|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
69-299 |
5.80e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 162.77 E-value: 5.80e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 69 EINQQYQETAKREKNRvQELMVDAAHQMRTPITSMVMFAELLQSD-QLTASESQEFLARLSFDSNRLNWLVEEFLHMSKF 147
Cdd:COG2205 1 ELEEALEELEELERLK-SEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 148 ETESMQLTIVNQKINETIQQAIHQNSEKEYQKKRFIVNENDYELPH---DVKWTREAISNVLENALKYAYEDSKIELSID 224
Cdd:COG2205 80 ESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLvyaDPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498433900 225 RLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNtIEGFGIGLYLTKLICEAQGGYVLADSQSEV-TTISLFL 299
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG-EGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
8-299 |
1.98e-40 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 144.70 E-value: 1.98e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 8 ILFFLVILILFLFQMRKQHEEELSNIEEVLDAVLKGDHPENATIYQEGQESKLIFKTLRIAEINQQYQETAKREKNRvQE 87
Cdd:COG5002 89 LLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMR-RE 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 88 LMVDAAHQMRTPITSMVMFAELLQSDQL-TASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQLTIVNQKINETIQ 166
Cdd:COG5002 168 FVANVSHELRTPLTSIRGYLELLLDGAAdDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLE 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 167 QAIHQNSEKEYQKK---RFIVNENDYELPHDVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISR 243
Cdd:COG5002 248 EVVEELRPLAEEKGielELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPE 327
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 498433900 244 EELPNLFSKYYRGSQYRN-TIEGFGIGLYLTKLICEAQGGYVLADSQSEV-TTISLFL 299
Cdd:COG5002 328 EDLPRIFERFYRVDKSRSrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTITL 385
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
2-299 |
6.34e-40 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 141.97 E-value: 6.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 2 FLYALTILFFLVILILFLFQMRKQHEEELSNIEEVLDAVLKGDHPENATIYQEGQESKLIFKTLRIAEINQQYQETAKRE 81
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 82 KnrvQELMVDAAHQMRTPITSMVMFAELLQSDqlTASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQLTIVNQKI 161
Cdd:COG0642 110 K---SRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 162 NETIQQAIHQNSEKEYQKK---RFIVNENDYELPHDVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRG 238
Cdd:COG0642 185 AELLEEVVELFRPLAEEKGielELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTG 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498433900 239 KTISREELPNLFSKYYRGSQYRNTiEGFGIGLYLTKLICEAQGGYVLADSQSEV-TTISLFL 299
Cdd:COG0642 265 PGIPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESEPGKgTTFTVTL 325
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
199-299 |
7.59e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 90.79 E-value: 7.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 199 REAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTIEGFGIGLYLTKLICE 278
Cdd:smart00387 7 RQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVE 86
|
90 100
....*....|....*....|..
gi 498433900 279 AQGGYVLADSQSEV-TTISLFL 299
Cdd:smart00387 87 LHGGEISVESEPGGgTTFTITL 108
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
194-288 |
4.22e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 78.10 E-value: 4.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 194 DVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTIEGFGIGLYLT 273
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLV 81
|
90
....*....|....*
gi 498433900 274 KLICEAQGGYVLADS 288
Cdd:cd16948 82 KKLCDKLGHKIDVES 96
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
194-299 |
8.99e-18 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 77.02 E-value: 8.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 194 DVKWTREAISNVLENALKYAYEDSKIELSIDRlISYTRISIKNRGKTISREELPNLFSKYYRGSqyRNTIEGFGIGLYLT 273
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTAD--KRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*..
gi 498433900 274 KLICEAQGGYVLADSQSEV-TTISLFL 299
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGgTTVTLTL 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
91-297 |
1.63e-16 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 79.43 E-value: 1.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 91 DAAHQMRTPITSMVMFAELLQSDQLTASESQEFLArlsfdSNrlnwlVEEFLHMSKFETESMQLTIV--NQKINETIQQA 168
Cdd:PRK09835 268 DIAHEIRTPITNLITQTEIALSQSRSQKELEDVLY-----SN-----LEELTRMAKMVSDMLFLAQAdnNQLIPEKKMLD 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 169 IHQNSEKEYQKKRFIVNENDYEL-----PH----DVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGK 239
Cdd:PRK09835 338 LADEVGKVFDFFEAWAEERGVELrfvgdPCqvagDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGT 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498433900 240 TISREELPNLFSKYYR--GSQYRNTiEGFGIGLYLTKLICEAQGGYVLADSQSEVT--TISL 297
Cdd:PRK09835 418 PIAPEHLPRLFDRFYRvdPSRQRKG-EGSGIGLAIVKSIVVAHKGTVAVTSDARGTrfVISL 478
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
93-299 |
2.71e-16 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 78.47 E-value: 2.71e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 93 AHQMRTPITSMVMFAELLQ---SDQLT--ASESQEFLARLSFDSNRLNWLVEEFLHMSKfeTESMQLTIVNqkINETIQQ 167
Cdd:COG5000 209 AHEIKNPLTPIQLSAERLRrklADKLEedREDLERALDTIIRQVDRLKRIVDEFLDFAR--LPEPQLEPVD--LNELLRE 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 168 AIHQNSEKEYQKKRFIVNENDYELPH---DVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISRE 244
Cdd:COG5000 285 VLALYEPALKEKDIRLELDLDPDLPEvlaDRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEE 364
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 245 ELPNLFSKYY----RGSqyrntiegfGIGLYLTKLICEAQGGYVLADSQSEV-TTISLFL 299
Cdd:COG5000 365 VLERIFEPFFttkpKGT---------GLGLAIVKKIVEEHGGTIELESRPGGgTTFTIRL 415
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
2-289 |
5.31e-16 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 77.90 E-value: 5.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 2 FLYALTILFFLVILILFLFQMRKQHEEELSNIEEVLDAVLKGDHPENATIYQEGQESKLIFKTLRIAEINQQYQETAKRE 81
Cdd:COG4251 196 LLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAEL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 82 KNRVQEL-----MvdAAHQMRTPITSMVMFAELLQSD---QLTAsESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQ 153
Cdd:COG4251 276 ERSNEELeqfayV--ASHDLREPLRKISGFSQLLEEDygdKLDE-EGREYLERIRDAAERMQALIDDLLAYSRVGRQELE 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 154 LTIVNqkINETIQQAIHQNSEKEYQKK-RFIVNEndyeLPH---DVKWTREAISNVLENALKYA--YEDSKIELSIDRLI 227
Cdd:COG4251 353 FEPVD--LNELLEEVLEDLEPRIEERGaEIEVGP----LPTvrgDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREG 426
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498433900 228 SYTRISIKNRGKTISREELPNLFSKYYRGSQyRNTIEGFGIGLYLTKLICEAQGGYVLADSQ 289
Cdd:COG4251 427 GEWVFSVRDNGIGIDPEYAEKIFEIFQRLHS-RDEYEGTGIGLAIVKKIVERHGGRIWVESE 487
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
198-299 |
5.52e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 69.34 E-value: 5.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 198 TREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTiEGFGIGLYLTKLIC 277
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT-EGAGLGLSIAKAII 79
|
90 100
....*....|....*....|..
gi 498433900 278 EAQGGYVLADSQSEVTTISLFL 299
Cdd:cd16923 80 ELHGGSASAEYDDNHDLFKVRL 101
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
66-289 |
4.91e-14 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 72.13 E-value: 4.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 66 RIAEINQQYQETAKREKNRVQ--ELMVDAAHQMRTPITSMVMFAELLQSDQLTASESQEFLARLSFDSNRLNWLVEEFLH 143
Cdd:PRK10364 216 RYLRSRQLLQDEMKRKEKLVAlgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLE 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 144 MSKFETESMQLTIVNQKINETIqQAIHQNSEKEYQKKRFIVNENDYELPHDVKWTREAISNVLENALKYAYEDSKIELSI 223
Cdd:PRK10364 296 LVKPTHLALQAVDLNDLINHSL-QLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTA 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498433900 224 DRLISYTRISIKNRGKTISREELPNLFSKYYRGSQyrntiEGFGIGLYLTKLICEAQGGYVLADSQ 289
Cdd:PRK10364 375 SESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA-----EGTGLGLAVVHNIVEQHGGTIQVASQ 435
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
201-286 |
1.86e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 65.42 E-value: 1.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 201 AISNVLENALKYAyeDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNT-IEGFGIGLYLTKLICEA 279
Cdd:cd16949 4 ALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDReSGGTGLGLAIAERAIEQ 81
|
....*..
gi 498433900 280 QGGYVLA 286
Cdd:cd16949 82 HGGKIKA 88
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
87-300 |
3.03e-13 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 70.00 E-value: 3.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 87 ELMVDAAHQMRTPITSMVMFAELLQsDQLTASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQLTIVNQKINET-- 164
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWR-QQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVlq 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 165 -IQQAIHQNSEKeyqkkrfIVNENDYELPH---DVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTR-ISIKNRGK 239
Cdd:PRK11360 471 lFQTAGVQARVD-------FETELDNELPPiwaDPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVaVSIEDNGC 543
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498433900 240 TISREELPNLFSKYYRGSQyrntiEGFGIGLYLTKLICEAQGGYVLADSQSEV-TTISLFLQ 300
Cdd:PRK11360 544 GIDPELLKKIFDPFFTTKA-----KGTGLGLALSQRIINAHGGDIEVESEPGVgTTFTLYLP 600
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
85-254 |
9.60e-13 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 67.95 E-value: 9.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 85 VQELmvdaAHQMRTPITSMVMFAELLQsDQLTASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQLTIVNQKINET 164
Cdd:PRK11100 260 VQTL----THELKSPLAAIRGAAELLQ-EDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAAL 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 165 IQQAI-HQNSEKEYQKKRFIVNENDYELPHDVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISR 243
Cdd:PRK11100 335 LEELVeAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPD 414
|
170
....*....|.
gi 498433900 244 EELPNLFSKYY 254
Cdd:PRK11100 415 YALPRIFERFY 425
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
94-274 |
8.09e-12 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 65.03 E-value: 8.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 94 HQMRTPITSMVMFAELLQSDQLTASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQLtiVNQKIN-----ETIQQA 168
Cdd:PRK11006 213 HELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTID--LNEKVDvpmmlRVLERE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 169 IHQNSEKEyQKKRFIVNE------NDYELphdvkwtREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTIS 242
Cdd:PRK11006 291 AQTLSQGK-HTITFEVDNslkvfgNEDQL-------RSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIA 362
|
170 180 190
....*....|....*....|....*....|....
gi 498433900 243 REELPNLFSKYYR--GSQYRNTiEGFGIGLYLTK 274
Cdd:PRK11006 363 PEHIPRLTERFYRvdKARSRQT-GGSGLGLAIVK 395
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
89-289 |
1.04e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 64.59 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 89 MVdaAHQMRTPITSMVMFAELLQSDQLTASE--SQEFLARLsFDSNR-----LNWLVEEFLHMSKfeTESMQLTIVNQKI 161
Cdd:PRK09303 157 ML--AHDLRTPLTAASLALETLELGQIDEDTelKPALIEQL-QDQARrqleeIERLITDLLEVGR--TRWEALRFNPQKL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 162 N-ETIQQAIHQNSEKEYQKKRFIVNE---NDyeLPH---DVKWTREAISNVLENALKYAYEDSKIELSI-DRLISYTRIS 233
Cdd:PRK09303 232 DlGSLCQEVILELEKRWLAKSLEIQTdipSD--LPSvyaDQERIRQVLLNLLDNAIKYTPEGGTITLSMlHRTTQKVQVS 309
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 498433900 234 IKNRGKTISREELPNLFSKYYRGSQYRNTiEGFGIGLYLTKLICEAQGGYVLADSQ 289
Cdd:PRK09303 310 ICDTGPGIPEEEQERIFEDRVRLPRDEGT-EGYGIGLSVCRRIVRVHYGQIWVDSE 364
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
52-297 |
3.53e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 63.99 E-value: 3.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 52 YQEGQESKLIFKTLRIaEINQQYQETAKReknrvQELMVDAAHQMRTPITSMVMFAELLQSDQLTASESQEFLARLSFDS 131
Cdd:PRK09959 685 WQDITETRDLIHALEV-ERNKAINATVAK-----SQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATG 758
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 132 NRLNWLVEEFLHMSKFETESMQLTIVNQKINETIQQAIHQNSEKEYQKKRFI----VNENDYELPHDVKWTREAISNVLE 207
Cdd:PRK09959 759 QSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALscssTFPDHYLVKIDPQAFKQVLSNLLS 838
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 208 NALKYAYEDS-KIELS---IDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTIeGFGIGLYLTK-LICEAQGG 282
Cdd:PRK09959 839 NALKFTTEGAvKITTSlghIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT-GSGLGLMICKeLIKNMQGD 917
|
250
....*....|....*
gi 498433900 283 YVLADSQSEVTTISL 297
Cdd:PRK09959 918 LSLESHPGIGTTFTI 932
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
1-299 |
1.94e-10 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 60.97 E-value: 1.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 1 MFLYALTILFFLVILILFLFQMRKQHEEELSNIEEVLDAVLKGDHPENATIYQEGQESKLIFKTLRIAEINQQYQETAKR 80
Cdd:COG4191 50 LLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELREL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 81 EKNRVQ--------ELMVDAAHQMRTPITSMVMFAELLQ---SDQLTASESQEFLARLSFDSNRLNWLVEEFLHMSKFET 149
Cdd:COG4191 130 QEQLVQseklaalgELAAGIAHEINNPLAAILGNAELLRrrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 150 ESMQLTIVNQKINETIqqAIHQNsekEYQKKRFIVnenDYELPHDVKWTR-------EAISNVLENALkYAYEDS---KI 219
Cdd:COG4191 210 EEREPVDLNELIDEAL--ELLRP---RLKARGIEV---ELDLPPDLPPVLgdpgqleQVLLNLLINAI-DAMEEGeggRI 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 220 ELSIDRLISYTRISIKNRGKTISREELPNLFSKYY----RGsqyrntiEGFGIGLYLTKLICEAQGGYVLADSQSEV-TT 294
Cdd:COG4191 281 TISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkpVG-------KGTGLGLSISYGIVEKHGGRIEVESEPGGgTT 353
|
....*
gi 498433900 295 ISLFL 299
Cdd:COG4191 354 FTITL 358
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
26-299 |
2.07e-10 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 61.14 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 26 HEEELSNIEEVLDAVLKGDHPENATIYQEGQESKLIFKTLRIAEINQQYQE----------TAKREK----------NRV 85
Cdd:COG5809 191 HSDDQENVAAFISQLLKDGGIAQGEVRFWTKDGRWRLLEASGAPIKKNGEVdgiviifrdiTERKKLeellrkseklSVV 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 86 QELMVDAAHQMRTPITSMVMFAELLQSDqlTASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQLTIVNQKINETI 165
Cdd:COG5809 271 GELAAGIAHEIRNPLTSLKGFIQLLKDT--IDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVI 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 166 Q----QAIHQNSEKEYqkkrfivnENDYELPH---DVKWTREAISNVLENALKYAYEDSKIELSIDRLI-SYTRISIKNR 237
Cdd:COG5809 349 PllqpQALLKNVQIEL--------ELEDDIPDilgDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDdDKVVISVTDE 420
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498433900 238 GKTISREELPNLFSKYYrgsqyrNTIE-GFGIGLYLTKLICEAQGGYVLADSQSEV-TTISLFL 299
Cdd:COG5809 421 GCGIPEERLKKLGEPFY------TTKEkGTGLGLMVSYKIIEEHGGKITVESEVGKgTTFSITL 478
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
199-284 |
2.17e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 56.69 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 199 REAISNVLENALKYAyeDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRnTIEGFGIGLYLTKLICE 278
Cdd:cd16950 2 KRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR-GTSGTGLGLAIVQRISD 78
|
....*.
gi 498433900 279 AQGGYV 284
Cdd:cd16950 79 AHGGSL 84
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
194-287 |
7.20e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 55.55 E-value: 7.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 194 DVKWTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTIE-GFGIGLYL 272
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASgGSGLGLAI 80
|
90
....*....|....*
gi 498433900 273 TKLICEAQGGYVLAD 287
Cdd:cd16946 81 CHNIALAHGGTISAE 95
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
88-284 |
7.98e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 59.15 E-value: 7.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 88 LMVDAAHQMRTPITSMVMFAELLqsdqltaSESQEFLAR-LSFDSNRLNWLVEEFL-HMSKFETESMQLTIVNQKINETI 165
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEMM-------SEEDGYLAEsINKDIEECNAIIEQFIdYLRTGQEMPMEMADLNALLGEVI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 166 QqaihqnSEKEYQKKrfIVNE-NDYELP---HDVKWTReAISNVLENALKYAYEDSKIELSIDRliSYTRISIKNRGKTI 241
Cdd:PRK09467 305 A------AESGYERE--IETAlQPGPIEvpmNPIAIKR-ALANLVVNAARYGNGWIKVSSGTEG--KRAWFQVEDDGPGI 373
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 498433900 242 SREELPNLFSKYYRGSQYRNTiEGFGIGLYLTKLICEAQGGYV 284
Cdd:PRK09467 374 PPEQLKHLFQPFTRGDSARGS-SGTGLGLAIVKRIVDQHNGKV 415
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
76-291 |
8.29e-10 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 59.66 E-value: 8.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 76 ETAKREKNRVQ---ELMVDAAHQMRTPITsmVMF--AELLQSDqlTASESQEFLARLS------FDSNRLnwlVEEFLHM 144
Cdd:PRK10490 652 EQARLASEREQlrnALLAALSHDLRTPLT--VLFgqAEILTLD--LASEGSPHARQASeirqqvLNTTRL---VNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 145 SKFETESMQLTIVNQKINETIQQAIHQnseKEYQKKRFIVNEN---DYELPH-DVKWTREAISNVLENALKYAYEDSKIE 220
Cdd:PRK10490 725 ARIQSGGFNLRKEWLTLEEVVGSALQM---LEPGLSGHPINLSlpePLTLIHvDGPLFERVLINLLENAVKYAGAQAEIG 801
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498433900 221 LSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQyRNTIEGFGIGLYLTKLICEAQGGYVLADSQSE 291
Cdd:PRK10490 802 IDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNK-ESAIPGVGLGLAICRAIVEVHGGTIWAENRPE 871
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
83-146 |
1.37e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 53.37 E-value: 1.37e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498433900 83 NRVQELMVDAAHQMRTPITSMVMFAELLQSDQLTASESQEFLARLSFDSNRLNWLVEEFLHMSK 146
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
201-282 |
8.18e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 52.46 E-value: 8.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 201 AISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTIEGFGIGLYLTKLICEAQ 280
Cdd:cd16975 8 ALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKNLVEKH 87
|
..
gi 498433900 281 GG 282
Cdd:cd16975 88 GG 89
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
67-299 |
8.71e-09 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 55.62 E-value: 8.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 67 IAEINQQYQETAKREKNR-VQELMVDAAHQMRTPITSMVMFAELLQSDqLTASESQEFLARLSFDSNRLNWLVEEFLHMS 145
Cdd:COG3852 116 ITERKRLERELRRAEKLAaVGELAAGLAHEIRNPLTGIRGAAQLLERE-LPDDELREYTQLIIEEADRLNNLVDRLLSFS 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 146 KfeTESMQLTIVNqkINETIQQAIhQNSEKEYQKKRFIVNENDYELPH---DVKWTREAISNVLENALKYAYEDSKIELS 222
Cdd:COG3852 195 R--PRPPEREPVN--LHEVLERVL-ELLRAEAPKNIRIVRDYDPSLPEvlgDPDQLIQVLLNLVRNAAEAMPEGGTITIR 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 223 IDRLISYT----------RISIKNRGKTISREELPNLFSKYYRGSQyrntiEGFGIGLYLTKLICEAQGGYVLADSQ-SE 291
Cdd:COG3852 270 TRVERQVTlgglrprlyvRIEVIDNGPGIPEEILDRIFEPFFTTKE-----KGTGLGLAIVQKIVEQHGGTIEVESEpGK 344
|
....*...
gi 498433900 292 VTTISLFL 299
Cdd:COG3852 345 GTTFRIYL 352
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
199-300 |
9.85e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 52.33 E-value: 9.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 199 REAISNVLENALKYAYED--SKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRgSQYRNTIEGFGIGLYLTKLI 276
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQR-LHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 498433900 277 CEAQGGYVLADSQ-SEVTTISLFLQ 300
Cdd:cd16921 81 IERHGGRIWLESEpGEGTTFYFTLP 105
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
86-273 |
1.58e-08 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 55.32 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 86 QELMVDAAHQMRTPITSMVMFAELLQSDQltaSESQEfLARLSFDSNRLNWLVEEFLHMSKFETESmQLTIVNQKINEtI 165
Cdd:PRK09470 244 QRLLSDISHELRTPLTRLQLATALLRRRQ---GESKE-LERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANS-L 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 166 QQAIHQNS--EKEYQKKRFIVNE--NDYELPHDVKWTREAISNVLENALKYAYedSKIELSIDRLISYTRISIKNRGKTI 241
Cdd:PRK09470 318 WSEVLEDAkfEAEQMGKSLTVSAppGPWPINGNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGLTITVDDDGPGV 395
|
170 180 190
....*....|....*....|....*....|..
gi 498433900 242 SREELPNLFSKYYRGSQYRNTIEGfGIGLYLT 273
Cdd:PRK09470 396 PEEEREQIFRPFYRVDEARDRESG-GTGLGLA 426
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
91-150 |
1.62e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 50.29 E-value: 1.62e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 91 DAAHQMRTPITSMVMFAELLQSDQLTaSESQEFLARLSFDSNRLNWLVEEFLHMSKFETE 150
Cdd:pfam00512 8 NLSHELRTPLTAIRGYLELLRDEKLD-EEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
86-150 |
2.16e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.87 E-value: 2.16e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498433900 86 QELMVDAAHQMRTPITSMVMFAELLQSDQLTaSESQEFLARLSFDSNRLNWLVEEFLHMSKFETE 150
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
56-295 |
5.92e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 53.58 E-value: 5.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 56 QESKLIFKTLR-IAEINQQYQETAKREK-NRVQELMVDAAHQMRTPITSMVMFAELLQSDQltasESQEFLARLSFDS-N 132
Cdd:COG5805 256 GSVKGILVILRdITEKKEAEELMARSEKlSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGI----EDKEEYFDIMLSElD 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 133 RLNWLVEEFLHMSKFETESMQLTIVNQKINETI----QQAIHQNsekeyQKKRFIVNENDYELPHDVKWTREAISNVLEN 208
Cdd:COG5805 332 RIESIISEFLALAKPQAVNKEKENINELIQDVVtlleTEAILHN-----IQIRLELLDEDPFIYCDENQIKQVFINLIKN 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 209 ALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQyrntiEGFGIGLYLTKLICEAQGGYVLADS 288
Cdd:COG5805 407 AIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE-----KGTGLGLMVSYKIIENHNGTIDIDS 481
|
....*..
gi 498433900 289 QSEVTTI 295
Cdd:COG5805 482 KVGKGTT 488
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
197-299 |
1.24e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 49.33 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 197 WTREAISNVLENALKYAYEDSKIELSIDRLiSYTRISIKNRGKTISREELPNLFSKYYRgSQYRNTiEGFGIGLYLTKLI 276
Cdd:cd16940 13 LLFLLLRNLVDNAVRYSPQGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYR-SDGQNY-GGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 498433900 277 CEAQGGYV-LADSQSEVTTISLFL 299
Cdd:cd16940 90 VELHGGQIfLGNAQGGGLEAWVRL 113
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
3-276 |
1.31e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 52.34 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 3 LYALTILFFLVILILflfqmrkqhEEELSNIEEvLDAVLKGDHPENATIYQEGQesklIFKTLR--IAEINQQYQetakr 80
Cdd:PRK10337 168 LVALPIMLIILMVLL---------GRELAPLKK-LALALRMRDPDSETPLNATG----VPSEVRplVEALNQLFA----- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 81 eknRVQELMV-------DAAHQMRTPITSMVMFAELLQSDQLTASESQEFLARLSFDSNRLNWLVEEFLHMSKFETESMQ 153
Cdd:PRK10337 229 ---RTHAMMVrerrftsDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 154 LTIVNQKINETIQQAIHQNSEKEYQKKRfivnENDYELP-HDVKWTREA------ISNVLENALKYAYEDSKIELSidrl 226
Cdd:PRK10337 306 QDVAEIPLEDLLQSAVMDIYHTAQQAGI----DVRLTLNaHPVIRTGQPlllsllVRNLLDNAIRYSPQGSVVDVT---- 377
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 498433900 227 ISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTieGFGIGLYLTKLI 276
Cdd:PRK10337 378 LNARNFTVRDNGPGVTPEALARIGERFYRPPGQEAT--GSGLGLSIVRRI 425
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
81-287 |
7.49e-07 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 50.02 E-value: 7.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 81 EKNRV--QELMVDAAHQMRTPITsmVMFAEL--LQSD--QLTAsesqEFLARLSFDSNRLNWLVEEfLH---MSKFETES 151
Cdd:PRK10549 234 EKNEQmrRDFMADISHELRTPLA--VLRGELeaIQDGvrKFTP----ESVASLQAEVGTLTKLVDD-LHqlsLSDEGALA 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 152 MQLTIVNqkINETIQQAIHQNSEKeYQKKRFIVnenDYELPHDVKW------TREAISNVLENALKYAYEDSKIELSIDR 225
Cdd:PRK10549 307 YRKTPVD--LVPLLEVAGGAFRER-FASRGLTL---QLSLPDSATVfgdpdrLMQLFNNLLENSLRYTDSGGSLHISAEQ 380
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498433900 226 LISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNTIE-GFGIGLYLTKLICEAQGGYVLAD 287
Cdd:PRK10549 381 RDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASgGSGLGLAICLNIVEAHNGRIIAA 443
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
199-274 |
8.38e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 46.81 E-value: 8.38e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498433900 199 REAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYR--GSQYRNTiEGFGIGLYLTK 274
Cdd:cd16952 2 RSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRvdIERCRNT-GGTGLGLAIVK 78
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
89-290 |
1.96e-06 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 48.83 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 89 MVDA-AHQMRTPITSMVMFAELlqSDQLTASESQEflarLSFDSNRLNWLVEEFLHMSKFETESMQLTIVNQKINETIQQ 167
Cdd:PRK10604 215 LIDGiAHELRTPLVRLRYRLEM--SDNLSAAESQA----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLST 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 168 AIH--QNSEKEYQKKRFIVNENDYeLPHDVKWTREAISNVLENALKYAyeDSKIELSIDRLISYTRISIKNRGKTISREE 245
Cdd:PRK10604 289 HLAdiQAVTPEKTVRLDTPHQGDY-GALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEE 365
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 498433900 246 LPNLFSKYYRGSQYRN-TIEGFGIGLYLTKLICEAQGGYVLADSQS 290
Cdd:PRK10604 366 RERVFEPFVRLDPSRDrATGGCGLGLAIVHSIALAMGGSVNCDESE 411
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
204-295 |
4.23e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 45.20 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 204 NVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYRGSQYRNT-IEGFGIGLYLTKLICEAQGG 282
Cdd:cd16947 27 NLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSaKQGNGLGLTITKRLAESMGG 106
|
90
....*....|...
gi 498433900 283 YVLADSQSEVTTI 295
Cdd:cd16947 107 SIYVNSKPYEKTV 119
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
197-284 |
1.12e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 43.60 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 197 WTREAISNVLENALKYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYR----GSQYRNTiegfGIGLYL 272
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprpHSGQKST----GLGLAF 79
|
90
....*....|..
gi 498433900 273 TKLICEAQGGYV 284
Cdd:cd16945 80 VQEVAQLHGGRI 91
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
202-295 |
1.15e-05 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 46.38 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 202 ISNVLENAL----KYAYEDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYY--RGSQYRntiegfGIGLYLTKL 275
Cdd:COG3290 286 LGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFstKLGEGR------GLGLALVKQ 359
|
90 100
....*....|....*....|
gi 498433900 276 ICEAQGGYVLADSQSEVTTI 295
Cdd:COG3290 360 IVEKYGGTIEVESEEGEGTV 379
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
201-287 |
3.30e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 42.03 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 201 AISNVLENALKYAyeDSKIELSIDRLISYTRISIKNRGKTISREELPNLFSKYYR--GSQYRNTiEGFGIGLYLTKLICE 278
Cdd:cd16939 4 ALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldPSRDRAT-GGFGLGLAIVHRVAL 80
|
....*....
gi 498433900 279 AQGGYVLAD 287
Cdd:cd16939 81 WHGGHVECD 89
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
199-289 |
3.99e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 42.09 E-value: 3.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 199 REAISNVLENALKYAyEDSKIELSIDRL-----ISYTRISIKNRGKTISREELPNLFSKYYR-GSQYRNTIEGFGIGLYL 272
Cdd:cd16922 2 RQILLNLLGNAIKFT-EEGEVTLRVSLEeeeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQaDSSTTRKYGGTGLGLAI 80
|
90
....*....|....*..
gi 498433900 273 TKLICEAQGGYVLADSQ 289
Cdd:cd16922 81 SKKLVELMGGDISVESE 97
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
57-299 |
1.51e-04 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 43.09 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 57 ESKLIFKTLRIAEINQQyqetAKREKNRVQELMVDAAHQMRTPITSMVMFAELLQSDQLTAsESQEFLARLSFDSNRLNW 136
Cdd:PRK15347 374 ENKVAERTQALAEAKQR----AEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTA-EQMDLADTARQCTLSLLA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 137 LVEEFLHMSKFETESMQLTIVNQKINETIQQAIH----QNSEKEYQKKRFIVNENDYELPHDVKWTREAISNVLENALKY 212
Cdd:PRK15347 449 IINNLLDFSRIESGQMTLSLEETALLPLLDQAMLtiqgPAQSKSLTLRTFVGAHVPLYLHLDSLRLRQILVNLLGNAVKF 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 213 AyEDSKIELSI----DRLIsytrISIKNRGKTISREELPNLFSKYYrgsQYRNTIEGFGIGLYLTKLICEAQGGYVLADS 288
Cdd:PRK15347 529 T-ETGGIRLRVkrheQQLC----FTVEDTGCGIDIQQQQQIFTPFY---QADTHSQGTGLGLTIASSLAKMMGGELTLFS 600
|
250
....*....|..
gi 498433900 289 QSEV-TTISLFL 299
Cdd:PRK15347 601 TPGVgSCFSLVL 612
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
174-282 |
4.91e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 39.54 E-value: 4.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 174 EKEYQKKRFIVNendYELPHDVKWT------REAISNVLENALKYAyeDSKIELSIDRLISYTRISIKNRGKTISREELP 247
Cdd:cd16954 11 NKVYQRKGVSIS---LDISPELRFPgerndlMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRS 85
|
90 100 110
....*....|....*....|....*....|....*
gi 498433900 248 NLFSkyyRGSQYRNTIEGFGIGLYLTKLICEAQGG 282
Cdd:cd16954 86 KIFQ---RGQRLDEQRPGQGLGLAIAKEIVEQYGG 117
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
199-299 |
1.59e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 37.52 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 199 REAISNVLENALKYAYE------DSKIELSID-------RLIsytrISIKNRGKTISREELPNLFSKYYRGSQyrntiEG 265
Cdd:cd16944 2 TTQISQVLTNILKNAAEaiegrpSDVGEVRIRveadqdgRIV----LIVCDNGKGFPREMRHRATEPYVTTRP-----KG 72
|
90 100 110
....*....|....*....|....*....|....*
gi 498433900 266 FGIGLYLTKLICEAQGGYV-LADSQSEVTTISLFL 299
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRIsLSNREAGGACIRIIL 107
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
202-291 |
3.18e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 36.61 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 202 ISNVLENALK--YAYEDSKIELSIDRLIS---YTRISIKNRGKTISREELPNLFSKYYRgsqyrNTIEGFGIGLYLTKLI 276
Cdd:cd16920 5 LINLVRNGIEamSEGGCERRELTIRTSPAddrAVTISVKDTGPGIAEEVAGQLFDPFYT-----TKSEGLGMGLSICRSI 79
|
90
....*....|....*
gi 498433900 277 CEAQGGYVLADSQSE 291
Cdd:cd16920 80 IEAHGGRLSVESPAG 94
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
73-289 |
5.50e-03 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 38.38 E-value: 5.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 73 QYQ---ETAKREKNRvqeLMVDAAHQMRTPITSMVMFAELLQSDQLTaSESQEFLARLSFDSNRLNWLVEEFLHMSKFET 149
Cdd:PRK11091 271 RYQdalEKASRDKTT---FISTISHELRTPLNGIVGLSRILLDTELT-AEQRKYLKTIHVSAITLGNIFNDIIDMDKMER 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498433900 150 ESMQLTivNQKIN--------ETIQQAIHQnsekeyQKKRFIVNENDYELPH----DVKWTREAISNVLENALKYAYEdS 217
Cdd:PRK11091 347 RKLQLD--NQPIDftdfladlENLSGLQAE------QKGLRFDLEPLLPLPHkvitDGTRLRQILWNLISNAVKFTQQ-G 417
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498433900 218 KIELSIDRLISYT-RISIKNRGKTISREELPNLFSKYY--RGSQYRNTIEGFGIGLYLTKLICEAQGGYVLADSQ 289
Cdd:PRK11091 418 GVTVRVRYEEGDMlTFEVEDSGIGIPEDELDKIFAMYYqvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSE 492
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
199-270 |
6.11e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 37.33 E-value: 6.11e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 498433900 199 REAISNVLEnALKYAYEDSKIELSIDRL-ISYTRISIKNRGKTISREELPNLFSKYYRGSQYRN--TIEGFGIGL 270
Cdd:cd16933 25 RELVENSLD-ATEEAGILPDIKVEIEEIgKDHYKVIVEDNGPGIPEEQIPKVFGKVLYGSKYHNkqSRGQQGLGI 98
|
|
| |
