
Cdd:COG4552   71 PMAGITGVAVAPEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRYTIPPESLPLRPDAPGRV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 170 ERL-PVDHPDVYRVYQKFAAQNHGALFRSQFHWEEYWRFENKEERTAAIYYTKEHEPIGVLFYWVAEE----IFHVKEMF 244
Cdd:COG4552  151 RRVdPDDAELLAALYERFARRRPGALDRDEAWWERVLRDLGGEPLRAAVHYDEDGEPDGYVLYRVKDGgdggTLEVRELV 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 245 YLNQEARNGLWNFISAHFSMVYWVHGDIYKNEPLAFLIEDS-QIKEQIEPYYMARIVDVKEFLKQFPFVSTAKPFHFIVE 323
Cdd:COG4552  231 ALTPEARRALWRFLASHDSQVDRVRWRLPVDDPLPLLLPDPrAAKTTIRPGLMLRIVDVPAALEARGYPAGDGDLVLEVT 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 324 DPIASWNNGVFGLVWnEDGQLDVVDEPVGQSVQLSIQTLSCLMMNYRRPSYLARIERIK-TDDETLKTLELILPNMEAYF 402
Cdd:COG4552  311 DPLLPWNAGRFRLEV-DDGRATVERTDAEADLTLDIRALSALYLGGVSPAALARAGRLTeGDPEALAALDALFPGRAPYL 389


                 ....
gi 498431920 403 SDYF 406
Cdd:COG4552  390 SDYF 393
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 12-145 1.28e-44

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 150.80  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920   12 LKPVTEKDVDQFNELLSYVFQVTEADieesgfeskgAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNIHGKPYKM 91
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEYAFQDEDSP----------ELREYFRPLLEEGRVLGAFDDGELVSTLALYPFELNVPGKTLPA 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 498431920   92 GGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEI 145
Cdd:pfam13527  71 AGITGVATYPEYRGRGVMSRLLRRSLEEMRERGVPLSFLYPSSYPIYRRFGYEI 124
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
10-306 4.85e-06

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 48.39  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  10 LELKPVTEKDVDQFNELLSYVFQVTEADieesgfeskgAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNI-HGKP 88
Cdd:PRK01346   7 ITIRTATEEDWPAWFRAAATGFGDSPSD----------EELEAWRALVEPDRTLGAFDGDEVVGTAGAFDLRLTVpGGAV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  89 YKMGGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEIMSDKLTFKI--RDTQLPKNVPVD 166
Cdd:PRK01346  77 LPAAGVTAVTVAPTHRRRGLLTALMREQLRRIRERGEPVAALTASEGGIYGRFGYGPATYSQSLSVdrRRARLRPDVPDG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 167 GmveRLPVDHPDVYR-----VYQKFAAQNHGALFRSQFHWEeyWRFENKEERTA------AIYYTKEHEPIGVLFY---- 231
Cdd:PRK01346 157 G---RVRLVDPAEARdllpaVYERWRRARPGALSRPPAWWD--DVLADRESRRGggsplrALVHPDDGEVDGYALYrvdd 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 232 -W---VAEEIFHVKEMFYLNQEARNGLWNF---------ISAHfsmvyWVHGDiyknEPLAFLIEDS---QIKEQIEPYY 295
Cdd:PRK01346 232 tWgfrGPDGTVEVEELVAATPAAYAALWRFllsldlverVRAG-----IAPPD----DPLPHLLADPraaRTTGVSDGLW 302

                        330
                 ....*....|.
gi 498431920 296 MaRIVDVKEFL 306
Cdd:PRK01346 303 L-RIVDVPAAL 312
 
Name Accession Description Interval E-value
Eis COG4552
Predicted acetyltransferase [General function prediction only];
10-406 1.82e-142

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 411.21  E-value: 1.82e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  10 LELKPVTEKDVDQFNELLSYVFqvteadieesGFESKGAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNIHGKPY 89
Cdd:COG4552    1 MEIRPLTEDDLDAFARLLAYAF----------GPEPDDEELEAYRPLLEPGRVLGVFDDGELVGTLALYPFTLNVGGARV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  90 KMGGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEIMSDKLTFKIRDTQLPKNVPVDGMV 169
Cdd:COG4552   71 PMAGITGVAVAPEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRYTIPPESLPLRPDAPGRV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 170 ERL-PVDHPDVYRVYQKFAAQNHGALFRSQFHWEEYWRFENKEERTAAIYYTKEHEPIGVLFYWVAEE----IFHVKEMF 244
Cdd:COG4552  151 RRVdPDDAELLAALYERFARRRPGALDRDEAWWERVLRDLGGEPLRAAVHYDEDGEPDGYVLYRVKDGgdggTLEVRELV 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 245 YLNQEARNGLWNFISAHFSMVYWVHGDIYKNEPLAFLIEDS-QIKEQIEPYYMARIVDVKEFLKQFPFVSTAKPFHFIVE 323
Cdd:COG4552  231 ALTPEARRALWRFLASHDSQVDRVRWRLPVDDPLPLLLPDPrAAKTTIRPGLMLRIVDVPAALEARGYPAGDGDLVLEVT 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 324 DPIASWNNGVFGLVWnEDGQLDVVDEPVGQSVQLSIQTLSCLMMNYRRPSYLARIERIK-TDDETLKTLELILPNMEAYF 402
Cdd:COG4552  311 DPLLPWNAGRFRLEV-DDGRATVERTDAEADLTLDIRALSALYLGGVSPAALARAGRLTeGDPEALAALDALFPGRAPYL 389


                 ....
gi 498431920 403 SDYF 406
Cdd:COG4552  390 SDYF 393
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 12-145 1.28e-44

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 150.80  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920   12 LKPVTEKDVDQFNELLSYVFQVTEADieesgfeskgAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNIHGKPYKM 91
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEYAFQDEDSP----------ELREYFRPLLEEGRVLGAFDDGELVSTLALYPFELNVPGKTLPA 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 498431920   92 GGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEI 145
Cdd:pfam13527  71 AGITGVATYPEYRGRGVMSRLLRRSLEEMRERGVPLSFLYPSSYPIYRRFGYEI 124
Acetyltransf_17 pfam17668
Acetyltransferase (GNAT) domain;
192-299 2.08e-32

Acetyltransferase (GNAT) domain;


Pssm-ID: 435960 [Multi-domain]  Cd Length: 112  Bit Score: 118.23  E-value: 2.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  192 GALFRSQFHWEEYWRfENKEERTAAIYYTKEHEPIGVLFYWV-----AEEIFHVKEMFYLNQEARNGLWNFISAHFSMVY 266
Cdd:pfam17668   1 GALVRDEAWWRRRLL-DDPDDPLRAVYYRDADGPDGYAIYRVkrdpnGDDTLHVRELVALTPAAYRALWRFLLSHDSLVD 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 498431920  267 WVHGDIYKNEPLAFLIEDSQIKEQIEPYYMARI 299
Cdd:pfam17668  80 TVEWSLPPDDPLPLLLPDPRAAETIRPYMMVRI 112
SCP2_2 pfam13530
Sterol carrier protein domain;
302-403 7.85e-30

Sterol carrier protein domain;


Pssm-ID: 463910 [Multi-domain]  Cd Length: 105  Bit Score: 111.24  E-value: 7.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  302 VKEFLKQFPFVSTAK-PFHFIVEDPIASWNNGVFGLVWNEDGQLDVVDEPVGQS--VQLSIQTLSCLMMNYRRPSYLARI 378
Cdd:pfam13530   1 VEAALEARPYPPGIEgDLVLEVTDPLLPWNNGRFRLSIEDGGASEVGRESEDGAadLTLDIQTLAALYLGYRSPSELARL 80

                          90       100
                  ....*....|....*....|....*
gi 498431920  379 ERIKTDDETLKTLELILPNMEAYFS 403
Cdd:pfam13530  81 GRIEGAEEALARLDRLFPDEAPYLS 105
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
10-306 4.85e-06

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 48.39  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  10 LELKPVTEKDVDQFNELLSYVFQVTEADieesgfeskgAFIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNI-HGKP 88
Cdd:PRK01346   7 ITIRTATEEDWPAWFRAAATGFGDSPSD----------EELEAWRALVEPDRTLGAFDGDEVVGTAGAFDLRLTVpGGAV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  89 YKMGGVTGVGTYPEYANHGLMQDLILVALDNMRKNKQWISYLYPYSVPYYRRKGWEIMSDKLTFKI--RDTQLPKNVPVD 166
Cdd:PRK01346  77 LPAAGVTAVTVAPTHRRRGLLTALMREQLRRIRERGEPVAALTASEGGIYGRFGYGPATYSQSLSVdrRRARLRPDVPDG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 167 GmveRLPVDHPDVYR-----VYQKFAAQNHGALFRSQFHWEeyWRFENKEERTA------AIYYTKEHEPIGVLFY---- 231
Cdd:PRK01346 157 G---RVRLVDPAEARdllpaVYERWRRARPGALSRPPAWWD--DVLADRESRRGggsplrALVHPDDGEVDGYALYrvdd 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920 232 -W---VAEEIFHVKEMFYLNQEARNGLWNF---------ISAHfsmvyWVHGDiyknEPLAFLIEDS---QIKEQIEPYY 295
Cdd:PRK01346 232 tWgfrGPDGTVEVEELVAATPAAYAALWRFllsldlverVRAG-----IAPPD----DPLPHLLADPraaRTTGVSDGLW 302

                        330
                 ....*....|.
gi 498431920 296 MaRIVDVKEFL 306
Cdd:PRK01346 303 L-RIVDVPAAL 312
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
12-148 4.99e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 36.99  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498431920  12 LKPVTEKDVDQFNELLSYVF-QVTEADIeesgfeskgafIRSKRPILELSEVFGWFHHNKLISQIAIYPCEVNihgKPYK 90
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFgPGREAEL-----------VDRLREDPAAGLSLVAEDDGEIVGHVALSPVDID---GEGP 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498431920  91 MGGVTGVGTYPEYANHGLMQDLILVALDNMRKnkQWISYLY----PYSVPYYRRKGWEIMSD 148
Cdd:COG3153   67 ALLLGPLAVDPEYRGQGIGRALMRAALEAARE--RGARAVVllgdPSLLPFYERFGFRPAGE 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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