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NADP-dependent malic enzyme [Glaesserella parasuis]
Protein Classification
NADP-dependent malic enzyme ( domain architecture ID 11482649 )
NADP-dependent malic enzyme catalyzes the conversion of (S)-malate to pyruvate and carbon dioxide using NADP as a cofactor
List of domain hits
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
5-755
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1435.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 5 S QL R QAALD F H E FP I PGKIEVTPTK S LATQRDL A LAYSPGVA E PCLEI E KDPA A AY R YT SK GNLVAVISNGTAVLGLGNI 84
Cdd:PRK07232 1 E QL K QAALD Y H R FP R PGKIEVTPTK P LATQRDL S LAYSPGVA A PCLEI A KDPA D AY K YT AR GNLVAVISNGTAVLGLGNI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 85 GALA G KPVMEGKGVLFKKFAGIDVFDIE IN E K DP E K LV E II A S LEPTFGGINLEDIKAPECFYIE Q KLRER LN IPVFHDD 164
Cdd:PRK07232 81 GALA S KPVMEGKGVLFKKFAGIDVFDIE VD E E DP D K FI E AV A A LEPTFGGINLEDIKAPECFYIE E KLRER MD IPVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 QHGTAIISAAA VI NAL RI V D KKIE E V RL V A SGAGAA S IACLNLLV S LG M K R ENI V VCDSKGVIYK D R DDR MD DT K KH YA I 244
Cdd:PRK07232 161 QHGTAIISAAA LL NAL EL V G KKIE D V KI V V SGAGAA A IACLNLLV A LG A K K ENI I VCDSKGVIYK G R TEG MD EW K AA YA V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 245 D d NGW RTL GD A MPN AD I FLG C SAAG A LT QD MV RT MA AH PII L ALANP N PEITP P EAKA A RPDAI VC TGRSDYPNQVNNVL 324
Cdd:PRK07232 241 D - TDA RTL AE A IEG AD V FLG L SAAG V LT PE MV KS MA DN PII F ALANP D PEITP E EAKA V RPDAI IA TGRSDYPNQVNNVL 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 325 CFP F IFRGALDVGATTINEEMK R AAV Y AIA D LA LA E QNEV V TS AYGG EGTT FG AD YIIP R PFDPRLIV R IAPAVAKAAM E 404
Cdd:PRK07232 320 CFP Y IFRGALDVGATTINEEMK L AAV R AIA E LA RE E VSDE V AA AYGG QKLS FG PE YIIP K PFDPRLIV K IAPAVAKAAM D 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 405 SGVATRPI T D WE AY H EKL TQ FVYKT N L F MKPIF SQ AK AEK KR I V L AEGEE DK VL H A T QEVV SM GLA Y P V LIGR T E I I K A K 484
Cdd:PRK07232 400 SGVATRPI A D MD AY R EKL EA FVYKT G L V MKPIF AK AK KDP KR V V F AEGEE ER VL R A A QEVV DE GLA K P I LIGR P E V I E A R 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 485 IKKLGL HIV AG Q DF DVIDN E HNSQHD E L W KR YY SIMK RKG I T EAI A K R V V TSNT TVI ASLL V EM G Y AD GLV CGL F G T Y SR 564
Cdd:PRK07232 480 IKKLGL DLK AG V DF EIVNP E DDPRYE E Y W QY YY ELLQ RKG V T PED A R R L V RRDR TVI GAMM V AR G D AD AMI CGL T G R Y HE 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 565 HL EAI R DI IG VKES V KVP AA L N S L V L PT GN V FI T DTYVN A DPTAEELAEI T LMAA R E I RRFGIEP A VALLSHSNFGSS NM 644
Cdd:PRK07232 560 HL RPV R QV IG LRPG V HTA AA M N A L L L KG GN L FI A DTYVN E DPTAEELAEI A LMAA E E V RRFGIEP R VALLSHSNFGSS DS 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 645 LG A P KMR KVL E IV RER D P A L MI DGEMHGD L AL S E KL R R D YM P D S P LKG S AN L L I MPN M EAA R ISYNLL RATTTAI T V GPI 724
Cdd:PRK07232 640 PS A R KMR EAV E LL RER A P D L EV DGEMHGD A AL N E EI R K D LY P F S R LKG P AN V L V MPN L EAA N ISYNLL KELGGGV T I GPI 719
730 740 750
....*....|....*....|....*....|.
gi 498484236 725 LLGM N K SA HIL N P VSS VRRI I NM V A F A A V K A 755
Cdd:PRK07232 720 LLGM A K PV HIL T P SAT VRRI V NM T A L A V V D A 750
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
5-755
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1435.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 5 S QL R QAALD F H E FP I PGKIEVTPTK S LATQRDL A LAYSPGVA E PCLEI E KDPA A AY R YT SK GNLVAVISNGTAVLGLGNI 84
Cdd:PRK07232 1 E QL K QAALD Y H R FP R PGKIEVTPTK P LATQRDL S LAYSPGVA A PCLEI A KDPA D AY K YT AR GNLVAVISNGTAVLGLGNI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 85 GALA G KPVMEGKGVLFKKFAGIDVFDIE IN E K DP E K LV E II A S LEPTFGGINLEDIKAPECFYIE Q KLRER LN IPVFHDD 164
Cdd:PRK07232 81 GALA S KPVMEGKGVLFKKFAGIDVFDIE VD E E DP D K FI E AV A A LEPTFGGINLEDIKAPECFYIE E KLRER MD IPVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 QHGTAIISAAA VI NAL RI V D KKIE E V RL V A SGAGAA S IACLNLLV S LG M K R ENI V VCDSKGVIYK D R DDR MD DT K KH YA I 244
Cdd:PRK07232 161 QHGTAIISAAA LL NAL EL V G KKIE D V KI V V SGAGAA A IACLNLLV A LG A K K ENI I VCDSKGVIYK G R TEG MD EW K AA YA V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 245 D d NGW RTL GD A MPN AD I FLG C SAAG A LT QD MV RT MA AH PII L ALANP N PEITP P EAKA A RPDAI VC TGRSDYPNQVNNVL 324
Cdd:PRK07232 241 D - TDA RTL AE A IEG AD V FLG L SAAG V LT PE MV KS MA DN PII F ALANP D PEITP E EAKA V RPDAI IA TGRSDYPNQVNNVL 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 325 CFP F IFRGALDVGATTINEEMK R AAV Y AIA D LA LA E QNEV V TS AYGG EGTT FG AD YIIP R PFDPRLIV R IAPAVAKAAM E 404
Cdd:PRK07232 320 CFP Y IFRGALDVGATTINEEMK L AAV R AIA E LA RE E VSDE V AA AYGG QKLS FG PE YIIP K PFDPRLIV K IAPAVAKAAM D 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 405 SGVATRPI T D WE AY H EKL TQ FVYKT N L F MKPIF SQ AK AEK KR I V L AEGEE DK VL H A T QEVV SM GLA Y P V LIGR T E I I K A K 484
Cdd:PRK07232 400 SGVATRPI A D MD AY R EKL EA FVYKT G L V MKPIF AK AK KDP KR V V F AEGEE ER VL R A A QEVV DE GLA K P I LIGR P E V I E A R 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 485 IKKLGL HIV AG Q DF DVIDN E HNSQHD E L W KR YY SIMK RKG I T EAI A K R V V TSNT TVI ASLL V EM G Y AD GLV CGL F G T Y SR 564
Cdd:PRK07232 480 IKKLGL DLK AG V DF EIVNP E DDPRYE E Y W QY YY ELLQ RKG V T PED A R R L V RRDR TVI GAMM V AR G D AD AMI CGL T G R Y HE 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 565 HL EAI R DI IG VKES V KVP AA L N S L V L PT GN V FI T DTYVN A DPTAEELAEI T LMAA R E I RRFGIEP A VALLSHSNFGSS NM 644
Cdd:PRK07232 560 HL RPV R QV IG LRPG V HTA AA M N A L L L KG GN L FI A DTYVN E DPTAEELAEI A LMAA E E V RRFGIEP R VALLSHSNFGSS DS 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 645 LG A P KMR KVL E IV RER D P A L MI DGEMHGD L AL S E KL R R D YM P D S P LKG S AN L L I MPN M EAA R ISYNLL RATTTAI T V GPI 724
Cdd:PRK07232 640 PS A R KMR EAV E LL RER A P D L EV DGEMHGD A AL N E EI R K D LY P F S R LKG P AN V L V MPN L EAA N ISYNLL KELGGGV T I GPI 719
730 740 750
....*....|....*....|....*....|.
gi 498484236 725 LLGM N K SA HIL N P VSS VRRI I NM V A F A A V K A 755
Cdd:PRK07232 720 LLGM A K PV HIL T P SAT VRRI V NM T A L A V V D A 750
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
1-426
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 704.08
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 1 M DDKSQ L R Q A AL DF H EFPIP GKI E V T PT KS L A TQ R DL A LAY S PGVAE P CLEI EK DP AA AY R YT S KGNLVAV ISN GTAVLG 80
Cdd:COG0281 3 M ERVET L E Q E AL EY H RIYDR GKI L V Y PT VP L H TQ E DL S LAY T PGVAE A CLEI AE DP RL AY G YT A KGNLVAV VTD GTAVLG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 81 LG N IG A LAG K PVMEGK G VLFK K FAGID V F D I EINEK DP EKL VE IIAS LEPTFGGINLEDIKAP E CF Y IE QK LRE R L N IPV 160
Cdd:COG0281 83 LG D IG P LAG M PVMEGK A VLFK A FAGID A F P I CLDTN DP DEF VE AVKA LEPTFGGINLEDIKAP N CF E IE ER LRE E L D IPV 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 161 FHDDQHGTAI ISA AA VI NAL RI V D KK I E EVRL V AS GAGAA S IA CLN LLV SL G MKR ENI VVC DSKG VI Y KD R D D r MDDT K K 240
Cdd:COG0281 163 FHDDQHGTAI VVL AA LL NAL KL V G KK L E DQKI V IN GAGAA G IA IAR LLV AA G LSE ENI IMV DSKG LL Y EG R T D - LNPY K R 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 241 HY A I D D N GWR --- TL GD A MPN AD I F L G C SA A GA L T QD MV RT MA AH PII L ALANP N PEITP PE AKA ARPD AIV C TGRSDYP 317
Cdd:COG0281 242 EF A R D T N PRG lkg TL AE A IKG AD V F I G V SA P GA F T EE MV KS MA KR PII F ALANP T PEITP ED AKA WGDG AIV A TGRSDYP 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 318 NQVNNVL C FP F IFRGALDV G AT T I NE EMK R AA VY A I ADL ALA E Q nevvtsayggegtt F G A DYIIP R PFDPR LIVRI A P A 397
Cdd:COG0281 322 NQVNNVL I FP G IFRGALDV R AT R I TD EMK L AA AR A L ADL VDE E E -------------- L G P DYIIP S PFDPR VSPAV A A A 387
410 420
....*....|....*....|....*....
gi 498484236 398 VAKAA M ESGVA T RPI TD we A Y H E K L TQFV 426
Cdd:COG0281 388 VAKAA I ESGVA R RPI DE -- D Y R E A L EARM 414
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
432-752
1.10e-121
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 367.41
E-value: 1.10e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 432 F MKP IF SQ AK AE KKRIV LA EGE EDK VL H A T Q EVVSM G L A Y P V LIG RTEI IKAK IKK L G L HIVA gqd FDVI D N E HNSQHD E 511
Cdd:pfam01515 1 F LER IF ER AK KA KKRIV FP EGE DER VL K A A Q KLLQQ G I A D P I LIG DEIE IKAK ALG L D L DLDG --- IEIV D P E TSPRLE E 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 512 LWKR YY SIM KRKG I T EA IA KRV V T s NTTVI A SL LV EM G Y ADG L V C G LFG T YSRH L EAIRD IIG V K ES VK VPAALNSLV LP 591
Cdd:pfam01515 78 YADF YY ELR KRKG M T PE IA REI V R - DPNYF A AM LV KL G E ADG M V S G AVN T TADT L RPALQ IIG T K PG VK TVSSVFIML LP 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 592 T G NV F IT D TY VN AD PTAEELAEI T LM A A REIR RFG - IEP A VALLS H S N FGS SNMLGAP K M R KVLE IVRER D P A L MI DGE M 670
Cdd:pfam01515 157 D G LL F FA D CA VN PN PTAEELAEI A LM S A KTAK RFG i IEP R VALLS Y S T FGS GKGEDVE K V R EATK IVRER A P D L VV DGE L 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 671 HG D L AL S E KLRRDYM PDSP LK G S AN LLIM P NM EA AR I S Y NLLRATTT A ITV GPIL L G MN K SAHI L NPVS SV RR I I N MV A F 750
Cdd:pfam01515 237 QF D A AL V E EVAAQKA PDSP VA G K AN VFVF P DL EA GN I G Y KIAQRLGG A EAI GPIL Q G LA K PVND L SRGA SV ED I V N TA A I 316
..
gi 498484236 751 A A 752
Cdd:pfam01515 317 T A 318
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
165-403
3.11e-111
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 337.08
E-value: 3.11e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 Q H GTAI ISA A AVI NAL R I VD KK I E EV R L V AS GAGAA S I ACLN LLV SL G M KR E NI VVC DSKG VIY K D R D D RMDDT KK HY A I 244
Cdd:smart00919 1 Q Q GTAI VVL A GLL NAL K I TG KK L E DQ R I V VN GAGAA G I GIAK LLV AA G V KR K NI WLV DSKG LLT K G R E D NLNPY KK PF A R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 245 DD N GWR -- TL GD A MPN AD IFL G C S A - A GA L T QD MV RT MA AH PII L AL A NP N PEI T P PE A K A A R P - D AIV C TGRSDYPNQV 320
Cdd:smart00919 81 KT N ERE tg TL EE A VKG AD VLI G V S G p G GA F T EE MV KS MA ER PII F AL S NP T PEI E P TA A D A Y R W t A AIV A TGRSDYPNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 321 NNVL C FP F IF R GALDV G A TT I NE EMK R AA VY A I AD LALAEQN E vvtsayggegtt F G AD YIIP R PFD P R LIV R I A P AVAK 400
Cdd:smart00919 161 NNVL I FP G IF L GALDV R A RR I TD EMK L AA AE A L AD AVPVSEE E ------------ L G PG YIIP S PFD R R VSA R V A V AVAK 228
...
gi 498484236 401 AA M 403
Cdd:smart00919 229 AA I 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
165-402
1.30e-102
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 314.59
E-value: 1.30e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 QHGTAI ISA A AVI NAL RI V D KKIEEV RL V AS GAGAA S IA CLN LL VSL G M K R ENIVV C DSKGVIY KD R D D ---- RMDDTK K 240
Cdd:cd05311 1 QHGTAI VTL A GLL NAL KL V G KKIEEV KI V IN GAGAA G IA IAR LL LAA G A K P ENIVV V DSKGVIY EG R E D dlnp DKNEIA K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 241 HYAIDDN G w R TL GD A MPN AD I F L G C S AA G ALTQD M VRT MA AH PI IL ALANP N PEI T P P EAK A A RP D a IV C TGRSD Y PNQV 320
Cdd:cd05311 81 ETNPEKT G - G TL KE A LKG AD V F I G V S RP G VVKKE M IKK MA KD PI VF ALANP V PEI W P E EAK E A GA D - IV A TGRSD F PNQV 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 321 NNVL C FP F IFRGALDV G AT T I N EEMK R AA VY AIADLA laeqnevvtsaygg E GTTF G AD YIIP R PFDPR LIV R I A P AVAK 400
Cdd:cd05311 159 NNVL G FP G IFRGALDV R AT K I T EEMK L AA AE AIADLA -------------- E EEVL G EE YIIP T PFDPR VVP R V A T AVAK 224
..
gi 498484236 401 AA 402
Cdd:cd05311 225 AA 226
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
5-755
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1435.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 5 S QL R QAALD F H E FP I PGKIEVTPTK S LATQRDL A LAYSPGVA E PCLEI E KDPA A AY R YT SK GNLVAVISNGTAVLGLGNI 84
Cdd:PRK07232 1 E QL K QAALD Y H R FP R PGKIEVTPTK P LATQRDL S LAYSPGVA A PCLEI A KDPA D AY K YT AR GNLVAVISNGTAVLGLGNI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 85 GALA G KPVMEGKGVLFKKFAGIDVFDIE IN E K DP E K LV E II A S LEPTFGGINLEDIKAPECFYIE Q KLRER LN IPVFHDD 164
Cdd:PRK07232 81 GALA S KPVMEGKGVLFKKFAGIDVFDIE VD E E DP D K FI E AV A A LEPTFGGINLEDIKAPECFYIE E KLRER MD IPVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 QHGTAIISAAA VI NAL RI V D KKIE E V RL V A SGAGAA S IACLNLLV S LG M K R ENI V VCDSKGVIYK D R DDR MD DT K KH YA I 244
Cdd:PRK07232 161 QHGTAIISAAA LL NAL EL V G KKIE D V KI V V SGAGAA A IACLNLLV A LG A K K ENI I VCDSKGVIYK G R TEG MD EW K AA YA V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 245 D d NGW RTL GD A MPN AD I FLG C SAAG A LT QD MV RT MA AH PII L ALANP N PEITP P EAKA A RPDAI VC TGRSDYPNQVNNVL 324
Cdd:PRK07232 241 D - TDA RTL AE A IEG AD V FLG L SAAG V LT PE MV KS MA DN PII F ALANP D PEITP E EAKA V RPDAI IA TGRSDYPNQVNNVL 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 325 CFP F IFRGALDVGATTINEEMK R AAV Y AIA D LA LA E QNEV V TS AYGG EGTT FG AD YIIP R PFDPRLIV R IAPAVAKAAM E 404
Cdd:PRK07232 320 CFP Y IFRGALDVGATTINEEMK L AAV R AIA E LA RE E VSDE V AA AYGG QKLS FG PE YIIP K PFDPRLIV K IAPAVAKAAM D 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 405 SGVATRPI T D WE AY H EKL TQ FVYKT N L F MKPIF SQ AK AEK KR I V L AEGEE DK VL H A T QEVV SM GLA Y P V LIGR T E I I K A K 484
Cdd:PRK07232 400 SGVATRPI A D MD AY R EKL EA FVYKT G L V MKPIF AK AK KDP KR V V F AEGEE ER VL R A A QEVV DE GLA K P I LIGR P E V I E A R 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 485 IKKLGL HIV AG Q DF DVIDN E HNSQHD E L W KR YY SIMK RKG I T EAI A K R V V TSNT TVI ASLL V EM G Y AD GLV CGL F G T Y SR 564
Cdd:PRK07232 480 IKKLGL DLK AG V DF EIVNP E DDPRYE E Y W QY YY ELLQ RKG V T PED A R R L V RRDR TVI GAMM V AR G D AD AMI CGL T G R Y HE 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 565 HL EAI R DI IG VKES V KVP AA L N S L V L PT GN V FI T DTYVN A DPTAEELAEI T LMAA R E I RRFGIEP A VALLSHSNFGSS NM 644
Cdd:PRK07232 560 HL RPV R QV IG LRPG V HTA AA M N A L L L KG GN L FI A DTYVN E DPTAEELAEI A LMAA E E V RRFGIEP R VALLSHSNFGSS DS 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 645 LG A P KMR KVL E IV RER D P A L MI DGEMHGD L AL S E KL R R D YM P D S P LKG S AN L L I MPN M EAA R ISYNLL RATTTAI T V GPI 724
Cdd:PRK07232 640 PS A R KMR EAV E LL RER A P D L EV DGEMHGD A AL N E EI R K D LY P F S R LKG P AN V L V MPN L EAA N ISYNLL KELGGGV T I GPI 719
730 740 750
....*....|....*....|....*....|.
gi 498484236 725 LLGM N K SA HIL N P VSS VRRI I NM V A F A A V K A 755
Cdd:PRK07232 720 LLGM A K PV HIL T P SAT VRRI V NM T A L A V V D A 750
PRK12862
PRK12862 malic enzyme; Reviewed
1-755
0e+00
malic enzyme; Reviewed
Pssm-ID: 183799 [Multi-domain]
Cd Length: 763
Bit Score: 1317.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 1 MDD K SQ LR Q AALD F H E FP I PGKIE VT PTK S LA T QRDLALAYSPGVA E PCLEI EK DPA A A Y RYTS K GNLVAV I SNGTAVLG 80
Cdd:PRK12862 5 ASA K AE LR E AALD Y H R FP T PGKIE IA PTK P LA N QRDLALAYSPGVA A PCLEI AA DPA N A A RYTS R GNLVAV V SNGTAVLG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 81 LGNIG A LA G KPVMEGK G VLFKKFAGIDVFDIE IN E K DP E KLVEI I A S LEPTFGGINLEDIKAPECFYIE QK LRER LN IPV 160
Cdd:PRK12862 85 LGNIG P LA S KPVMEGK A VLFKKFAGIDVFDIE LD E S DP D KLVEI V A A LEPTFGGINLEDIKAPECFYIE RE LRER MK IPV 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 161 FHDDQHGTAII S AAA VI N A L RI V D K K IE E V R LVASGAGAA SI ACL N LLVSLG M KRENI V V C D S KGV I Y KD R DDR MD DT K K 240
Cdd:PRK12862 165 FHDDQHGTAII V AAA LL N G L KL V G K D IE D V K LVASGAGAA AL ACL D LLVSLG V KRENI W V T D I KGV V Y EG R TEL MD PW K A 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 241 H YA IDDNG w RTL GDAMPN AD I FLG C SAAG A L TQD MV RT MA AH P I I L ALANP N PEI T P P EA K A A RPDAI VC TGRSDYPNQV 320
Cdd:PRK12862 245 R YA QKTDA - RTL AEVIEG AD V FLG L SAAG V L KPE MV KK MA PR P L I F ALANP T PEI L P E EA R A V RPDAI IA TGRSDYPNQV 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 321 NNVLCFP F IFRGALDVGATTINEEMK R AAV Y AIA D LA LA EQ NE VV TS AYGGE GTT FG A DY I IP R PFDPRLI VR IAPAVA K 400
Cdd:PRK12862 324 NNVLCFP Y IFRGALDVGATTINEEMK I AAV R AIA E LA RE EQ SD VV AA AYGGE DLS FG P DY L IP K PFDPRLI LK IAPAVA Q 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 401 AAM E SGVATRPI T D WE AY H E K L T QFVY KTN L F MKP I F SQ AKA EK KR I V L AEGE EDK VL H A T Q E VV SM GLA Y P V LIGR TEI 480
Cdd:PRK12862 404 AAM D SGVATRPI E D MD AY R E Q L N QFVY HSG L I MKP V F AA AKA AP KR V V F AEGE DER VL R A A Q V VV DE GLA K P I LIGR PAV 483
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 481 I K A K I KKL GL HIVA G Q DF DVIDN E HNSQHDEL W KR Y YSI M K RKG I T EAI A K R V V TSN TT V I ASLL V EM G Y AD GLV CG LF G 560
Cdd:PRK12862 484 I E A R I ERA GL RLRP G V DF EIVNP E DDPRYRDY W DT Y HAL M G RKG V T PEM A R R E V RRR TT L I GAMM V KR G E AD AMI CG TE G 563
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 561 T Y S RHLE AIRDI IG VKES V K V P AA LNS L V LP TGNV F IT DT Y VN A DPTAEELAEIT LM AA R E I RRFGIEP A VALLSHSNFG 640
Cdd:PRK12862 564 R Y E RHLE FVLQV IG KRPG V R V Y AA MSL L I LP GRTL F LA DT H VN E DPTAEELAEIT IL AA E E V RRFGIEP K VALLSHSNFG 643
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 641 SS NMLG A P KMR KV LEI V RER D P A L MI DGEMHGD L AL S E K LR RDYM PDS P L K G S ANLL IM PN ME AA R I S YNLL RATTT - AI 719
Cdd:PRK12862 644 SS DSPS A R KMR EA LEI L RER A P D L EV DGEMHGD A AL D E E LR DRIF PDS R L E G E ANLL VF PN LD AA N I A YNLL KTAAG n GL 723
730 740 750
....*....|....*....|....*....|....*.
gi 498484236 720 T VGPILLG MN K SA HIL N P VSS VRRI I NM V A F A AVK A 755
Cdd:PRK12862 724 A VGPILLG AA K PV HIL T P SAT VRRI V NM T A L A VAD A 759
PRK12861
PRK12861 malic enzyme; Reviewed
1-755
0e+00
malic enzyme; Reviewed
Pssm-ID: 183798 [Multi-domain]
Cd Length: 764
Bit Score: 996.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 1 M DDKSQL RQAALD F HEFP I PGKI E V TPT K S L A TQRDLALAY S PGVA EP C L EI EK DP AA A Y R Y TS K GNLV A VI S NGTAVLG 80
Cdd:PRK12861 1 M KQTETQ RQAALD Y HEFP T PGKI S V VAS K P L V TQRDLALAY T PGVA SA C E EI AA DP LN A F R F TS R GNLV G VI T NGTAVLG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 81 LGNIGALA G KPVMEGK G VLFKKFAGIDVFDIEINE K DP E KLV E IIA S LEPTFGGINLEDIKAPECF YI E Q KLRER LN IPV 160
Cdd:PRK12861 81 LGNIGALA S KPVMEGK A VLFKKFAGIDVFDIEINE T DP D KLV D IIA G LEPTFGGINLEDIKAPECF TV E R KLRER MK IPV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 161 FHDDQHGTAI ISA AA V IN A L RI V D K K I E EV RL V A SGAGAA SI ACL N LLV S LG MKR ENI V V C D SK GV I Y KD R DDR MD DT K K 240
Cdd:PRK12861 161 FHDDQHGTAI TVS AA F IN G L KV V G K S I K EV KV V T SGAGAA AL ACL D LLV D LG LPV ENI W V T D IE GV V Y RG R TTL MD PD K E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 241 HY A IDDNG w RTL GDAMPN AD I FLG C SA A G A L TQD M VRT MAA H P I ILALANP N PEI T P PE A K A A R P D AIVC TGRSDYPNQV 320
Cdd:PRK12861 241 RF A QETDA - RTL AEVIGG AD V FLG L SA G G V L KAE M LKA MAA R P L ILALANP T PEI F P EL A H A T R D D VVIA TGRSDYPNQV 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 321 NNVLCFP F IFRGALDVGATTI NE EM KR AAV Y AIA D LA LA EQN E VV TS AYG GEGTT FG AD Y I IP R PFDPRLIVRIAPAVAK 400
Cdd:PRK12861 320 NNVLCFP Y IFRGALDVGATTI TR EM EI AAV H AIA G LA EE EQN D VV AA AYG AYDVS FG PQ Y L IP K PFDPRLIVRIAPAVAK 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 401 AAME S GVATRPI T D WE AY H E K L T QFVY KTNL FMKP I F SQ A K ----- AE K K RIV LA EGE EDK VL H A T Q EV V SMG LA Y P V L I 475
Cdd:PRK12861 400 AAME G GVATRPI A D LD AY V E Q L Q QFVY HSGA FMKP L F AA A R qlvrd GG K A RIV FT EGE DER VL R A V Q VI V DEK LA R P I L V 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 476 GR T E IIK A K I KKL GL HIVA GQD FD V IDN E HNSQHDEL W KR Y YSIMK R K GI TEAI A KRVVTSNT T V I ASLL V EM G Y ADG LV 555
Cdd:PRK12861 480 GR P E VLL A R I ERF GL RLRL GQD VE V TNP E YDERFPQY W TT Y WELRC R D GI SKEM A RVEMRRRL T L I GAMM V RL G D ADG MI 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 556 CG LF G T Y SR HL EAIRDI IG V K ESVKVP AA L N S L V L PTGN V FIT DT Y VN AD P T AE EL AE I T LM AAR EIRRFGIE P A VALLS 635
Cdd:PRK12861 560 CG TV G E Y HN HL RFVDEV IG R K PGASTY AA M N I L L L DQRT V ALV DT H VN DN P D AE QI AE F T IA AAR QMEWLNLT P K VALLS 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 636 H SNFGS SNMLGAP KMR KV LEIVRE RD P A L MI DGEMHGD L AL S E K LR RDYM P D SPLKG S ANLL IM PN ME A AR I S YNLL R - A 714
Cdd:PRK12861 640 R SNFGS GSAASGV KMR RA LEIVRE QA P D L EA DGEMHGD C AL D E G LR ARLL P M SPLKG A ANLL VC PN VD A GN I A YNLL K t E 719
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 498484236 715 TTTAIT VGP I LLG M N KSAH IL NPVSS VRRI I NM V A FAAVK A 755
Cdd:PRK12861 720 AGSNVA VGP F LLG V N APVN IL TSSAT VRRI V NM A A LTVIE A 760
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
1-426
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 704.08
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 1 M DDKSQ L R Q A AL DF H EFPIP GKI E V T PT KS L A TQ R DL A LAY S PGVAE P CLEI EK DP AA AY R YT S KGNLVAV ISN GTAVLG 80
Cdd:COG0281 3 M ERVET L E Q E AL EY H RIYDR GKI L V Y PT VP L H TQ E DL S LAY T PGVAE A CLEI AE DP RL AY G YT A KGNLVAV VTD GTAVLG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 81 LG N IG A LAG K PVMEGK G VLFK K FAGID V F D I EINEK DP EKL VE IIAS LEPTFGGINLEDIKAP E CF Y IE QK LRE R L N IPV 160
Cdd:COG0281 83 LG D IG P LAG M PVMEGK A VLFK A FAGID A F P I CLDTN DP DEF VE AVKA LEPTFGGINLEDIKAP N CF E IE ER LRE E L D IPV 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 161 FHDDQHGTAI ISA AA VI NAL RI V D KK I E EVRL V AS GAGAA S IA CLN LLV SL G MKR ENI VVC DSKG VI Y KD R D D r MDDT K K 240
Cdd:COG0281 163 FHDDQHGTAI VVL AA LL NAL KL V G KK L E DQKI V IN GAGAA G IA IAR LLV AA G LSE ENI IMV DSKG LL Y EG R T D - LNPY K R 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 241 HY A I D D N GWR --- TL GD A MPN AD I F L G C SA A GA L T QD MV RT MA AH PII L ALANP N PEITP PE AKA ARPD AIV C TGRSDYP 317
Cdd:COG0281 242 EF A R D T N PRG lkg TL AE A IKG AD V F I G V SA P GA F T EE MV KS MA KR PII F ALANP T PEITP ED AKA WGDG AIV A TGRSDYP 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 318 NQVNNVL C FP F IFRGALDV G AT T I NE EMK R AA VY A I ADL ALA E Q nevvtsayggegtt F G A DYIIP R PFDPR LIVRI A P A 397
Cdd:COG0281 322 NQVNNVL I FP G IFRGALDV R AT R I TD EMK L AA AR A L ADL VDE E E -------------- L G P DYIIP S PFDPR VSPAV A A A 387
410 420
....*....|....*....|....*....
gi 498484236 398 VAKAA M ESGVA T RPI TD we A Y H E K L TQFV 426
Cdd:COG0281 388 VAKAA I ESGVA R RPI DE -- D Y R E A L EARM 414
Pta
COG0280 Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production ...
432-753
1.08e-135
Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production and conversion];
Pssm-ID: 440049 [Multi-domain]
Cd Length: 320
Bit Score: 403.29
E-value: 1.08e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 432 F MK P IFSQ AKA EK KRIV L AEGE EDK VL H A T QE VVSM GLA Y P V L I GR T E I I K A KIKK LGL HI vag QD F DV ID N E HNSQHD E 511
Cdd:COG0280 2 F FR P LIER AKA AP KRIV F AEGE DER VL R A A QE ALDE GLA E P I L V GR P E K I E A RAEE LGL DL --- SG F EI ID P E DSPRYE E 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 512 LWKR YY SIM KRKG I T EAI A KRV V T s NTTVI A SLL V EM G Y ADGLV C G LF GT YSRH L EAIRD IIG VKES VK VPAALNSLV LP 591
Cdd:COG0280 79 YAEA YY ELR KRKG V T PEE A REL V R - DAAYF A AMM V RL G E ADGLV K G AV GT TADL L RPVLQ IIG LRPG VK RVSHVFLME LP 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 592 TGNV FITDT Y VN A DPTAE E LA E I TLM AA REI R R FGIEP A VALLS H S N FGS SNMLGAP K M R KVLEIV R ERD P A L MI DGE MH 671
Cdd:COG0280 158 DRLL FITDT A VN I DPTAE Q LA D I AIN AA DTA R A FGIEP K VALLS A S E FGS PKGPSTD K V R EATKMA R GQI P D L EV DGE LQ 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 672 G D L ALS EKLRRDYM PDSP LK G S AN L L IM P NM EA AR I S Y N LL RATTT A ITV GPILLG MN K SA H I L NPVS SVR R I I N MV A F A 751
Cdd:COG0280 238 F D A ALS PEAAKRKG PDSP VA G D AN V L VF P DL EA GN I L Y K LL QRLAG A EAI GPILLG LA K PV H L L SRGD SVR D I V N SI A L A 317
..
gi 498484236 752 AV 753
Cdd:COG0280 318 AV 319
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
432-752
1.10e-121
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 367.41
E-value: 1.10e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 432 F MKP IF SQ AK AE KKRIV LA EGE EDK VL H A T Q EVVSM G L A Y P V LIG RTEI IKAK IKK L G L HIVA gqd FDVI D N E HNSQHD E 511
Cdd:pfam01515 1 F LER IF ER AK KA KKRIV FP EGE DER VL K A A Q KLLQQ G I A D P I LIG DEIE IKAK ALG L D L DLDG --- IEIV D P E TSPRLE E 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 512 LWKR YY SIM KRKG I T EA IA KRV V T s NTTVI A SL LV EM G Y ADG L V C G LFG T YSRH L EAIRD IIG V K ES VK VPAALNSLV LP 591
Cdd:pfam01515 78 YADF YY ELR KRKG M T PE IA REI V R - DPNYF A AM LV KL G E ADG M V S G AVN T TADT L RPALQ IIG T K PG VK TVSSVFIML LP 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 592 T G NV F IT D TY VN AD PTAEELAEI T LM A A REIR RFG - IEP A VALLS H S N FGS SNMLGAP K M R KVLE IVRER D P A L MI DGE M 670
Cdd:pfam01515 157 D G LL F FA D CA VN PN PTAEELAEI A LM S A KTAK RFG i IEP R VALLS Y S T FGS GKGEDVE K V R EATK IVRER A P D L VV DGE L 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 671 HG D L AL S E KLRRDYM PDSP LK G S AN LLIM P NM EA AR I S Y NLLRATTT A ITV GPIL L G MN K SAHI L NPVS SV RR I I N MV A F 750
Cdd:pfam01515 237 QF D A AL V E EVAAQKA PDSP VA G K AN VFVF P DL EA GN I G Y KIAQRLGG A EAI GPIL Q G LA K PVND L SRGA SV ED I V N TA A I 316
..
gi 498484236 751 A A 752
Cdd:pfam01515 317 T A 318
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
165-403
3.11e-111
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 337.08
E-value: 3.11e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 Q H GTAI ISA A AVI NAL R I VD KK I E EV R L V AS GAGAA S I ACLN LLV SL G M KR E NI VVC DSKG VIY K D R D D RMDDT KK HY A I 244
Cdd:smart00919 1 Q Q GTAI VVL A GLL NAL K I TG KK L E DQ R I V VN GAGAA G I GIAK LLV AA G V KR K NI WLV DSKG LLT K G R E D NLNPY KK PF A R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 245 DD N GWR -- TL GD A MPN AD IFL G C S A - A GA L T QD MV RT MA AH PII L AL A NP N PEI T P PE A K A A R P - D AIV C TGRSDYPNQV 320
Cdd:smart00919 81 KT N ERE tg TL EE A VKG AD VLI G V S G p G GA F T EE MV KS MA ER PII F AL S NP T PEI E P TA A D A Y R W t A AIV A TGRSDYPNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 321 NNVL C FP F IF R GALDV G A TT I NE EMK R AA VY A I AD LALAEQN E vvtsayggegtt F G AD YIIP R PFD P R LIV R I A P AVAK 400
Cdd:smart00919 161 NNVL I FP G IF L GALDV R A RR I TD EMK L AA AE A L AD AVPVSEE E ------------ L G PG YIIP S PFD R R VSA R V A V AVAK 228
...
gi 498484236 401 AA M 403
Cdd:smart00919 229 AA I 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
165-402
1.30e-102
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 314.59
E-value: 1.30e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 QHGTAI ISA A AVI NAL RI V D KKIEEV RL V AS GAGAA S IA CLN LL VSL G M K R ENIVV C DSKGVIY KD R D D ---- RMDDTK K 240
Cdd:cd05311 1 QHGTAI VTL A GLL NAL KL V G KKIEEV KI V IN GAGAA G IA IAR LL LAA G A K P ENIVV V DSKGVIY EG R E D dlnp DKNEIA K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 241 HYAIDDN G w R TL GD A MPN AD I F L G C S AA G ALTQD M VRT MA AH PI IL ALANP N PEI T P P EAK A A RP D a IV C TGRSD Y PNQV 320
Cdd:cd05311 81 ETNPEKT G - G TL KE A LKG AD V F I G V S RP G VVKKE M IKK MA KD PI VF ALANP V PEI W P E EAK E A GA D - IV A TGRSD F PNQV 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 321 NNVL C FP F IFRGALDV G AT T I N EEMK R AA VY AIADLA laeqnevvtsaygg E GTTF G AD YIIP R PFDPR LIV R I A P AVAK 400
Cdd:cd05311 159 NNVL G FP G IFRGALDV R AT K I T EEMK L AA AE AIADLA -------------- E EEVL G EE YIIP T PFDPR VVP R V A T AVAK 224
..
gi 498484236 401 AA 402
Cdd:cd05311 225 AA 226
eutD
PRK09653 phosphotransacetylase;
432-755
4.79e-61
phosphotransacetylase;
Pssm-ID: 236609 [Multi-domain]
Cd Length: 324
Bit Score: 208.16
E-value: 4.79e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 432 FMKPIFSQ AK AE KK R IVL A EGE EDK VL H A TQEVVSM GL AY P V L I G RT E I I K AK I K K LGL HI vag QDFDV ID N E HNSQHD E 511
Cdd:PRK09653 3 LFESLKEK AK GK KK K IVL P EGE DER VL K A AKRLQKE GL VE P I L L G NP E E I R AK A K E LGL DL --- DGVEI ID P E TYPLLE E 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 512 LWKRYYSIM K R KG IT E AI A KRVVTS N tt VIASL LV EM G Y ADG L V C G LFGTYSRH L EAIRD II GV K ES VK V paalnslvlp 591
Cdd:PRK09653 80 FAEAFVELR K G KG TE E DA A ELLKDP N -- YFGTM LV KL G K ADG M V S G AIHSTADT L RPALQ II KT K PG VK T ---------- 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 592 TGN VFI ---------- T D TY VN AD PTAE E LAEI TLMA A REIRR FGI E P A VA L LS H S NF GS SNMLGAP K MRKVL EI VR E RD 661
Cdd:PRK09653 148 VSS VFI mvkgderyif A D CA VN PN PTAE Q LAEI AINS A ETAKA FGI D P K VA M LS F S TK GS AKGPEVD K VQEAT EI AK E LA 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 662 P A L M IDGE MHG D L A LSEKLRRDYM P D SP LK G S AN LLIM P NM EA AR I S Y NLLRATTTAIT VGPIL L G M NK SAHI L NPVS SV 741
Cdd:PRK09653 228 P D L K IDGE LQF D A A FVPEVAAKKA P G SP VA G K AN VFVF P SL EA GN I G Y KIAQRLGGFEA VGPIL Q G L NK PVND L SRGC SV 307
330
....*....|....
gi 498484236 742 RR I I N MVAFA A VK A 755
Cdd:PRK09653 308 ED I Y N LALIT A AQ A 321
malic
pfam00390 Malic enzyme, N-terminal domain;
20-153
1.64e-43
Malic enzyme, N-terminal domain;
Pssm-ID: 395314 [Multi-domain]
Cd Length: 182
Bit Score: 155.11
E-value: 1.64e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 20 P GK I EV TPT K S L A T Q -- R DL ALA Y S P G V A E P C LE I EKDPAAAY - R YTS K GNL ---------------- V A V ISN G TAV LG 80
Cdd:pfam00390 1 Q GK N EV LFY K L L S T H ie E DL PIV Y T P T V G E A C QA I SEIYRRPR g L YTS I GNL gkikdilknwpeedvr V I V VTD G ERI LG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 81 LG NI G A l AG K P V MEGK GV L FKK FAGID --- V FD I EINEK --------------------------- DPEKL VE IIAS L E P 130
Cdd:pfam00390 81 LG DL G V - AG M P I MEGK LA L YTA FAGID psr V LP I VLDVG tnnekllndplylglrhkrvrgeeyde FVDEF VE AVKA L F P 159
170 180
....*....|....*....|...
gi 498484236 131 T FGGI NL ED IK AP EC F Y I EQKL R 153
Cdd:pfam00390 160 P FGGI QF ED FG AP NA F E I LERY R 182
PRK05632
PRK05632 phosphate acetyltransferase; Reviewed
439-755
3.22e-42
phosphate acetyltransferase; Reviewed
Pssm-ID: 235537 [Multi-domain]
Cd Length: 684
Bit Score: 163.79
E-value: 3.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 439 Q A K A E KKRIVL A EG E E DKV L H A TQEVVSM G L A YP VL I G RT E I I KAKIKKL G LHIV AG qd FDV ID NE hn SQHDELWKRYYS 518
Cdd:PRK05632 372 R A R A A KKRIVL P EG D E PRT L K A AAICLER G I A DC VL L G NP E E I RRVAAAQ G VDLP AG -- IEI ID PS -- EVRERYVAPLVE 447
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 519 IM K R KG I TE AI A KRVVT s NTTVIASLLVEM G YA DGLV C G lfgty SR H LE A -- IR --- DI I GVKESV kvpaaln SLV ---- 589
Cdd:PRK05632 448 LR K H KG M TE EV A REQLE - DNVYFGTMMLAL G EV DGLV S G ----- AV H TT A nt IR pal QL I KTAPGS ------- SLV ssvf 514
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 590 --- LP TGNVFIT D TY VN A DPTAE E LAEI TLMA A REIRR FGIEP A VA L LS H S N f G S S nml G A ---- P K M R KVLEIV RER D P 662
Cdd:PRK05632 515 fml LP DQVLVYG D CA VN P DPTAE Q LAEI AIQS A DSAAA FGIEP R VA M LS Y S T - G T S --- G S gadv E K V R EATRLA RER R P 590
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 663 A L M IDG EMHG D L A LSEKLR R DYM P D SP LK G S A NLL I M P NMEAARIS Y NLLRATTT A ITV GP I L L G MN K sahiln PV ---- 738
Cdd:PRK05632 591 D L L IDG PLQY D A A VDPSVA R SKA P N SP VA G R A TVF I F P DLNTGNTT Y KAVQRSAG A VSI GP M L Q G LR K ------ PV ndls 664
330
....*....|....*....
gi 498484236 739 -- SS V RR I I N MV A FA A VK A 755
Cdd:PRK05632 665 rg AL V DD I V N TI A IT A IQ A 683
NAD_bind_1_malic_enz
cd05312 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the ...
167-418
1.36e-32
NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists of eukaryotic and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133454
Cd Length: 279
Bit Score: 127.66
E-value: 1.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 167 GTA IISA A AVIN ALRI VD K KIEEV R LVAS GAG A A S I ACLN L L VS LGMK -------- R EN I VVC DSKG VIY KDR D D r MDDT 238
Cdd:cd05312 3 GTA AVAL A GLLA ALRI TG K PLSDQ R ILFL GAG S A G I GIAD L I VS AMVR eglseeea R KK I WLV DSKG LLT KDR K D - LTPF 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 239 KK HY A ID D NGW -- RT L GDAMPNA -- DIFL G C S AA - GA L T QDM VR T MA AH --- PII L AL A NP -- NP E I T PPE A - K AARPD A 307
Cdd:cd05312 82 KK PF A RK D EEK eg KS L LEVVKAV kp TVLI G L S GV g GA F T EEV VR A MA KS ner PII F AL S NP ts KA E C T AED A y K WTDGR A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 308 IVCT G ---------- RSDY P N Q V NN VLC FP F I FR GA LDV GA TT I NE EM KR AA VY A I A D L ALA E QNE vvtsaygg E G TTF g 377
Cdd:cd05312 162 LFAS G spfppveyng KTYV P G Q G NN AYI FP G I GL GA ILS GA RH I TD EM FL AA AE A L A S L VTD E ELA -------- R G RLY - 232
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 498484236 378 adyii P RPFDP R L I - VR IA P AVAK A A M E S G V ATR -- P IT D W E A Y 418
Cdd:cd05312 233 ----- P PLSNI R E I s AQ IA V AVAK Y A Y E E G L ATR yp P PE D L E E Y 271
PLN03129
PLN03129 NADP-dependent malic enzyme; Provisional
69-422
3.91e-32
NADP-dependent malic enzyme; Provisional
Pssm-ID: 215594 [Multi-domain]
Cd Length: 581
Bit Score: 132.34
E-value: 3.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 69 V A V ISN G TAV LGLG NI G ALA - G K PV me GK GV L FKKFA GI D ------- VF D IEI N EK ---- DP ---------------- E K 120
Cdd:PLN03129 174 V I V VTD G ERI LGLG DL G VQG m G I PV -- GK LD L YTAAG GI R psavlpv CI D VGT N NE klln DP fyiglrqprltgeeyd E L 251
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 121 LV E IIASLEPTF G G --- INL ED IKAPEC F YIE Q KL R E rl NIPV F H DD QH GTA IISA A AVIN ALR IVDKKIEEV R LVAS GA 197
Cdd:PLN03129 252 VD E FMEAVKQRW G P kvl VQF ED FANKNA F RLL Q RY R T -- THLC F N DD IQ GTA AVAL A GLLA ALR ATGGDLADQ R ILFA GA 329
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 198 G A A SIACLN L LVSLGMK --------- R EN I VVC DSKG VIY K D R D D RMDDT KK HY A I D DNGWRT L GD A M ---- P na DIFL G 264
Cdd:PLN03129 330 G E A GTGIAE L IALAMSR qtgiseeea R KR I WLV DSKG LVT K S R K D SLQPF KK PF A H D HEPGAS L LE A V kaik P -- TVLI G 407
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 265 C S AA G - AL T QDMVRT MA AH --- PII L AL A NP -- NP E I T PP EA - KAARPD AI VCT ---------- G RSDY P N Q V NN VLC FP 327
Cdd:PLN03129 408 L S GV G g TF T KEVLEA MA SL ner PII F AL S NP ts KA E C T AE EA y TWTGGR AI FAS gspfdpveyn G KTFH P G Q A NN AYI FP 487
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 328 F I FR GAL DV GA TTINEE M KR AA VY A I A DLALA E QNEV vtsayggegttf GA D Y ii P RPFDP R L I - VRI A P AVA KA A M E S G 406
Cdd:PLN03129 488 G I GL GAL LS GA IRVTDD M LL AA AE A L A AQVTE E ELAK ------------ GA I Y -- P PFSRI R D I s AHV A A AVA AK A Y E E G 553
410
....*....|....*...
gi 498484236 407 V ATR P -- IT D WEA Y H E KL 422
Cdd:PLN03129 554 L ATR L pr PE D LVE Y A E SC 571
PTZ00317
PTZ00317 NADP-dependent malic enzyme; Provisional
37-410
3.09e-31
NADP-dependent malic enzyme; Provisional
Pssm-ID: 240357 [Multi-domain]
Cd Length: 559
Bit Score: 129.36
E-value: 3.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 37 L ALA Y S P G V A E P C LEI ---- EK D PAAAYRYTS KG NL ------------- V A VI SN G TAV LGLG NI GA l A G KPVME GK GV L 99
Cdd:PTZ00317 102 L PII Y T P T V G E A C QNY snlf QR D RGLYLSRAH KG KI reilknwpydnvd V I VI TD G SRI LGLG DL GA - N G MGISI GK LS L 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 100 FKKFA GI D ------- V F D IEI N E ----------------- K D P E ------ KLV E IIA S LE P T f GGINL ED IKAPE CF YIE 149
Cdd:PTZ00317 181 YVAGG GI N psrvlpv V L D VGT N N ekllndplylglrekrl D D D E yyelld EFM E AVS S RW P N - AVVQF ED FSNNH CF DLL 259
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 150 QKLRER ln IPV F H DD QH GT AIIS AA AVI NAL RIVDKKI EE V R L V AS GAG A A S I ACL N LLVS L ---- G MK RE ---- NIVVC 221
Cdd:PTZ00317 260 ERYQNK -- YRC F N DD IQ GT GAVI AA GFL NAL KLSGVPP EE Q R I V FF GAG S A A I GVA N NIAD L aaey G VT RE ealk SFYLV 337
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 222 DSKG VIYKD R D D RMDDT K KHY A ----- ID D NGWR TL G D AMPNA -- DIF LG C S A - A G AL T QDM V R TMA A --- H PII LA L A N 290
Cdd:PTZ00317 338 DSKG LVTTT R G D KLAKH K VPF A rtdis AE D SSLK TL E D VVRFV kp TAL LG L S G v G G VF T EEV V K TMA S nve R PII FP L S N 417
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 291 P -- NP E I T PPE A - K AARPD AIV CT G ---------- RSDY P N Q V NN VLC FP FIFR G ALDVGATT I NE EM KR AA VYAI A D L A 357
Cdd:PTZ00317 418 P ts KA E C T AED A y K WTNGR AIV AS G spfppvtlng KTIQ P S Q G NN LYV FP GVGL G CAIAQPSY I PD EM LI AA AASL A T L V 497
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 498484236 358 LA E QNEV vtsayg G E gttfgady II P RPF D P R L I - VR IA PA V AKA A M E S G V A TR 410
Cdd:PTZ00317 498 SE E DLRE ------ G K -------- LY P PLE D I R E I s AH IA VD V IEE A Q E M G I A KN 537
PRK13529
PRK13529 oxaloacetate-decarboxylating malate dehydrogenase;
69-417
7.11e-28
oxaloacetate-decarboxylating malate dehydrogenase;
Pssm-ID: 237414 [Multi-domain]
Cd Length: 563
Bit Score: 119.08
E-value: 7.11e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 69 VA V ISN G TAV LG L G NI G ALA - G K P V me GK GV L FKKFA GID ------- V F D IEI N EK ---- DP ------------------ 118
Cdd:PRK13529 149 LI V VTD G ERI LG I G DQ G IGG m G I P I -- GK LS L YTACG GID partlpv V L D VGT N NE qlln DP lylgwrhprirgeeydef 226
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 119 - EKL V EIIASLE P tfggi N L ---- ED IKAPECFY I EQKL R ER ln I PV F H DD QH GT AIISA A AVIN AL R I VDKKIEEV R L V 193
Cdd:PRK13529 227 v DEF V QAVKRRF P ----- N A llqf ED FAQKNARR I LERY R DE -- I CT F N DD IQ GT GAVTL A GLLA AL K I TGEPLSDQ R I V 299
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 194 asgagaasia C L ---------- NLL V S l G M K RE --------- NIVVC D SK G VIYK D RD D r MD D TK K H YA IDD --- NG W R T 251
Cdd:PRK13529 300 ---------- F L gagsagcgia DQI V A - A M V RE glseeeark RFFMV D RQ G LLTD D MP D - LL D FQ K P YA RKR eel AD W D T 367
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 252 L GD AMPNAD -------- IFL G C S A - A GA L T QDM V RT MAAH --- PII LA L A NP NPEI tpp EA KAA rp D -------- A I V C T 311
Cdd:PRK13529 368 E GD VISLLE vvrnvkpt VLI G V S G q P GA F T EEI V KE MAAH cer PII FP L S NP TSRA --- EA TPE -- D liawtdgr A L V A T 442
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 312 G ---------- RSDYPN Q V NN VLC FP FIFR G ALDV GA TTINEE M KR AA VY A I AD LALAEQN evvtsayggegttf G ADYI 381
Cdd:PRK13529 443 G spfapveyng KTYPIG Q C NN AYI FP GLGL G VIAS GA RRVTDG M LM AA AH A L AD CVPLAKP -------------- G EGAL 508
410 420 430
....*....|....*....|....*....|....*...
gi 498484236 382 I P RPF D P R LI - VR IA P AVAKAA M E S G V A TRP - IT D W E A 417
Cdd:PRK13529 509 L P PVE D I R EV s RA IA I AVAKAA I E E G L A RET s DE D L E Q 546
Malic_M
pfam03949 Malic enzyme, NAD binding domain;
167-402
1.43e-26
Malic enzyme, NAD binding domain;
Pssm-ID: 427608 [Multi-domain]
Cd Length: 257
Bit Score: 109.59
E-value: 1.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 167 GTA IISA A AVIN AL R I VD K KIE E V R L V AS GAG A A S I ACLNLLVS l G M K RE --------- N I VVC D SK G VIYK DR D D r MD D 237
Cdd:pfam03949 3 GTA AVAL A GLLA AL K I TG K PLS E Q R I V FF GAG S A G I GIADQIRD - A M V RE glseeeark R I WMV D RQ G LLTD DR E D - LT D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 238 TK K HY A ------ IDDNGWR TL GDAMPNA -- DIFL G C S A - A GA L T QDM VR T MAAH --- PII LA L A NP NP -- E I TP PE A - K A 302
Cdd:pfam03949 81 FQ K PF A rkrael KGWGDGI TL LEVVRKV kp TVLI G A S G v P GA F T EEI VR A MAAH ter PII FP L S NP TS ka E A TP ED A y K W 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 303 ARPD A IVC TG ---------- RSDYPN Q V NN VLC FP FIFR GA LDVG A TT I NE EM KR AA VY A I A DLALA E QN evvtsayg G E 372
Cdd:pfam03949 161 TDGR A LFA TG spfppveyng KTYHIG Q G NN AYI FP GLGL GA IVSR A RR I TD EM FL AA AE A L A SYVDE E EP -------- G Q 232
250 260 270
....*....|....*....|....*....|.
gi 498484236 373 G T tfgady II P RPF D P R LI - VR IA P AVAK A A 402
Cdd:pfam03949 233 G R ------ LL P PLS D I R EV s RK IA V AVAK Y A 257
NAD_bind_malic_enz
cd00762 NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid ...
165-402
6.34e-22
NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133442
Cd Length: 254
Bit Score: 95.75
E-value: 6.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 165 QH GTA IISA A AVIN AL RIVD KKI E E VRLVAS GAGAA SIACL NL L V S L GM K R -------- EN I VVC D S KG VIY K D R DD r MD 236
Cdd:cd00762 1 IQ GTA SVAV A GLLA AL KVTK KKI S E HKVLFN GAGAA ALGIA NL I V * L *V K E giskeeac KR I W*V D R KG LLV K N R KE - TC 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 237 DTKK H Y A IDD N GW R --- T L G DA M -- PNA D IFL G C S AA G - A L T QDMV R TM A A --- H P I I L AL A NP NP -- E I T PP EA - K A AR 304
Cdd:cd00762 80 PNEY H L A RFA N PE R esg D L E DA V ea AKP D FLI G V S RV G g A F T PEVI R A* A E ine R P V I F AL S NP TS ka E C T AE EA y T A TE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 305 PD AI VCT G RSD ---------- Y P N Q V NN VLC FP FIFR G ALDVGATT I NEEMKRA A VY AIA dlalaeqn EV VT SAYGGE G T 374
Cdd:cd00762 160 GR AI FAS G SPF hpvelnggty K P G Q G NN LYI FP GVAL G VILCRIRH I TDDVFLS A AE AIA -------- SS VT EESLKP G R 231
250 260
....*....|....*....|....*....
gi 498484236 375 tfgady II P RP FD PRLI - VR IA P AVAK A A 402
Cdd:cd00762 232 ------ LY P PL FD IQEV s LN IA V AVAK Y A 254
PRK05805
PRK05805 phosphate butyryltransferase; Validated
436-726
8.41e-10
phosphate butyryltransferase; Validated
Pssm-ID: 180267
Cd Length: 301
Bit Score: 60.88
E-value: 8.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 436 I F S Q AK A - EK K R I VL A EGEEDK VL H A TQ E VVSM G L A YPV L I G RT E I IK AKI K KLGLHI vag Q DF DV ID nehnsqhdelwk 514
Cdd:PRK05805 8 I L S K AK E q PP K T I SV A VAQDEP VL E A VK E AKEL G I A NAI L V G DK E K IK EIA K EIDMDL --- E DF EI ID ------------ 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 515 ryysimk R K GITE A IA K rvvtsnttvi A SL LV EM G Y AD GLVC GL FG T y SRH L E A IRDI - IG VKES v K VPAALNSLVL P TG 593
Cdd:PRK05805 73 ------- E K DNRK A AL K ---------- A VE LV SS G K AD MVMK GL VD T - ANF L R A VLNK e IG LRTG - K TMSHVAVFEV P KY 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 594 N -- V F I TD TYV N AD P TAE E LAE I TLM A AREIRRF GIE - P A VA LLSHSNFGSSN M --- L G A PKMR K VLE iv R ERDPALMI D 667
Cdd:PRK05805 134 D rl L F L TD AAF N IA P DLK E KID I INN A VTVAHAI GIE n P K VA PICAVEVVNPK M pat L D A ALLS K MSD -- R GQIKGCIV D 211
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 498484236 668 G EMHG D L ALSE KLRRDYMP D S P LK G S A NL L IM PN M EA ARIS Y NL L RATTTA ---- IT VG --- P IL L 726
Cdd:PRK05805 212 G PLAL D N ALSE EAAKHKGI D G P VA G N A DI L LV PN I EA GNVM Y KT L TYFADC kngg LL VG tsa P VV L 277
PRK11890
PRK11890 phosphate acetyltransferase; Provisional
458-704
2.97e-04
phosphate acetyltransferase; Provisional
Pssm-ID: 183361
Cd Length: 312
Bit Score: 43.44
E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 458 L HATQ E VVSM GL AY P V L I G RTEI I K A KIKKL GL HI vag QDFDVI D NE H nsqhdelwkryysimkrkgi TE A I A KRV V T sn 537
Cdd:PRK11890 36 L RGAV E AAQL GL IT P I L V G PRAR I E A VAAEC GL DL --- SGYEIV D AP H -------------------- SH A A A AKA V E -- 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 538 ttviasl LV EM G Y A DG L VC G LFG T YSRHLEAIRDII G VKES -------- VK VP AALNS L vlptgnv F ITD TY VN AD PT A E 609
Cdd:PRK11890 91 ------- LV RE G E A EA L MK G SLH T DELMSAVVARDT G LRTE rrishvfv MD VP GYPKP L ------- I ITD AA VN IA PT L E 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498484236 610 EL A E I TLM A AREIRRF G I - EP A VA L LS HSNFGSSNM --- L G A PKMR K VLE iv R ERDPALMI DG EMHG D L A L S EKLR R DYM 685
Cdd:PRK11890 157 DK A D I VQN A IDLAHAL G F d EP R VA I LS AVETVNPKI pst L D A AALC K MAD -- R GQITGAIL DG PLAF D N A I S PEAA R IKG 234
250
....*....|....*....
gi 498484236 686 PD SP LK G S A NL L IM P NM EA 704
Cdd:PRK11890 235 IV SP VA G D A DI L VV P DL EA 253
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
