|
Name |
Accession |
Description |
Interval |
E-value |
| BglG |
COG3711 |
Transcriptional antiterminator [Transcription]; |
24-649 |
2.38e-79 |
|
Transcriptional antiterminator [Transcription];
Pssm-ID: 442925 [Multi-domain] Cd Length: 618 Bit Score: 264.41 E-value: 2.38e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 24 QITDLSQRELVTQLSAIGGEVQQNTVSI-----------PSLSANEWGKQLFQQRQAIYSEAERQALIFLLTYSEIEELS 92
Cdd:COG3711 19 KKLNVSERTIRYDIKKINEWLKKNGLEIiskkgigfrldIDDEQKEKLLQLLEKSEDPLSPKERVAYILLRLLLAGDPIS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 93 VYHYQNFLDVSKGTILADIKKVRHQLATENIALSYERKRGFYLEGDEFRIRRFGKNWLARLLQQKSGTFALFcwLSQHQM 172
Cdd:COG3711 99 LDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLSELLSENDLLSLLL--LKLIPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 173 SQYAKMRDGIQLAVQEAQLQLVPSRLDEISYFLAFSQKRL--GKYKTVVWPENQLIQSLRAYPVSRRILSDL--VGPVAN 248
Cdd:COG3711 177 EDLELIEEIIEEAEKKLGIKLSDSIYINLTDHIAIAIKRIkkGKYIKLDNPLLWEIKKPKEYEIAKEILKLIeeRLGISL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 249 IETESLFFTICLMTALQG---ELRDTKLEFLLDISGEIIRKMELLAVVQFEQPRELLMNVYYHLVPAYFRINYGFYLPNV 325
Cdd:COG3711 257 PEDEIGYIALHLLGARLNndnELSEIITLEITKLIKEIINIIEEELGIDLDEDSLLYERLITHLKPAINRLKYGIPIRNP 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 326 LIKDIRQSYRSLYHLCEQALAPLEKLTKRSIPSEEIGFFTILFGGEIfgqKNEQRQEKLKALIVCPSGISSSLILQSELR 405
Cdd:COG3711 337 LLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHFGAAL---ERQKESKKKRVLVVCSSGIGTSRLLKSRLK 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 406 RLFPMIEFKETNAVREIENVSEKSYDIIFSTVPIETaKKVYLTKPIMSSLEKNQLMHQVQsdwllpgismpdvkdildal 485
Cdd:COG3711 414 KLFPEIEIIDVISYRELEEIDLEDYDLIISTVPLED-KPVIVVSPLLTEEDIEKIRKFLK-------------------- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 486 kpyislkkgvteaqlyrvlhrKMNKILEKEEDLRPMLSELLTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAM 565
Cdd:COG3711 473 ---------------------QIKKKLAKILFELLLLLLLLEEKEIIILLLLLLIEEALAADAIEELEEEEIEEELEEII 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 566 IQKVESFGPFIHICPDVALPHARPEDGVNQLGMSLLKIQKSVDLLEDPKHEIHLFICLAASDNETHLRALSSLTKILSKK 645
Cdd:COG3711 532 IIIVIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDDEALLVILLLLLLLIESSLLLLLLLELLLELELE 611
|
....
gi 498517651 646 ESLH 649
Cdd:COG3711 612 LLIL 615
|
|
| PTS_IIA_fru |
cd00211 |
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ... |
526-664 |
7.80e-29 |
|
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.
Pssm-ID: 238129 [Multi-domain] Cd Length: 136 Bit Score: 111.88 E-value: 7.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 526 LTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKvESFGPFIhICPDVALPHARPEDgVNQLGMSLLKIQK 605
Cdd:cd00211 1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLER-EKEGSTG-IGNGIAIPHAKSEA-VKKPGIAVLRLKE 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 498517651 606 SVDLLEDPKHEIHLFICLAASDNETHLRALSSLTKILSKKESLHRLVAAETVPEILSII 664
Cdd:cd00211 78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
|
|
| PTS_EIIA_2 |
pfam00359 |
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; |
525-665 |
4.37e-28 |
|
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
Pssm-ID: 459780 [Multi-domain] Cd Length: 139 Bit Score: 109.60 E-value: 4.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 525 LLTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFIHICpdVALPHARPEDgVNQLGMSLLKIQ 604
Cdd:pfam00359 1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGNG--IAIPHARSEA-VKKPGIAVLTLK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498517651 605 KSVDLLEDPKHEIHLFICLAASDNE-THLRALSSLTKILSKKESLHRLVAAETVPEILSIIQ 665
Cdd:pfam00359 78 EPVDFGSEDGKPVKLIFLLAAPDNEaSHLKILSQLARLLQDEEFVEKLLKAKDPEEILEILK 139
|
|
| cmtB |
PRK09854 |
PTS mannitol transporter subunit IIA; |
530-667 |
1.49e-21 |
|
PTS mannitol transporter subunit IIA;
Pssm-ID: 182114 [Multi-domain] Cd Length: 147 Bit Score: 91.21 E-value: 1.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 530 TVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFIHICPDVALPHARPEDGVNQLGMSLLKIQKSVDL 609
Cdd:PRK09854 11 SISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGVYF 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 610 L--EDPkheIHLFICLAASDNETHLRALSSLTKILSKKESLHRLVAAETVPEILSIIQEG 667
Cdd:PRK09854 91 PgnDEP---IKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISRG 147
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BglG |
COG3711 |
Transcriptional antiterminator [Transcription]; |
24-649 |
2.38e-79 |
|
Transcriptional antiterminator [Transcription];
Pssm-ID: 442925 [Multi-domain] Cd Length: 618 Bit Score: 264.41 E-value: 2.38e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 24 QITDLSQRELVTQLSAIGGEVQQNTVSI-----------PSLSANEWGKQLFQQRQAIYSEAERQALIFLLTYSEIEELS 92
Cdd:COG3711 19 KKLNVSERTIRYDIKKINEWLKKNGLEIiskkgigfrldIDDEQKEKLLQLLEKSEDPLSPKERVAYILLRLLLAGDPIS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 93 VYHYQNFLDVSKGTILADIKKVRHQLATENIALSYERKRGFYLEGDEFRIRRFGKNWLARLLQQKSGTFALFcwLSQHQM 172
Cdd:COG3711 99 LDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLSELLSENDLLSLLL--LKLIPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 173 SQYAKMRDGIQLAVQEAQLQLVPSRLDEISYFLAFSQKRL--GKYKTVVWPENQLIQSLRAYPVSRRILSDL--VGPVAN 248
Cdd:COG3711 177 EDLELIEEIIEEAEKKLGIKLSDSIYINLTDHIAIAIKRIkkGKYIKLDNPLLWEIKKPKEYEIAKEILKLIeeRLGISL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 249 IETESLFFTICLMTALQG---ELRDTKLEFLLDISGEIIRKMELLAVVQFEQPRELLMNVYYHLVPAYFRINYGFYLPNV 325
Cdd:COG3711 257 PEDEIGYIALHLLGARLNndnELSEIITLEITKLIKEIINIIEEELGIDLDEDSLLYERLITHLKPAINRLKYGIPIRNP 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 326 LIKDIRQSYRSLYHLCEQALAPLEKLTKRSIPSEEIGFFTILFGGEIfgqKNEQRQEKLKALIVCPSGISSSLILQSELR 405
Cdd:COG3711 337 LLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHFGAAL---ERQKESKKKRVLVVCSSGIGTSRLLKSRLK 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 406 RLFPMIEFKETNAVREIENVSEKSYDIIFSTVPIETaKKVYLTKPIMSSLEKNQLMHQVQsdwllpgismpdvkdildal 485
Cdd:COG3711 414 KLFPEIEIIDVISYRELEEIDLEDYDLIISTVPLED-KPVIVVSPLLTEEDIEKIRKFLK-------------------- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 486 kpyislkkgvteaqlyrvlhrKMNKILEKEEDLRPMLSELLTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAM 565
Cdd:COG3711 473 ---------------------QIKKKLAKILFELLLLLLLLEEKEIIILLLLLLIEEALAADAIEELEEEEIEEELEEII 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 566 IQKVESFGPFIHICPDVALPHARPEDGVNQLGMSLLKIQKSVDLLEDPKHEIHLFICLAASDNETHLRALSSLTKILSKK 645
Cdd:COG3711 532 IIIVIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDDEALLVILLLLLLLIESSLLLLLLLELLLELELE 611
|
....
gi 498517651 646 ESLH 649
Cdd:COG3711 612 LLIL 615
|
|
| PtsN |
COG1762 |
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ... |
520-668 |
1.71e-31 |
|
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 441368 [Multi-domain] Cd Length: 150 Bit Score: 119.57 E-value: 1.71e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 520 PMLSELLTTETVQVLPEVADWRAGITEAAKPLLKNGSI--TEKYIDAMIQKVESFGPFIHicPDVALPHARPEdGVNQLG 597
Cdd:COG1762 1 MMLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVldKEEYLEALLEREELGSTGIG--PGIAIPHARPE-GVKKPG 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498517651 598 MSLLKIQKSVDLLEDPKHEIHLFICLAA--SDNETHLRALSSLTKILSKKESLHRLVAAETVPEILSIIQEGE 668
Cdd:COG1762 78 IAVARLKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEAE 150
|
|
| PTS_IIA_fru |
cd00211 |
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ... |
526-664 |
7.80e-29 |
|
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.
Pssm-ID: 238129 [Multi-domain] Cd Length: 136 Bit Score: 111.88 E-value: 7.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 526 LTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKvESFGPFIhICPDVALPHARPEDgVNQLGMSLLKIQK 605
Cdd:cd00211 1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLER-EKEGSTG-IGNGIAIPHAKSEA-VKKPGIAVLRLKE 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 498517651 606 SVDLLEDPKHEIHLFICLAASDNETHLRALSSLTKILSKKESLHRLVAAETVPEILSII 664
Cdd:cd00211 78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
|
|
| PTS_EIIA_2 |
pfam00359 |
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; |
525-665 |
4.37e-28 |
|
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
Pssm-ID: 459780 [Multi-domain] Cd Length: 139 Bit Score: 109.60 E-value: 4.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 525 LLTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFIHICpdVALPHARPEDgVNQLGMSLLKIQ 604
Cdd:pfam00359 1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGNG--IAIPHARSEA-VKKPGIAVLTLK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498517651 605 KSVDLLEDPKHEIHLFICLAASDNE-THLRALSSLTKILSKKESLHRLVAAETVPEILSIIQ 665
Cdd:pfam00359 78 EPVDFGSEDGKPVKLIFLLAAPDNEaSHLKILSQLARLLQDEEFVEKLLKAKDPEEILEILK 139
|
|
| PTS_IIB_bgl_like |
cd05568 |
PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory ... |
384-467 |
2.42e-23 |
|
PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved in sugar utilization. The domain architecture of the IIB-containing protein includes a region N-terminal to the IIB domain which is homologous to the BglG transcription antiterminator with an RNA-binding domain followed by two homologous domains, PRD1 and PRD2 (PTS Regulation Domains). C-terminal to the IIB domain is a domain similar to the PTS IIA domain. In this system, the BglG-like region and the IIB and IIA-like domains are all expressed together as a single multidomain protein. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include this sensory system with similarity to the bacterial bgl system, chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, and fructose systems.
Pssm-ID: 99910 Cd Length: 85 Bit Score: 94.11 E-value: 2.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 384 LKALIVCPSGISSSLILQSELRRLFPMIEFKETNAVREIENVSEKSYDIIFSTVPIE-TAKKVYLTKPIMSSLEKNQLMH 462
Cdd:cd05568 1 KKALVVCPSGIGTSRLLKSKLKKLFPEIEIIDVISLRELEEVDLDDYDLIISTVPLEdTDKPVIVVSPILTEEDIKKIRK 80
|
....*
gi 498517651 463 QVQSD 467
Cdd:cd05568 81 FIKKL 85
|
|
| cmtB |
PRK09854 |
PTS mannitol transporter subunit IIA; |
530-667 |
1.49e-21 |
|
PTS mannitol transporter subunit IIA;
Pssm-ID: 182114 [Multi-domain] Cd Length: 147 Bit Score: 91.21 E-value: 1.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 530 TVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFIHICPDVALPHARPEDGVNQLGMSLLKIQKSVDL 609
Cdd:PRK09854 11 SISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGVYF 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 610 L--EDPkheIHLFICLAASDNETHLRALSSLTKILSKKESLHRLVAAETVPEILSIIQEG 667
Cdd:PRK09854 91 PgnDEP---IKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISRG 147
|
|
| MtlA2 |
COG4668 |
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ... |
523-668 |
2.09e-18 |
|
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];
Pssm-ID: 443705 [Multi-domain] Cd Length: 143 Bit Score: 82.13 E-value: 2.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 523 SELLTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFI--HIcpdvALPHARPE--DGVNQLGM 598
Cdd:COG4668 1 MLILTKENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTYLgnGI----AIPHGTNEakDLVLKTGI 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 599 SLLKIQKSVDLLEDpkHEIHLFICLAASDNEtHLRALSSLTKILSKKESLHRLVAAETVPEILSIIQEGE 668
Cdd:COG4668 77 SVLQFPDGVDWGDG--NTVYLVIGIAAKSDE-HLEILRQLARVLSDEENVEKLAKATDAEEILALLTGEN 143
|
|
| PRK10372 |
PRK10372 |
PTS ascorbate transporter subunit IIA; |
518-664 |
6.34e-18 |
|
PTS ascorbate transporter subunit IIA;
Pssm-ID: 182417 [Multi-domain] Cd Length: 154 Bit Score: 81.17 E-value: 6.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 518 LRPMLSElltTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFIHICPDVALPHARPEDGVNQLG 597
Cdd:PRK10372 3 LRDSLAE---NKSIRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 498517651 598 MSLLKIQKSVDLLEDPKHEIHLFICLAASDNETHLR-ALSSLTKILSKKESLHRLVAAETVPEILSII 664
Cdd:PRK10372 80 FALVTLKKPLEFNHEDNDPVDILITMAAVDANTHQEvGIMQIVNLFEDEANFDRLRACRTEQEVLDLI 147
|
|
| PRD |
pfam00874 |
PRD domain; The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory ... |
282-370 |
9.14e-15 |
|
PRD domain; The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterized by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators pfam03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99) and inactive state (pdb:1tlv), revealing massive structural rearrangements upon activation.
Pssm-ID: 459973 [Multi-domain] Cd Length: 90 Bit Score: 69.97 E-value: 9.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 282 EIIRKMELLAVVQFEQpRELLMNVYYHLVPAYFRINYGFYLPNVLIKDIRQSYRSLYHLCEQALAPLEKLTKRSIPSEEI 361
Cdd:pfam00874 2 EIIELIEKKLGITFDD-DILYIRLILHLAFAIERIKEGITIENPLLEEIKEKYPKEFEIAKKILEILEEELGIELPEDEI 80
|
....*....
gi 498517651 362 GFFTILFGG 370
Cdd:pfam00874 81 GYIALHFLS 89
|
|
| PTS_IIB |
cd00133 |
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the ... |
385-464 |
1.09e-13 |
|
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system. The PTS is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, polyols, amino sugars, and other sugar derivatives. The four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB), can phosphorylate or interact with numerous non-PTS proteins thereby regulating their activity.
Pssm-ID: 99904 Cd Length: 84 Bit Score: 66.90 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 385 KALIVCPSGISSSLILQSELRRLFPMIEFKETNAVREIENV-SEKSYDIIFSTVPI---ETAKKVYLTKPIMSSLEKNQL 460
Cdd:cd00133 1 KILVVCGSGIGSSSMLAEKLEKAAKELGIEVKVEAQGLSEViDLADADLIISTVPLaarFLGKPVIVVSPLLNEKDGEKI 80
|
....
gi 498517651 461 MHQV 464
Cdd:cd00133 81 LEKL 84
|
|
| PRK15083 |
PRK15083 |
PTS system mannitol-specific transporter subunit IICBA; Provisional |
544-664 |
1.47e-04 |
|
PTS system mannitol-specific transporter subunit IICBA; Provisional
Pssm-ID: 237905 [Multi-domain] Cd Length: 639 Bit Score: 45.04 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 544 ITEAAKPLLKNGSITEKYIDAMIQKvESFGPfIHICPDVALPHARPE--DGVNQLGMSLLKIQKSVDLLEDPKHEIHLFI 621
Cdd:PRK15083 515 IRFAGEQLVKGGYVEPEYVDAMLDR-EKLTS-TYLGESIAVPHGTVEakDRVLKTGVVFCQYPEGVRFGEEEDDIARLVI 592
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 498517651 622 CLAASDNEtHLRALSSLTKILSKKESLHRLVAAETVPEILSII 664
Cdd:PRK15083 593 GIAARNNE-HIQVITSLTNALDDESVIERLAHTTSVDEVLELL 634
|
|
| PRK11109 |
PRK11109 |
fused PTS fructose transporter subunit IIA/HPr protein; |
521-669 |
9.10e-04 |
|
fused PTS fructose transporter subunit IIA/HPr protein;
Pssm-ID: 236849 [Multi-domain] Cd Length: 375 Bit Score: 42.24 E-value: 9.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 521 MLSelLTTETVQVLPEVADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPFIHicPDVALPHARPE--DGVNQLGM 598
Cdd:PRK11109 1 MFQ--LSVQDIHLGQQAGNKEEAIRQVAAALTQAGNVAEGYVDGMLAREQQTSTFLG--NGIAIPHGTTDtrDLVLKTGV 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498517651 599 SLLKIQKSVDLLEDpkHEIHLFICLAASDNEtHLRALSSLTKILSKKESLHRLVAAETVPEILSIIQeGEK 669
Cdd:PRK11109 77 QVFQFPQGVTWGDG--QTAYVAIGIAAKSDE-HLGLLRQLTHVLSDDSVAEQLKSATTAEELRALLM-GEK 143
|
|
| LevR |
COG3933 |
Transcriptional regulatory protein LevR, contains PRD, AAA+ and EIIA domains [Transcription]; |
304-390 |
1.16e-03 |
|
Transcriptional regulatory protein LevR, contains PRD, AAA+ and EIIA domains [Transcription];
Pssm-ID: 443134 [Multi-domain] Cd Length: 916 Bit Score: 42.41 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 304 NVYY----HLVPAYFRINYGFYLPNVLIKDIRQSYRSLYHLCEQALAPLEKLTKRSIPSEEIGFFTILFggeIFGQKNEQ 379
Cdd:COG3933 479 NFIYalslHLSSFIERIKEGKEIINPNLNEIKKKYPKEFKVAKEIKELIEQELDIEIPEDEVGFLTLFL---VSLNENNE 555
|
90
....*....|.
gi 498517651 380 rQEKLKALIVC 390
Cdd:COG3933 556 -SGKVGVIVLA 565
|
|
| PTS_IIB |
pfam02302 |
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ... |
385-440 |
3.92e-03 |
|
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.
Pssm-ID: 396744 Cd Length: 92 Bit Score: 36.93 E-value: 3.92e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 498517651 385 KALIVCPSGISSSLILQSELRRLFP---MIEFKETNAVREIEN-VSEKSYDIIFSTVPIE 440
Cdd:pfam02302 1 KILTACGAGMATSLMAAEALEKAAKelgIVEAQGAAGVNELTAeDIADDADVVILAPDVA 60
|
|
| |
