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Conserved domains on  [gi|499214951|ref|WP_010912491|]
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helix-turn-helix domain-containing protein [Mesorhizobium japonicum]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
8-106 2.23e-33

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 111.88  E-value: 2.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499214951   8 YGCPVEFALDALGGKWKTVIIARIKQGPLRYSELRRMIPSLSDKMLTQRLADLVEIGFVVLETSPDGKGR--YALTERGQ 85
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRveYSLTEKGR 87

                         90       100
                 ....*....|....*....|.
gi 499214951  86 DLAAALQALYDWGSVHGRAEG 106
Cdd:COG1733   88 SLLPVLDALAEWGEEHLPEIE 108
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
8-106 2.23e-33

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 111.88  E-value: 2.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499214951   8 YGCPVEFALDALGGKWKTVIIARIKQGPLRYSELRRMIPSLSDKMLTQRLADLVEIGFVVLETSPDGKGR--YALTERGQ 85
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRveYSLTEKGR 87

                         90       100
                 ....*....|....*....|.
gi 499214951  86 DLAAALQALYDWGSVHGRAEG 106
Cdd:COG1733   88 SLLPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 19-105 7.99e-23

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 84.66  E-value: 7.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499214951   19 LGGKWKTVIIARIKQGPLRYSELRRMIPSLSDKMLTQRLADLVEIGFVVLETSPDGKGR--YALTERGQDLAAALQALYD 96
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKveYSLTEKGRSLEPILQELCD 81


                  ....*....
gi 499214951   97 WGSVHGRAE 105
Cdd:pfam01638  82 WGEEYLEPE 90
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
8-106 2.23e-33

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 111.88  E-value: 2.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499214951   8 YGCPVEFALDALGGKWKTVIIARIKQGPLRYSELRRMIPSLSDKMLTQRLADLVEIGFVVLETSPDGKGR--YALTERGQ 85
Cdd:COG1733    8 ADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRveYSLTEKGR 87

                         90       100
                 ....*....|....*....|.
gi 499214951  86 DLAAALQALYDWGSVHGRAEG 106
Cdd:COG1733   88 SLLPVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 19-105 7.99e-23

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 84.66  E-value: 7.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499214951   19 LGGKWKTVIIARIKQGPLRYSELRRMIPSLSDKMLTQRLADLVEIGFVVLETSPDGKGR--YALTERGQDLAAALQALYD 96
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKveYSLTEKGRSLEPILQELCD 81


                  ....*....
gi 499214951   97 WGSVHGRAE 105
Cdd:pfam01638  82 WGEEYLEPE 90
DUF4364 pfam14277
Domain of unknown function (DUF4364); This family of proteins is found in bacteria and archaea. ...
 27-84 4.04e-03

Domain of unknown function (DUF4364); This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 180 amino acids in length.


Pssm-ID: 464122  Cd Length: 162  Bit Score: 34.77  E-value: 4.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 499214951   27 IIARIKQgPLRYSELRRMIpsLSDK-----MLTQRLADLVEIGFVVLETSpDGKGRYALTERG 84
Cdd:pfam14277   8 ILNKVDF-PLTNSQISDFI--LENGytnyfDLQQALSELVESGLITEETT-DNNTYYSITEKG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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