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Conserved domains on  [gi|498437111|ref|WP_010742780|]
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MULTISPECIES: DUF6434 domain-containing protein [Enterococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF6434 super family cl45408
Domain of unknown function (DUF6434); This domain of unknown function is found in ...
 74-125 4.35e-15

Domain of unknown function (DUF6434); This domain of unknown function is found in uncharacterized proteins mainly from bacteria, but it is also found in eukaryotes. Some proteins containing this domain also contain zinc finger C2H2-type domains. There are three conserved motifs: TxI/V, RxFF and FxF, and a conserved W/Y residue at the C-terminal.


The actual alignment was detected with superfamily member pfam20026:

Pssm-ID: 466263  Cd Length: 64  Bit Score: 66.48  E-value: 4.35e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 498437111   74 LTLDSLIEQGIVFSEKHRAFFKSELGDTFVFKVAFQNWLKENAGKTYREAIA 125
Cdd:pfam20026   8 ITRDTPITDSYKNTQNVRRFFKSQCGEAFKFDRDFMAWIKSGTGKTMGDAAD 59
SAP_new25 pfam18953
SAP domain-containing new25; This family includes Schizosaccharomyces specific SAP domain ...
 15-62 3.86e-14

SAP domain-containing new25; This family includes Schizosaccharomyces specific SAP domain containing proteins such as gene product new25. SAP ( SAF-A/B, Acinus and PIAS) motif is a DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins. For instance, the SAP domain of SUMO E3 ligase PIAS1 from human is shown to bind an A/T-rich DNA.


:

Pssm-ID: 465931  Cd Length: 51  Bit Score: 63.68  E-value: 3.86e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 498437111   15 EVFSEYYYLKVELQDFCQEQGLAKPGSKADLNQRITHYLRTGERLASK 62
Cdd:pfam18953   1 EEFKKYYWLKEELVAFCRELGLPTSGSKAELTERIAAYLDGGEIKKPK 48
 
Name Accession Description Interval E-value
DUF6434 pfam20026
Domain of unknown function (DUF6434); This domain of unknown function is found in ...
 74-125 4.35e-15

Domain of unknown function (DUF6434); This domain of unknown function is found in uncharacterized proteins mainly from bacteria, but it is also found in eukaryotes. Some proteins containing this domain also contain zinc finger C2H2-type domains. There are three conserved motifs: TxI/V, RxFF and FxF, and a conserved W/Y residue at the C-terminal.


Pssm-ID: 466263  Cd Length: 64  Bit Score: 66.48  E-value: 4.35e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 498437111   74 LTLDSLIEQGIVFSEKHRAFFKSELGDTFVFKVAFQNWLKENAGKTYREAIA 125
Cdd:pfam20026   8 ITRDTPITDSYKNTQNVRRFFKSQCGEAFKFDRDFMAWIKSGTGKTMGDAAD 59
SAP_new25 pfam18953
SAP domain-containing new25; This family includes Schizosaccharomyces specific SAP domain ...
 15-62 3.86e-14

SAP domain-containing new25; This family includes Schizosaccharomyces specific SAP domain containing proteins such as gene product new25. SAP ( SAF-A/B, Acinus and PIAS) motif is a DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins. For instance, the SAP domain of SUMO E3 ligase PIAS1 from human is shown to bind an A/T-rich DNA.


Pssm-ID: 465931  Cd Length: 51  Bit Score: 63.68  E-value: 3.86e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 498437111   15 EVFSEYYYLKVELQDFCQEQGLAKPGSKADLNQRITHYLRTGERLASK 62
Cdd:pfam18953   1 EEFKKYYWLKEELVAFCRELGLPTSGSKAELTERIAAYLDGGEIKKPK 48
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
23-53 2.77e-05

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 39.78  E-value: 2.77e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 498437111    23 LKV-ELQDFCQEQGLAKPGSKADLNQRITHYL 53
Cdd:smart00513   4 LKVsELKDELKKRGLSTSGTKAELVDRLLEAL 35
 
Name Accession Description Interval E-value
DUF6434 pfam20026
Domain of unknown function (DUF6434); This domain of unknown function is found in ...
 74-125 4.35e-15

Domain of unknown function (DUF6434); This domain of unknown function is found in uncharacterized proteins mainly from bacteria, but it is also found in eukaryotes. Some proteins containing this domain also contain zinc finger C2H2-type domains. There are three conserved motifs: TxI/V, RxFF and FxF, and a conserved W/Y residue at the C-terminal.


Pssm-ID: 466263  Cd Length: 64  Bit Score: 66.48  E-value: 4.35e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 498437111   74 LTLDSLIEQGIVFSEKHRAFFKSELGDTFVFKVAFQNWLKENAGKTYREAIA 125
Cdd:pfam20026   8 ITRDTPITDSYKNTQNVRRFFKSQCGEAFKFDRDFMAWIKSGTGKTMGDAAD 59
SAP_new25 pfam18953
SAP domain-containing new25; This family includes Schizosaccharomyces specific SAP domain ...
 15-62 3.86e-14

SAP domain-containing new25; This family includes Schizosaccharomyces specific SAP domain containing proteins such as gene product new25. SAP ( SAF-A/B, Acinus and PIAS) motif is a DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins. For instance, the SAP domain of SUMO E3 ligase PIAS1 from human is shown to bind an A/T-rich DNA.


Pssm-ID: 465931  Cd Length: 51  Bit Score: 63.68  E-value: 3.86e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 498437111   15 EVFSEYYYLKVELQDFCQEQGLAKPGSKADLNQRITHYLRTGERLASK 62
Cdd:pfam18953   1 EEFKKYYWLKEELVAFCRELGLPTSGSKAELTERIAAYLDGGEIKKPK 48
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
23-53 2.77e-05

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 39.78  E-value: 2.77e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 498437111    23 LKV-ELQDFCQEQGLAKPGSKADLNQRITHYL 53
Cdd:smart00513   4 LKVsELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 23-53 5.53e-03

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 33.14  E-value: 5.53e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 498437111   23 LKV-ELQDFCQEQGLAKPGSKADLNQRITHYL 53
Cdd:pfam02037   4 LTVaELKEELRKRGLPTSGKKAELIERLQEYL 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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